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DTSTART;TZID=America/Toronto:20230503T090000
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UID:41338-1683104400-1683108000@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Kibaek Choe
DESCRIPTION:In Vivo Live Cell Imaging by Three-Photon (3P) Microscopy\nDr. Kibaek Choe\,\nPostdoctoral Associate\, Cornell University\nIn vivo confocal and two-photon (2P) microscopies have been a major driving force in deepening our understanding of cell dynamics by enabling the visualization of migration\, distribution\, morphology\, and cell-cell interactions in three dimensions and at subcellular resolution. In this talk\, I will first discuss the key features of confocal and 2P microscopes for in vivo imaging and introduce bio-applications in various mouse organs such as the small intestine\, bone marrow\, and lymph nodes. \nSecondly\, I will talk about 3P microscopy\, which overcomes the depth limitation of confocal and 2P imaging. We applied 3P microscopy to visualize dynamic immune cell behavior in mouse lymph nodes for the first time. We determined safe laser parameters by monitoring immune cell motility in various imaging conditions to prevent photo-damage. Using the safe laser conditions\, we were able to visualize blood vessels through the entire depth of mouse popliteal lymph node in vivo. Additionally\, we could measure the motility of CD4+ and CD8+ T cells through the entire depth of T cell zone in vivo\, allowing us to discover the depth dependence of CD4+ T cell motility in the T cell zone during lipopolysaccharide-induced inflammation. \nThus\, in vivo 3P microscopy has the potential to uncover previously unknown cellular dynamics in deeper regions of many other organs beyond the depth limit of conventional confocal and 2P microscopies. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-kibaek-choe/
LOCATION:MS3153
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Kibaek-Choe.v4.jpg
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DTSTART;TZID=America/Toronto:20230518T090000
DTEND;TZID=America/Toronto:20230518T100000
DTSTAMP:20260419T093944
CREATED:20230515T152033Z
LAST-MODIFIED:20230516T203337Z
UID:41613-1684400400-1684404000@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Ilke Uguz
DESCRIPTION:Development of High-Density Active Neural Interfaces using Conjugated Polymers\nDr. Ilke Uguz\nPostdoctoral Research Associate\, Columbia University\nPrecise\, stable\, and biocompatible neural interfaces are crucial for effective brain-machine interfaces and therapeutic interventions. Conjugated polymers offer exceptional potential for such applications\, owing to their softness\, biocompatibility\, and mixed ionic and electronic charge transport properties. By integrating CPs at the front-end\, we can achieve active pixels comparable in size to individual neurons while maintaining mechanical properties similar to surrounding tissue. During the talk\, I will delve into microfabrication and design strategies used to develop implantable CP-based neural interfaces with electrical and optical functionalities. Specifically\, I will address the technological challenges associated with scalability and present examples that demonstrate the successful generation of complex circuitries on flexible substrates\, as well as their monolithic integration onto drive electronics. Additionally\, I will demonstrate large-scale electrophysiology and optogenetic manipulation of neuronal circuits with high spatiotemporal resolution\, highlighting the potential of CPs as a foundation for high-density active front-end arrays. \nTalk will be virtual only\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-ilke-uguz/
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/05/Ilke-Uguz.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230519T130000
DTEND;TZID=America/Toronto:20230519T140000
DTSTAMP:20260419T093944
CREATED:20230509T183039Z
LAST-MODIFIED:20230509T183039Z
UID:41568-1684501200-1684504800@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Nova Pishesha
DESCRIPTION:Exploiting Antigen Presentation Pathways for Precision Immune Engineering \nDr. Nova Pishesha\,\nJunior Fellow\, Society of Fellows at Harvard University\nCurrent treatments for autoimmunity rely on general immunosuppression\, which exposes patients to opportunistic infections. Hence\, immunoregulatory modalities\, which educate the immune system to induce antigen-specific tolerance are desirable. My doctoral research revolved around engineered red blood cells (RBCs) to treat preclinical models of autoimmune diseases by hijacking the tolerogenic RBC clearance pathways. As a postdoctoral fellow\, I worked on an alpaca-derived single domain antibody fragment (nanobody)-based platform. I have engineered these nanobodies to efficiently target antigen presenting cells and transmit either tolerogenic or vaccinal signal to antigen-specific immune cells. I showed that a single dose of a VHH that recognizes major histocompatibility complex class II/MHCII (VHHMHCII)\, conjugated to a myelin peptide and an anti-inflammatory corticosteroid\, i.e. dexamethasone (VHHMHCII-MOG-DEX)\, affords lasting protection in a mouse model of multiple sclerosis (MS). A single dose of VHHMHCII-MOG-DEX also reverses paralyses in mice without compromising the capacity of the immune system to fight pathogens. I further developed this technology for treating type 1 diabetes and as a SARS-CoV-2 vaccine. My independent group will aspire to produce novel treatments for autoimmune and infectious diseases. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-nova-pishesha/
LOCATION:MS3153
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/05/1517545306211.jpg
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