Graduate Student Seminar Series – Dianoosh Kalhory

Graduate Student Seminar Series
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Location: MS2158 – 1 King’s College Circle
Presentation Title: In Vitro Model for Screening RNA/Drug Delivery by Lipid Nanoparticles for Treatment of Lung Diseases
Abstract:
The goal of my research is to create a medium- or high-throughput LOC model for screening RNA-based drugs encapsulated in LNPs by using a bioprinting-on-chip technique. To reach this goal, my thesis will be structured around three specific aims that will develop into a MF platform for in vitro lung disease modeling and screening RNA-based drugs for the treatment of lung diseases.
Aim 1: Formation of a gel-embedded bi-layer lung epithelial cells and microvascular endothelial cells at the air-liquid interface
Aim 2: Design, fabrication, and development of a lung-on-chip platform
Aim 3: Encapsulation of micro-ribonucleic acids in lipid nanoparticles and their delivery to lung cells
Supervisor Name: Eugenia Kumacheva & Gilbert Walker
Year of Study: 2
Program of Study: PhD
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