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DTSTART;TZID=America/Toronto:20221214T123000
DTEND;TZID=America/Toronto:20221214T130000
DTSTAMP:20220829T170757Z
CREATED:20220829T170757Z
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SUMMARY:Graduate Seminar Series: Clinical Stream - Michael Tisi
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Machine Learning Assisted Pulmonary Function Assessment via Intrabreath Oscillometry\nAbstract:\nIntrabreath oscillometry is a pulmonary function test that enables the dynamic tracking of mechanical changes in the respiratory system by measuring airway impedance. Raw volume\, pressure\, and flow measurements from intrabreath oscillometry tests were input to a novel classification architecture to resolve one of the following physiologies: normal\, restrictive\, obstructive\, or mixed obstructive-restrictive functionality. The MiniROCKET algorithm was first used to generate features from input time series\ndata and train a ridge regression classifier model. When used for inference\, output classifier scores are utilized in a soft voting scheme to acquire a final\, confident prediction of pulmonary function based on all valid intrabreath oscillometry trials for\na given subject. The proposed classification architecture was able to distinguish between normal\, restrictive\, and obstructive pulmonary function with state of the art accuracy; however\, it struggled\, at first\, to differentiate between restrictive and mixed obstructive-restrictive physiologies. After identifying and removing anomalous training examples and defining a region of uncertainty instead of a rigid decision boundary for the classifier\, the proposed architecture was also able to distinguish between restrictive and mixed obstructive-restrictive pulmonary function with state of the art accuracy.\nSupervisor Name: Chung-Wai Chow; Shahrokh Valaee\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-michael-tisi-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221214T120000
DTEND;TZID=America/Toronto:20221214T123000
DTSTAMP:20221213T193756Z
CREATED:20220823T165238Z
LAST-MODIFIED:20221213T193756Z
UID:10000036-1671019200-1671021000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Atousa Assadi
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Risk Assessment and Prediction of Opioids Induced Respiratory Adverse Events\nAbstract: Opioids induced respiratory adverse events during sleep is a major health challenge. These adverse events are mainly characterized as prolonged reduction of airflow and respiratory rate and reduced blood oxygen saturation. The consequences are cardiopulmonary complications\, increased morbidity\, hospital length of stay\, costs\, 30-day readmission\, and higher mortality. The risk factors include age\, sex\, body mass index\, opioids’ dosage\, comorbid sleep and cardiac disorders\, and concomitant use of other medications. While identifying high-risk individuals\, proper monitoring of their respiratory function\, and timely interventions can significantly prevent the adverse events\, current techniques have low accuracy\, lack external validation\, have false errors\, cannot predict adverse respiratory events. Therefore\, in this research project\, our goal is to develop algorithms based on signal processing and artificial intelligence techniques for risk assessment and prediction of respiratory adverse events during sleep in individuals who are taking opioids. The outcome of this research can help identify high-risk individuals for more frequent monitoring of their respiratory function. Moreover\, the monitoring and prediction algorithm can be used to alert the caregivers in advance of an adverse event for initiating proper intervention.\nSupervisor Name: Dr. Azadeh Yadollahi\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-atousa-assadi/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221213T130000
DTEND;TZID=America/Toronto:20221213T160000
DTSTAMP:20221102T184632Z
CREATED:20221102T184304Z
LAST-MODIFIED:20221102T184632Z
UID:10000153-1670936400-1670947200@bme.utoronto.ca
SUMMARY:BME Holiday Cocktail Party 2022
DESCRIPTION:Institute of Biomedical Engineering (BME) is proud to host this year’s Institute-wide holiday celebration! Get out of your labs and offices\, socialize\, get to know one another\, and help build our community. \nDate and Time:  December 13\, 2022\, 1:00-4:00 pm\nVenue:  Great Hall\, Hart House
URL:https://bme.utoronto.ca/event/bme-holiday-cocktail-party-2022/
LOCATION:Great Hall\, Hart House\, 7 Hart House Cir\, Toronto\, Ontario\, M5S 3H3\, Canada
CATEGORIES:Events & Workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221213T120000
DTEND;TZID=America/Toronto:20221213T130000
DTSTAMP:20221205T195238Z
CREATED:20220512T152615Z
LAST-MODIFIED:20221205T195238Z
UID:10000019-1670932800-1670936400@bme.utoronto.ca
SUMMARY:Invited Academic Seminar Series - Vivian Mushahwar- Walking Again after Spinal Cord Injury (Virtual Only)
DESCRIPTION:Speaker\nVivian Mushahwar\nProfessor in the Division of Physical Medicine and Rehabilitation\nFaculty of Medicine & Dentistry\nUniversity of Alberta \n\nAbstract\nThe overall goal of the work in my lab is to develop interventions that improve function after neural injury or disease. In this talk\, I will focus on spinal cord injury (SCI)\, a devastating condition that drastically alters a person’s functional abilities and quality of life. I will describe our work\, which merges neuroscience\, engineering and rehabilitation\, in restoring the ability to walk after SCI. This will include a spinal micro-implant we developed for restoring standing and walking after complete SCI and a therapeutic approach we developed to improve walking after incomplete SCI.  Our interventions have the potential to improve function\, reduce the incidence of secondary complications and improve quality of life. \n\nHost\nKei Masani
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-vivian-mushahwar/
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2022/05/VivianMushahwar.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221209T123000
DTEND;TZID=America/Toronto:20221209T130000
DTSTAMP:20221208T193924Z
CREATED:20220910T180742Z
LAST-MODIFIED:20221208T193924Z
UID:10000105-1670589000-1670590800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Eric Floro
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Towards a Live-Cell Fluorescent Biosensor to Image Beta-cell Endoplasmic Reticulum Stress\nAbstract: Endoplasmic Reticulum (ER) stress is caused by an accumulation of misfolded proteins. When unmitigated\, it results in metabolic dysfunction and apoptosis\, and is a key mechanism responsible for the progression of beta-cell failure leading to Type 2 Diabetes. In response to protein misfolding\, a transmembrane stress-sensing protein called IRE1α can activate the Unfolded Protein Response (UPR). In the early stages of the UPR\, protein translation is attenuated to allow for refolding and repair. If unsuccessful\, degradation of protein and RNA begins\, and apoptosis may be triggered. To measure the dynamics of ER stress in living beta-cells\, we are developing a genetically encoded sensor based on IRE1α. This sensor uses a fluorescent protein-tagged IRE1α\, which homo-oligomerizes to dimeric and tetrameric conformations under early and chronic ER stress\, respectively. These conformational changes can be quantified through changes in the fluorescent polarization ratio of the sensor. To validate this sensor\, we have demonstrated the sensor responds to chemical and physiological (high glucose) stress induction in a rat beta-cell line (INS-1E) and mouse islets. Preliminary data suggest that UPR-associated XBP1 mRNA splicing is highly correlated with sensor response. Furthermore\, individual cells with the highest sensor response (correlating to late-stage UPR) show elevated levels of pro-apoptotic protein TXNIP. These data are consistent with a working sensor that can be used to investigate ER stress dynamics in beta-cells.\nSupervisor Name: Jonathan Rocheleau\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-eric-floro/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221209T120000
DTEND;TZID=America/Toronto:20221209T123000
DTSTAMP:20221208T193924Z
CREATED:20220902T172311Z
LAST-MODIFIED:20221208T193924Z
UID:10000092-1670587200-1670589000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Ayokunle Lekuti
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Dr. Warren Chan\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-ayokunle-lekuti/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221208T120000
DTEND;TZID=America/Toronto:20221208T123000
DTSTAMP:20221207T193728Z
CREATED:20220829T170757Z
LAST-MODIFIED:20221207T193728Z
UID:10000077-1670500800-1670502600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Lauren Banh
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Joint-on-a-chip: advanced in vitro models to recapitulate the osteoarthritic knee joint with microfluidic organ-on-a-chip technology\nAbstract: The “joint-on-a-chip” (JOC) model is an instrumental tool for assessing human-relevant drug responses to novel osteoarthritis (OA) therapies. OA is a whole-joint disease presenting with chronic pain. Symptom management approaches are commonly used as treatment options\, but invasive joint replacement surgery is eventually required because there is currently no cure for OA. The lack of effective therapies is partially due to the absence of experimental models that replicate the complex human joint pathology\, dynamics\, and immune cellular responses. Therefore\, our objective is to develop a novel microfluidic cell culture platform referred to as a “JOC” that provides a more physiologically relevant model of the human joint. Our proposed JOC builds on our static “joint-on-a-dish” model that captures the importance of incorporating multiple tissue crosstalk with immune cells. It will include multiple joint tissues\, a circulatory immune compartment\, and a diffusional joint space to mimic a pathologically relevant OA joint. The JOC is currently being built in modules that contain human cartilage explant tissue and vascularized synovium tissue on two separate chips. Preliminary results reveal that cartilage explants on-chip have a similar gene expression and extracellular matrix degradation profile to the joint-on-a-dish model and that a vascular network forms on-chip by day three of culture. Ongoing experiments are being conducted to combine the modules with various components. Once all components are integrated\, our JOC model will allow for the elucidation of complex mechanisms necessary for targeted drug development and will facilitate the screening of potential therapeutics before entering the clinical setting.\nSupervisor Name: Dr. Sowmya Viswanathan and Dr. Edmond Young\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-lauren-banh/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221208T120000
DTEND;TZID=America/Toronto:20221208T123000
DTSTAMP:20220829T170757Z
CREATED:20220829T170757Z
LAST-MODIFIED:20220829T170757Z
UID:10000079-1670500800-1670502600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Lauren Banh
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Joint-on-a-chip: advanced in vitro models to recapitulate the osteoarthritic knee joint with microfluidic organ-on-a-chip technology\nAbstract: The “joint-on-a-chip” (JOC) model is an instrumental tool for assessing human-relevant drug responses to novel osteoarthritis (OA) therapies. OA is a whole-joint disease presenting with chronic pain. Symptom management approaches are commonly used as treatment options\, but invasive joint replacement surgery is eventually required because there is currently no cure for OA. The lack of effective therapies is partially due to the absence of experimental models that replicate the complex human joint pathology\, dynamics\, and immune cellular responses. Therefore\, our objective is to develop a novel microfluidic cell culture platform referred to as a “JOC” that provides a more physiologically relevant model of the human joint. Our proposed JOC builds on our static “joint-on-a-dish” model that captures the importance of incorporating multiple tissue crosstalk with immune cells. It will include multiple joint tissues\, a circulatory immune compartment\, and a diffusional joint space to mimic a pathologically relevant OA joint. The JOC is currently being built in modules that contain human cartilage explant tissue and vascularized synovium tissue on two separate chips. Preliminary results reveal that cartilage explants on-chip have a similar gene expression and extracellular matrix degradation profile to the joint-on-a-dish model and that a vascular network forms on-chip by day three of culture. Ongoing experiments are being conducted to combine the modules with various components. Once all components are integrated\, our JOC model will allow for the elucidation of complex mechanisms necessary for targeted drug development and will facilitate the screening of potential therapeutics before entering the clinical setting.\nSupervisor Name: Dr. Sowmya Viswanathan and Dr. Edmond Young\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-lauren-banh-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221207T140000
DTEND;TZID=America/Toronto:20221207T150000
DTSTAMP:20221103T143044Z
CREATED:20221103T143044Z
LAST-MODIFIED:20221103T143044Z
UID:10000155-1670421600-1670425200@bme.utoronto.ca
SUMMARY:The Future of Drug Development through Companion Diagnostics and Therapeutics approaches
DESCRIPTION:The Future of Drug Development through Companion Diagnostics and Therapeutics approaches \nNathan Yoganathan\, President & Chief Scientific Officer \nJN Nova Pharma Inc.  (more info) https://jnnova.com/ \nWednesday\, December 7\, 2022 \nRS 207: 2:00-3:00 PM \nRosebrugh Building (RS): 164 College St\, Toronto\, ON M5S 3E2\nhttps://goo.gl/maps/bVujArG4VdA7MHEo7 \nAbstract:  Dr. Nathan Yoganathan\, President & CSO of JN Nova Pharma (will be presenting their novel technology. JN Nova is a pre-clinical-stage biopharmaceutical company\, focused on efficiently developing innovative treatments that address significant unmet medical needs. JN Nova’s lead product candidate\, JN2019 is a novel anti-COVID-19 molecule. The company is collaborating with Canadian Government labs and Canadian academic centers to accelerate its COVID-19 therapeutic development. This proprietary drug class blocks pan-COVID infection from all variants\, with important renal\, cardiovascular\, and pulmonary protective properties. The lead therapeutic molecules are corona-viral neutralizing agents which trap and inhibit viral entry to the lungs via an enhanced ACE2 enzymatic decoy and cause viral clearance via immunological conjugation and have full ACE2 enzyme replacement activity\, supporting protection from acute kidney injury and enhanced recovery from the acute respiratory syndrome in ICU settings.  Extremely potent vs emergent viral variants: drugs will be developed as accessible\, rapidly administered therapeutic interventions in symptomatic pre-hospitalized and early symptomatic hospitalized patients for people that are infected by these vaccine-escape mutants\, such as Delta\, Omicron\, and beyond. \nThe Institute for Advanced Non-Destructive and Non-Invasive Diagnostic Technologies (IANDIT) in the Faculty of Applied Science and Engineering presents its inaugural guest speaker seminar series with Dr Nathan Yoganathan. The IANDIT  seminar series features leading experts in Non-Destructive Evaluation (NDE) and Non-Invasive Bio-diagnostics (NIB) research in manufacturing industry and healthcare sector in Ontario and beyond. \nJN Nova is interested in collaborating with UofT scientists and engineers to develop non-invasive COVID-19 related technologies including detection and treatment.  \nInterested members of the U of T community who would like to attend the seminars and meet the speaker can email to iandit@mie.utoronto.ca. \nBiography \nDr. T. Nathan Yoganathan is currently the President and Chief Scientific Officer of JN Nova Pharma Inc. Dr. Yoganathan is a university and industrial research scientist\, turned entrepreneur who became an experienced CEO\, having successfully launched several private and a public biotechnology companies. He has over twenty-five years of experience in scientific research in cell signaling and gene expression technology and instrumentation\, has published several articles\, and is an inventor of many patents. \nDr. Yoganathan is the recipient of numerous awards\, including from the Natural Sciences and Engineering Research Council of Canada\, and the Thyroid Foundation of Canada. He serves on a number of advisory boards for both government and industry\, including the CIHR Strategic Training Program in the Bioinformatics Advisory Board\, BIOTE Canada’s Emerging Companies Advisory Board\, and past member of the Ontario Research Fund Advisory Board. He was elected as a Fellow of the Royal Society of Biology. Dr. Yoganathan was a faculty member of the Department of Medicine at the University of Toronto\, and was affiliated with the Lunenfeld and Tanenbaum Research Institute of Mount Sinai Hospital. He holds a B.Sc. (Honours) from the University of North London\, a M.Sc. from the University of Sussex\, and a Ph.D. from the University of Oslo.
URL:https://bme.utoronto.ca/event/the-future-of-drug-development-through-companion-diagnostics-and-therapeutics-approaches/
LOCATION:RS207\, 164 College St\, Toronto\, Ontario\, M5S 3E2\, Canada
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221207T123000
DTEND;TZID=America/Toronto:20221207T130000
DTSTAMP:20221206T193754Z
CREATED:20220831T170758Z
LAST-MODIFIED:20221206T193754Z
UID:10000085-1670416200-1670418000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Seyed-Youns Sadat-Nejad
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Challenging the Labels of Autism and ADHD – A Data-Driven Graph-Based Approach\nAbstract: More than 600\,000 children in Canada are diagnosed with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). These diagnoses are currently based on specific behaviours (e.g.\, social communication difficulties\, inattention)\, which may not correspond to the distinct and unique underlying biology. Moreover\, the labels of ASD and ADHD often do not predict a child’s response to a specific treatment. Instead\, care decisions are made based on each child’s unique behavioural presentation. In many cases\, existing treatments are not effective\, can have adverse side-effects\, and many children continue to experience significant distress and often have poor outcomes as adults (e.g.\, mental health\, employment\, and independence). Collectively\, these challenges suggest that ASD and ADHD may not exist as uniquely-defined diagnostic constructs and highlight the need to discover other groupings that may be more closely aligned with biology and/or response to treatment. To address this need\, the proposed project will perform a data-driven approach to question the validity of current diagnostic labels and identify new groupings for children with ASD and ADHD that are biologically relevant. I will do this through an interdisciplinary approach that employs computer science-based machine learning approaches to go beyond traditional analytics methods in this field. The objective of this project is to validate existing groupings or discover new groupings based on unique and distinct biological data. To this end\, I will pursue a novel analytical approach: instead of comparing diagnostic groups as currently done\, I use an innovative data-driven approach that looks to the data to discover new groups that transcend the existing diagnostic labels or those that validate the current groups but that also explain why the current treatments are ineffective for many individuals in part because of their adverse side effects. I will do this by use of graph clustering method and graph neural network. This approach is capable of identifying groups who share similar neuroanatomical characteristics/complexities\, regardless of diagnosis.\nSupervisor Name: Dr.Azadeh Kushki\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-seyed-youns-sadat-nejad/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221207T120000
DTEND;TZID=America/Toronto:20221207T123000
DTSTAMP:20221206T193754Z
CREATED:20220913T210754Z
LAST-MODIFIED:20221206T193754Z
UID:10000113-1670414400-1670416200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Bonnie Chao
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBA\nAbstract: TBA\nSupervisor Name: Dr. Shaf Keshavjee\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-bonnie-chao/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221207T110000
DTEND;TZID=America/Toronto:20221207T120000
DTSTAMP:20221121T210335Z
CREATED:20221121T210335Z
LAST-MODIFIED:20221121T210335Z
UID:10000159-1670410800-1670414400@bme.utoronto.ca
SUMMARY:TBEP Research Seminar: Defining the cardiac fibroblast and its role in health and disease
DESCRIPTION:Jeffery Molkentin\, Ph.D.\nDivision Director of Molecular Cardiovascular Biology and Heart Institute Co-Director\, Cincinnati Children’s Hospital \nProfessor of Pediatrics\, University of Cincinnati Children’s Hospital Medical Center \nRegister for the seminar via Zoom \nAbstract: Collagen production in the adult heart is primarily mediated by the tissue resident interstitial fibroblast. Indeed\, adult fibroblast-specific deletion of the molecular chaperones required for procollagen biosynthesis\, heat-shock protein 47 (Hsp47)\, prevents new fibrillar collagen production in the adult heart. More specifically\, myofibroblast-specific ablation of Hsp47 blocked fibrosis and deposition of collagens type-I\, -III and -V following pressure overload\, which unexpectedly significantly reduced cardiac hypertrophy. These results suggested that an inability to generate new supportive ECM material by cardiac fibroblasts in response to pressure overload was sensed by the cardiomyocyte as it attempted to hypertrophy. To examine this potential mechanism further we also generated Col1a2-loxP targeted mice so that fibroblast specific deletion could be performed to then examine the hypothesis that reduced structural rigor of the newly synthesized type I fibrillar collagen network in the pressure loaded mouse heart would not support the same degree of cardiac hypertrophy. Indeed\, myofibroblast- specific deletion of Col1a2 in the adult heart following 1 week of pressure overload compromised the hypertrophic response. Importantly\, deletion of Col1a2 from the heart resulted in reduced stiffness and structural integrity\, at both baseline with developmental deletion as well as in the adult heart with inducible deletion. Unexpectedly\, developmental deletion of Col1a2 from the mouse heart resulted in a secondary fibrotic response with increased fibroblast number\, which is likely a compensatory response to the decreased stiffness of the ECM due to defective type I collagen. Collectively our results suggest that the cardiac fibroblast communicates with the cardiomyocyte in the heart through the integrity of the ECM\, which also effects fibroblast dynamics.
URL:https://bme.utoronto.ca/event/tbep-research-seminar-defining-the-cardiac-fibroblast-and-its-role-in-health-and-disease/
CATEGORIES:External Speaker Series
ORGANIZER;CN="Translational Biology and Engineering Program (TBEP)":MAILTO:reception.tbep@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221202T123000
DTEND;TZID=America/Toronto:20221202T130000
DTSTAMP:20221201T193733Z
CREATED:20220922T213739Z
LAST-MODIFIED:20221201T193733Z
UID:10000123-1669984200-1669986000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Shana Alexander
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Effect of Fc targeting on induction of T cell responses by DNA origami vaccine\nAbstract: Cancer immunotherapy aims to educate the body’s own immune system to fight cancer in ways analogous to how they fend off disease-causing pathogens. As such\, cancer therapies targeting T cells\, like immune checkpoint blockade and adoptive cell therapy\, have revolutionized the field of oncology. However\, only a subset of cancers seem to respond because 1) the patient lacks pre-existing T cells that can recognize the tumor and 2) the delivery of the therapeutics is ineffective. Cancer vaccines are a promising class of immunotherapy that I believe can overcome the first barrier. Cancer vaccines promote the expansion of fresh antigen-specific T cells that are better equipped with antitumour functions. They do this by delivering unique molecular identifiers of tumour cells (antigens) and immunostimulatory molecules (adjuvants)\, to dendritic cells. Dendritic cells baring the vaccine interact with the killer cells of our immune system (T cells) and program them to selectively target tumour cells for destruction. The second barrier\, ineffective delivery\, can be overcome using DNA nanostructures (DNs) which can achieve targeted co-delivery of vaccine components directly to the target cell. Lastly\, I am proposing that controlling the DN cellular uptake pathway by engaging Fc receptors on the surface of dendritic cells may enhance T cell expansion\, as demonstrated in viral infections. Therefore\, my research will focus on developing an Fc targeted DN vaccine that can enhance antigen presentation and antigen-specific T cell expansion compared to untargeted DN vaccines. The results of my thesis will demonstrate how we can use DNA nanotechnology to design therapeutic cancer vaccines with greater T cell responses leading to increased tumour eradication. The discovery of these principles may be incorporated into many cancer vaccination strategies and thus\, will impact the current and future of cancer therapeutics.\nSupervisor Name: Leo Chou\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-shana-alexander/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221202T120000
DTEND;TZID=America/Toronto:20221202T123000
DTSTAMP:20221201T193733Z
CREATED:20220922T213739Z
LAST-MODIFIED:20221201T193733Z
UID:10000124-1669982400-1669984200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Teddi Shaw
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Improving AAV targeting through nanobody inclusion by alternative splicing.\nAbstract: Adeno-associated viruses (AAVs) are viral vectors that can be engineered to act as a gene therapy. AAVs contain a single-stranded DNA genome\, with a capsid protein shell. Although AAVs have desirable characteristics for a gene therapy\, their targeting and specificity can be improved. To increase the specificity of AAV targeting\, the inclusion of nanobodies into the surface of the AAV capsid is proposed. This concept will be proven in plasmids by synthetically developing alternative splicing\, specifically\, intron retention. This results in intron inclusion in the final protein. In this construct\, the nanobody will become the intron so\, we can optimize how many copies of the nanobody are included in the final product. To alter the strength of the splicing\, various properties will be modified. Firstly\, linker sequences that flank the intron differentiate the intron-exon border and promote splicing of the intron. The 5’ linker sequence contains the splice donor and the 3’ linker contains the splice acceptor\, polypyrimidine tract (PPT) and the branch point. These features promote the assembly of the spliceosome\, thereby increasing splicing activity. Secondly\, G triplets located in the interior of an intron enforce intron-exon borders. To investigate splicing activity\, three constructs are proposed. The first is read-through\, or no splicing\, where both the linker sequences and G triplets are absent. In the weak splicing construct\, only linker sequences are present. Finally\, in the strong splicing construct\, linker sequences and G triplets are present. When intronic elements are included in the construct\, the splice percentage is increased\, thereby lowering the inclusion of the intron. Once this methodology is proven in plasmids\, it will be applied to AAVs.\nSupervisor Name: Dr. Kevin Truong\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-teddi-shaw/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221201T123000
DTEND;TZID=America/Toronto:20221201T130000
DTSTAMP:20221130T192258Z
CREATED:20221125T192234Z
LAST-MODIFIED:20221130T192258Z
UID:10000162-1669897800-1669899600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Jo Nguyen
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Proposing a contractility checkpoint defining muscle cell cycle heterogeneity\nAbstract: Skeletal muscle tissues allow us to move\, smile\, and breathe. Our muscles get injured on a daily basis but fortunately\, they are capable of self-repair. This repair capacity owes in large to muscle stem cells\, residing in-between muscle fibers. Mechanical niche factors like stiffness can control muscle stem cells’ repair potential and activity\, but the mechanisms for such regulation remain elusive. In this study\, we propose contractility heterogeneity as a framework to study stiffness-dependent functional heterogeneity in myogenic cells.\nSupervisor Name: Penney Gilbert\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-jo-nguyen/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221201T120000
DTEND;TZID=America/Toronto:20221201T123000
DTSTAMP:20221130T192258Z
CREATED:20220908T180738Z
LAST-MODIFIED:20221130T192258Z
UID:10000101-1669896000-1669897800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Lauren Baerg
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Leveraging probiotic-derived membrane vesicles as a postbiotic therapeutic for Crohn’s disease\nAbstract: Bacterial membrane vesicles (BMVs) are bilipid nanoparticles produced as a conserved method of intercellular communication for the delivery of diverse bacterial products. These biological nanoparticles have potential for significant biomedical application\, such as in the context of Crohn’s disease (CD). CD is a chronic inflammatory bowel disease that is influenced by host-microbe interactions. In CD\, NOD2 signalling pathway is disrupted by genetic and environmental factors. Overcoming NOD2 hypoactivity presents a novel therapeutic target for restoring host-microbe communication in CD. However\, muramyl dipeptide (MDP)\, the NOD2 agonist\, is a poor drug candidate due to its large molecular weight and hydrophilicity. MDP is a product of bacterial peptidoglycan (PG) degradation and is a potential cargo of BMVs. We propose the application of probiotic-derived BMVs as an MDP delivery system for the management of CD. In preliminary work\, we demonstrated that isolated BMVs from B. subtilis carry PG fragments capable of inducing IL-8 secretion and CXCL1 expression in HCT116 cells in a NOD2-dependent manner. In addition\, we applied metabolic engineering approaches to optimize BMV production and MDP packaging through the inducible expression of PG hydrolases in both Gram-positive and Gram-negative bacteria. Overexpression of PG hydrolases resulted in increased production of BMVs and coincided with increased NOD2 activity of bacterial supernatants. Facilitated delivery of MDP by probiotic-derived BMVs demonstrates a promising strategy to enhance NOD2 signalling activity. This work contributes to the advancement of complementary CD therapeutics\, towards the goal of improving therapeutic outcomes and quality of life for CD patients.\nSupervisor Name: Radhakrishnan Mahadevan\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-lauren-baerg/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221130T123000
DTEND;TZID=America/Toronto:20221130T130000
DTSTAMP:20221129T192229Z
CREATED:20220830T170739Z
LAST-MODIFIED:20221129T192229Z
UID:10000081-1669811400-1669813200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Srdjan Sumarac
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Machine learning approach for predicting severity of symptoms in Parkinson’s disease from intraoperative single-neuron recordings\nAbstract: We hypothesized that pathophysiologically-relevant information about the symptoms of Parkinson’s disease may be directly encoded within neurophysiological features of individual neurons in the basal ganglia. Using an extensive database of intracranial recordings acquired during awake deep brain stimulation surgery (n=225 patients)\, we calculated spiketrain features (e.g.\, firing rate\, burst index\, and spiketrain oscillations in different frequency bands) from 1614 high-quality single-neuron segments of the subthalamic nucleus\, substantia nigra pars reticulata\, or globus pallidus internus. Corresponding preoperative Unified Parkinson’s Disease Rating Scale Part III (UPDRSIII) motor scores were also amalgamated for each patient. To account for multiple observations per patient\, we used linear mixed models (LMM) to study the relationships between spiketrain features and UPDRSIII scores. We also trained a light gradient boosting machine (LightGBM) regressor combined with mixed effects random forests (MERF) to predict the severity of patients’ parkinsonian symptoms using a combination of features. Our machine learning framework could accurately predict patients’ total UPDRSIII scores across various symptoms and disease subtypes. Our feature importance analysis also revealed that synchronization coding generally had a higher impact on model prediction than rate coding. Overall\, our findings suggest that the activity of individual neurons contains valuable information about parkinsonian symptom severity.\nSupervisor Name: Luka Milosevic\, Milos R Popovic\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-srdjan-sumarac/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221130T120000
DTEND;TZID=America/Toronto:20221130T123000
DTSTAMP:20221129T192229Z
CREATED:20220824T165254Z
LAST-MODIFIED:20221129T192229Z
UID:10000056-1669809600-1669811400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Andrew Effat
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Combined photothermal therapy\nAbstract: Lung cancer remains the leading cause of cancer death among Canadians and continues to place a heavy cost on the health care system. Screening programs have significantly increased early-stage detection; this has been key in reducing mortality\, and in driving the need for innovation in minimally invasive treatment methods. Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) are novel treatment modalities that may fill that need. PDT relies on the interaction of light with a cancer targeting particle to create reactive molecular species which damage vital structures required for cell survival. PTT generates heat in tissue through light absorption\, which results in protein unfolding and eventually\, cell death. In isolation\, their efficacy is limited based on application. A combination of the two treatments is garnering interest due to the potential for synergistic effects. In this project\, we are working towards developing a treatment protocol for this combination therapy.\nSupervisor Name: Dr. Yasufuku & Dr. Weersink\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-andrew-effat/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221125T123000
DTEND;TZID=America/Toronto:20221125T130000
DTSTAMP:20221124T192232Z
CREATED:20220824T165251Z
LAST-MODIFIED:20221124T192232Z
UID:10000055-1669379400-1669381200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Aaron Troy
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Exploring metabolic remodeling in heart failure with preserved ejection fraction\nAbstract: TBD\nSupervisor Name: Hai-Ling Margaret Cheng\, Phyllis Billia\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-aaron-troy/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221125T120000
DTEND;TZID=America/Toronto:20221125T123000
DTSTAMP:20221124T192231Z
CREATED:20220827T170739Z
LAST-MODIFIED:20221124T192231Z
UID:10000071-1669377600-1669379400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Angelico Obille
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Identification and Characterization of a Freshwater Mussel Adhesive Protein\nAbstract: TBD\nSupervisor Name: Angelico Obille\nYear of Study: 5\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-angelico-obille/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221124T123000
DTEND;TZID=America/Toronto:20221124T130000
DTSTAMP:20221123T192238Z
CREATED:20221001T213822Z
LAST-MODIFIED:20221123T192238Z
UID:10000138-1669293000-1669294800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Doris Adao
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: The role of microRNAs in hypertrophic cardiomyopathy\nAbstract: Hypertrophic cardiomyopathy (HCM) is a genetic disease involving hypertrophy or thickening of the heart muscle\, and is the leading cause of sudden cardiac death among young adults and athletes. Mutations in genes encoding for cardiac structural proteins such as myosin binding protein C (MYBPC3) and myosin heavy chain (MYH7) have been identified as the cause of this condition\, but the mechanisms by which cardiomyocytes (CMs) undergo hypertrophy in response to these mutations is unclear. MicroRNAs (miRNAs) are one of the factors that could influence CM hypertrophy because of their ability to regulate gene expression\, but the role of miRNAs in HCM progression remains elusive. Because of their ability to control gene expression of various factors\, miRNAs could be a key target in regulating disease states such as HCM. The objective of my project is to identify and target differentially expressed miRNAs between healthy and HCM states in order to mitigate the progression of cardiomyocyte hypertrophy. The use of induced pluripotent stem cells (iPSCs) could allow us to investigate miRNAs in HCM\, but most studies lack human tissue validation to ensure findings from iPSC models are accurate and representative of disease states. With no specific treatment options\, investigating the role of miRNAs could allow a new set of therapeutics to improve disease management and outcomes for patients with HCM.\nSupervisor Name: Dr. Phyllis Billia; Prof. Craig Simmons\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-doris-adao/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221124T120000
DTEND;TZID=America/Toronto:20221124T123000
DTSTAMP:20221123T192238Z
CREATED:20220902T172310Z
LAST-MODIFIED:20221123T192238Z
UID:10000091-1669291200-1669293000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Amber Xue
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract:\n160 College St\n530\nSupervisor Name: Molly Shoichet\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-amber-xue/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221118T120000
DTEND;TZID=America/Toronto:20221118T123000
DTSTAMP:20221117T205253Z
CREATED:20221029T030419Z
LAST-MODIFIED:20221117T205253Z
UID:10000152-1668772800-1668774600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Yufeng Wang
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Design of an Islet-on-a-Chip Device to Dynamically Measure Insulin Secretion from Individual Islets\nAbstract: Glucose-stimulated insulin secretion (GSIS) from pancreatic islets shows a biphasic pattern. Investigation of temporal dynamics and patterns of GSIS could give insights into mechanisms underlying β-cell function and dysfunction. Here\, we present a novel microfluidic device to detect insulin secretion from individual islets on-chip through miniaturizing a fluorescence anisotropy immunoassay (FAIA). Insulin is co-secreted with c-peptide within ~5-10 min of glucose stimulation. Here we designed a c-peptide sensor with a fluorophore tagged to a synthetic c-peptide fragment and optimized assay parameters to maximize the sensitivity of the FAIA. Subsequently\, a continuous-flow method was applied to monitor reaction kinetics to determine the equilibrium time of the assay. Using the maximum time required to reach equilibrium\, we designed an islet-on-a-chip that captures the islet effluent and sufficiently mixes it with the reagents within the ~100 s residence time. This assay is downstream of the islet and leaves an ideal optical window to simultaneously image islet responses (e.g.\, Ca2+ activity). Ultimately\, this device was used to measure c-peptide secretion from 4 individual mouse pancreatic islets simultaneously. The secretion detected on-chip shows the characteristic biphasic pattern and was further validated with pharmacological activators (ex. tolbutamide) for insulin secretion. In the future\, the islet-on-a-chip could be coupled with other sensors\, such as Ca2+ and oxygen consumption rate sensors to further probe β-cell metabolism.\nSupervisor Name: Dr. Jonathan Rocheleau\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-yufeng-wang/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221116T123000
DTEND;TZID=America/Toronto:20221116T130000
DTSTAMP:20221112T203802Z
CREATED:20220927T213832Z
LAST-MODIFIED:20221112T203802Z
UID:10000130-1668601800-1668603600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Reza Basiri
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Diabetic Foot Ulcer Detection and Classification\nAbstract: Diabetic Foot Ulcers (DFUs) are deliberating wounds that can result in amputation and lower the quality of life. Automatic detection and classification of these wounds are crucial for at-home therapy and expanding high-quality care. In this project\, we are developing an autonomous deep learning platform to detect and classify DFUs using multi-modal networks.\nSupervisor Name: Dr. Milos Popovic\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-reza-basiri/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221116T123000
DTEND;TZID=America/Toronto:20221116T130000
DTSTAMP:20220829T170757Z
CREATED:20220829T170757Z
LAST-MODIFIED:20220829T170757Z
UID:10000076-1668601800-1668603600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Aisha Raji
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Feasibility of a Collaborative Robot for Retraining Reaching and Grasping Functions in Stroke and Spinal Cord Injury\nAbstract:\nStroke and spinal cord injury (SCI) are causes of neurological disability that prominently affect the upper extremity. Across all ages\, these disabilities negatively impact an individual’s quality of life\, increase independence\, and has an enormous financial implication on both the individuals and the economy.\nRehabilitation is crucial in reducing morbidity and improving functional independence. Robot-assisted therapy (RT) is one of the strategies used to assist individuals within these populations in restoring their lost hand function. However\, there is presently no evidence that robot-assisted therapy alone is superior to existing conventional therapies. Our goal is to develop a new application for using robots to retrain reaching and grasping functions of the upper extremity among individuals with stroke and SCI. For this purpose\, the UR5e collaborative robot will be used alongside objects in the Toronto Rehabilitation Institute – Hand Function Test (TRI-HFT) to assist individuals perform various activities of daily living and to see if this approach will be efficient in making robot-assisted therapy more effective than other conventional therapies for upper extremity rehabilitation.\nSupervisor Name: Dr. Milos Popovic and Dr. Cesar Marquez-Chin\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-aisha-raji-3/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221116T120000
DTEND;TZID=America/Toronto:20221116T123000
DTSTAMP:20221112T203802Z
CREATED:20220909T180736Z
LAST-MODIFIED:20221112T203802Z
UID:10000102-1668600000-1668601800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Stefanie Bradley
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Quantifying the neural\, muscular\, and functional gait changes following exoskeleton-powered gait rehabilitation in children with CP and other mobility impairments\nAbstract: Non-ambulatory children with cerebral palsy (CP) and similar childhood-onset neuromotor conditions face many challenges to fulsome participation in everyday life. Recent initial phase research suggests that physiotherapy paired with use of robotic exoskeletons\, such as the Trexo robotic exoskeleton (“The Trexo”; Trexo Robotics\, Canada) provides a novel opportunity for children with severe mobility challenges to experience active walking that is individualized to their movement potential (guiding and powering leg movements) and upright support needs. This before-and-after study is assessing the first-time experience of 12 non-ambulatory children (ages 4-6) using the exoskeleton for 6 weeks of twice weekly physiotherapy sessions\, and evaluate associated brain\, muscle and functional outcomes including accomplishment of individualized goals. To study clinical feasibility\, we are simultaneously capturing physiotherapists’ (PTs) and PT assistants’ (PTAs) training/learning/user experiences with the exoskeleton’s first time use within our center’s out-patient program and on-site affiliated school.\nSupervisor Name: Dr. Tom Chau\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-stefanie-bradley-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221110T120000
DTEND;TZID=America/Toronto:20221110T130000
DTSTAMP:20220714T162325Z
CREATED:20220704T182652Z
LAST-MODIFIED:20220714T162325Z
UID:10000040-1668081600-1668085200@bme.utoronto.ca
SUMMARY:Global Speaker Series: Martin Fussenegger\, PhD – ETH Zurich
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians.\nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Martin Fussenegger\, PhD\, Professor\, Department of Biosystems Science and Engineering\, ETH Zurich.\nThe title of this talk will be\, tbc\nIn Person – Register Here\nVirtual – Register Here\nHybrid event\, with in-person and virtual options\nIn-person will be held at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.\nVirtual event links will be sent after registration.\n Learn more about Martin Fussenegger
URL:https://bme.utoronto.ca/event/global-speaker-series-martin-fussenegger-phd-eth-zurich/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
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DTSTART;TZID=America/Toronto:20221109T123000
DTEND;TZID=America/Toronto:20221109T130000
DTSTAMP:20221108T203736Z
CREATED:20220829T170756Z
LAST-MODIFIED:20221108T203736Z
UID:10000074-1667997000-1667998800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Aisha Raji
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Feasibility of a Collaborative Robot for Retraining Reaching and Grasping Functions in Stroke and Spinal Cord Injury\nAbstract:\nStroke and spinal cord injury (SCI) are causes of neurological disability that prominently affect the upper extremity. Across all ages\, these disabilities negatively impact an individual’s quality of life\, increase independence\, and has an enormous financial implication on both the individuals and the economy.\nRehabilitation is crucial in reducing morbidity and improving functional independence. Robot-assisted therapy (RT) is one of the strategies used to assist individuals within these populations in restoring their lost hand function. However\, there is presently no evidence that robot-assisted therapy alone is superior to existing conventional therapies. Our goal is to develop a new application for using robots to retrain reaching and grasping functions of the upper extremity among individuals with stroke and SCI. For this purpose\, the UR5e collaborative robot will be used alongside objects in the Toronto Rehabilitation Institute – Hand Function Test (TRI-HFT) to assist individuals perform various activities of daily living and to see if this approach will be efficient in making robot-assisted therapy more effective than other conventional therapies for upper extremity rehabilitation.\nSupervisor Name: Dr. Milos Popovic and Dr. Cesar Marquez-Chin\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-aisha-raji/
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20221109T120000
DTEND;TZID=America/Toronto:20221109T123000
DTSTAMP:20221108T203736Z
CREATED:20221017T220745Z
LAST-MODIFIED:20221108T203736Z
UID:10000148-1667995200-1667997000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Ali Barzegar Khanghah
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: A Novel Automatic Tele-Rehabilitation System Using Vision Technology\nAbstract:\nBackground: Tele-rehabilitation has the potential to considerably change the way patients are monitored from their homes during the care process by providing equitable access without the need to travel to rehab centers or the high cost of personal in-home services. Developing a tele-rehab platform with the capability to automate exercise guidance and support efficient communication with the therapists will have a significant impact on rehabilitation outcomes of aging population. Our goal is to design and validate a biofeedback system to identify the quality of performed exercises and inform the patients to refine their movements to get the most out of their plan of care.\nMethods: Various datasets were reviewed and Miron et al.  dataset including depth videos was selected. This data was collected from 30 participants performing 9 different rehabilitation exercises. Each exercise was labeled as “Correctly” or “Incorrectly” executed by a clinician. We have used a pre-trained 3D Convolution Neural Network (3D-CNN) to design our biofeedback system.\nResults: The proposed biofeedback system achieved an average accuracy of 91.05% and an average F1-Score of 64.20% using Leave-One-Subject-Out cross-validation.\nConclusion: The proposed 3D-CNN was able to classify the rehabilitation videos and feedback on the quality of exercises to the users to help them modify their movement patterns. We are expanding our platform to also extract other features such as the inter-relationships of the various body parts; muscles and their coordination to enable the therapist better to understand the rehab exercises\, remotely.\n A. Miron\, N. Sadawi\, W. Ismail\, H. Hussain\, and C. Grosan\, “Intellirehabds (Irds)—a dataset of physical rehabilitation movements\,” Data\, vol. 6\, no. 5\, pp. 1–13\, 2021\, doi: 10.3390/DATA6050046.\nSupervisor Name: Dr. Atena Roshan Fekr\, Professor Geoff Fernie\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-ali-barzegar-khanghah-2/
CATEGORIES:Graduate Seminar Series
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DTSTART;TZID=America/Toronto:20221108T120000
DTEND;TZID=America/Toronto:20221108T130000
DTSTAMP:20221102T202000Z
CREATED:20220512T152126Z
LAST-MODIFIED:20221102T202000Z
UID:10000018-1667908800-1667912400@bme.utoronto.ca
SUMMARY:NRC+CRAFT Speaker - Invited Academic Seminar Series - Ankur Singh - Lymphoid Organoids and Multiscale Technologies for Untangling Immunity in Infectious Diseases and Cancers (Hybrid Delivery)
DESCRIPTION:Speaker\nAnkur Singh\nWoodruff Faculty Fellow and Associate Professor\nGeorge W. Woodruff School of Mechanical Engineering\nWallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University School of Medicine \n\nAbstract\nFor many life-threatening global infectious diseases\, effective vaccinations are still lacking. There are numerous challenges in understanding disease transmission\, and pathology\, and developing new vaccines\, including a limited understanding of immune correlates of protection\, identification of viable vaccine candidates\, and off-target effects that must be evaluated in staged clinical trials. To generate these antibodies\, B cells are activated by T cells to form germinal centers\, which are sub-anatomical structures in the B cell follicles of lymph nodes. In germinal centers\, B cells rapidly proliferate and mutate to form somatically mutated high-affinity antibody-secreting cells. In this talk\, I will discuss my laboratory’s effort in developing murine and human ex vivo immune organoids using cells from individuals to generate antibody-secreting cells in a dish or as organ-on-chip against viral infections and antibiotic-resistant bacteria. I will subsequently describe designer bio-adhesive hydrogels and lymphatic-mimicking technologies for understanding the role of the lymphoid microenvironment in genetically diverse lymphomas and potential causes of drug resistance. \nBio: Ankur Singh is a Woodruff Faculty Fellow and an Associate Professor with a joint appointment in George W. Woodruff School of Mechanical Engineering at Georgia Institute of Technology and Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. Before Georgia Tech\, he was a tenured Associate Professor at Cornell University. His laboratory develops immune organoids and enabling technologies to understand healthy and diseased immune cells and translate therapeutics. He has received funding from the National Institute of Health\, National Science Foundation\, Wellcome Leap HOPE\, Department of Defense\, Defense Threat Reduction Agency\, the Curci Foundation\, and Lymphoma and Leukemia Society. He has published >65 articles in peer-reviewed journals\, including Nature Methods\, Nature Materials\, Nature Nanotechnology\, Nature Immunology\, Nature Communications\, Nature Reviews Materials\, Nature Protocols\, Science Advances\, Cell Reports\, PNAS\, Blood\, and Advanced Materials. He has written multiple editorials for Science Translational Medicine. He is a recipient of the NSF CAREER\, Society for Biomaterials Young Investigator Award\, CMBE Young Innovator Award\, CMBE Rising Star Award\, 3M Faculty Award\, DoD Career award\, Cornell’s Teaching Excellence Award\, and Cornell’s Research Excellence Award. His immune organoids were identified among the Top 100 Discoveries of 2015 by Discover Magazine. He is the Founder and past Chair of the Immune Engineering SIG at the Society for Biomaterials and Controlled Release Society. He currently serves as the Associate Editor for Science Advances\, Biomaterials\, and Cellular and Molecular Bioengineering.  \n\nHost\nMilica Radisic
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-ankur-singh/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2022/05/ASINGH-768x1024-1.jpg
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