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Synthetic Extracellular Matrices: Bringing Viscoelasticity into the Game

July 15 @ 11:00 am - 12:00 pm EDT

|Recurring Event (See all)

One event on August 14, 2022 at 11:00 am

Date: Friday July 15, 2022

Time: 11:00am – 12:00pm

Location: Donnelly Centre

160 College Street, 2nd Floor, Red Seminar Room

 

Dr. Vianney Delplace, PhD

Institut national de la santé et de la recherche médicale (INSERM)

Abstract

In the booming fields of 3D cell culture and cell delivery, it is now commonly accepted that biomaterial scaffolds should ideally recapitulate the composition and mechanical properties of natural extracellular matrices. In particular, it is now admitted that viscoelasticity plays a key role on encapsulated cell functions. Yet, designing viscoelastic hydrogels with tunable properties remains a challenge. In this context, we developed a viscoelastic hydrogel platform based on a new dynamic covalent crosslinking strategy. The new viscoelastic gels advantageously combine ease of synthesis, cytocompatibility, long-term stability, and complete tunability in terms of composition and mechanics. More importantly, the dynamic nature of the crosslinking mechanism makes these gels injectable and self-healing, with a wide range of potential biomedical applications. In this talk, we will explore the use of these ultra-tunable viscoelastic hydrogels for two applications: a material-assisted cell therapy, and the design of innovative bioinks for 4D bioprinting. Come and see the magic in chemistry!

Biography

Vianney Delplace is a researcher in the INSERM research centre “Regenerative Medicine and Skeleton” (RMeS), in Nantes (France). Chemist by training, he completed a PhD in polymer science and nanomedicine at the Institut Galien Paris-Sud (France) in 2014. He then worked as a postdoctoral fellow at the University of Toronto, where he developed a variety of hydrogel-based systems for the investigation and treatment of degenerative diseases. His current work focuses on the design

of synthetic extracellular matrices for 3D cell culture, bioprinting and material-assisted cell therapy.

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