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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231012T150000
DTEND;TZID=America/Toronto:20231012T200000
DTSTAMP:20230911T193440Z
CREATED:20230911T193440Z
LAST-MODIFIED:20230911T193440Z
UID:10000281-1697122800-1697140800@bme.utoronto.ca
SUMMARY:ECHO PITCH 2023
DESCRIPTION:Igniting Cardiovascular Innovation \nJoin us at ECHO PITCH 2023: a special event where six start-ups in the cardiovascular health sector will compete live for up to $250\,000 before a panel of judges. All are welcome to register and be part of the live audience! \nWHEN: Thursday Oct. 12\, 2023\, 3:00-8:00 PM \nWHERE: MaRS Auditorium (MaRS Discovery District\, 101 College St\, Toronto) \nWHAT: \n·        Watch six inspiring innovators of cardiovascular technologies pitch their novel ideas. \n·        Meet\, connect and share ideas with exceptional entrepreneurs\, scientists\, clinicians\, business leaders and investors. \n·        Gain insights from a multi-sectoral panel of judges as well as expert keynote speakers. \n·        Enjoy an afternoon of entertainment\, food and beverages. \nFor event details and registration please visit our event page – space is limited so reserve your spot soon! \nThe Entrepreneurship for Cardiovascular Health Opportunities (ECHO) program is funded and organized by the Translational Biology and  Engineering Program\, at the University of Toronto and the Ted Rogers Centre for Heart Research\, in partnership with the Health Innovation Hub (H2i). For more information on the ECHO program\, please visit: https://tedrogersresearch.ca/echo
URL:https://bme.utoronto.ca/event/echo-pitch-2023/
LOCATION:MaRS Auditorium\, 101 College Street\, Toronto\, Ontario\, M5G 1L7\, Canada
CATEGORIES:Events & Workshops
ATTACH;FMTTYPE=image/png:https://bme.utoronto.ca/wp-content/uploads/2023/09/ECHO-2023.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231012T122500
DTEND;TZID=America/Toronto:20231012T124000
DTSTAMP:20231012T160728Z
CREATED:20230829T212235Z
LAST-MODIFIED:20231012T160728Z
UID:10000251-1697113500-1697114400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - David Crompton
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Computational Modelling of Deep Brain Stimulation\nAbstract: Deep brain stimulation is a common treatment for Parkinson’s disease\,however the mechanisms that make DBS treatment effective are not fully known. The firing rate of activity of regions in the basal ganglia during DBS can serve as an indicator of successful treatment of PD. How DBS reduces neuronal activity to a normal level in PD is not known\, however computational models have provided some insight. Other markers have also been found that may be indicative of successful DBS treatment\, such as the evoked resonant neural activity observed in response to DBS treatment in some locations of the subthalamic nucleus. Computational models have also done well to reveal the possible mechanism of action of ERNA. The accessibility of neural activity throughout the basal ganglia during DBS is limited. Biophysically realistic computational models allow exploration of hypotheses of DBS mechanisms and the PD state. Computational modelling is required to explore features of DBS impact and network dynamics that are sufficient for relevant clinical markers in humans. The aim of this research is to build on the mechanistic understanding of DBS\, as well as the network impact DBS has and the importance of incorporating biophysical details such as morphology and synaptic distribution. The results of this research will be used to design optimal patterns of DBS pulses that maximize clinical outcomes.\nSupervisor Name: Milad Lankarany\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-david-crompton/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231012T121000
DTEND;TZID=America/Toronto:20231012T122500
DTSTAMP:20231012T160728Z
CREATED:20230829T212235Z
LAST-MODIFIED:20231012T160728Z
UID:10000253-1697112600-1697113500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Laura Medlock
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Encoding of tactile stimuli by mechanoreceptors in rodent glabrous skin\nSupervisor Name: Dr. Steve Prescott\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-laura-medlock/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231010T120000
DTEND;TZID=America/Toronto:20231010T130000
DTSTAMP:20231010T151308Z
CREATED:20230804T145029Z
LAST-MODIFIED:20231010T151308Z
UID:10000230-1696939200-1696942800@bme.utoronto.ca
SUMMARY:High Resolution Diffusion MRI of the Human Brain – Christian Beaulieu
DESCRIPTION:Location: Enter from the Elm Street entrance and take the stairs on the left hand side to the second floor. \nSpeaker\nChristian Beaulieu\nProfessor of Radiology and Diagnostic Imaging & Biomedical Engineering\, University of Alberta\nScientific Director of Peter S Allen MRI Research Centre\nCanada Research Chair \n\nAbstract\nMagnetic resonance imaging (MRI) has made major advances for the non-invasive study of the human body in unprecedented ways that has led to improvements in disease diagnosis and yielded fundamental insights about the human body and disease. At a glance\, MRI appears to possess only gross anatomical information at coarse resolution\, but the image contrast generated is due to the interactions of water (the molecule typically being measured in MRI) with its local tissue micro-environment at the level of the cells. This talk will focus on one type of MRI contrast and one core organ\, namely diffusion MRI of the human brain which will be shown to benefit greatly from the acquisition of high spatial resolution images. The emphasis will be on diffusion imaging of the hippocampus and cortex\, which are small\, complex\, critical regions for brain function\, and how they change with typical ‘healthy’ development and aging over the lifespan as well as what insight is provided in neurological disorders such as epilepsy\, stroke\, and multiple sclerosis. \nBio: Dr. Christian Beaulieu is a Professor of Radiology and Diagnostic Imaging & Biomedical Engineering at the University of Alberta (where he has been for 24 years)\, Scientific Director of the Peter S Allen MRI Research Centre\, and a Canada Research Chair. His background includes a BSc in Physical Chemistry at the University of Manitoba\, PhD in Biomedical Engineering at the University of Alberta\, and a postdoctoral fellowship at the Lucas MRI Centre in Radiology at Stanford University. His research expertise lies in the development of new quantitative magnetic resonance imaging (MRI) methods\, mainly diffusion and sodium MRI\, and their application to better detect differences of the human brain in individuals with typical development/aging across the lifespan and with neurological (e.g. stroke\, epilepsy\, multiple sclerosis) or neurodevelopment (e.g. fetal alcohol spectrum disorders) disorders \n\nHost\nHai-Ling Margaret Cheng
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-christian-beaulieu/
LOCATION:TRI-UC – 2nd floor Auditorium\, 550 University Avenue\, 550 University Ave\, Toronto\, ON\, M5G 2A2\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/08/Christian-Beaulieu-scaled_800p.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231005T124000
DTEND;TZID=America/Toronto:20231005T125500
DTSTAMP:20231004T222251Z
CREATED:20230912T215247Z
LAST-MODIFIED:20231004T222251Z
UID:10000287-1696509600-1696510500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Safwat Khan
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Uncovering the transcriptomic profile of pancreatic endothelial cells\nAbstract: The pancreatic islet vasculature displays tissue-specific physiological and functional adaptations that support rapid glucose sensing and insulin response by β-cells. To uncover the transcriptomic basis of this specialization\, we performed a meta-analysis of multi-organ single cell RNA sequencing atlases employing a unique strategy to avoid transcriptomic contamination. We identified biologically relevant genes involved in sphingosine-1-phosphate-mediated insulin-secretion (PLPP1\, RDX\, CDC42EP1)\, islet basement membrane formation (SPARC\, COL15A1)\, endothelial cell (EC) permeability (PLVAP\, EHD4)\, membrane transporters (CD320\, SLCO2A1) and developmental transcription factors (NKX2-3\, AHR). These were validated in silico in independent datasets. We further established the first integrated transcriptomic atlas of human pancreatic ECs and described two unique capillary subpopulations: exocrine and endocrine pancreas ECs. We validated the spatial localization of key markers using RNAscope™ and immunofluorescence staining on mouse pancreatic tissue cross-sections. Our findings provide novel insights into pancreatic EC heterogeneity and islet EC function with potential implications in therapeutic strategies.\nSupervisor Name: Sara Vasconcelos\nYear of Study: 5\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-safwat-khan/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231005T121000
DTEND;TZID=America/Toronto:20231005T122500
DTSTAMP:20231004T222250Z
CREATED:20230901T212311Z
LAST-MODIFIED:20231004T222250Z
UID:10000271-1696507800-1696508700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Melissa Marquez Chin
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Transcutaneous Electrodes for Functional Electrical Stimulation\nSupervisor Name: Milos R. Popovic\nYear of Study: 5\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-melissa-marquez-chin/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230929T120000
DTEND;TZID=America/Toronto:20230929T140000
DTSTAMP:20230911T193735Z
CREATED:20230911T193735Z
LAST-MODIFIED:20230911T193735Z
UID:10000282-1695988800-1695996000@bme.utoronto.ca
SUMMARY:CARTE 2023 Student Networking Event
DESCRIPTION:Attention University of Toronto students: Join us for an in-person networking event to learn from your peers about opportunities to get involved in Analytics/Artificial Intelligence/Machine Learning research projects. \nConfirmed speakers include: \n\nNadia Muhe\, Statistical Support Specialist at UofT’s Map and Data Library\nSoumita Ghosh\, Eric and Wendy Schmidt AI in Science Postdoctoral Fellow at UofT\nPreet Mistry\, Data Sciences Institute (DSI) Summer Undergraduate Data Science (SUDS) Scholar\nGemma Postill and Abhishek Moturu\, Student Education Co-Leads at UofT Temerty Centre for Artificial Intelligence Research and Education in Medicine (T-CAIREM)\nWilliam Gao\, Transform Heart Failure Trainee Awardee\nBilal Taha\, Schwartz Reisman Institute for Technology and Society Graduate Fellow\nSreeja Guhan\, MITACS Accelerate Intern in Analytics/Artificial Intelligence/Machine Learning\nNimit Bhanshali and Richard Shuai\, UofT Machine Intelligence Student Team (UTMIST) Co-Presidents\nMai Ali\, Indigenous and Black Engineering and Technology (IBET) Momentum Fellow\n\nThis is an in-person event at the University of Toronto St. George campus. Capacity is limited and free registration is required. To register\, please fill out this form. Location will be shared with confirmed registrants.
URL:https://bme.utoronto.ca/event/carte-2023-student-networking-event/
LOCATION:Myhal Centre for Engineering Innovation & Entrepreneurship\, 55 St George St.\, Toronto\, Ontario\, M5S 0C9\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230928T124000
DTEND;TZID=America/Toronto:20230928T125500
DTSTAMP:20230927T222255Z
CREATED:20230906T213729Z
LAST-MODIFIED:20230927T222255Z
UID:10000273-1695904800-1695905700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Vrushali Guruji
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Echocardiogram-Based Detection of Congenital Valvular Malformations\nAbstract:\nBicuspid aortic valve disease (BAVD) is a congenital abnormality that impacts over 2% of the global population. The condition involves the fusion of two of the three leaflets of the aortic valve\, leading to aberrant blood flow into the aorta. Disturbed hemodynamics is associated with increased risk of aortopathies\, such as ascending aortic dilatation (AAD)\, which can lead to fatal aortic dissection or rupture.\nWe hypothesize that the elevated risk of developing AAD in BAVD is a result of disruptions local cell function and signaling caused by changes in hemodynamics. To test this hypothesis\, we will leverage a novel mouse model with a mutation in natriuretic peptide 2 receptor (Npr2): ~10% of Npr2+/- mice develop BAVD\, whereas the remaining 90% have normal tricuspid aortic valves (TAV)\, enabling the effects of BAVD-associated hemodynamics to be decoupled from the underlying genetic mutation.\nWe first established echocardiography-based criteria to identify normal tricuspid vs. congenitally abnormal (bicuspid) aortic valves in neonatal Npr2+/- mice. Approximately 10-15% of neonatal mice exhibited echocardiographic features associated with valve malformations and disrupted flow\, including: i) regurgitation and recirculation by color Doppler; ii) peak systolic velocities >1300 mm/sec by pulse Doppler; and iii) putative fusion of leaflets along commissures by electrocardiogram-gated kilohertz visualization. Valves with these echographic features were confirmed by gross anatomy visualization to have stenotic and thickened leaflets\, with partial to full bicuspid fusions. Movat’s pentachrome staining confirmed a range of fusions in BAVs\, mimicking the gradient of malformations observed in human BAVD.\nThis study establishes a robust method to classify and characterize valve morphologies in neonatal mice as an essential first step to studying the role of BAV-associated hemodynamics in AAD. On-going work will determine focal transcriptional and proteomic perturbations in the ascending aorta specifically associated with BAV-associated hemodynamics.\nSupervisor Name: Craig Simmons\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-vrushali-guruji/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230928T122500
DTEND;TZID=America/Toronto:20230928T124000
DTSTAMP:20230829T212235Z
CREATED:20230829T212235Z
LAST-MODIFIED:20230829T212235Z
UID:10000249-1695903900-1695904800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Kate MacQuarrie
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Endothelization and perfusion of a tubular D-PHI/PCNU vascular construct using patient-derived HAMVECs supported by VSMCs and monocytes\nAbstract:\nCoronary and peripheral artery disease are two forms of cardiovascular disease that cause occlusion in small-diameter arteries. The treatment of these conditions has been a challenge\, as endovascular procedures do not provide long-term revascularization\, and synthetic grafts that remain patent at larger diameters quickly stenose at diameters under 6 mm. While autologous grafts using the internal mammary artery or the saphenous vein are the current gold standard\, these vessels have limited availability\, and their quality may be compromised in patients with ischemic conditions. When synthetic grafts are used at small diameters\, the primary modes of failure are thrombosis and intimal hyperplasia\, often due to the lack of a luminal endothelium\, and a mismatch in mechanical properties between the graft and the native vasculature.\nThe objective of my work is to generate a tissue-engineered vascular graft composed of a novel electrospun polyurethane/polycarbonate scaffold\, co-cultured with endothelial cells and stromal cells isolated from patients’ adipose tissue. Briefly\, the four objectives of my project include: (1) evaluating the utility of indirectly co-culturing stromal and endothelial cells across the electrospun membrane\, (2) determining which types of support cells are optimal for the production of a biomimetic vascular graft (differentiated or undifferentiated stromal cells)\, (3) endothelializing the support cell-seeded graft in a perfusion bioreactor\, then treating the construct with physiological levels of shear stress\, and (4) implanting the endothelialized graft in a small animal model for preliminary in vivo studies.\nSupervisor Name: Paul Santerre\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-kate-macquarrie-2/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230928T122500
DTEND;TZID=America/Toronto:20230928T124000
DTSTAMP:20230927T222255Z
CREATED:20230829T212235Z
LAST-MODIFIED:20230927T222255Z
UID:10000250-1695903900-1695904800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Kate MacQuarrie
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Endothelization and perfusion of a tubular D-PHI/PCNU vascular construct using patient-derived HAMVECs supported by VSMCs and monocytes\nAbstract:\nCoronary and peripheral artery disease are two forms of cardiovascular disease that cause occlusion in small-diameter arteries. The treatment of these conditions has been a challenge\, as endovascular procedures do not provide long-term revascularization\, and synthetic grafts that remain patent at larger diameters quickly stenose at diameters under 6 mm. While autologous grafts using the internal mammary artery or the saphenous vein are the current gold standard\, these vessels have limited availability\, and their quality may be compromised in patients with ischemic conditions. When synthetic grafts are used at small diameters\, the primary modes of failure are thrombosis and intimal hyperplasia\, often due to the lack of a luminal endothelium\, and a mismatch in mechanical properties between the graft and the native vasculature.\nThe objective of my work is to generate a tissue-engineered vascular graft composed of a novel electrospun polyurethane/polycarbonate scaffold\, co-cultured with endothelial cells and stromal cells isolated from patients’ adipose tissue. Briefly\, the four objectives of my project include: (1) evaluating the utility of indirectly co-culturing stromal and endothelial cells across the electrospun membrane\, (2) determining which types of support cells are optimal for the production of a biomimetic vascular graft (differentiated or undifferentiated stromal cells)\, (3) endothelializing the support cell-seeded graft in a perfusion bioreactor\, then treating the construct with physiological levels of shear stress\, and (4) implanting the endothelialized graft in a small animal model for preliminary in vivo studies.\nSupervisor Name: Paul Santerre\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-kate-macquarrie/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230921T121000
DTEND;TZID=America/Toronto:20230921T122500
DTSTAMP:20230920T215240Z
CREATED:20230829T212235Z
LAST-MODIFIED:20230920T215240Z
UID:10000248-1695298200-1695299100@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Nicolas Ivanov
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Towards user-centric brain-computer interface development: Markov chain-based user assessment for mental imagery EEG-BCIs\nSupervisor Name: Tom Chau\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-nicolas-ivanov/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230919T183000
DTEND;TZID=America/Toronto:20230919T200000
DTSTAMP:20230911T143546Z
CREATED:20230911T143546Z
LAST-MODIFIED:20230911T143546Z
UID:10000280-1695148200-1695153600@bme.utoronto.ca
SUMMARY:Global Data and AI Future Catalyst Program Information Session
DESCRIPTION:Sanofi is recruiting for our Global Data and AI Future Catalyst Program based out of our Global AI Centre of Excellence in Toronto. This is a unique experience designed to grow future leaders into subject matter experts or leaders in the data and AI space\, learning from industry experts and former academic leaders. \nJoin us in chasing the miracles of science through our Data and AI Future Catalyst program. \nIn this 2-year program\, you will join the Global Data and AI Future Catalyst Program as an Analyst in one of the following areas: \n\nData Science\nData and Business\nData and ML (Machine Learning) Engineering\nSoftware Engineering\nData and AI Strategy\n\nWe will be hosting an information session at the University of Toronto (In-Person) and two virtual information sessions. A Zoom link will be sent to the individuals who registered prior to the virtual events. \n  \nEVENT: Global Data & AI Catalyst Rotational Info Session at the University of Toronto (In-Person)  \nWHEN: Wednesday\, September 19\, 2023 \nTIME:  6:30 – 8:00 PM \nLOCATION: Wallberg Memorial Building (WB 116)\,184 College St\, Toronto\, ON M5S 3E4 \n  \nThe two virtual sessions are open to all universities\, please select 1 Zoom session to attend if you are unable to attend onsite. Sign-up for the information session by clicking on the link after each session details. \n  \nEVENT: Global Data & AI Catalyst Rotational Info Session 1  \nWHEN: Wednesday\, September 13\, 2023 \nTIME: 5:30-7:00 PM \nRegistration Link: https://sanofi.zoom.com/meeting/register/tJIsf-Ctrj8uGtWh6vory5XLJ9d-M2HOQtLu \n  \nEVENT: Global Data & AI Catalyst Rotational Info Session 2  \nWHEN: Thursday\, September 21\, 2023 \nTIME: 5:30-7:00 PM \nRegistration Link: https://sanofi.zoom.com/meeting/register/tJ0pc-6hpz0iEtChZ46rX06sPVWGxVN14TGf \n  \nApplications for the Global Data and AI Future Catalyst Program will start on Tuesday\, September 12th\, 2023.  
URL:https://bme.utoronto.ca/event/global-data-and-ai-future-catalyst-program-information-session/
LOCATION:Wallberg Memorial Building (WB 116)\,184 College St\, Toronto\, ON M5S 3E4
CATEGORIES:Events & Workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230914T121000
DTEND;TZID=America/Toronto:20230914T122500
DTSTAMP:20230913T215235Z
CREATED:20230828T212231Z
LAST-MODIFIED:20230913T215235Z
UID:10000243-1694693400-1694694300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Jonathan Wu
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Investigation of wearable spectroscopy systems for the characterization of depth-resolved tissue oxygenation\nAbstract: Recent advances in optical sensor technology will enable the evaluation and monitoring of ischemic diseases at home. Near infrared spectroscopy (NIRS) is a standard tool in the evaluation of tissue ischemia and a cost-effective method for estimating hemoglobin oxygenation and tissue perfusion without an invasive procedure. However\, most continuous-wave NIRS systems are wired\, bed-side systems and assume an averaged tissue oxygenation for the tissue depths it probes. The ability to resolve tissue oxygenation at specific tissue layers may allow for greater accuracy and the detection of dynamic vascular activity. The objective of this proposed study is to evaluate the effectiveness of wearable technology in measuring depth-resolved tissue oxygenation. I will achieve this through: (1) fabrication of a wearable multi-detector\, continuous-wave spectroscopy device (2) developing a numerical algorithm for the discretization of hemodynamic properties at stratified tissue depths via optical simulations\, and (3) evaluation of wearables and methods compared to photoacoustic imaging in healthy individuals during vasomodulatory stimuli. By completing this study\, I will develop a method and technology for monitoring tissue ischemia in ambulatory patients. This study will provide valuable insight into the feasibility of using wearable technology to non-invasively monitor tissue oxygenation at different depths\, which could have important applications in the monitoring of wound healing and tissue perfusion in medical conditions such as diabetes and peripheral artery disease.\nSupervisor Name: Daniel Franklin\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-jonathan-wu/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230913T073000
DTEND;TZID=America/Toronto:20230913T173000
DTSTAMP:20230711T185056Z
CREATED:20230711T185056Z
LAST-MODIFIED:20230711T185056Z
UID:10000229-1694590200-1694626200@bme.utoronto.ca
SUMMARY:CRANIA Conference 2023
DESCRIPTION:We are thrilled to invite you to the 2nd annual CRANIA Conference hosted by the Center for Advancing Neurotechnological Innovation to Application—Canada’s top academic\, research\, and clinical hub for neuromodulation. The conference is a forum for students and professionals to exchange ideas and expand their network through engaging workshops and captivating panel discussions about the future of neuromodulation. Tickets are limited.
URL:https://bme.utoronto.ca/event/crania-conference-2023/
LOCATION:Ontario
CATEGORIES:Events & Workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230912T120000
DTEND;TZID=America/Toronto:20230912T130000
DTSTAMP:20230911T170643Z
CREATED:20230815T143943Z
LAST-MODIFIED:20230911T170643Z
UID:10000238-1694520000-1694523600@bme.utoronto.ca
SUMMARY:Neuromodulation and Neuroplasticity - Dr. Milos Popovic
DESCRIPTION:Speaker\nMilos Popovic\, Dipl. El. Eng.\, Ph.D.\, FCAE\, FAIMBE\, P.Eng.\n\nAbstract\nIn this lecture\, I will share the journey my trainees\, colleagues\, and I embarked on over the past twenty-five years\, crafting numerous clinically relevant therapies. First\, I’ll delve into FES therapy’s role in restoring motor functions. Next\, I’ll explore the augmentation of FES therapies through brain-machine interfaces. We’ll then uncover the potential of electrical fields to enhance stem cell production and guide their movement. Finally\, I’ll discuss the application of facial stimulation for depression treatment. With the exception of stem cell therapy\, all interventions have undergone patient testing and demonstration\, with several already established as commercially viable products. \n\nBio\nMilos R. Popovic is the Director of The KITE Research Institute at the Toronto Rehabilitation Institute – University Health Network and the Director of the Institute of Biomedical Engineering at the University of Toronto.  Dr. Popovic is a Fellow of the Canadian Academy of Engineering and a Fellow of the American Institute of Medical and Biological Engineering.  He is the co-founder and director of MyndTec and the Canadian Spinal Cord Injury Rehabilitation Association.  Dr. Popovic is the co-founder and previous director of the Centre for Advancing Neurotechnological Innovation to Application (CRANIA) at the University Health Network and the University of Toronto and the CRANIA Neuromodulation Institute at the University of Toronto.  He is also the founder of FabrIc-Based REsearch (FIBRE) Platform and the Rehabilitation Engineering Laboratory\, both located at the KITE Research Institute\, Toronto Rehabilitation Institute – University Health Network.  Dr. Popovic held the Toronto Rehab Chair in Spinal Cord Injury Research appointment from 2007 until 2017. \nDr. Popovic received his Ph.D. degree in mechanical engineering from the University of Toronto\, Canada\, in 1996\, and the Dipl. Electrical Engineer degree from the University of Belgrade\, Serbia\, in 1990.  His fields of expertise are functional electrical stimulation\, neuroprostheses\, neuro-rehabilitation\, neuromodulation\, brain-machine interfaces\, physiological control systems\, assistive technology\, modelling and control of linear and non-linear dynamic systems\, robotics\, and signal processing. \nIn 1997\, together with Dr. Keller\, he received the Swiss National Science Foundation Technology Transfer Award – 1st place.  In 2008\, Dr. Popovic was awarded the Engineering Medal for Research and Development from the Professional Engineers of Ontario and the Ontario Society of Professional Engineers.  In 2012\, company MyndTec Inc.\, which Dr. Popovic co-founded in 2008\, won the 1st Prize and the Best Intellectual Property Award at the annual TiEQuest Business Venture Competition.  In 2013\, he received the Morris (Mickey) Milner Award for outstanding contributions in the area of Assistive Technologies from the Health Technology Exchange.  Also\, in 2013\, together with Drs. Prodic\, Lehn\, Huerta-Olivares\, and Tarulli\, Dr. Popovic received the University of Toronto Inventor of the Year Award.  In 2015\, Dr. Popovic received the 2014 University Health Network’s Inventor of the Year Award.  In 2017\, he won the Accessibility Innovation Showcase and Tech Pitch Competition Award at the Ontario Centers of Excellence Discovery 2017 Conference.  In 2018\, Dr. Popovic received a Jonas Salk Lifetime Achievement Award for his lifetime contributions from the March of Dimes Canada.  In 2019\, he was awarded the Engineering Medal for Entrepreneurship from the Professional Engineers of Ontario and the Ontario Society of Professional Engineers.  The same year he was named the Honorary Professor at the Nanjing Medical University\, Nanjing\, China.  In 2020 he received the Dave Lostchuck Memorial Award for Outstanding Research from the Canadian Spinal Research Organization\, Toronto\, Canada. \n  \n  \n 
URL:https://bme.utoronto.ca/event/neuromodulation-and-neuroplasticity-dr-milos-popovic/
LOCATION:Medical Science Building\, Room 2170\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/08/Milos-Popovic_landscape-scaled_800p.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230823T100000
DTEND;TZID=America/Toronto:20230823T110000
DTSTAMP:20230815T145746Z
CREATED:20230815T145746Z
LAST-MODIFIED:20230815T145746Z
UID:10000240-1692784800-1692788400@bme.utoronto.ca
SUMMARY:Immune Engineering: Detection and Treatment of Undesired Immune Responses - Dr. Johnna Temenoff
DESCRIPTION:Speaker\nDr. Lonnie Shea\, PhD University of Michigan \nAbstract\nVaccines are the initial immunotherapy by providing a means to activate an immune response to specific antigens to protect against disease. This success has motivated the development of alternative immunotherapies for treating undesired immune responses\, such as those found in autoimmune disease\, allergy\, organ transplantation\, and cancer\, with the objective to attenuate responses. For autoimmune and allergic disease\, we have developed nanoparticles loaded with antigen or allergen\, which suppresses the antigen specific response without impacting the remainder of the immune system. The nanoparticles maintain the antigen until internalization by immune cells\, with subsequent presentation of the antigen coincident with down-regulation of the co-stimulatory factors and up-regulation of negative co-stimulators. Similar nanoparticles have been applied to attenuate inflammation\, such as that associated with cancer progression. A critical need for treating undesired immune responses is the identification of disease prior to significant tissue damage\, with disease such as Type 1 Diabetes\, multiple sclerosis\, or metastatic cancer often detected through patients self- reporting symptoms. We have developed scaffold implants that support the formation of tissues that function as an immunological niche to represent the immune function in endogenous tissues. The early detection and treatment of undesired immune responses provides an opportunity to ameliorate disease while preserving tissue function. \nBiography\nLonnie Shea is the Steven A. Goldstein Collegiate Professor in the Department of Biomedical Engineering at the University of Michigan (U-M)\, which is joint between the College of Engineering and the School of Medicine. He received his PhD in chemical engineering and scientific computing from U-M in 1997\, working with Professor Jennifer Linderman. He then served as a postdoctoral fellow with then Chemical Engineering Professor David Mooney in the Department of Biologic and Materials Science at the U-M Dental School. \nShea was recruited to Northwestern University’s Department of Chemical and Biological Engineering and was on the faculty from 1999 to 2014. In 2014\, Shea returned to the University of Michigan as chair of the Department of Biomedical Engineering\, with his recruitment coinciding with the endowment of the chair position by William and Valerie Hall. His term as chair completed on June 30\, 2021. He is the Steven A. Goldstein Collegiate Professor of Biomedical Engineering and is an internationally recognized researcher at the interface of regenerative medicine\, drug and gene delivery\, and immune-engineering\, whose focus is on preventing tissue degeneration or promoting tissue regeneration. His projects include islet transplantation for diabetes therapies\, nerve regeneration for treating paralysis\, and diagnostics for immune dysfunction in cancer and autoimmunity. He is currently PI or co-PI on multiple NIH grants. \nShea has published more than 270 manuscripts. He served as director of Northwestern’s NIH Biotechnology Training Grant. He has received the Clemson Award from the Society for Biomaterials\, and also the recipient of their 2021 Technology Innovation and Development Award for his development of nanoparticles for tolerance in autoimmune disease. Shea is a fellow of the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES)\, a member of the editorial boards for multiple journals such as Molecular Therapy\, Biotechnology and Bioengineering\, and the Journal of Immunology and Regenerative Medicine.
URL:https://bme.utoronto.ca/event/immune-engineering-detection-and-treatment-of-undesired-immune-responses-dr-johnna-temenoff/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230821T130000
DTEND;TZID=America/Toronto:20230821T133000
DTSTAMP:20230818T132252Z
CREATED:20230816T163634Z
LAST-MODIFIED:20230818T132252Z
UID:10000241-1692622800-1692624600@bme.utoronto.ca
SUMMARY:Mon Aug 21st – Carter Teal’s Public Seminar
DESCRIPTION:Dear BME community:  \nFor anyone interested\, Carter Teal will be having their public seminar on August 21st @ 1:00PM in the Red Room at the Donnley center. Anyone interested in attending please see details below.  \nPublic Seminar: “Affinity-Based Approaches for Controlling Release of Therapeutic Proteins from Biopolymer Hydrogels”\nName: Carter Teal\nExam Date: August 21\, 2023\nTime: 1:00PM\nLocation: Red Seminar Room in the Donnley (160 College Street).\nAbstract: Carter Teal – PhD Thesis Abstract_\nPulic Seminar Link: Join Zoom Meeting\nhttps://utoronto.zoom.us/j/86965840489 \nMeeting ID: 869 6584 0489\nPasscode: 593511
URL:https://bme.utoronto.ca/event/mon-aug-21st-carter-teals-public-seminar/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230821T103000
DTEND;TZID=America/Toronto:20230821T113000
DTSTAMP:20230815T145518Z
CREATED:20230815T145518Z
LAST-MODIFIED:20230815T145518Z
UID:10000239-1692613800-1692617400@bme.utoronto.ca
SUMMARY:Delivery of Biologics for Rotator Cuff Muscle Healing - Dr. Johnna Temenoff
DESCRIPTION:Speaker\nDr. Johnna Temenoff\, PhD Georgia Tech/Emory University \nAbstract\nAfter rotator cuff tendon tear\, marked degeneration of the attached muscle is apparent clinically\, with both fibrous and fatty infiltration of the tissue. Our laboratory is working on delivery strategies for biologics\, including proteins and cells\, that might slow or reverse this degeneration. In particular\, our laboratory has focused on “jump-starting” host regenerative processes through use of glycosaminoglycan (GAG)-based biomaterials for release of cytokines to promote the recruitment of pro-healing cell populations\, such as pro- resolving macrophages\, and mesenchymal stromal cells (MSCs)\, into the muscle. In other work\, we have explored priming strategies for MSCs to alter their immunomodulatory properties as a means to reduce inflammation\, such as that which occurs in muscle after rotator cuff tendon tear. \nBiography\nDr. Johnna S. Temenoff is the Carol Ann and David D. Flanagan Professor the Coulter Department of Biomedical Engineering at Georgia Tech/Emory University. She is also currently the Deputy Director of a NSF Engineering Research Center in Cell Manufacturing Technologies (CMaT). Scientifically\, Dr. Temenoff is interested in tailoring the molecular interactions between glycosaminoglycans and proteins/cells for use in regenerative medicine applications. Her laboratory focuses primarily on promoting repair after injuries to the tissues of the shoulder\, including cartilage\, tendon\, and muscle. \nDr. Temenoff has been honored with several prestigious awards\, such as the NSF CAREER Award\, Arthritis Foundation Investigator Award and Society for Biomaterials (SFB) Clemson Award for Contributions to the Literature\, and was named to the College of Fellows of the American Institute for Medical and Biological Engineers (AIMBE)\, as a Fellow of the Biomedical Engineering Society (BMES) and as a Fellow of Biomaterials Science and Engineering\, International Union of Societies for Biomaterials Science and Engineering (IUSBSE). She has co-authored a highly successful introductory textbook – Biomaterials: The Intersection of Biology and Materials Science\, by J.S. Temenoff and A.G. Mikos (now in a 2nd edition)\, for which Dr. Temenoff and Dr. Mikos were awarded the American Society for Engineering Education’s Meriam/Wiley Distinguished Author Award for best new engineering textbook.
URL:https://bme.utoronto.ca/event/delivery-of-biologics-for-rotator-cuff-muscle-healing-dr-johnna-temenoff/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230810T103000
DTEND;TZID=America/Toronto:20230810T113000
DTSTAMP:20230808T182856Z
CREATED:20230808T182726Z
LAST-MODIFIED:20230808T182856Z
UID:10000237-1691663400-1691667000@bme.utoronto.ca
SUMMARY:Tiny Bubbles: New Applications of Nanoscale Contrast Media in Ultrasound-based Cancer Diagnosis and Therapy
DESCRIPTION:Princess Margaret Special Seminar presents: \n  \nAGATA EXNER\, Ph.D\nHenry Willson Payne Professor & Vice Chair for Basic Research \nDepartment of Radiology \nCase Western Reserve University School of Medicine \nUniversity Hospitals of Cleveland\, Ohio \n  \nHost: Dr. Gang Zheng \nSponsored by Medical Biophysics\, University of Toronto
URL:https://bme.utoronto.ca/event/tiny-bubbles-new-applications-of-nanoscale-contrast-media-in-ultrasound-based-cancer-diagnosis-and-therapy/
LOCATION:Princess Margaret Cancer Research Tower (PMCRT) Room 4-204\, 101 College St\, 4th Floor\, Rm 4-204\, Toronto\, Ontario\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230714T100000
DTEND;TZID=America/Toronto:20230714T110000
DTSTAMP:20230713T203825Z
CREATED:20230707T132519Z
LAST-MODIFIED:20230713T203825Z
UID:10000228-1689328800-1689332400@bme.utoronto.ca
SUMMARY:Following the Rabbit into Chemical Space
DESCRIPTION:Dr. Brian K. Shoichet\, PhD\nUniversity of California\, San Francisco \nhttps://utoronto.zoom.us/j/86086638773 \nMeeting ID: 860 8663 8773 \nPasscode: 484696 \nStructure-based docking can be used to screen compound libraries for novel ligands. Recently\, docking libraries  have expanded from three million “in-stock” to over four billion make-on-demand (“tangible”) molecules. Docking these new libraries versus the dopamine\, melatonin\, and 2 receptors have revealed novel scaffolds with nM and sub-nM potencies directly from the docking. I will discuss recent applications to the alpha2a-adrenergic\, serotonin\, and cannabinoid receptors\, and the serotonin transporter\, where in vivo active leads have been developed for analgesia\, depression\, and opioid withdrawal.  \nMethods questions will also be considered: the effect of bias toward bio-like molecules in the virtual libraries\, how and if docking score improves as the libraries grow\, how number tested affects the quality of the experimental actives\, and whether we have reached a plateau in the results we can expect from large library docking\, or if bigger remains better.  \nBiography  \nBrian Shoichet received a B.Sc. in Chemistry and a B.Sc. in History in 1985\, from MIT. MIT appears to have no record of this. He received his Ph.D. for work with Tack Kuntz on molecular docking in 1991\, from UCSF. Shoichet’s postdoctoral research was largely experimental\, focusing on protein structure and stability with Brian Matthews at the Institute of Molecular Biology in Eugene\, Oregon\, as a Damon Runyon Fellow. Colleagues from Eugene have only sketchy  \nmemories of his time there. One recalls\, “He seemed to travel a lot.” Matthews himself was unavailable for comment. Shoichet joined the faculty at Northwestern University in the Dept.of Molecular Pharmacology & Biological Chemistry as an Assistant Professor in 1996. No record of this Department’s existence can be found outside of one locked filing cabinet in Gene Silinsky’s office. Silinsky was unavailable for comment. In a fit of absent-mindedness\, Shoichet was promoted to a tenured Associate Professor in 2002\, only one year after his younger sister\, Molly Shoichet\, received tenure at the University of Toronto. Shoichet denies any sensitivity around this issue. Around that time he was recruited back to UCSF\, where he is now a Professor in the Department of Pharmaceutical Chemistry. We confused him with Kevan Shokat\, admits a member of the recruiting committee at UCSF. A charismatic speaker\, he is recalled as giving ‘the best talk at the worst Keystone Conference I ever attended\,’ by a senior NIH Program Officer.  \nResearch in the Shoichet Lab seeks to bring chemical reagents to biology\, combining computational simulation and experiment. An unanticipated observation emerging from the theory/experiment cycle was the colloidal aggregation of organic molecules. This phenomenon has great effects in early and late drug discovery\, and we continue to investigate it. More broadly\, we adopt a protein-centric approach that seeks new ligands to complement protein structures. This involves new docking methods\, model experimental systems to test them. Using a ligand-centric approach\, we seek new targets for established drugs and reagents. Whereas this lacks the physical foundation of the structure-based research program\, it returns to an older\, pharmacological view of biological relationships\, bringing to it a quantitative model. A focus for both approaches is ligand discovery against G Protein-Coupled Receptors (GPCRs).  \n\nHosted by Dr. Molly Shoichet Snacks and refreshments will be served. 
URL:https://bme.utoronto.ca/event/following-the-rabbit-into-chemical-space/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230713T140000
DTEND;TZID=America/Toronto:20230713T150000
DTSTAMP:20230705T202752Z
CREATED:20230705T202752Z
LAST-MODIFIED:20230705T202752Z
UID:10000227-1689256800-1689260400@bme.utoronto.ca
SUMMARY:Carbon nanomaterials for cardiac regenerative medicine
DESCRIPTION:Dr. Sanjiv Dhingra\, PhD\nUniversity of Manitoba\nAbstract: Donor derived allogeneic stem cells including mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) are being tested in animal studies and clinical trials for cardiac regeneration and repair. The outcome of initial studies was very encouraging and transplanted cells were safe in the recipient heart. However\, poor survival of transplanted stem cells in the infarcted heart has impaired the clinical translation of stem cells-based therapies. We have performed investigations to understand the mechanisms of poor survival of implanted stem cells in the heart. We found that allogeneic stem cells after transplantation in the ischemic heart turned immunogenic and were subsequently rejected by host immune system. In our ongoing studies we are focusing on understanding the mechanisms of increase in immunogenicity of allogeneic stem cells. We are also developing biomaterials-based strategies to prevent rejection of transplanted cells in the heart. We synthesized and characterized MXene quantum dots (MQDs). MQDs possess intrinsic immunomodulatory properties and selectively reduce activation of CD4+IFN-γ+ T-lymphocytes and promote expansion of immunosuppressive CD4+CD25+FoxP3+ regulatory T-cells in an activated lymphocyte population. We also incorporated MQDs into a chitosan-based hydrogel to create a 3D platform for stem cell delivery to the heart. This composite immunomodulatory hydrogel-based platform improved survival of stem cells and mitigated allo-immune responses. We also found that MQDs have potential to mitigate allograft vasculopathy and prevent rejection of transplanted organs. These studies highlight the potential of MXene based next generation biomaterials for cardiac regenerative medicine. \nAbout the speaker: Dr. Sanjiv Dhingra is a Professor at the University of Manitoba\,  Director of Canada Italy Tissue Engineering Program Institute of Cardiovascular Sciences and a researcher at St. Boniface Hospital Research Regenerative Medicine Program. He is a Professor at the Department of Physiology and Pathophysiology\, Biomedical Engineering Program Max Rady College of Medicine\, Rady Faculty of Health Sciences University of Manitoba.
URL:https://bme.utoronto.ca/event/carbon-nanomaterials-for-cardiac-regenerative-medicine/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230711T100000
DTEND;TZID=America/Toronto:20230711T110000
DTSTAMP:20230705T135639Z
CREATED:20230705T135506Z
LAST-MODIFIED:20230705T135639Z
UID:10000226-1689069600-1689073200@bme.utoronto.ca
SUMMARY:Polymer Nanoparticle Design and Delivery Strategies to Resolve Vascular Inflammation
DESCRIPTION:Dr. Laura Bracaglia\, PhD Villanova University\nPolymer nanoparticles (NPs) can provide a safe and efficient delivery mechanism for therapy directly at specific tissues and cells\, but achieving sufficient levels of NPs and therefore therapeutics in target tissues in humans has remained a barrier to the translation of this technology. The in vivo efficacy of polymeric NPs is dependent on their pharmacokinetics\, including time in circulation and resulting tissue tropism\, as well as intracellular trafficking and behavior. In this work\, we examine tunable chemical and molecular characteristics of polymer NPs to tailor the design for an intended therapeutic delivery – both to and within the target cell. We are particularly interested in designing NPs and delivery strategies which can direct therapeutics to endothelial cells to correct dysfunctional inflammation in the vasculature. I will present several approaches for nucleic acid and small molecule delivery using polymeric NPs in vitro\, in vivo\, and in ex vivo models of human tissue\, and show the impact of design changes on reducing inflammatory signaling. Our goal is to optimize NP design to combat dysfunctional inflammation locally and with more impact than globally administered therapies. \nBiography \nDr. Bracaglia joined the faculty at Villanova University in the fall of 2022 as an Assistant Professor in the Department of Chemical and Biological Engineering. She is continuing her research into NP-based therapeutic delivery to human vasculature and integrating these strategies with tissue-engineering to create tools for long-term immune \nmodulation. Specifically\, materials that provide support for tissue regrowth while temporarily inhibiting inflammation-related injury\, thus reducing the burden of chronic inflammation. This work was born out of work that Dr. Bracaglia conducted as a Postdoctoral Fellow in Biomedical Engineering at Yale University as part of Dr. W. Mark Saltzman’s research group\, as well as her graduate work\, where she developed vascular\, tissue engineered constructs using a combination of biological and synthetic materials at the University of Maryland with Dr. John Fisher in Bioengineering. \n\nHosted by Dr. Molly Shoichet Snacks and refreshments will be served
URL:https://bme.utoronto.ca/event/polymer-nanoparticle-design-and-delivery-strategies-to-resolve-vascular-inflammation/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230620T120000
DTEND;TZID=America/Toronto:20230620T130000
DTSTAMP:20230615T195953Z
CREATED:20230615T195640Z
LAST-MODIFIED:20230615T195953Z
UID:10000225-1687262400-1687266000@bme.utoronto.ca
SUMMARY:Enlightening Panel discussion: Navigating the Path to a Professorship Position
DESCRIPTION:Time: June 20th\, 12-1PM \nLocation: KITE\, UC Lecture theatre (basement) \n  \nAre you concerned how to secure a job in academia\, post-COVID? \nWe have four outstanding panelists who will start their career as Assistant Professors this fall. Please join us at a vibrant event\, co-sponsored by IEEE-EMBS Toronto and FIBRE\, to hear from our panelist and ask your questions. \nAnd\, there will be pizza too ? \nTo facilitate logistics of the event\, please kindly register at:   https://events.vtools.ieee.org/m/363572 \nIf you have any questions\, please feel free to reach out to Ivana Culjak at Ivana.Culjak@uhn.ca
URL:https://bme.utoronto.ca/event/enlightening-panel-discussion-navigating-the-path-to-a-professorship-position/
LOCATION:Ontario
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230620T110000
DTEND;TZID=America/Toronto:20230620T120000
DTSTAMP:20230607T141938Z
CREATED:20230607T141938Z
LAST-MODIFIED:20230607T141938Z
UID:10000224-1687258800-1687262400@bme.utoronto.ca
SUMMARY:The Journey from Concept to Commercial
DESCRIPTION:  \nPlease join us for an ECHO webinar featuring Garrett Schwab\, who will provide an overview of his vast experience developing and commercializing novel therapeutic medical technologies. \nXII Medical is a privately held medical technology company developing a novel neurostimulation system designed to improve patient experience and outcomes for the millions suffering from Obstructive Sleep Apnea. \nGuest Speaker\nGarrett Schwab\, BA\, MBA \nPresident and CEO\, XII Medical \nRegister in advance for this webinar. After registering\, you will receive a confirmation email containing information about joining the webinar.\nECHO is an entrepreneurship training program\, funded and organized in a partnership between (i) the Translational Biology and Engineering Program (TBEP)\, the University of Toronto component of the Ted Rogers Centre for Heart Research\, and (ii) the Health Innovation Hub (H2i). For more information\, visit: https://tedrogersresearch.ca/echo/
URL:https://bme.utoronto.ca/event/the-journey-from-concept-to-commercial/
LOCATION:Ontario
CATEGORIES:Events & Workshops
ORGANIZER;CN="Translational Biology and Engineering Program (TBEP)":MAILTO:reception.tbep@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230609T140000
DTEND;TZID=America/Toronto:20230609T150000
DTSTAMP:20230509T151030Z
CREATED:20230509T151030Z
LAST-MODIFIED:20230509T151030Z
UID:10000220-1686319200-1686322800@bme.utoronto.ca
SUMMARY:Plasmon-enhanced Fluorescence Induced Stimulated Raman Scattering as Non-destructive Non-linear Optical Method in Nanobiosensing and Bioimaging
DESCRIPTION:Mohammad E. Khosroshahi\nNanobiophotonics & Biomedical Research Laboratory\, MIS-Electronics Inc.\, \nRichmond Hill\, Canada \n  \nAbstract \nThis work describes the generation and observation of multi-wavelengths due to stimulated Raman scattering (SRS) from deep red to near-infrared (NIR) induced by plasmon-enhanced fluorescence (PEF) of fluorescein isothiocyanate (FITC) conjugated gold nanoparticles (F-AuNP). The plasmonic solution was excited by a 488 nm diode laser and the PEF due to overlapping of FITC\, and localized surface plasmon resonance (LSPR) of AuNP resonance peaks provided an efficient coupling between the near-field of LSPR of AuNPs as a nano-antenna and the molecules followed by an enhanced emission. Resonance Rayleigh scattering and PEF conditions are both satisfied. PEF acts as Stokes radiation and secondary pump beam for further optical excitation within the medium. Longer wavelengths with higher output power and shorter wavelengths with lower are detected at varying angles. Time-resolved PEF spectroscopy revealed the effect of enhanced emission followed by its quenching. In addition\, F-AuNPs were incubated and taken up by the king oyster mushroom (KOM) grown in the lab studied by phase contrast microscope (PCM) and fluorescence microscope (FM). The results showed PEF and SRS visible colors within the mycelium hyphae. Therefore\, it is concluded that non-linear optical mechanisms can be utilized for non-destructive biomedical applications such as invitro and in vivo contrast-enhanced fluorescence sensing and nano-bioimaging of cells and tissues as monitoring techniques. \nBiography \nProfessor Mohammad E. Khosroshahi received his Ph.D. in Applied Physics (Application of Lasers in Medicine) from Hull University (UK) in 1993 with the thesis on ophthalmological tissue ablation with tunable mid-IR and excimer lasers in collaboration with Moorefields hospital in London. He joined the Biomaterial and Tissue Engineering group of the Faculty of Biomedical Engineering at Amirkabir University of Technology (AUT) in Tehran where he was a Full Professor. He has been the Director of AUT Laser and Optics Research Center\, Associate Dean of Research\, and Chair of Biomaterial Group. In 2013\, he joined the University of Toronto\, Department of Mechanical & Industrial Engineering (MIE) as a Visiting Professor working on ‘’Contrast-enhanced photoacoustic imaging of Tumor’’ at the Center for Advanced Diffusion-Wave and Photoacoustic Technologies (CADIPT). He then continued as a research associate at CADIPT working on the contrast-enhanced imaging of blood and became the faculty adjunct Professor in 2018. \nProfessor Khosroshahi is the author of two books:  Laser Applications in Medicine\, and Applications of Biophotonics and Nanobiomaterials in Biomedical Engineering\, and co-author of two book chapters on Laser surface modification of titanium alloys as biomedical implants. He has published 110 peer-reviewed papers and has 2 patents and patent-pending related to nanobiosensors. His main research interests are Nanobiophotonics\, Nanomedicine\, Multifunction nanostructures\, Targeted drug delivery\, Targeted photothermal therapy\, Guided bioimaging\, biological chaos\, Cancer thermodynamics\, Optical detection of dental decay\, Photoacoustic and Photothermal characterization. Currently\, Professor Khosroshahi is Director of the Nanobiophotonics and Biomedical Research Lab at MIS-Electronics in Richmond Hill where he is working on the development of novel colloidal and substrate nanobiosensors based on the Plasmon-enhanced fluorescence spectroscopy (PEFS) and Enhanced-surface-enhanced Raman scattering (E-SERS) for targeted detection of breast cancer biomarkers such as HER-II and CA 15-3\, dual-mode guided bioimaging\, fluorescence microscopy\, and contrast phase microscopy. He is a member of the Editorial Board of the Journal of Nanomedicine and Nanotechnology\, a fellow member of the Institute of Nanotechnology\, a member of the Canadian Association of Physics\, Canadian Medical and Biological Engineering Society\, Optical Society of America\, and SPIE.
URL:https://bme.utoronto.ca/event/plasmon-enhanced-fluorescence-induced-stimulated-raman-scattering-as-non-destructive-non-linear-optical-method-in-nanobiosensing-and-bioimaging/
LOCATION:MC 331\, 5 King's College Rd\, Toronto\, ON\, M5S 3G8\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230530T110000
DTEND;TZID=America/Toronto:20230530T120000
DTSTAMP:20230504T155027Z
CREATED:20230504T155027Z
LAST-MODIFIED:20230504T155027Z
UID:10000219-1685444400-1685448000@bme.utoronto.ca
SUMMARY:Start-up Lessons: Concept to Commercialization of a Wearable Medical Monitoring Solution for Acute Care Patients
DESCRIPTION:  \nPlease join us for an ECHO webinar featuring Dr. Devin McCombie\, who will provide an overview of his vast experience commercializing wearable medical monitoring solutions at Sotera and Dexcom. \nDexcom Inc. develops\, manufactures\, produces\, and distributes continuous glucose monitoring systems for diabetes management. Sotera Inc. is a digital health start-up company that commercialized and sold a first-of-its-kind wearable vital sign monitoring solution to detect deterioration of acute care patients on the hospital general ward. \n  \nGuest Speaker \nDr. Devin McCombie\, PhD \nPast CEO\, Sotera Digital Health \nPresident\, Theorem Medtech LLC \nPrincipal Tech Lead\, Dexcom Inc. \n  \nRegister in advance for this webinar. After registering\, you will receive a confirmation email containing information about joining the webinar. \nECHO is an entrepreneurship training program\, funded and organized in a partnership between (i) the Translational Biology and Engineering Program (TBEP)\, the University of Toronto component of the Ted Rogers Centre for Heart Research\, and (ii) the Health Innovation Hub (H2i). For more information\, visit: https://tedrogersresearch.ca/echo/
URL:https://bme.utoronto.ca/event/start-up-lessons-concept-to-commercialization-of-a-wearable-medical-monitoring-solution-for-acute-care-patients/
LOCATION:Ontario
CATEGORIES:Events & Workshops
ORGANIZER;CN="Translational Biology and Engineering Program (TBEP)":MAILTO:reception.tbep@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230519T130000
DTEND;TZID=America/Toronto:20230519T140000
DTSTAMP:20230509T183039Z
CREATED:20230509T183039Z
LAST-MODIFIED:20230509T183039Z
UID:10000221-1684501200-1684504800@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Nova Pishesha
DESCRIPTION:Exploiting Antigen Presentation Pathways for Precision Immune Engineering \nDr. Nova Pishesha\,\nJunior Fellow\, Society of Fellows at Harvard University\nCurrent treatments for autoimmunity rely on general immunosuppression\, which exposes patients to opportunistic infections. Hence\, immunoregulatory modalities\, which educate the immune system to induce antigen-specific tolerance are desirable. My doctoral research revolved around engineered red blood cells (RBCs) to treat preclinical models of autoimmune diseases by hijacking the tolerogenic RBC clearance pathways. As a postdoctoral fellow\, I worked on an alpaca-derived single domain antibody fragment (nanobody)-based platform. I have engineered these nanobodies to efficiently target antigen presenting cells and transmit either tolerogenic or vaccinal signal to antigen-specific immune cells. I showed that a single dose of a VHH that recognizes major histocompatibility complex class II/MHCII (VHHMHCII)\, conjugated to a myelin peptide and an anti-inflammatory corticosteroid\, i.e. dexamethasone (VHHMHCII-MOG-DEX)\, affords lasting protection in a mouse model of multiple sclerosis (MS). A single dose of VHHMHCII-MOG-DEX also reverses paralyses in mice without compromising the capacity of the immune system to fight pathogens. I further developed this technology for treating type 1 diabetes and as a SARS-CoV-2 vaccine. My independent group will aspire to produce novel treatments for autoimmune and infectious diseases. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-nova-pishesha/
LOCATION:MS3153
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/05/1517545306211.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230518T180000
DTEND;TZID=America/Toronto:20230518T190000
DTSTAMP:20230425T141531Z
CREATED:20230425T141510Z
LAST-MODIFIED:20230425T141531Z
UID:10000218-1684432800-1684436400@bme.utoronto.ca
SUMMARY:Operability of the heart lung machine
DESCRIPTION:
URL:https://bme.utoronto.ca/event/operability-of-the-heart-lung-machine/
LOCATION:Ontario
CATEGORIES:External Speaker Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230518T090000
DTEND;TZID=America/Toronto:20230518T100000
DTSTAMP:20230516T203337Z
CREATED:20230515T152033Z
LAST-MODIFIED:20230516T203337Z
UID:10000223-1684400400-1684404000@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Ilke Uguz
DESCRIPTION:Development of High-Density Active Neural Interfaces using Conjugated Polymers\nDr. Ilke Uguz\nPostdoctoral Research Associate\, Columbia University\nPrecise\, stable\, and biocompatible neural interfaces are crucial for effective brain-machine interfaces and therapeutic interventions. Conjugated polymers offer exceptional potential for such applications\, owing to their softness\, biocompatibility\, and mixed ionic and electronic charge transport properties. By integrating CPs at the front-end\, we can achieve active pixels comparable in size to individual neurons while maintaining mechanical properties similar to surrounding tissue. During the talk\, I will delve into microfabrication and design strategies used to develop implantable CP-based neural interfaces with electrical and optical functionalities. Specifically\, I will address the technological challenges associated with scalability and present examples that demonstrate the successful generation of complex circuitries on flexible substrates\, as well as their monolithic integration onto drive electronics. Additionally\, I will demonstrate large-scale electrophysiology and optogenetic manipulation of neuronal circuits with high spatiotemporal resolution\, highlighting the potential of CPs as a foundation for high-density active front-end arrays. \nTalk will be virtual only\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-ilke-uguz/
LOCATION:Ontario
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/05/Ilke-Uguz.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230512T063000
DTEND;TZID=America/Toronto:20230512T223000
DTSTAMP:20230404T194420Z
CREATED:20230404T194243Z
LAST-MODIFIED:20230404T194420Z
UID:10000203-1683873000-1683930600@bme.utoronto.ca
SUMMARY:Post-Conference Celebration Dinner and Award Ceremony
DESCRIPTION:BME would like to invite you to the dinner reception at the Royal Ontario Museum (ROM). It has been a crazy last two years and it is a great time for us to get together\, celebrate our achievements\, and meet each other. Students\, faculty\, post-doc\, and administrators will be attending the event. \nThis dinner is free of charge to BME students\, staff\, core faculty members\, and primary cross-appointment faculty members. This will also be extended to non-BME students in core faculty member labs\, research associates in core faculty member labs\, and post-doctoral fellows in core faculty member labs. \nRegister here
URL:https://bme.utoronto.ca/event/post-conference-celebration-dinner-and-award-ceremony/
LOCATION:Royal Ontario Museum\, 100 Queens Park\, Toronto\, ON\, M5S 2C6\, Canada
CATEGORIES:Events & Workshops
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END:VCALENDAR