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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230201T120000
DTEND;TZID=America/Toronto:20230201T123000
DTSTAMP:20260522T221356
CREATED:20221213T193757Z
LAST-MODIFIED:20230131T212250Z
UID:39534-1675252800-1675254600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Taseen Jawad
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Selective recording in human median nerve using CNNs – A simulation study\nAbstract: Limb loss\, specifically hand amputations can result in significant reduction in the quality of life of people. While modern prosthetics exist that are capable of performing the operations of the human hand\, controlling the limb is often cumbersome and a primary factor in prosthetic abandonment. This study attempts to expand on selective recording methods that have been applied to rat sciatic nerves. These methods are used on data derived from extraneural implants which is a type of neural interface for peripheral nerves. Previous works are expanded by applying the methodologies to more complex human median nerves in contrast to rat sciatic nerves. Due to the application of convolutional neural networks as part of the pipeline\, a simulation of the median nerve is be the method of investigation and simulated action potentials are used to train the algorithm. The aim of this study is to use modelled extraneural electrode data of simulated action potentials to isolate the source fascicles within the nerve responsible for the action potential.\nSupervisor Name: Jose Zariffa\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-taseen-jawad/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230201T123000
DTEND;TZID=America/Toronto:20230201T130000
DTSTAMP:20260522T221356
CREATED:20230111T203730Z
LAST-MODIFIED:20230131T212250Z
UID:39700-1675254600-1675256400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Adam Gravitis
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Ictal ECG-based assessment of sudden unexpected death in epilepsy\nAbstract: We discuss a metric for assessing SUDEP risk from ECG recordings using SSA-ICA and phase-phase cross frequency coupling (PPC). This metric expands traditional ECG features (heart rate\, heart rate variability\, QT interval) for cardiac investigations. The metric reveals significant differences between SUDEP and non-SUDEP for generalized seizures\, but not focal seizures.\nSupervisor Name: Berj Bardakjian\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-adam-gravitis/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230202T120000
DTEND;TZID=America/Toronto:20230202T123000
DTSTAMP:20260522T221356
CREATED:20220929T213735Z
LAST-MODIFIED:20230201T212234Z
UID:38963-1675339200-1675341000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Erik Jacques
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: A 3D biomimetic culture assay models MuSC quiescence\nAbstract: Adult skeletal muscle harbors a population of muscle stem cells (MuSCs) that are required to repair or reform multinucleated myofibers after tissue injury. In youth\, MuSCs return to a reversible state of cell cycle arrest termed ‘quiescence’ after injury resolution. By contrast\, a proportion of MuSCs in aged muscle remain in a semi-activated state\, causing a premature response to subsequent injury cues that results in incomplete tissue repair and eventual stem cell depletion. Regulation of the balance between MuSC quiescence and activation in youth and in age may hold the key to restoring tissue homeostasis with age\, but is incompletely understood. To fill this gap\, we developed a simple and tractable in vitro method\, with a 96-well footprint\, to rapidly inactivate MuSCs freshly isolated from young skeletal muscle tissue\, and return them to a quiescent-like state for at least one-week. This was achieved by introducing MuSCs into a three-dimensional (3D) bioartificial niche comprised of a thin sheet of multinucleated myotubes\, which we iterate\, and analyze temporally\, to show that these in vivo niche features provide the minimal cues necessary to inactivate MuSCs and induce quiescence.\nSupervisor Name: Dr. Penney Gilbert\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-erik-jacques/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230203T120000
DTEND;TZID=America/Toronto:20230203T130000
DTSTAMP:20260522T221356
CREATED:20230103T192757Z
LAST-MODIFIED:20230103T192759Z
UID:39634-1675425600-1675429200@bme.utoronto.ca
SUMMARY:OncoSim – A Free Cancer Simulation Tool to Advance Cancer Control
DESCRIPTION:CARTE Industry Speaker Seminar Series welcome Jean Yong and Dr. Rochelle Garner\, for an in-person industry speaker seminar. \nTopic: OncoSim – A Free Cancer Simulation Tool to Advance Cancer Control \nDate and Time: Friday Feb 3\, 2023 (12:00 – 1:00 PM EST) \nSpeakers: Jean Yong (Canadian Partnership Against Cancer) and Dr. Rochelle Garner (Statistics Canada) \nRegistration: Please register by filling out this form. Capacity is limited. Please register early to avoid disappointment. \nVenue: Sandford Fleming Building (10 King’s College Rd\, Toronto\, ON M5S 3G4)\, Room 3201 \nAbstract: Simulation models are essential tools for evaluating healthcare interventions; however\, developing these complex models is resource-intensive\, and the results may not be timely for informing policy decisions. OncoSim is the only cancer simulation tool that is available for free to users; they can modify the model inputs to answer their policy questions. Combining Canadian data from the real world\, expert opinion and clinical trials\, OncoSim projects health and economic outcomes and attributes them to 19 risk factors\, such as smoking and physical inactivity. OncoSim currently models four cancer sites and related screening programs in detail (breast\, colorectal\, lung and cervical cancers) and provides high-level projections for 25 other cancer sites. OncoSim’s projections have helped inform cancer control planning decisions across Canada. In this presentation\, we will introduce OncoSim and share our experience in developing and maintaining a cancer simulation tool aimed at informing policy decisions. \nLearning Objectives: \n\nTo learn about OncoSim – a microsimulation model built with Canadian data to inform cancer control policy decisions\nTo learn about the experience of developing and maintaining disease-based simulation models (how are they different than the conventional models built to answer one specific question?)\n To learn about the successes and challenges in keeping disease-based models useful for policymakers\n\n  \nSpeakers Bios: \nJean Yong: Jean completed her training in Operations Research and Health Economics at the University of Toronto. She has more than 15 years’ experience in generating evidence to inform healthcare resource allocation decisions. In addition to developing Markov models for health technology assessments\, she has worked on a discrete event simulation model to manage surgical resources\, a data portal and a spatial web application for infectious disease planning\, and disease-based simulation models built to answer different policy questions. \nRochelle Garner: Rochelle received her doctorate in epidemiology from McMaster University in 2007. She started her post-doctoral career conducting population health research in the Health Analysis Division at Statistics Canada\, with a particular focus on statistical methods and novel analytic approaches. She is presently the manager of the Microsimulation and Modelling Section in the Heath Analysis Division at StatCan\, where her team develops and maintains microsimulation models\, including OncoSim and POHEM\, and other epidemiological and predictive models.
URL:https://bme.utoronto.ca/event/oncosim-a-free-cancer-simulation-tool-to-advance-cancer-control/
LOCATION:Sandford Fleming Building\, 10 King's College Rd\, Toronto\, Ontario\, M5S 3G4\, Canada
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230205T093000
DTEND;TZID=America/Toronto:20230205T160000
DTSTAMP:20260522T221356
CREATED:20230112T182119Z
LAST-MODIFIED:20230112T182206Z
UID:39723-1675589400-1675612800@bme.utoronto.ca
SUMMARY:"Radiance" - TEDxUofT 2023 Conference
DESCRIPTION:Bringing the very best of UofT together.\n\n\nLike a radiant light\, ideas originate from an individual to a community\, providing a presence felt by the ears\, the eyes\, and the mind. TEDxUofT is proud to bring back our first in-person conference since 2019 in an entirely new context of a post-COVID world. From decrypting the art of networking to learning how to think positively in the face of adversity\, to student leaders breaking stories through journalism\, our expertly curated masters of their craft are bringing their radiance to the University of Toronto. \nDoors Open: 9:30am \nThere will be intermissions during the show. \nTEDxUofT is committed to creating an accessible space; for special accessibility needs\, please email chiefofstaff@tedxuoft.com \nUse code earlybird through the end of December for 10% off your tickets!
URL:https://bme.utoronto.ca/event/radiance-tedxuoft-2023-conference/
LOCATION:Isabel Bader Theatre\, 93 Charles Street West\, Toronto\, ON\, M5S 2C7\, Canada
CATEGORIES:Events & Workshops
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/01/f90347748c2ace11e43d0f5856c3e658-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230208T120000
DTEND;TZID=America/Toronto:20230208T123000
DTSTAMP:20260522T221356
CREATED:20220930T213739Z
LAST-MODIFIED:20230207T212237Z
UID:38974-1675857600-1675859400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Kiah Spencer
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Leveraging synaptic plasticity for long-lasting motor-recovery in Parkinson’s disease\nAbstract: TBA\nSupervisor Name: Dr. Luka Milosevic\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-kiah-spencer/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230208T123000
DTEND;TZID=America/Toronto:20230208T130000
DTSTAMP:20260522T221356
CREATED:20221213T193757Z
LAST-MODIFIED:20230207T212237Z
UID:39535-1675859400-1675861200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Ali Howidi
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Arterial Blood Pressure Estimation By Electrical Recording\nAbstract: This research aims to explore a novel form of recording continuous blood pressure through an implanted device. Blood pressure is consistently examined for its tie to overall body health. Significant differences in blood pressure such as in hypertension and hypotension can lead to drastic complications. Previous literature has found correlations between blood pressure variability and other chronic conditions as well as mortality. Despite recent neuroprosthetic research finding success using baroreceptor stimulation to modulate blood pressure\, all these devices use passive stimulation to lower blood pressure. Blood pressure modulation does not have a feedback system for any specific increase in blood pressure. Our approach explores the implementation of a cuff electrode to estimate blood pressure. Successful results would provide a tool for an individual to passively track their blood pressure patterns without the use of any external devices.\nSupervisor Name: Paul Yoo\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-ali-howidi/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230214T120000
DTEND;TZID=America/Toronto:20230214T130000
DTSTAMP:20260522T221356
CREATED:20220512T153455Z
LAST-MODIFIED:20230203T183030Z
UID:37315-1676376000-1676379600@bme.utoronto.ca
SUMMARY:Invited Academic Seminar Series - Silvestro Micera- Soft Embodiment for Engineering Artificial Limbs (Virtual Only)
DESCRIPTION:Speaker\nSilvestro Micera\nFull Professor\, Bertarelli Foundation Chair in Translational Neuroengineering\nEcole Polytechnique Fédérale de Lausanne (EPFL) \n\nAbstract\nNeural engineering is a novel discipline combining engineering including micro and nanotechnology\, electrical and mechanical\, and computer science with cellular\, molecular\, cognitive neuroscience. Our of the most important goals of neural engineering is to develop approaches to repair\, restore\, and augment sensory and motor functions. \nWe recently proposed to achieve this goal by exploiting also a new general approach\, which we term ‘soft embodiment’. We posit that the objective for (neural) engineers is not always to create systems that are processed exactly like their natural counterparts. It is also to create technologies that can exploit the processing of the body for their own sake.  In short\, the aim is not always to mimic but also to “recycle” neural resources. \nIn this presentation\, I will provide several examples on how this concept can be used to develop bionic systems to restore and augment sensory and motor functions in different conditions. In particular\, I will show how implantable interfaces can be used to restore sensory (tactile and temperature feedback for artificial limbs\, visions)\, motor (grasping\, locomotion)\, and autonomic functions (for cardiovascular problems) and how it is possible to develop effective control strategies for supernumerary limbs. \n\nHost\nMilos Popovic
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-silvestro-micera/
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2022/05/silvestro-micera.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230215T120000
DTEND;TZID=America/Toronto:20230215T123000
DTSTAMP:20260522T221356
CREATED:20230210T212230Z
LAST-MODIFIED:20230214T212239Z
UID:40561-1676462400-1676464200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Jakson Paterson
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Automated Safety and Usability Assessment Methods for Outdoor Street Crossings\nAbstract:\nPedestrians (including wheeled mobility device users) can face safety and usability challenges at street crossings because of the inherent risks associated with winter weather\, low lighting levels\, and by interactions with other road users (e.g.\, bicycles\, vehicles). Each of these environmental factors have both physical and psychological influences on the perceived safety and risk of fall and injury. As a result\, many older adults and persons with disabilities choose to reduce their outdoor activity levels and become more isolated in their homes\, restricting their daily mobility\, and potentially triggering a downward spiral of deconditioning\, frailty\, and physical decline.\nHowever\, these challenges have gotten limited attention\, likely because of a lack of efficient methods for practical analysis of pedestrian movements and interactions with external risk factors in real-world outdoor settings. The objective of this project is to develop an automated pedestrian detection and tracking system that can help assess the behavior of pedestrians and understand the day-to-day challenges these at-risk road users face at street crossings in urban environments.\nThe pedestrian street crossing evaluation system will use a portable video recording setup that includes a 4k video camera (Z-CAM E2) mounted on a 10 m tall mast to capture the movements of pedestrians and other road users. Computer vision approaches including YOLOv7 and DeepSORT will be used automate the detection and measurement pedestrian walking speed and trajectory\, as well as the classification of conflicts between pedestrians and other road users.\nThis project will provide new automated observation tools for evaluating the safety and usability of street crossings. The goal of this work is to understand the complex relationship between pedestrians and the built environment and highlight limitations in current infrastructure design and/or maintenance so that they can be made safer and more accessible for all individuals.\nSupervisor Name: Tilak Dutta\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-jakson-paterson/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230216T120000
DTEND;TZID=America/Toronto:20230216T123000
DTSTAMP:20260522T221356
CREATED:20221207T193729Z
LAST-MODIFIED:20230215T212253Z
UID:39487-1676548800-1676550600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Benedikt Licht
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Extracellular Matrix Modification of Vascularizing Methacrylic Acid-based Hydrogel\nAbstract: Pancreatic islet transplantation is a promising therapy for type 1 diabetes that can re-introduce intrinsic glycemic regulation. The Sefton lab has shown that an inherently vascularizing\, degradable poly(sodium methacrylate)-poly(ethylene glycol) (MAA-PEG) hydrogel is a suitable material for subcutaneous islet delivery. However\, enzymatic digestion of the native extracellular matrix (ECM) during islet isolation (collagenase) disrupts islet cell-matrix communications\, impairing islet function and inducing anoikis (apoptosis due to a loss of ECM connections). We hypothesize that the addition of collagen to the synthetic MAA-PEG hydrogel will restore cell-matrix communication\, thereby improving islet health and function after transplantation.\nSupervisor Name: Michael Sefton\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-benedikt-licht/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230217T120000
DTEND;TZID=America/Toronto:20230217T123000
DTSTAMP:20260522T221356
CREATED:20230217T155506Z
LAST-MODIFIED:20230217T155514Z
UID:40900-1676635200-1676637000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Tahmid Hussain
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Towards reconstructing the Human Olfactory System in-vitro\nAbstract: G-protein-coupled receptors (GPCRs) form a large group of cell surface receptors that is involved with the majority of physiological responses to a variety of molecules\, both biological and synthetic. As a result\, the function and response of GPCRs is a major target for drug development research and studies of intercellular signalling mechanisms. Almost 50% of drugs present in the market target GPCRs. Another fascinating aspect of GPCRs is that the human genome encodes for more than 800 different GPCRs and almost half of them are olfactory receptors. However\, the expression of olfactory receptors (ORs) in other non-olfactory cells like the kidneys and heart leads to the theory that olfactory receptors may have other physiological functions beyond olfaction. However\, due to the nature of ORs\, their sheer number and current receptor observation methods\, the identification of receptors and linking them to a particular molecule is a daunting task. In fact\, presently\, only a small fraction of olfactory GPCRs have been linked to a particular ligand. The goal of the research project is to create a microfluidic platform that can act as a bioelectronic nose which can simulate the sense of smell as faithfully as it exists in nature. The platform will utilize heterologous expression of olfactory GPCRs on HEK-293 cells detect real-time activation of GPCRs in a manner that allows for rapid\, reliable\, and repeatable measurements using the same cell culture.\nSupervisor Name: Michael Garton\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-tahmid-hussain/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230217T123000
DTEND;TZID=America/Toronto:20230217T130000
DTSTAMP:20260522T221356
CREATED:20230210T212230Z
LAST-MODIFIED:20230217T155514Z
UID:40562-1676637000-1676638800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Danielle Serra
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Building a Synthetic Biology based Toolkit for Regenerative Medicine\nAbstract: Synthetic biology has been used to engineer new biological components and allow the construction of synthetic gene circuits with a broad array of useful applications. Creating these circuits requires components with consistent and predictable function\, that can be efficiently delivered and expressed by the host organism. Organism-specific toolkits with standardized building blocks such as promoters\, coding sequences\, and terminators have been developed for a wide range of useful organisms and cell types. These have been highly effective in accelerating the design–build–test cycle\, supporting communities with a validated repository\, and ensuring reproducibility. However\, despite an oft vaunted promise of synthetic biology to revolutionize cell-based therapeutics\, a standardized synthetic biology toolkit for human stem cells and tissues derived from them does not currently exist. Translation of synthetic gene circuits from immortalized cell line models to stem cells remains poor\, due to epigenetic silencing\, off target effects\, and resource loading\, among other challenges. We posit that a dedicated toolkit\, with parts designed to mitigate these issues\, is required for the field to move forward effectively. In this study I venture to establish a synthetic biology toolkit for stem cells and their derived progeny. A testbed circuit is first established to measure promoter expression intensity\, allowing high-throughput promoter design–build–testing of constitutive\, tissue-specific\, and inducible promoters. Development of these and other validated parts will aid creation of a therapeutically relevant genetic circuit that can toggle therapeutic circuits on\, off\, or prompt self-excision from the genome. Generating standardized stem-cell validated parts will aid in the development of sophisticated cell and gene therapies in regenerative medicine.\nSupervisor Name: Dr. Michael Garton\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-danielle-serra-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230222T120000
DTEND;TZID=America/Toronto:20230222T123000
DTSTAMP:20260522T221356
CREATED:20230113T203749Z
LAST-MODIFIED:20230222T162232Z
UID:39760-1677067200-1677069000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Aleksandra Dojnov
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Feasibility of non-invasively measuring neural activity evoked by saphenous nerve stimulation in humans\nAbstract: Rationale and Objectives. Overactive bladder (OAB) is a large problem\, affecting 14-18% of the population in Canada and the US. Saphenous nerve stimulation is an emerging therapy for treating OAB. Stimulation-evoked neural signals can produce the subjective perception of paresthesia\, but this does not confirm whether the neural target has been sufficiently activated and may be difficult in patients with impaired sensory processing. An objective measurement of non-invasive nerve stimulation could provide a more accurate representation of neural activation. Unfortunately\, since the saphenous nerve is a purely sensory nerve\, visible confirmation cannot be accomplished by measuring muscle contraction. This study investigated the feasibility of measuring evoked neural activity evoked as sensed by several cutaneous recording electrode configurations. Methodology. In 17 healthy volunteers (11 male; age = 24 ± 2.1 years\, range: 20-28; BMI = 22.5 ± 2.8)\, stimulation evoked neural activity was measured and analyzed for 4 recording configurations obtained using 5 electrodes located linearly on the top surface of the foot: monopolar\, bipolar\, tripolar\, and tetrapolar (see figure). Peak-to-peak amplitude (Vpp) was measured. Results. A high signal-to-noise ratio can be achieved by averaging the neural signals from a minimum of 70 pulses (i.e.\, 7 seconds at 10 Hz). Vpp at maximal recruitment ranged between 2-11 µV\, which is consistent with literature. Different stimulation thresholds follow patterns associated with stimulation-evoked physiological phenomena and reflect expected neural recruitment behaviour. The tetrapolar configuration yielded the largest Vpp. Conclusion and Significance. The results support the feasibility of using non-invasive recording electrodes to measure stimulation-evoked signals from the saphenous nerve. A tetrapolar configuration may provide the best recorded signal as it produces the greatest Vpp. Further work is needed to translate these initial findings into a clinical therapeutic device.\nSupervisor Name: Paul Yoo\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-aleksandra-dojnov/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230222T123000
DTEND;TZID=America/Toronto:20230222T130000
DTSTAMP:20260522T221356
CREATED:20221010T220747Z
LAST-MODIFIED:20230222T162233Z
UID:39056-1677069000-1677070800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Vida Adeli Mosabbeb
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Vision-based gait assessment in older adults with dementia\nAbstract: Falls are a leading cause of morbidity and mortality in older adults with dementia residing in long-term care. Having access to a frequently updated and accurate estimate of short-term fall risk for each resident will enable care staff to provide targeted interventions to prevent falls and resulting injuries. To this end\, machine learning models to estimate and frequently update the short-term fall risk were trained on longitudinal data from 54 older adult participants with dementia. This study is the first to present a machine learning model capable of dynamically estimating short-term fall risk for older adults with dementia. The model used baseline fall risk scores\, gait measurements from baseline and in the past 6 days\, and daily dose of antipsychotic medication in the past 6 days.\nSupervisor Name: Babak Taati\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-vida-adeli-mosabbeb/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230223T120000
DTEND;TZID=America/Toronto:20230223T123000
DTSTAMP:20260522T221356
CREATED:20230124T210732Z
LAST-MODIFIED:20230223T162237Z
UID:39980-1677153600-1677155400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Johnathan Lex
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Machine Learning to Predict and Optimize Arthroplasty Resource Utilization and Patient Outcomes\nAbstract:\nBackground\nThe gold-standard therapy for end-stage arthritis of the knee and hip is total knee and hip arthroplasty (TKA and THA\, respectively). They are the most common orthopaedic procedures carried out in the US\, with over 1.3 million of these operations performed in 2018\, a 21.9% increase from 2008. Global ageing and the continued obesity epidemic will cause this figure to continue to rise. Inefficiencies in surgical services are a major cause of Canadian healthcare’s growing costs and wait times. OR scheduling is a critical consideration in surgical care delivery with direct impacts on staffing and inventory planning across multiple hospital units (post- operative care units\, inpatient wards\, intensive care units). Manual scheduling requires that the human planner simultaneously reason about unknowns such as case-specific length-of-surgery\, hard constraints on the total amount of available OR time\, surgeon availability and caseload\, and soft constraints such as patient wait times\, case priorities\, and post-operative quality of life improvement\, all while maximizing throughput.\nSpecific Aims\n1. To evaluate neural network prediction models incorporating patient and operational factors for the prediction of duration of surgery and length of stay for primary and revision TKA/THA.\n2. To compare the impact of a two-stage machine learning and optimization approach on operating room efficiency compared to using historic scheduling practices (surgeon- estimated DOS)\, mean DOS\, mean surgeon-specific DOS and rolling mean surgeon- specific DOS.\n3. Determine if neural networks with patient\, surgeon and implant features can accurately predict improvement in patient reported outcome measures following TKA/THA.\nSupervisor Name: Dr. Cari Whyne\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-johnathan-lex/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230223T123000
DTEND;TZID=America/Toronto:20230223T130000
DTSTAMP:20260522T221356
CREATED:20221004T213737Z
LAST-MODIFIED:20230223T162237Z
UID:39008-1677155400-1677157200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Ryan Yee
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Sara Vasconcelos\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-ryan-yee/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230224T120000
DTEND;TZID=America/Toronto:20230224T123000
DTSTAMP:20260522T221356
CREATED:20230209T212231Z
LAST-MODIFIED:20230224T162229Z
UID:40537-1677240000-1677241800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Brendan Samaroo
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: An Adaptable Permeable Tissue Mimicking Phantom for Realistic Tumor Representation\, Calibration\, and Validation in DCE imaging\nAbstract:\nThe concept of dynamic contrast enhanced (DCE) imaging in combination with pharmacokinetic modeling of contrast agents (CA) is becoming an important tool in assessing a given tissue’s response to targeted interventions and the efficacy of drug delivery mechanisms . To calibrate DCE imaging and validate tracer pharmacokinetics\, such as perfusion\, vascular permeability\, diffusion and convection\, 3D structures known as phantoms are required to replace the need for tumors\, providing a simplified and controlled test environment . There are two main caveats with contemporary phantoms\, 1) they do not precisely represent the tumor microenvironment and microvasculature and 2) phantoms are constructed with non-tissue mimicking materials . Based on this\, the goal of this project is to improve on phantom design and validate its imaging functionality using tracers of varying molecular weights\, expanding upon traditional proof-of-concept methods.\nIt is hypothesized: implementing features of a highly disorganized capillary network\, representative of abnormal tissues\, in a novel hydrogel phantom\, then we should be capable of obtaining accurate and reproducible tracer kinetics through the tumor space\, allowing for the testing of image-derived pharmacokinetics.\nThis study will optimize phantom usage in radiation oncology and introduce a new 3D-printed/bio-printed adaptable phantom design that can expand scope and assess image-based pharmacokinetics of other nanoparticles\, chemotherapeutics\, and anti-cancer drugs through an apparatus that closely represents characteristics of the tumor space\, highlighting its transdisciplinary nature. Subsequently this will allow exploration how past\, present\, and future treatments behave\, and indicate potential drug-related inefficiencies\, within the tumor microenvironment.\nSupervisor Name: Catherine Coolens\nSupervisor Name: Catherine Coolens\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-brendan-samaroo/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230224T123000
DTEND;TZID=America/Toronto:20230224T130000
DTSTAMP:20260522T221356
CREATED:20230208T212308Z
LAST-MODIFIED:20230224T162229Z
UID:40403-1677241800-1677243600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Travis Douglas
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Spatially defined and decorated DNA nanoparticles to investigate macrophage polarization\nAbstract: –\nSupervisor Name: Dr. Leo Chou\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-travis-douglas/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230228T110000
DTEND;TZID=America/Toronto:20230228T120000
DTSTAMP:20260522T221356
CREATED:20230207T175407Z
LAST-MODIFIED:20230207T175407Z
UID:40104-1677582000-1677585600@bme.utoronto.ca
SUMMARY:Translating 3D Bioprinting Tools From Lab to Market: an Academic’s Perspective on Starting a Company
DESCRIPTION:Please join us for an ECHO webinar featuring Prof. Stephanie Willerth\, who will provide an overview of Axolotl Biosciences\, its technologies and the story behind its success. \nAxolotl Biosciences – an award-winning spin-off company from the University of Victoria – sells high quality reagents for 3D printing human tissue models. https://www.axolotlbiosciences.com/  \n\nGuest Speaker\nProf. Stephanie Willerth\, PhD\, PEng \nChief Executive Officer\, Axolotl Biosciences \nProfessor and Canada Research Chair in Biomedical Engineering\, University of Victoria \n\nRegister in advance for this webinar. After registering\, you will receive a confirmation email containing information about joining the webinar. \nECHO is an entrepreneurship training program\, funded and organized in a partnership between (i) the Translational Biology and Engineering Program (TBEP)\, the University of Toronto component of the Ted Rogers Centre for Heart Research\, and (ii) the Health Innovation Hub (H2i). For more information\, visit: https://tedrogersresearch.ca/echo/
URL:https://bme.utoronto.ca/event/translating-3d-bioprinting-tools-from-lab-to-market-an-academics-perspective-on-starting-a-company/
CATEGORIES:External Speaker Series
ORGANIZER;CN="Translational Biology and Engineering Program (TBEP)":MAILTO:reception.tbep@utoronto.ca
END:VEVENT
END:VCALENDAR