BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute of Biomedical Engineering (BME) - ECPv6.17.4.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institute of Biomedical Engineering (BME)
X-ORIGINAL-URL:https://bme.utoronto.ca
X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Toronto
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20250309T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20251102T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240930T175500
DTEND;TZID=America/Toronto:20240930T181000
DTSTAMP:20240930T193831Z
CREATED:20240903T173728Z
LAST-MODIFIED:20240930T193831Z
UID:10000472-1727718900-1727719800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Suyue Lyu
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Variational autoencoder for design of synthetic viral vector serotypes\nAbstract: Recent\, rapid advances in deep generative models for protein design have focused on small proteins with lots of data. Such models perform poorly on large proteins with limited natural sequences\, for instance\, the capsid protein of adenoviruses and adeno-associated virus\, which are common delivery vehicles for gene therapy. Generating synthetic viral vector serotypes could overcome the potent pre-existing immune responses that most gene therapy recipients exhibit—a consequence of previous environmental exposure. We present a variational autoencoder (ProteinVAE) that can generate synthetic viral vector serotypes without epitopes for pre-existing neutralizing antibodies. A pre-trained protein language model was incorporated into the encoder to improve data efficiency\, and deconvolution-based upsampling was used for decoding to avoid degenerate repetition seen in long protein sequence generation. ProteinVAE is a compact generative model with just 12.4 million parameters and was efficiently trained on the limited natural sequences. Viral protein sequences generated were used to produce structures with thermodynamic stability and viral assembly capability indistinguishable from natural vector counterparts. ProteinVAE can be used to generate a broad range of synthetic serotype sequences without epitopes for pre-existing neutralizing antibodies in the human population\, effectively addressing one of the major challenges of gene therapy. It could be used more broadly to generate different types of viral vector\, and any large\, therapeutically valuable proteins\, where available data are sparse.\nSupervisor Name: Michael Garton\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-suyue-lyu-3/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240930T174000
DTEND;TZID=America/Toronto:20240930T175500
DTSTAMP:20240930T193831Z
CREATED:20240823T172235Z
LAST-MODIFIED:20240930T193831Z
UID:10000453-1727718000-1727718900@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Grayson Tilstra
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Design of ionizable lipids for mRNA delivery\nSupervisor Name: Omar F. Khan\nYear of Study: 5\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-grayson-tilstra/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240930T172500
DTEND;TZID=America/Toronto:20240930T174000
DTSTAMP:20240930T193831Z
CREATED:20240823T172235Z
LAST-MODIFIED:20240930T193831Z
UID:10000454-1727717100-1727718000@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Julien Couture-Senecal
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Rational design of ionizable lipids for mRNA vaccines\nSupervisor Name: Omar F. Khan\nYear of Study: 5\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-julien-couture-senecal/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240923T175500
DTEND;TZID=America/Toronto:20240923T181000
DTSTAMP:20240923T192233Z
CREATED:20240828T173729Z
LAST-MODIFIED:20240923T192233Z
UID:10000469-1727114100-1727115000@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Nicholas Yee
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Development of a hip fracture screening tool using computer vision assisted ultrasound imaging\nSupervisor Name: Cari Whyne\nYear of Study: 2\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-nicholas-yee/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240923T174000
DTEND;TZID=America/Toronto:20240923T175500
DTSTAMP:20240923T192233Z
CREATED:20240910T190750Z
LAST-MODIFIED:20240923T192233Z
UID:10000483-1727113200-1727114100@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mohammad Parsa Oveisi
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Using Computational Modeling to Disentangle Physiological Underpinnings of Excitability in TMS\nAbstract:\nTranscranial Magnetic Stimulation (TMS) is a powerful neuromodulation technique\, yet its efficacy is hindered by variability in individual responses. This variability is largely attributed to differences in brain excitability\, which is influenced by both external factors (e.g.\, stimulation intensity) and internal\, brain-dependent factors. To disentangle these contributions and elucidate their interactions\, we employed a novel approach combining empirical TMS-EEG measurements with advanced computational modeling.\nWe collected TMS-EEG data from the dorsolateral prefrontal cortex (DLPFC) at various stimulation intensities. Analysis of TMS-Evoked Potentials (TEPs) revealed multiple intensity-sensitive components (N45\, P60\, N120\, P200\, and Cluster Amplitude Variability)\, each showing distinct scaling properties. Notably\, brain-dependent metrics\, such as Resting Motor Threshold (RMT)\, proved to be superior predictors of TEP amplitude compared to stimulator output intensity.\nTo investigate the underlying physiological mechanisms\, we utilized a whole-brain computational model “WhoBPyT”. The model successfully captured empirical dynamics with high accuracy and reproduced observed correlation patterns between excitability metrics. Importantly\, different model parameters correlated with distinct excitability peaks\, suggesting that various TEP components may reflect different neural processes. Network analysis further indicated that some components (e.g.\, N120) result from global network reverberations\, while others (e.g.\, N45) represent more localized responses.\nOur findings demonstrate that TMS-induced cortical responses are shaped by multiple\, partially independent excitability-related processes. This work provides novel insights into the physiological underpinnings of TMS effects and offers a promising approach for developing more targeted and individualized TMS protocols. Future research should focus on incorporating these insights into clinical applications to enhance the efficacy of TMS therapies.\nSupervisor Name: Drs. John D. Griffiths & Christoph Zrenner\nYear of Study: 3\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mohammad-parsa-oveisi/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240923T174000
DTEND;TZID=America/Toronto:20240923T175500
DTSTAMP:20240910T190750Z
CREATED:20240910T190750Z
LAST-MODIFIED:20240910T190750Z
UID:10000484-1727113200-1727114100@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mohammad Parsa Oveisi
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Using Computational Modeling to Disentangle Physiological Underpinnings of Excitability in TMS\nAbstract:\nTranscranial Magnetic Stimulation (TMS) is a powerful neuromodulation technique\, yet its efficacy is hindered by variability in individual responses. This variability is largely attributed to differences in brain excitability\, which is influenced by both external factors (e.g.\, stimulation intensity) and internal\, brain-dependent factors. To disentangle these contributions and elucidate their interactions\, we employed a novel approach combining empirical TMS-EEG measurements with advanced computational modeling.\nWe collected TMS-EEG data from the dorsolateral prefrontal cortex (DLPFC) at various stimulation intensities. Analysis of TMS-Evoked Potentials (TEPs) revealed multiple intensity-sensitive components (N45\, P60\, N120\, P200\, and Cluster Amplitude Variability)\, each showing distinct scaling properties. Notably\, brain-dependent metrics\, such as Resting Motor Threshold (RMT)\, proved to be superior predictors of TEP amplitude compared to stimulator output intensity.\nTo investigate the underlying physiological mechanisms\, we utilized a whole-brain computational model “WhoBPyT”. The model successfully captured empirical dynamics with high accuracy and reproduced observed correlation patterns between excitability metrics. Importantly\, different model parameters correlated with distinct excitability peaks\, suggesting that various TEP components may reflect different neural processes. Network analysis further indicated that some components (e.g.\, N120) result from global network reverberations\, while others (e.g.\, N45) represent more localized responses.\nOur findings demonstrate that TMS-induced cortical responses are shaped by multiple\, partially independent excitability-related processes. This work provides novel insights into the physiological underpinnings of TMS effects and offers a promising approach for developing more targeted and individualized TMS protocols. Future research should focus on incorporating these insights into clinical applications to enhance the efficacy of TMS therapies.\nSupervisor Name: Drs. John D. Griffiths & Christoph Zrenner\nYear of Study: 3\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mohammad-parsa-oveisi-2/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240923T172500
DTEND;TZID=America/Toronto:20240923T174000
DTSTAMP:20240923T192233Z
CREATED:20240823T172235Z
LAST-MODIFIED:20240923T192233Z
UID:10000452-1727112300-1727113200@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Savina Cammalleri
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Developing a Spatial Multi-Omics Platform to Study Microglia Morphology and Functipn\nSupervisor Name: Aaron Wheeler\nYear of Study: 2\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-savina-cammalleri/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240923T171000
DTEND;TZID=America/Toronto:20240923T172500
DTSTAMP:20240923T192232Z
CREATED:20240822T172239Z
LAST-MODIFIED:20240923T192232Z
UID:10000433-1727111400-1727112300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Sheldon Mei
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Developing an Analytical NMR Technique for Studying Interactions between Spin-Coated Contact Lens Materials and Soluble Proteins\nSupervisor Name: Dr. Frank Gu\nYear of Study: 2\nProgram of Study: MASc\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-sheldon-mei/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240916T175500
DTEND;TZID=America/Toronto:20240916T181000
DTSTAMP:20240904T175231Z
CREATED:20240904T175231Z
LAST-MODIFIED:20240904T175231Z
UID:10000474-1726509300-1726510200@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Katrina Meng
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Characterizing Conventional Transradial Prosthesis Design to Inform Digital Design Workflow\nSupervisor Name: Jan Andrysek\nYear of Study: 2\nProgram of Study: MASc\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-katrina-meng/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240916T174000
DTEND;TZID=America/Toronto:20240916T175500
DTSTAMP:20240916T190739Z
CREATED:20240823T172234Z
LAST-MODIFIED:20240916T190739Z
UID:10000450-1726508400-1726509300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Minnie Menezes
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Identifying Challenges in the Operating Room through a Surgical Process Analysis of Orthopaedic Teams\nAbstract:\nBackground & Purpose\nSurgical performance is a key factor in the success of operative interventions\, affecting patient outcomes and operating room (OR) efficiency. This is dependent on the skills of the individual surgeons\, nurses\, anesthesiologists\, and radiation technologists and their interactions. However\, the multidisciplinary nature of OR performance is often overlooked when studying surgical processes. Including interdisciplinary interactions and associated challenges may yield a more comprehensive workflow understanding. As such\, the aim of this study was to conduct a multidisciplinary surgical process analysis of orthopaedic teams undertaking operative hip fracture repair.\nMethods\nWe conducted an ethnographic study that incorporated observations and semi-structured interviews. The observations were of hip fracture fixation procedures\, both in-person and via intraoperative recordings. Intraoperative recordings were captured using the OR Black Box\, which includes audio\, video (from five perspectives)\, and patient vitals\, and then annotated. Semi-structured interviews were conducted with experts in four disciplines (surgery\, anesthesia\, nursing\, and radiation technology). Two members of the research team analyzed the interview data inductively to identify themes. The researchers ensured intercoder reliability through dialogue and consensus.\nResults & Discussion\nA process analysis map was created from the intraoperative recording annotations and in-person observations\, including phases\, steps\, and activities conducted by each discipline in chronological order. The intricacies of collaborations between disciplines and challenges in the OR were visually demonstrated on the map. Four themes were identified from the interview data that describes the surgical process: the main responsibilities of each discipline; system-level\, case-specific\, and interdisciplinary challenges; the impact/consequences of challenges on individual workflows; and a breakdown of the OR culture.\nConclusion\nWe created a multidisciplinary surgical process map that demonstrates the interconnections and challenges present in the orthopaedic OR during hip fracture repair. Challenges identified will inform quality improvement initiatives and educational interventions\, towards improving communication and reducing workflow disruptions.\nSupervisor Name: Cari Whyne\nYear of Study: 2\nProgram of Study: MASc\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-minnie-menezes/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240916T172500
DTEND;TZID=America/Toronto:20240916T174000
DTSTAMP:20240904T225201Z
CREATED:20240904T225201Z
LAST-MODIFIED:20240904T225201Z
UID:10000478-1726507500-1726508400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Saleh Tabatabaei
DESCRIPTION:Presentation Title: An AI-enabled Study of Osteosarcopenia Progression in Prostate Cancer \nAbstract: Osteosarcopenia\, a condition that combines osteopenia and sarcopenia\, poses significant challenges to the musculoskeletal health of prostate cancer patients\, especially due to the prolonged impact of disease and treatment. Despite its prevalence\, the combined effects of osteopenia and sarcopenia have been insufficiently explored\, with existing studies often relying on single time-point evaluations. This study aims to quantify the progression of osteosarcopenia in patients with advanced prostate cancer by utilizing artificial intelligence (AI) to analyze electronic medical records (EMR) and imaging biomarkers from serial 3D CT scans. The hypothesis is that AI-enhanced analysis can predict osteosarcopenia progression and evaluate the impact of cancer treatments on both bone and muscle health. The methodology involves a retrospective analysis of medical imaging and EMR from over 1\,500 patients across multiple international cancer centers. A biomarker extraction pipeline\, employing advanced deep learning techniques\, is developed to assess osteosarcopenia in CT scans. Predictive modeling utilizes time-series analysis and deep neural networks to understand disease progression and treatment effects. This research seeks to transform osteosarcopenia management by providing robust progression quantification and insights into the interplay between sarcopenia and osteopenia\, ultimately improving diagnosis and treatment strategies. \nSupervisor Name: Cari Whyne\, Michael Hardisty \nYear of Study: 3 \nProgram of Study: PhD
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-saleh-tabatabaei-4/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240910T120000
DTEND;TZID=America/Toronto:20240910T130000
DTSTAMP:20240820T200047Z
CREATED:20240722T130649Z
LAST-MODIFIED:20240820T200047Z
UID:10000419-1725969600-1725973200@bme.utoronto.ca
SUMMARY:Innovation Illuminated: Through Personal and Professional Breakthroughs- Jeff Karp
DESCRIPTION:Abstract\nFeeling stuck in a rut\, trapped in the repetitive motions of daily life? Imagine if the key to breaking free was already within your grasp\, ready to be unlocked by adopting transformative tools and mindsets. \n\n\nJoin us for an enlightening lecture with Jeff Karp\, a distinguished professor at Brigham and Women’s Hospital and a dedicated innovator in medical research at Harvard Medical School and MIT. Jeff’s journey from a child struggling with learning differences and ADHD to a scientist and entrepreneur is a testament to the power of unconventional thinking and deliberate action. \nJeff developed a set of innovative tools and processes\, which he calls “Life Ignition Tools\,” by drawing inspiration from nature. These tools helped him not only adapt and flourish but also led to significant innovations in science and industry. His achievements include co-founding 12 companies\, securing over 100 patents\, and receiving awards for innovations like a tissue glue that seals holes in a beating heart. \nIn his new book\, “LIT: Life Ignition Tools: Use Nature’s Playbook to Energize Your Brain\, Spark Ideas\, and Ignite Action\,” Jeff shares profound lessons on how to intercept routine patterns and actively think and decide instead of reacting with habitual responses. This lecture will delve into the key principles from “LIT” that helped Jeff overcome learning challenges and transform cutting-edge research into real-world solutions. \nDiscover how adopting these Life Ignition Tools can help you break free from autopilot\, make intentional decisions\, and lead a more creative and purposeful life. \n\n\nBiography \nhttps://hsci.harvard.edu/people/jeffrey-karp-phd
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-jeff-karp/
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2024/07/Speaker-2024-2025-Jeff-Karp.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240909T174000
DTEND;TZID=America/Toronto:20240909T175500
DTSTAMP:20240904T224828Z
CREATED:20240904T224828Z
LAST-MODIFIED:20240904T224828Z
UID:10000477-1725903600-1725904500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mohammad Rezaei
DESCRIPTION:Presentation Title: Cognitive State Inference and the Impact of Deep Brain Stimulation on Decision-Making in Parkinson’s Disease \nAbstract: Human cognition arises from the intricate interplay of neural and behavioral signals\, shaped by dynamic interactions across distributed brain networks. Understanding these hidden cognitive states is particularly important in neurological disorders like Parkinson’s disease (PD)\, which impair cognitive functions and disrupt normal brain activity. This thesis focuses on developing computational models to infer cognitive states from high-dimensional neural and behavioral data and to evaluate the impact of deep brain stimulation (DBS) on cognitive abilities during decision-making processes. Specifically\, it explores the temporal effects of DBS on PD patients’ cognitive abilities in high-conflict and no-conflict decision-making situations\, introducing the Cognet model. This model\, which simulates the dynamic interactions between the subthalamic nucleus (STN) and the medial prefrontal cortex (mPFC)\, provides insights into the optimal timing and modulation strategies for DBS to enhance cognitive function. The proposed models open new pathways for understanding the generation of neural and behavioral signals and the effects of neuromodulation on cognitive processes\, contributing to the advancement of cognitive state inference and therapeutic interventions in neuroscience. \nSupervisor Name: Milos Popovic \nYear of Study: 5 \nProgram of Study: PhD
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mohammad-rezaei-6/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240909T172500
DTEND;TZID=America/Toronto:20240909T174000
DTSTAMP:20240904T224620Z
CREATED:20240904T224620Z
LAST-MODIFIED:20240904T224620Z
UID:10000476-1725902700-1725903600@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mohammad Rezaei
DESCRIPTION:Location: HS610 – 155 College St\, Room 610 \nPresentation Title: Inferring cognitive state underlying conflict choices in verbal Stroop task Abstract: The subthalamic nucleus (STN) within the basal ganglia interacts with the medial prefrontal cortex (mPFC) to form a control loop\, particularly active when the brain encounters contradictory information from different sensory systems or conflicting inputs from sensory data and pre-existing knowledge. Experimental studies have shown that significant increases in theta activity (2–8 Hz) in both the STN and mPFC\, along with enhanced phase synchronization between these regions\, are key features of conflict processing. While these neural markers highlight the critical role of the STN-mPFC circuitry in managing conflicts\, a low-dimensional representation of the mPFC-STN interaction—referred to as a cognitive state—that links neural activities to behavioral outcomes\, such as response time\, remains to be fully understood. To address this\, we propose the heterogeneous input discriminative-generative decoder (HI-DGD) model\, designed to infer cognitive states underlying decision-making by integrating neural activities from the STN and mPFC with behavioral signals\, specifically response times recorded from ten Parkinson’s disease (PD) patients performing a Stroop task. PD patients may experience conflict processing that differs quantitatively\, and possibly qualitatively\, from that of healthy individuals. Our results\, derived from extensive synthetic and experimental data\, demonstrate that the HI-DGD model can simultaneously process neural and behavioral data to estimate cognitive states in conflict and non-conflict trials more effectively than traditional methods. Moreover\, the HI-DGD model identifies which neural features significantly contribute to conflict and non-conflict decisions\, with the inferred features closely aligning with those reported in experimental studies. Importantly\, the HI-DGD model’s ability to estimate cognitive states from single trials makes it highly suitable for use in closed-loop neuromodulation systems. \nSupervisor Name: Milos Popovic \nYear of Study: 5 \nProgram of Study: PhD
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mohammad-rezaei-5/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240909T171000
DTEND;TZID=America/Toronto:20240909T172500
DTSTAMP:20240909T190733Z
CREATED:20240822T172239Z
LAST-MODIFIED:20240909T190733Z
UID:10000431-1725901800-1725902700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Laura Kondrataviciute
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons\nSupervisor Name: Dr Taufik Valiante\, Dr Luka Milosevic\nYear of Study: 3\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-laura-kondrataviciute/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240906T120000
DTEND;TZID=America/Toronto:20240906T140000
DTSTAMP:20240730T201330Z
CREATED:20240730T124447Z
LAST-MODIFIED:20240730T201330Z
UID:10000421-1725624000-1725631200@bme.utoronto.ca
SUMMARY:Institute of Biomedical Engineering Barbeque
DESCRIPTION:We are thrilled to invite you to the Fall BBQ hosted by the Institute of Biomedical Engineering! Join us for an afternoon of delicious food\, great company\, and a chance to connect with incoming students and BME community members. \nThis event is open to students\, faculty\, and staff at the Institute of Biomedical Engineering. Please register below so we may order food accordingly. \nDate: Friday\, September 6\, 2024  \nTime: 12:00 PM – 2:00 PM  \nLocation: Bahen Courtyard \nRegister here.\n 
URL:https://bme.utoronto.ca/event/institute-of-biomedical-engineering-barbeque/
CATEGORIES:Events & Workshops
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2024/07/BME_BBQ_2022-07.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240802T100000
DTEND;TZID=America/Toronto:20240802T110000
DTSTAMP:20240731T134930Z
CREATED:20240731T134930Z
LAST-MODIFIED:20240731T134930Z
UID:10000422-1722592800-1722596400@bme.utoronto.ca
SUMMARY:Bioinspired Protein-based Cancer Immunotherapy (Dr. Yanpu He\, UBC)
DESCRIPTION:Abstract\nImmunotherapy has revolutionized the field of cancer treatment over the past two decades\, though only a small fraction of patients treated will achieve complete remission. As such\, new paradigms to overcome resistance to immunotherapies are urgently needed. My research seeks to tailor immunotherapies towards individual differences in immune systems and the inherent heterogeneity of cancer. For this talk\, I will share my work on a key therapeutic target against cancer called the STimulator of INterferon Genes (STING) signaling. I first addressed an innate immunodeficiency caused by a loss-of-function mutation of STING protein affecting 20% of the human population\, using the cytosolic domain of STING (STINGΔTM) as a functional agonist carrier to activate signaling in STING-deficient cells. Subsequently\, I developed a therapeutic cancer vaccine based on this platform by fusing STINGΔTM with immune checkpoint blockade (ICB) nanobodies. The treatment eliminated subcutaneous colon and melanoma tumors in 70-100% of mice and protected all cured mice against rechallenge\, while mechanistic studies revealed a distinct STING-mediated anti-tumor immunity driven by robust TH1 polarization and Treg suppression in CD4+ T cells\, followed by the collaboration of CD8+ T and NK cells to eliminate tumors. For my independent group\, I will continue these prospects in designing protein therapeutics and leveraging the full potential of CD4+ T cells\, initially towards personalized cancer immunotherapies and expanding to other monogenic immunodeficiencies and drug delivery challenges in the long run. \nSpeaker Bio\nYanpu He is an incoming assistant professor at the School of Biomedical Engineering at the University of British Columbia (UBC)\, starting Jan. 2025. He completed his postdoctoral training with Prof. Angela Belcher in the Department of Biological Engineering at the Massachusetts Institute of Technology (MIT) from 2021 to 2024\, and his Ph.D. in Chemical Engineering at MIT in 2021\, co-advised by Profs. Paula Hammond and Darrell Irvine. He received MIT Marble Center Cancer Nanomedicine postdoctoral fellowship from 2021-2023 and was named Convergence Scholar at MIT Koch Institute in 2021. His research focuses on protein and cellular engineering to develop immunotherapies for cancer\, infectious disease\, and neurodegenerative disorders. \nHost\nMolly Shoichet
URL:https://bme.utoronto.ca/event/bioinspired-protein-based-cancer-immunotherapy-dr-yanpu-he-ubc/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240723
DTEND;VALUE=DATE:20240725
DTSTAMP:20240626T155709Z
CREATED:20240626T155709Z
LAST-MODIFIED:20240626T155709Z
UID:10000417-1721692800-1721865599@bme.utoronto.ca
SUMMARY:2024 Toronto Robotics Conference
DESCRIPTION:Interested in learning more about cutting-edge AI-robotics research at U of T and beyond? Join the Robotics Institute at the 2024 Toronto Robotics Conference for two days of mobility and healthcare tech talks with special guest speakers and robotics experts from across the university. \nBy attending the conference\, you will: \n\nhear keynote addresses from robotics research and industry leaders\, including John McPhee (University of Waterloo) and Graeme Smith (Oxa).\nlisten to faculty and student tech talks from 11 labs across U of T.\nexperience demos of the latest robotics technology from Kinova and Maple Advanced Robotics.\nexplore current graduate student research in our poster session.\nnetwork with faculty\, students\, exhibitors and invited speakers.\n\nConference info and registration
URL:https://bme.utoronto.ca/event/2024-toronto-robotics-conference/
LOCATION:5th Floor Atrium\, Myhal Centre for Engineering Innovation & Entrepreneurship (MY 532)\, 55 St. George Street\, Toronto\, Ontario\, M5S0C9\, Canada
CATEGORIES:Lectures, seminars and workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240711T110000
DTEND;TZID=America/Toronto:20240711T120000
DTSTAMP:20240704T143258Z
CREATED:20240704T143258Z
LAST-MODIFIED:20240704T143258Z
UID:10000418-1720695600-1720699200@bme.utoronto.ca
SUMMARY:PRiME Connaught Global Speaker Series
DESCRIPTION:Speaker:\nDr. Jean-Christophe Leroux\nFull Professor at the Department of Chemistry and Applied Biosciences\nDeputy Head of Institute of Pharmaceutical Sciences\, ETH Zürich \nDate: Thursday\, July 11\, 2024\, 11:00AM – 12:00PM (Refreshments will be provided)\nLocation: Red Seminar Room\, Terrence Donnelly Centre\, 160 College Street \nTitle: 3D Printing of Drug Eluting Polymeric Medical Devices\nThree-dimensional (3D) printing is a versatile technology enabling the cost-effective production of personalized medical devices. Among various 3D printing methods\, digital light processing (DLP) stands out for its ability to rapidly create objects with high precision. However\, the fabrication of bioresorbable medical devices using DLP is in part limited by the limited choice of suitable biomedical inks. In this study\, we developed innovative polyester-based inks enabling DLP printing of therapeutic devices with adjustable mechanical characteristics and degradation profiles. The most promising materials were utilized to design biodegradable customized airway stents. These stents degraded into soft hydrogels in vitro and completely disappeared seven weeks after insertion in rabbits. Additionally\, the 3D printed stents could be loaded with drugs like levofloxacin or nintedanib\, and their release kinetics could be tailored by modifying the copolymer composition. Furthermore\, we engineered near-infrared (NIR) light-responsive stents containing gold nanorods using tunable ink compositions. This allowed for the creation of shape-memory stents that expand upon NIR light activation\, facilitating easy deployment. Lastly\, DLP served as a prototyping method for the fabrication and optimization of mucosal suction patches investigated for transbuccal drug delivery. These studies open new perspectives for the rapid manufacturing of complex devices with superior properties. \nAbout Dr. Jean-Christophe Leroux\nJean-Christophe Leroux is a full professor of Drug Formulation and Delivery at the Institute of Pharmaceutical Sciences at the ETH Zurich\, Switzerland. He has made important fundamental and applied contributions to the fields of biomaterials and drug delivery and has been involved in the development of innovative bio-detoxification systems for the treatment of metabolite disorders. He is a fellow of the AAPS\, EURASC\, French Academy of Pharmacy\, and the CRS\, and the co-founder of the start-up pharmaceutical companies Versantis AG\, Inositec AG and OBaris AG.
URL:https://bme.utoronto.ca/event/prime-connaught-global-speaker-series/
CATEGORIES:Events & Workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240621T113000
DTEND;TZID=America/Toronto:20240621T173000
DTSTAMP:20240604T132526Z
CREATED:20240508T124449Z
LAST-MODIFIED:20240604T132526Z
UID:10000416-1718969400-1718991000@bme.utoronto.ca
SUMMARY:2024 TBEP Trainee Day
DESCRIPTION:The Ted Rogers Centre for Heart Research presents our 2024 Trainee Day\, featuring keynotes\, a career panel\, and networking opportunities!\n\n\nThe Ted Rogers Centre for Heart Research is excited to announce that this year’s Trainee Day will be held on Friday\, June 21\, 2024. This special half-day event brings together a diverse community of clinical and basic science trainees throughout the TRCHR ecosystem. \nThis event is open to clinical and basic science trainees affiliated with the Centre at our partner institutions: SickKids\, University Health Network\, and the University of Toronto. \nYou can expect exciting keynote presentations from Drs. Dinesh Thavendiranathan and Zahra Shakeri\, a career panel session\, trainee talks\, and a networking session to close the event. Topics will include navigating careers in academia\, strategies for dealing with career setbacks\, the future of journals and publishing\, managing competing priorities\, diverse career paths\, and more. \nLunch and refreshments will be provided. \n*Please note: registrants must use their institutional address to gain access to tickets.
URL:https://bme.utoronto.ca/event/2024-trainee-day/
LOCATION:Private: BMO Education & Conference Centre\, 60 Leonard Avenue\, Toronto\, ON\, M5T 2R1\, Canada
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2024/05/b4d9a1597d9f3eca2c6a493210a1a050.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240528
DTEND;VALUE=DATE:20240531
DTSTAMP:20231012T163254Z
CREATED:20231012T163254Z
LAST-MODIFIED:20231012T163254Z
UID:10000296-1716854400-1717113599@bme.utoronto.ca
SUMMARY:CMBEC46 / CESO Joint Conference
DESCRIPTION:The Canadian Medical and Biological Engineering Society (CMBES) and the Clinical Engineering Society of Ontario (CESO) is proud to announce the CMBEC46 / CESO Joint Conference.   \n\n\nPlease join us in Toronto\, Ontario at the Double Tree Hotel\, by Hilton on Tuesday May 28th to Thursday May 30th for fantastic presentations\, great networking opportunities\, and a wide variety of informative exhibitors from industry and beyond!  https://www.cmbes.ca/uploads/ck/files/call_for_papers_cmbec46_extended.pdf \n\n\nWe are now accepting submissions for poster and oral presentations\, either a 1-page abstract or 2-4 page paper.  Please use the online paper management system at  https://proceedings.cmbes.ca \nThe paper submission deadline has been extended to December 15\, 2023.\n\n\nPlease feel free to share the attached poster with your network and stay tuned for more details! https://www.cmbes.ca/uploads/ck/files/call_for_papers_cmbec46_extended.pdf
URL:https://bme.utoronto.ca/event/cmbec46-ceso-joint-conference/
CATEGORIES:Events & Workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240510T080000
DTEND;TZID=America/Toronto:20240510T170000
DTSTAMP:20240304T145813Z
CREATED:20240304T145250Z
LAST-MODIFIED:20240304T145813Z
UID:10000366-1715328000-1715360400@bme.utoronto.ca
SUMMARY:40th Toronto Biomedical Engineering Conference
DESCRIPTION:Toronto Biomedical Engineering Conference (ToBE)\nMay 10\, 2024\n \nThe Toronto Biomedical Engineering Conference (ToBE) is a student-organized event aimed at bringing together the biomedical engineering community at the University of Toronto. \nSince 1985\, the name of the conferences has evolved from IBBME Scientific Day to iARC (Institute of Biomaterials and Biomedical Engineering Annual Research Conference) and eventually to ToBE (Toronto Biomedical Engineering Conference). Today\, this BME conference still acts as a hub for scientific discussions\, research collaborations\, and community building. The conference has attracted many high-profile speakers in the past and is open to the broader community at the University of Toronto and its affiliated hospitals\, providing an opportunity for over 300+ students and 100+ faculty to learn recent advances in the field of biomedical engineering. \nAbstract submission deadline:\nMarch 20\nConference registration deadline:\nApril 10\n250 capacity\nAward ceremony registration deadline:\nApril 10\n200 capacity\nRegister & submit your abstract\n\n \n\nPost-Conference Award Ceremony\nMay 13\, 2024\n \nBME will be hosting an award ceremony at The Carlu to celebrate the achievement of students by announcing the winners of podium presentations\, poster presentations\, and more from the ToBE conference. This will also be an opportunity to socialize with your colleagues. \nThis event is free of charge to BME students\, staff\, core faculty members\, and primary cross-appointment faculty members. This will also be extended to non-BME students in core faculty member labs\, research associates in core faculty member labs\, and post-doctoral fellows in core faculty member labs. \nRegister for award ceremony here\n 
URL:https://bme.utoronto.ca/event/40th-toronto-biomedical-engineering-conference/
CATEGORIES:Events & Workshops
ORGANIZER;CN="Toronto Biomedical Engineering Conference (ToBE)":MAILTO:tobeconferenceteam@gmail.com
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240506
DTEND;VALUE=DATE:20240508
DTSTAMP:20240403T153925Z
CREATED:20240403T153925Z
LAST-MODIFIED:20240403T153925Z
UID:10000391-1714953600-1715126399@bme.utoronto.ca
SUMMARY:International Conference on Aging\, Innovation & Rehabilitation
DESCRIPTION:The International Conference on Aging\, Innovation & Rehabilitation drives discovery\, collaboration and invention in the health-care and age tech sectors. \nICAIR is designed to inspire academics\, clinicians\, scientists\, entrepreneurs and innovators to develop solution that improve the lives of people living with the effects of aging\, disability and illness. \nJoin us at the historic Carlu event venue in downtown Toronto\, Canada on May 6th & 7th for ICAIR 2024. \n\n\n\n\nMonday\, May 6th – AfternoonDay 1\n\n\n\n\nRegistration\n\n\nTrainee Brunch\n\n\nOpening Remarks\n\n\nKeynote Speaker: Dr. Stanisa Raspopovic\n\n\nICAIR Scientific Spotlight Series Competition:Journal presentation competition\, where leading rehabilitation scientists will present their published research\, for a chance to earn the title of “ICAIR Paper of the Year”\n\n\nNutrition Break & Poster Viewing Session\n\n\nICAIR Scientific Spotlight Series Competition (continued)\n\n\nConference Reception\n\n\n\n\n\n\n\n\nTuesday\, May 7th\, 2024 – MorningDay 2\n\n\n\n\nRegistration\n\n\nOpening Remarks:Dr. Milos Popovic – Institute Director\, KITE Research Institute at UHN and Director\, Institute of Biomedical Engineering at the University of TorontoDr. Jennifer Campos – Associate Director – Academic\, and Senior Scientist\, KITE Research InstituteDr. Bradly G. Wouters – Executive VP Science and Research\, UHNDr. Angela Colantonio – Director of the Rehabilitation Sciences Institute at the University of Toronto\n\n\nKeynote Speaker: André Picard\n\n\nPower Play Innovative Concept Competition:Up-and-coming entrepreneurs present their exciting\, creative and innovative early stage change-making ideas in a Dragon’s Den-style competition.\n\n\nNutrition Break:\n\n\nPower Play Innovative Start-up Competition:Start-up companies looking to fill a gap in the healthcare industry present their concepts\, prototypes\, and healthcare innovations in a Dragon’s Den-style competition.\n\n\nTuesday\, May 7th\, 2024 – Afternoon\n\n\nPoster Viewing Session & Lunch\n\n\nKeynote Speaker: Elise Roy\n\n\n3-Minute Talks:The next generation of aging and rehabilitation leaders present their findings and ideas in a three-minute Ted Talk style competition.\n\n\nAwards Ceremony
URL:https://bme.utoronto.ca/event/international-conference-on-aging-innovation-rehabilitation/
CATEGORIES:Events & Workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240502T160000
DTEND;TZID=America/Toronto:20240502T180000
DTSTAMP:20240425T133731Z
CREATED:20240425T133731Z
LAST-MODIFIED:20240425T133731Z
UID:10000415-1714665600-1714672800@bme.utoronto.ca
SUMMARY:Book Launch for LIT: Life Ignition Tools by Jeff Karp
DESCRIPTION:Celebrate the launch of LIT: Life Ignition Tools with author Jeff Karp and the University of Toronto’s Milica Radisic.\n\n\nJoin author Jeff Karp to celebrate the launch of his much-anticipated new book\, LIT: Life Ignition Tools. The event will feature a conversation between Jeff Karp and University of Toronto Professor Dr. Milicia Radisic\, followed by a reading\, Q&A\, and signing. \n \nAbout the Speakers\nJeff Karp\, PhD\, is an acclaimed mentor and biomedical engineering professor at Harvard Medical School and MIT\, a Distinguished Chair at Brigham and Women’s Hospital\, and a fellow of the National Academy of Inventors. He has dedicated his research to bioinspired medical problem-solving\, and his lab’s technologies have led to the formation of twelve companies. The technologies they have developed include a tissue glue that can seal holes inside a beating heart; targeted therapy for osteoarthritis\, Crohn’s disease\, and brain disorders; “smart needles” that automatically stop when they reach their target; a nasal spray that neutralizes pathogens; and immunotherapy approaches to annihilate cancer. Dr. Karp is also head of innovation at Geoversity\, Nature’s University\, a rainforest conservancy located in one of the top biodiversity hotspots in the world. He was selected as the Outstanding Faculty Undergraduate Mentor among all faculty at MIT and the top graduate student mentor of Harvard-MIT students. Dr. Karp lives in Brookline\, Massachusetts\, with his wife\, children\, and two Cavalier King Charles spaniels. \nDr. Milica Radisic is a Professor at the University of Toronto\, Tier 1 Canada Research Chair in Organ-on-a-Chip Engineering and a Senior Scientist at the Toronto General Research Institute. She is also Director of the NSERC CREATE Training Program in Organ-on-a-Chip Engineering & Entrepreneurship and a co-lead for the Center for Research and Applications in Fluidic Technologies. She is a Fellow of the Royal Society of Canada-Academy of Science\, Canadian Academy of Engineering\, the American Institute for Medical & Biological Engineering\, Tissue Engineering & Regenerative Medicine Society as well as Biomedical Engineering Society. Her impressive accolades include being recognized in the MIT Technology Review Top 35 Under 35\, as well as receiving the Queen Elizabeth II Diamond Jubilee Medal\, NSERC E.W.R Steacie Fellowship\, YWCA Woman of Distinction Award\, Killam Fellowship\, Acta Biomaterialia Silver Medal\, and Humboldt Research Award to name a few. Her research focuses on organ-on-a-chip engineering and development of new biomaterials that promote healing and attenuate scarring. \n \nAbout LIT: Life Ignition Tools\nIn the age of convenience\, information overload\, and endless exposure to stimuli\, it’s easy to trudge through the motions of life\, pressured\, distracted\, and seeking instant gratification. When this way of living becomes the norm\, it can immobilize us\, making it feel impossible to reclaim control of our lives with intention and enthusiasm. \nIn LIT (William Morrow; April 9\, 2024)\, Harvard Medical School professor\, Mass General Brigham and MIT researcher\, and renowned bioinspirationalist Jeff Karp\, PhD\, teaches us to harness the vital wisdom and power of nature to place us into a lit state. Lit is a life magnifier\, a heightened state of awareness that drives curiosity\, connection\, and energy. In short: being lit takes us off autopilot and helps us stay alert\, present\, and fully engaged. \nDiagnosed with learning differences and ADHD at a young age\, Karp persisted through nearly insurmountable struggles. After discovering that he could think about thinking at age seven\, he became his own science experiment\, tapping into the lit state through trial and error to achieve hyper-awareness and explore his curiosity\, creativity\, and connection to nature. Decades later\, as a biotech innovator\, husband\, and father\, lit continues to encourage opportunities for innovation in his professional and personal lives. \nHe has honed those methods into a diverse toolkit that he calls Life Ignition Tools (LIT)\, which help us: \n\nBreak out of habitual thinking to discover our own imaginative power.\nStimulate creativity and excitement at work.\nIntegrate our spiritual and personal lives to repair and deepen our relationships.\nNavigate multiple streams of sensory input and manage information overload.\n\nLit has inspired Dr. Karp’s innovative medical discoveries such as surgical glue inspired by slugs\, a diagnostic for cancer based on the tentacles of jellyfish\, and surgical staples based on the quills of a porcupine – but you don’t have to be a scientist to live lit. Anyone can use these principles to redirect their lives with energy\, focus\, creativity\, and motivation to create the lives they truly want to lead.
URL:https://bme.utoronto.ca/event/book-launch-for-lit-life-ignition-tools-by-jeff-karp/
LOCATION:University of Toronto Bookstore\, 214 College Street\, Toronto\, ON\, M5T 3A1\, Canada
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2024/04/d3c80d5789804afaf6b96bf7aea59ed7.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240501T090000
DTEND;TZID=America/Toronto:20240501T110000
DTSTAMP:20240419T150716Z
CREATED:20240419T150716Z
LAST-MODIFIED:20240419T150716Z
UID:10000410-1714554000-1714561200@bme.utoronto.ca
SUMMARY:P.Eng. Licence Seminar
DESCRIPTION:Hear from Professional Engineers Ontario (PEO) licensing staff about the various ways to meet the requirements and qualifications for a licence. You can attend in-person (location on the St. George campus) or virtually\, and the session will also be recorded. This seminar is for faculty\, postdocs\, staff and students at U of T Engineering interested in obtaining an engineering license.  \nThis event is hosted by the Assistant Dean\, Diversity\, Inclusion and Professionalism\, Marisa Sterling\, P.Eng.\, a past president of PEO. \nRegister by Friday\, April 26
URL:https://bme.utoronto.ca/event/p-eng-licence-seminar/
LOCATION:Online and at a location on the St. George campus
CATEGORIES:Info sessions
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T144000
DTEND;TZID=America/Toronto:20240425T145500
DTSTAMP:20240424T215234Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215234Z
UID:10000409-1714056000-1714056900@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Evan Kotler
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Transcription factor-driven recovery of nucleus pulposus and notochordal phenotype\nSupervisor Name: Rita Kandel & Paul Santerre\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-evan-kotler-3/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T142500
DTEND;TZID=America/Toronto:20240425T144000
DTSTAMP:20240424T215234Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215234Z
UID:10000407-1714055100-1714056000@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Ranim Maaieh
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Rational Design of the Adeno-associated Virus Capsid for Reduced Cytotoxic T-Cell Responses in Gene Therapy\nSupervisor Name: Michael Garton\nYear of Study: 5\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-ranim-maaieh-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T141000
DTEND;TZID=America/Toronto:20240425T142500
DTSTAMP:20240424T215234Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215234Z
UID:10000408-1714054200-1714055100@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Oreoluwa Kolade
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Computational analysis of donor heterogeneity and critical processing parameters in mesenchymal stromal cells identifies suitable donors and CPP conditions for improved MSC expansion and potency\nSupervisor Name: Sowmya Viswanathan and Julie Audet\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-oreoluwa-kolade-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T134000
DTEND;TZID=America/Toronto:20240425T135500
DTSTAMP:20240424T215233Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215233Z
UID:10000406-1714052400-1714053300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Nitya Gulati
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Comprehensive Investigation of Glucose Metabolism: From Murine Islets to SC-Derived Beta Cell Aggregates\nSupervisor Name: Jonathan Rocheleau\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-nitya-gulati-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T132500
DTEND;TZID=America/Toronto:20240425T134000
DTSTAMP:20240424T215233Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215233Z
UID:10000405-1714051500-1714052400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Campbell Thom
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Development of an In Vitro Model of the Outer Annulus Fibrosus-Cartilage Endplate Interface within a Perfusion Bioreactor\nAbstract: BACKGROUND: Lower back pain is a leading cause of disability worldwide and is often associated with intervertebral disc (IVD) degeneration. IVDs are fibrocartilaginous tissues between the vertebral bodies of the spine which facilitate load transmission and enable spinal flexibility. Once damaged there is a lack of treatment options that permanently restore functionality. Tissue engineering aims to address the limitations of existing therapeutics by generating living tissue constructs that could replace the diseased disc. Given the complex disc architecture coupled with the limitations of conventional static culturing methods\, the production of tissue constructs that recapitulate the structural features and mechanical strength of the native disc has yet to be achieved. The current study aims to develop an in vitro-formed model of the outer annulus fibrosus (OAF)-cartilage endplate interface\, which is often overlooked in current research despite its critical role in maintaining structural and biochemical integrity of the IVD. It is hypothesized that in vitro-formed OAF can be integrated with in vitro-grown cartilage tissue\, such that the interfacial strength of the tissue interface is significantly enhanced when cultured under perfusion flow within a bioreactor. \,\,METHODS: OAF cells are isolated from bovine caudal discs and seeded onto polyurethane scaffolds\, as described previously1\, in a spinning bioreactor to generate in vitro-formed OAF tissue. These tissues are then co-cultured with deep zone articular chondrocytes that have been isolated from bovine caudal metacarpal-phalangeal joints and cultured on PTFE membranes. OAF-chondrocyte constructs are co-cultured statically for 7 days in mineralizing media containing β-Glycerophosphate. Co-cultures are either maintained in static culture or transferred to a perfusion bioreactor system in which they are dynamically cultured using a flow rate of 5mL/min\, for an additional 7 days before performing histological or mechanical assessment. All experiments\, except for mechanical testing\, were repeated with 3 biological sets\, with each condition done in quadruplicate. Statistical analysis was performed using a T test and significance assigned at p<0.05.\,\,\,RESULTS:\,Co-culture of in vitro-formed OAF tissue and chondrocytes generated an integrated tissue interface composed of cartilage and AF tissue. More tissue appeared to be present\, histologically (Figure 1)\, in constructs grown in the perfusion bioreactor versus static conditions. The interface was also stronger in the perfused constructs as determined using a pull-apart testing\, where the average interfacial strength of perfused and static constructs was 53.3kPa and 18.9kPa\, respectively (preliminary data; N=1). Immunostaining of the OAF-cartilage constructs demonstrate collagen type I\, collagen type II\, and aggrecan distribution for both conditions appear similar to that of the native OAF-CEP interface (Figure 1). Von Kossa staining demonstrates cartilage mineralization under both perfusion and static culture conditions. However\, OAF-cartilage constructs that undergo perfusion appear to have more mineral deposition.\,\,CONCLUSIONS: This study provides a first-generation in vitro OAF-CEP model that incorporates key structural properties of the native interface\, and demonstrates that the use of a perfusion bioreactor enhances development of in vitro-grown IVD tissue interfaces. These findings fill a translation gap in the field of IVD tissue engineering and will support the scale-up of such tissues to physiological sizes.\nSupervisor Name: Rita Kandel\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-campbell-thom-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
END:VCALENDAR