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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART:20210314T070000
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DTSTART;TZID=America/Toronto:20230519T130000
DTEND;TZID=America/Toronto:20230519T140000
DTSTAMP:20260520T232604
CREATED:20230509T183039Z
LAST-MODIFIED:20230509T183039Z
UID:41568-1684501200-1684504800@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Nova Pishesha
DESCRIPTION:Exploiting Antigen Presentation Pathways for Precision Immune Engineering \nDr. Nova Pishesha\,\nJunior Fellow\, Society of Fellows at Harvard University\nCurrent treatments for autoimmunity rely on general immunosuppression\, which exposes patients to opportunistic infections. Hence\, immunoregulatory modalities\, which educate the immune system to induce antigen-specific tolerance are desirable. My doctoral research revolved around engineered red blood cells (RBCs) to treat preclinical models of autoimmune diseases by hijacking the tolerogenic RBC clearance pathways. As a postdoctoral fellow\, I worked on an alpaca-derived single domain antibody fragment (nanobody)-based platform. I have engineered these nanobodies to efficiently target antigen presenting cells and transmit either tolerogenic or vaccinal signal to antigen-specific immune cells. I showed that a single dose of a VHH that recognizes major histocompatibility complex class II/MHCII (VHHMHCII)\, conjugated to a myelin peptide and an anti-inflammatory corticosteroid\, i.e. dexamethasone (VHHMHCII-MOG-DEX)\, affords lasting protection in a mouse model of multiple sclerosis (MS). A single dose of VHHMHCII-MOG-DEX also reverses paralyses in mice without compromising the capacity of the immune system to fight pathogens. I further developed this technology for treating type 1 diabetes and as a SARS-CoV-2 vaccine. My independent group will aspire to produce novel treatments for autoimmune and infectious diseases. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-nova-pishesha/
LOCATION:MS3153
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/05/1517545306211.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230518T090000
DTEND;TZID=America/Toronto:20230518T100000
DTSTAMP:20260520T232604
CREATED:20230515T152033Z
LAST-MODIFIED:20230516T203337Z
UID:41613-1684400400-1684404000@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Ilke Uguz
DESCRIPTION:Development of High-Density Active Neural Interfaces using Conjugated Polymers\nDr. Ilke Uguz\nPostdoctoral Research Associate\, Columbia University\nPrecise\, stable\, and biocompatible neural interfaces are crucial for effective brain-machine interfaces and therapeutic interventions. Conjugated polymers offer exceptional potential for such applications\, owing to their softness\, biocompatibility\, and mixed ionic and electronic charge transport properties. By integrating CPs at the front-end\, we can achieve active pixels comparable in size to individual neurons while maintaining mechanical properties similar to surrounding tissue. During the talk\, I will delve into microfabrication and design strategies used to develop implantable CP-based neural interfaces with electrical and optical functionalities. Specifically\, I will address the technological challenges associated with scalability and present examples that demonstrate the successful generation of complex circuitries on flexible substrates\, as well as their monolithic integration onto drive electronics. Additionally\, I will demonstrate large-scale electrophysiology and optogenetic manipulation of neuronal circuits with high spatiotemporal resolution\, highlighting the potential of CPs as a foundation for high-density active front-end arrays. \nTalk will be virtual only\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-ilke-uguz/
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/05/Ilke-Uguz.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230503T090000
DTEND;TZID=America/Toronto:20230503T100000
DTSTAMP:20260520T232604
CREATED:20230419T152829Z
LAST-MODIFIED:20230421T131146Z
UID:41338-1683104400-1683108000@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Kibaek Choe
DESCRIPTION:In Vivo Live Cell Imaging by Three-Photon (3P) Microscopy\nDr. Kibaek Choe\,\nPostdoctoral Associate\, Cornell University\nIn vivo confocal and two-photon (2P) microscopies have been a major driving force in deepening our understanding of cell dynamics by enabling the visualization of migration\, distribution\, morphology\, and cell-cell interactions in three dimensions and at subcellular resolution. In this talk\, I will first discuss the key features of confocal and 2P microscopes for in vivo imaging and introduce bio-applications in various mouse organs such as the small intestine\, bone marrow\, and lymph nodes. \nSecondly\, I will talk about 3P microscopy\, which overcomes the depth limitation of confocal and 2P imaging. We applied 3P microscopy to visualize dynamic immune cell behavior in mouse lymph nodes for the first time. We determined safe laser parameters by monitoring immune cell motility in various imaging conditions to prevent photo-damage. Using the safe laser conditions\, we were able to visualize blood vessels through the entire depth of mouse popliteal lymph node in vivo. Additionally\, we could measure the motility of CD4+ and CD8+ T cells through the entire depth of T cell zone in vivo\, allowing us to discover the depth dependence of CD4+ T cell motility in the T cell zone during lipopolysaccharide-induced inflammation. \nThus\, in vivo 3P microscopy has the potential to uncover previously unknown cellular dynamics in deeper regions of many other organs beyond the depth limit of conventional confocal and 2P microscopies. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-kibaek-choe/
LOCATION:MS3153
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Kibaek-Choe.v4.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230421T130000
DTEND;TZID=America/Toronto:20230421T140000
DTSTAMP:20260520T232604
CREATED:20230417T183542Z
LAST-MODIFIED:20230417T183542Z
UID:41310-1682082000-1682085600@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Freeman Lan
DESCRIPTION:Revolutionizing biological discovery through ultrahigh-throughput experimentation\nDr. Freeman Lan\,\nPostdoctoral Fellow\, University of Winsconsin-Madison\nBiological assays have for decades been carried out primarily in reaction tubes and microtiter plates\, which are low throughput and difficult to scale. Microfluidics technology can overcome this limitation through miniaturization of reaction volumes and efficient scaling of liquid handling. I will describe my work pioneering droplet microfluidics as a platform to conduct biological assays at ultrahigh-throughput (>10\,000 assays per run) and how I am now applying this technology to study microbial systems. I show that ultrahigh-throughput experimentation can rapidly generate large amounts of data and bring fresh insights that would previously be unattainable using traditional methods. Given our rapidly increasing capacity to analyze large scale data through advances in machine learning\, ultrahigh-throughput experimentation will become an important way of conducting biological research in the future. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-freeman-lan/
LOCATION:MSB 4171
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Freeman-Lan.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230418T130000
DTEND;TZID=America/Toronto:20230418T140000
DTSTAMP:20260520T232604
CREATED:20230413T144237Z
LAST-MODIFIED:20230414T202721Z
UID:41281-1681822800-1681826400@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Tian He\, Harvard University
DESCRIPTION:Illuminating Bioelectricity in the Brain\nDr. He Tian\,\nPostdoctoral Associate\, Harvard University\nThe brain encodes and processes information through the dynamic membrane voltage of neurons. However\, in vivo electrophysiology\, i.e.\, the study of the membrane voltage of individual cells in live animals\, has been a major challenge for neuroscience. In this seminar\, I will present voltage imaging\, an emerging technology using genetically encoded voltage indicators (GEVIs) to visualize the membrane voltage dynamics of cells. Voltage imaging can be combined with optogenetic stimulation to enable “all-optical electrophysiology”\, a technology that enabled cell membrane voltage to be simultaneously recorded and perturbed with light\, opening a path for high-throughput electrophysiology study in live animals. Thus far\, the performance of GEVIs has been a bottleneck for many applications. I will describe my directed evolution effort to improve a far-red GEVI. In order to optimize the transient voltage response of this biosensor\, I developed a novel video-based pooled screening platform that enabled thousands of genetic variants to be screened expeditiously. Using this platform\, I developed far-red GEVIs with improved signal-to-noise ratios and kinetics. Importantly\, this platform may be adapted for many types of genetic screens where optical readouts are required. I will discuss the application of these new GEVIs for tracking electric signal propagation within neurons. In particular\, I will demonstrate how to use voltage imaging and all-optical electrophysiology to understand neuron network dynamics in the live mouse brain. Together\, these molecular and optical tools will greatly expand our ability to decipher the brain. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-tian-he-harvard-university/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Tian-He-faculty-search.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220707T140000
DTEND;TZID=America/Toronto:20220707T150000
DTSTAMP:20260520T232604
CREATED:20220624T143324Z
LAST-MODIFIED:20220624T151521Z
UID:37864-1657202400-1657206000@bme.utoronto.ca
SUMMARY:Faculty Search Candidate Talk - Unconventional Nanobiophotonics: Upconversion/Persistent Luminescence Nanoparticles for Anti-cancer Therapy
DESCRIPTION:Kai Huang\, PhD \nDepartment of Biochemistry and Molecular Biotechnology\nUniversity of Massachusetts Chan Medical School \nAbstract: Biophotonics has been widely applied as versatile and powerful approaches for biomedical applications\, such as for bioimaging\, biodetection\, photodynamic therapy\, and optogenetics. However\, conventional biophotonics suffers from several constraints. For example\, the short-wavelength excitation light cannot penetrate deep into the tissue\, thus requiring an invasive light delivery system for deep-tissue photodynamic therapy or optogenetics. In addition\, luminescence signal is interfered with autofluorescence noise\, bringing difficulties for high-quality bioimaging and biodetection. Here\, we address these issues by developing unconventional nanobiophotonics\, where we apply upconversion or persistent luminescence nanoparticles for anti-cancer therapy. Upconversion nanoparticles (UCNPs) convert near-infrared (NIR) excitation into short-wavelength visible light emission and thus serve as the light-transducer to bring deep tissue penetration NIR excitation for wireless photoactivations. We applied versatile nanoengineering approaches to produce UCNPs with controllable size/morphology\, tunable and enhanced luminescence\, and desirable biofunctionalizations. These UCNPs were applied for NIR-optogenetic control of CAR-T cell immunotherapy. We demonstrated that by wirelessly and spatiotemporally controlling the CAR-T cell activity\, we can achieve effective and safer immunotherapy of cancer\, overcoming the safety issue of conventional CAR-T immunotherapy. Persistent luminescence nanoparticles (PLNPs) are unique nanomaterials that emit long-lasting afterglow after excitation stops. PLNPs are significant for bioimaging by avoiding the autofluorescence induced by real-time excitation. We have developed the bottom-up syntheses of PLNPs with fine control of their energy traps\, heterostructures\, and energy accepting from dye-sensitizations\, contributing to enhanced persistent luminescence. We have demonstrated that PLNPs with enhanced luminescence are excellent for ultrasensitive imaging-guided tumor surgery. In addition\, we also demonstrated that by developing X-ray-excitable PLNPs\, we can achieve X-ray-photodynamic therapy with limitless tissue penetration and enhanced tumor eradication.
URL:https://bme.utoronto.ca/event/faculty-search-candidate-talk-2/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Faculty Search
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220623T130000
DTEND;TZID=America/Toronto:20220623T140000
DTSTAMP:20260520T232604
CREATED:20220609T144131Z
LAST-MODIFIED:20220609T150225Z
UID:37649-1655989200-1655992800@bme.utoronto.ca
SUMMARY:Faculty Search Candidate: Designer polymer excipients to enable next-generation insulin formulations
DESCRIPTION:Caitlin Maikawa\, PhD\nAbstract: Insulin was first isolated a century ago\, yet commercial formulations of insulin for hormone replacement therapy fall short of mimicking the endogenous glycemic control that occurs in non-diabetic individuals. Moreover\, diabetes management is increasingly relying on automated insulin delivery using closed-loop systems to improve glucose management and reduce patient burden. However\, improvements in insulin formulations\, sensors\, and algorithms are required to shift from hybrid systems to fully autonomous delivery. Insulin formulations that better mimic secretion from the beta-cells\, by enabling more rapid insulin absorption kinetics and/or co-delivering complementary hormones (i.e. amylin)\, would improve diabetes management. However\, formulation innovation is complicated by the poor stability of insulin monomers and amylin. Here\, I will discuss two polymeric excipient platforms (non-covalent PEGylation and amphiphilic copolymer excipients) that can be used to increase the stability of insulin in formulation and modulate insulin pharmacokinetics. Using these designer excipients\, I have developed three insulin formulations: (i) an ultrafast monomeric insulin lispro\, (ii) an insulin-amylin co-formulation and (iii) an ultrafast co-formulation. These enhanced insulin formulations are promising candidates to address formulation challenges related to achieving fully autonomous insulin delivery\, improve glucose control\, and reduce the burden of treatment management for patients with diabetes.
URL:https://bme.utoronto.ca/event/designer-polymer-excipients-to-enable-next-generation-insulin-formulations/
LOCATION:MS2172
CATEGORIES:BME Faculty Search
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220614T130000
DTEND;TZID=America/Toronto:20220614T140000
DTSTAMP:20260520T232604
CREATED:20220609T144415Z
LAST-MODIFIED:20220609T150017Z
UID:37653-1655211600-1655215200@bme.utoronto.ca
SUMMARY:Faculty Search Candidate Talk
DESCRIPTION:This event will be in person only.
URL:https://bme.utoronto.ca/event/faculty-search-talk-2-2022/
LOCATION:MS3153
CATEGORIES:BME Faculty Search
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220531T130000
DTEND;TZID=America/Toronto:20220531T140000
DTSTAMP:20260520T232604
CREATED:20220525T131335Z
LAST-MODIFIED:20220609T150149Z
UID:37435-1654002000-1654005600@bme.utoronto.ca
SUMMARY:Faculty Search Candidate Talk
DESCRIPTION:This event will be in person only.
URL:https://bme.utoronto.ca/event/faculty-search-candidate-talk/
LOCATION:Medical Science Building\, Room 3153\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Faculty Search
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