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DTSTART;TZID=America/Toronto:20230418T130000
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UID:41281-1681822800-1681826400@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Tian He\, Harvard University
DESCRIPTION:Illuminating Bioelectricity in the Brain\nDr. He Tian\,\nPostdoctoral Associate\, Harvard University\nThe brain encodes and processes information through the dynamic membrane voltage of neurons. However\, in vivo electrophysiology\, i.e.\, the study of the membrane voltage of individual cells in live animals\, has been a major challenge for neuroscience. In this seminar\, I will present voltage imaging\, an emerging technology using genetically encoded voltage indicators (GEVIs) to visualize the membrane voltage dynamics of cells. Voltage imaging can be combined with optogenetic stimulation to enable “all-optical electrophysiology”\, a technology that enabled cell membrane voltage to be simultaneously recorded and perturbed with light\, opening a path for high-throughput electrophysiology study in live animals. Thus far\, the performance of GEVIs has been a bottleneck for many applications. I will describe my directed evolution effort to improve a far-red GEVI. In order to optimize the transient voltage response of this biosensor\, I developed a novel video-based pooled screening platform that enabled thousands of genetic variants to be screened expeditiously. Using this platform\, I developed far-red GEVIs with improved signal-to-noise ratios and kinetics. Importantly\, this platform may be adapted for many types of genetic screens where optical readouts are required. I will discuss the application of these new GEVIs for tracking electric signal propagation within neurons. In particular\, I will demonstrate how to use voltage imaging and all-optical electrophysiology to understand neuron network dynamics in the live mouse brain. Together\, these molecular and optical tools will greatly expand our ability to decipher the brain. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-tian-he-harvard-university/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Tian-He-faculty-search.jpg
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UID:41310-1682082000-1682085600@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Freeman Lan
DESCRIPTION:Revolutionizing biological discovery through ultrahigh-throughput experimentation\nDr. Freeman Lan\,\nPostdoctoral Fellow\, University of Winsconsin-Madison\nBiological assays have for decades been carried out primarily in reaction tubes and microtiter plates\, which are low throughput and difficult to scale. Microfluidics technology can overcome this limitation through miniaturization of reaction volumes and efficient scaling of liquid handling. I will describe my work pioneering droplet microfluidics as a platform to conduct biological assays at ultrahigh-throughput (>10\,000 assays per run) and how I am now applying this technology to study microbial systems. I show that ultrahigh-throughput experimentation can rapidly generate large amounts of data and bring fresh insights that would previously be unattainable using traditional methods. Given our rapidly increasing capacity to analyze large scale data through advances in machine learning\, ultrahigh-throughput experimentation will become an important way of conducting biological research in the future. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-freeman-lan/
LOCATION:MSB 4171
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Freeman-Lan.jpg
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