Graduate Student Seminar Series – Muhammad Shan Sohail

Graduate Student Seminar Series
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Location: 2nd Floor Auditorium (TRI/KITE) – 550 University Ave
Presentation Title: Opto-DBS multimodal neural manipulation approaches to address Parkinson’s disease
Abstract:
Parkinson’s disease (PD) is a debilitating neurodegenerative movement disorder that impairs a patient’s ability to initiate and control movement. Deep brain stimulation (DBS) of the subthalamic nucleus (STN), delivered at high frequency (~130 Hz), is an established and effective therapy for alleviating motor symptoms. Despite its clinical success, DBS is associated with undesirable side effects and limited opportunities for rational optimization, largely because its underlying neural mechanisms remain poorly understood.
In our computational modeling and patient electrophysiology studies, we identified evoked resonant neural activity (ENRA) in the STN as a putative antiparkinsonian electrophysiological marker. Our analyses further suggest that ENRA originates from activity within the globus pallidus externus (GPe). However, to date, there is no direct experimental evidence establishing a causal link between GPe activity and STN ENRA during DBS.
My thesis addresses this gap using a multimodal approach in mice model integrating optogenetics, fiber photometry, single-unit electrophysiology, and DBS to test whether ERNA depends on GPe activity and mediates therapeutic effects.
Supervisor Name: Luka Milosevic
Year of Study: 3
Program of Study: PhD
Reschedule Reason: Updating location information
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