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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230301T120000
DTEND;TZID=America/Toronto:20230301T123000
DTSTAMP:20260411T043531
CREATED:20221123T192239Z
LAST-MODIFIED:20230301T162229Z
UID:39421-1677672000-1677673800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Paul Kang
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Design\, Modeling\, and Control of a Hybrid Concentric Tube Robot and Steerable Wrist for Epilepsy Surgery\nAbstract: Epilepsy is the disease characterized by the brain generating recurrent seizures\, inducing symptoms of drop attacks\, muscle stiffening\, and loss of awareness. Traditional surgeries for epilepsy use straight and rigid tools with large craniotomies where the open exposure leads to higher morbidity rates\, greater blood loss\, and longer recovery times. Concentric tube robots (CTR) and steerable wrist instruments are two separate technologies that have potential to reduce the exposure during surgery due to their super-elasticity\, curvilinear structure\, and thin form (outer diameters less than 3mm). Despite their advantages\, CTRs are unable to make high curvature bends\, and steerable wrists are unable to create complex configurations along its usually straight backbone. These tools have been studied independently\, but very few studies have aimed to combine them to overcome each of their limitations. This thesis aims to design\, model\, and control a surgical tool that integrates these two technologies to improve the current capabilities of minimally invasive epilepsy surgery.\nSupervisor Name: Dr. James Drake\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-paul-kang/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230301T123000
DTEND;TZID=America/Toronto:20230301T130000
DTSTAMP:20260411T043531
CREATED:20220929T213735Z
LAST-MODIFIED:20230301T162229Z
UID:38964-1677673800-1677675600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Nicholas Zhao
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Automated Hand Function Assessment from Egocentric Video\nAbstract:\nRestoration of arm and hand function is reported to be the top priority for rehabilitation by individuals with spinal cord injury (SCI). Clinical hand function assessments such as the Graded Redefined Assessment of Strength Sensibility and Prehension (GRASSP) are methods to evaluate the level of hand function of an individual with SCI\, but they must be done in person by a trained clinician. This restriction to an in-person clinical setting limits the accessibility of the assessment\, as well as its relevance to daily life. To address these limitations\, egocentric video is an emerging method that remotely provides detailed information about upper extremity movements\, as well as functional context. Previous works using egocentric video in rehabilitation have focused on detecting quantity of hand use and usage of compensatory grasping postures\, using deep computer vision models. However\, there have been no studies that assess the quality of hand function from egocentric video. A successful implementation of such a model would allow for automated remote monitoring of rehabilitation progress at home without requiring constant supervision from a clinician.\nThe objective of this study is to develop a deep learning model capable of predicting clinical hand function assessment scores from egocentric video. To achieve this objective\, the following research plan will be enacted: 1. Annotate a dataset with adapted GRASSP scoring. 2. Explore multiple deep learning architectures to determine the best performing model.\nSupervisor Name: Jose Zariffa\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-nicholas-zhao/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230302T120000
DTEND;TZID=America/Toronto:20230302T123000
DTSTAMP:20260411T043531
CREATED:20220922T213740Z
LAST-MODIFIED:20230302T163727Z
UID:38876-1677758400-1677760200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Dana Brinson
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: A culture platform with alveolar geometry for induced pluripotent stem cell-derived distal lung organoids\nAbstract: Induced pluripotent stem cell (iPSC)-derived distal lung organoids must be improved to better recapitulate the adult alveolar epithelium. Existing organoids do not contain all relevant cell types and the cells have fetal maturity. IPSCs are an ideal source of cells for patient-specific in vitro models\, cell therapy\, and tissue engineering. Traditionally\, organoids are grown embedded in droplets of Matrigel®. This does not provide mechanical cues similar to the native lung. The physical microenvironment plays an important role in alveolar epithelial cell (AEC) differentiation. Our lab has designed PDMS substrates with hemispheres that model the alveoli. We have previously characterized growth of A549 cells or primary mouse AECs on the substrates. Primary AECs are typically grown on flat culture dishes\, and within one week alveolar type two (AT2) cells lose their phenotype and differentiate into type one (AT1) cells. We found that the biomimetic substrate maintained a more stable balance of AT1 and AT2 cells compared to flat substrates. The next step is to study iPSC-derived lung progenitor cell differentiation first on the dimpled substrates and then in more complex alveolar geometry. 3D printing will generate a complex 3D mold. Differentiation will be compared amongst cells grown on the geometries\, flat substrates\, or in traditional Matrigel® droplets. Transcriptomics and epigenomics will be used to elucidate heterogeneity in expression of genes associated with differentiation to AT1 and AT2 cells. Characterizing cells on the biomimetic substrates will help uncover whether geometric cues play a role in aiding appropriate differentiation of AECs.\nSupervisor Name: Dr. Thomas Waddell and Dr. Golnaz Karoubi\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-dana-brinson/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230302T123000
DTEND;TZID=America/Toronto:20230302T130000
DTSTAMP:20260411T043531
CREATED:20230118T205243Z
LAST-MODIFIED:20230302T163727Z
UID:39818-1677760200-1677762000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Nooshin Abdollahi
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Effects of extracellular conductivity on action potential propagation.\nAbstract: Neurons use action potentials\, or spikes\, to encode and transmit information. Understanding neural coding thus requires that we understand how spikes are generated and transmitted. In myelinated axons\, spikes are transmitted rapidly and efficiently by regenerating the spikes at each node of Ranvier\, a process known as saltatory conduction. Experimental and theoretical work have demonstrated that when an action potential propagates down an axon\, it affects the extracellular electric field. As the extracellular electric field changes\, it can affect both the active and nearby axons. In this study we aimed to investigate the effects of extracellular medium on action potential propagation as well as the biophysical mechanism involved.\nSupervisor Name: Dr. Steve Prescott\nYear of Study: 5\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-nooshin-abdollahi/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230303T120000
DTEND;TZID=America/Toronto:20230303T123000
DTSTAMP:20260411T043531
CREATED:20220825T165236Z
LAST-MODIFIED:20230303T163843Z
UID:38523-1677844800-1677846600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Chelsea Leung
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Developing microbubble-mediated sonoporation strategies for safe and efficient cell transfection\nAbstract: TBD\nSupervisor Name: Dr. Gang Zheng\nYear of Study: 3\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-chelsea-leung/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230303T123000
DTEND;TZID=America/Toronto:20230303T130000
DTSTAMP:20260411T043531
CREATED:20220831T170759Z
LAST-MODIFIED:20230303T163843Z
UID:38605-1677846600-1677848400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Michael Valic
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Optimisation strategy for nanoparticle-based photodynamic therapy using clinical veterinary models of thyroid cancer\nAbstract:\nPhotodynamic therapy (PDT) is a nonsurgical ablative treatment strategy that can precisely target cancerous cells while sparing surrounding healthy cells. PDT involves administration of a photosensitiser drug that accumulates in tumour tissues and is activated by laser light to generate cytotoxic radical oxygen species. Delivery of photosensitisers using nanoparticles can further enhance the selectivity of drug delivery to tumour cells and improve the overall safety of PDT treatments in patients.\nThe success of PDT depends on three key treatment parameters: nanoparticle/drug dose\, drug-light interval (DLI)\, and light dose. Optimisation of these parameters are typically accomplished through pharmacokinetic and PDT efficacy studies in tumour-bearing rodents. While rodent models are convenient\, they often fail to reproduce the anatomical\, pathological\, and clinical complexities of human disease and frequently necessitate re-optimisation of PDT treatments in trial patients.\nTo overcome this translational barrier\, we have devised a strategy to optimise PDT treatment efficacy in clinical veterinary models with naturally occurring cancers prior to human clinical trials. In canine patients with resectable papillary thyroid cancer\, nanoparticle-based PDT treatments were performed varying the treatment parameters (i.e.\, nanoparticle dose\, DLI\, light dose) previously studied in rodents and the treatment efficacy evaluated with histopathology. The outcome of this study is a more robust PDT treatment protocol that can be reliably implemented in human patients with head and neck cancers.\nSupervisor Name: Gang Zheng\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-michael-valic/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230308T120000
DTEND;TZID=America/Toronto:20230308T123000
DTSTAMP:20260411T043531
CREATED:20230223T162237Z
LAST-MODIFIED:20230308T165230Z
UID:40942-1678276800-1678278600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Shaghayegh Chavoshian
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Investigating the Influence of Obstructive Sleep Apnea on Asthma and Proposing a Prediction Model\nAbstract:\nAsthma is an inflammatory disease of the airways that can make breathing difficult and sometimes impossible. There are a variety of factors and comorbidities in asthma that can lead to respiratory insufficiency or failure such as obstructive sleep apnea (OSA). Despite the large overlap between asthma and obstructive sleep apnea\, the underlying mechanisms of the pathophysiological link between these two disorders are in their infancy. Previously\, it has been shown that the fluid accumulation in the neck and thorax while supine can be a unifying mechanism for the overlap of asthma and OSA. However\, it is not clear how the rostral fluid shift in the thorax affects airway narrowing in asthma and how it can be managed. Our central hypothesis is that one mechanism by which OSA can predispose to small airway narrowing in asthma is by increasing negative intrathoracic pressure and aggravating fluid accumulation in the thorax during sleep.\nIn this study\, we aim to address the current gaps in asthma management through three interconnected objectives. First\, we will investigate the changes in mechanical properties of airways in patients with asthma and OSA due to increased negative intrathoracic pressure and thoracic fluid volume (TFV). Second\, we will investigate if OSA treatments by either removing intrathoracic pressure or reducing TFV would alleviate overnight narrowing in airways in populations with asthma and OSA. Third\, we will develop a model to predict asthma worsening by monitoring electrocardiogram (ECG) and respiration signals.\nBy accomplishing the objectives of this study\, more information about the interaction between asthma and OSA will be gained. Furthermore\, with the help of monitoring ECG and respiration signals\, there will be better ways for frequent monitoring of airway narrowing in asthma\, which may help develop better tools to manage asthma\, especially in those with asthma and OSA.\nSupervisor Name: Dr. Azadeh Yadollahi\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-shaghayegh-chavoshian/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230308T123000
DTEND;TZID=America/Toronto:20230308T130000
DTSTAMP:20260411T043531
CREATED:20230113T203750Z
LAST-MODIFIED:20230308T165231Z
UID:39761-1678278600-1678280400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Anat Usatinsky
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Implantable\, battery-free\, Bluetooth-enabled\, multiwavelength spectroscopy device for the remote monitoring of physiological biomarkers\nAbstract: Spectroscopy use is limited due to the innate limitation of light penetration depth. The recent miniaturization of optical sensors and advanced microprocessors enabled the use of spectroscopy systems in compact implantable formats. Our lab aims to evaluate the use of spectral sensors to monitor physiological biomarkers via a clinically translational implant. We integrated the miniaturized spectrometers onto implantable platforms allowing for red and near-infrared LED capabilities. We then demonstrated its functionality via in-vitro studies and in-vivo rodent studies. The data received was analyzed for breathing rate and heart rate. By showing that our technology could detect these biomarkers\, we demonstrate the use of the first-of-its-kind\, implantable\, multi- wavelength\, Bluetooth-operated\, RF utilizing\, modular-biosensor\, in tracking deep tissue hemodynamics. Currently\, we are further displaying device vitality in clinical settings via hypoxia studies and extending its wireless power capabilities.\nSupervisor Name: Dr. Daniel Franklin\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-anat-usatinsky/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230309T120000
DTEND;TZID=America/Toronto:20230309T123000
DTSTAMP:20260411T043531
CREATED:20230110T202256Z
LAST-MODIFIED:20230309T165237Z
UID:39692-1678363200-1678365000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Emilio Garcia Flores
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: The role of neural precursor cells in metformin-mediated recovery following spinal cord injury.\nAbstract: Spinal cord injury (SCI) is a common cause of death\, paralysis\, and other debilitating conditions. Although SCI begins as a traumatic event\, damage to the spinal cord (SC) continues in the following weeks in the form of neuronal cell death and demyelination\, the loss of oligodendrocytes. Currently\, there are limited therapeutic interventions aimed at promoting cellular repair\, however we have previously found that treatment with metformin\, a common Type II diabetes drug\, results in improved functional outcomes in mice. Correlated with these results\, we also observed 1) enhanced proliferation of endogenous neural precursor populations like the Sox2+ neural stem & progenitor cells (NSPCs) and the NG2+ oligodendrocyte progenitor cells (OPCs)\, as well as 2) increased oligodendrogenesis following metformin treatment. Here\, we explore whether NSPCs or OPCs (and both their roles in oligodendrogenesis) are required for metformin-mediated recovery. We hypothesize that NSPCs are required for metformin-mediated recovery\, and OPC are not. Using a Sox2TK ablation model\, we first propose to explore whether proliferating NSPCs are required for metformin-mediated recovery. Next\, using Sox2- and NG2- specific knockout models of Myrf (a transcription factor essential for oligodendrogenesis)\, we propose to test whether OPC- or NSPC-derived oligodendrogenesis is required for metformin-mediated recovery. Presently we have generated these models and validated them using both and in vitro and in vivo approaches. Notably\, preliminary results from our Sox2TK ablation model indicate that in the absence of proliferating NPSCs metformin-mediated recovery is lost. Together with ongoing Myrf knockout studies\, these findings will begin to elucidate the cellular basis for metformin-mediated recovery and help establish it as a therapeutic intervention aimed at promoting cellular repair.\nSupervisor Name: Dr. Cindi Morshead\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-emilio-garcia-flores/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230309T123000
DTEND;TZID=America/Toronto:20230309T130000
DTSTAMP:20260411T043531
CREATED:20230118T205244Z
LAST-MODIFIED:20230309T165237Z
UID:39819-1678365000-1678366800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Siti Nurfaezah Binti Zahari
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: MACHINE LEARNING-DRIVEN SENSORY ASSESSMENT OF SPINAL CORD INJURY\nAbstract: Spinal cord injury (SCI) often results in sensory deficits\, which can significantly impact the quality of life of affected individuals. Traditional methods of sensory assessment\, such as ISNCSCI using pinprick and light touch\, have limitations. Recently\, researchers have developed the Electrical Perceptual Threshold (EPT) test for sensory assessment\, which is considered a better method than traditional ones. However\, the current EPT test is performed manually\, which increases the risk of human error and bias. In this research study\, we propose to develop a computer-controlled EPT test using a controlled relay circuit for the sensory assessment of patients with SCI. The electrodes will be placed at 56 dermatomes before the stimuli begin. The computer-controlled EPT test will automatically control the stimulus intensity and deliver it through the electrodes at the ASIA points in random order. The aim of this study is to investigate the reliability and validity of the computer-controlled EPT test using a controlled relay circuit in comparison to traditional methods of sensory assessment in patients with SCI. In addition\, we also aim to use machine learning approaches to predict the extent of recovery in patients with sensory deficits at 12 or 24 months post-injury and identify potential predictors of recovery outcomes. We will collect data from 20 healthy subjects and 80 subjects with SCI. For healthy subjects\, the subjects will be in the same age group as males and females. While for subjects with SCI\, different ages for males and females will be collected. The data from SCI subjects will take from multiple time points\, such as one month\, three months\, six months and twelve months\, to track their recovery over time. We expect that the computer-controlled EPT test using a controlled relay circuit will be more accurate\, reliable\, and efficient than traditional methods of sensory assessment in patients with SCI and that it will help to improve the prediction of recovery outcomes.\nSupervisor Name: Prof Milos R Popovic and Dr Shehroz Khan\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-siti-nurfaezah-binti-zahari/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230310T120000
DTEND;TZID=America/Toronto:20230310T123000
DTSTAMP:20260411T043531
CREATED:20221005T215237Z
LAST-MODIFIED:20230310T165253Z
UID:39034-1678449600-1678451400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Zahra Sepahi
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Warren Chan\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-zahra-sepahi/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230310T123000
DTEND;TZID=America/Toronto:20230310T130000
DTSTAMP:20260411T043531
CREATED:20230207T212236Z
LAST-MODIFIED:20230310T165253Z
UID:40116-1678451400-1678453200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Ryan Lee Chan
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Functionalized DNA for Templated Biomineralization\nAbstract: DNA assemblies show promising biomimicry; they can fold into complex and highly ordered nanoarchitectures capable of mimicking naturally occurring structures. Further\, they can act as scaffolds and be functionalized at specific locations. To date\, there is limited research on DNA assemblies as guides for mineral growth. The objective is to develop DNA nanostructures functionalized with a mineral promoting peptide at precise locations to control mineralization. It is hypothesized that enhanced and selective mineral growth will occur by controlling nucleation sites using peptide-DNA nanostructures.\nSupervisor Name: Dr. Karina Carneiro\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-ryan-lee-chan-2/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230314T120000
DTEND;TZID=America/Toronto:20230314T130000
DTSTAMP:20260411T043531
CREATED:20220512T153722Z
LAST-MODIFIED:20230313T183736Z
UID:37318-1678795200-1678798800@bme.utoronto.ca
SUMMARY:Invited Academic Seminar Series - Peter Yingxiao Wang- Remote Control of the Genetics within Tumors via Focused Ultrasound for Cancer Immunotherapy (Hybrid Delivery)
DESCRIPTION:Speaker\nPeter Yingxiao Wang\nAssociate Professor\, Bioengineering\nUniversity of Southern California \n\nAbstract\nFocused ultrasound (FUS) can deliver energy safely and noninvasively into tissues at depths of centimeters. We show that the genetics and cellular functions of chimeric antigen receptor T cells (CAR-T cells) within tumors can be reversibly controlled by the heat generated by short pulses of FUS via a CAR cassette under the control of a promoter for the heat-shock protein. In mouse tumor models\, locally injected T cells with the inducible CAR and activated via FUS guided by magnetic resonance imaging (MRI) mitigated on-target off-tumor activity and enhanced the suppression of tumor growth\, compared with the performance of standard CAR-T cells. Integrated with CRISPR\, FUS was also be applied to modulate the genetics and epigenetics of tumor cells\, which facilitated and enhanced the efficacy of the CAR T immunotherapy. Therefore\, acoustogenetic control of tumor cells and CAR T by FUS may facilitate the design of safer cell therapies. \n\nHost\nLidan You
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-peter-yingxiao-wang/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2022/05/20180118-Wang_Peter-2513-full_res-export.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230315T120000
DTEND;TZID=America/Toronto:20230315T123000
DTSTAMP:20260411T043531
CREATED:20220824T165254Z
LAST-MODIFIED:20230314T165233Z
UID:38503-1678881600-1678883400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Aliaa Gouda
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Development and Evaluation of a Wearable Biofeedback System for Lower Limb Amputee Gait Training\nAbstract:\nndividuals with lower-limb amputations typically regain their independent mobility through focused gait rehabilitation . Since effective prosthesis use requires precise coordination between the neuromusculoskeletal processes of the body and the prosthesis\, focused training associated with motor-learning based strategies is important to maximize functional mobility outcomes . Conventional gait training consists of a physiotherapist guiding an individual through a variety of gait and balance exercises based on observation of gait deviations or atypical movement patterns \, . In some cases\, quantitative assessments of gait patterns\, using advanced lab- or clinic- based technologies\, are conducted to augment the rehabilitation process \, . However\, such technologies are not always easily accessible to many clinics due to the cost\, space and time for setup associated with it . Finally\, patients often have access to only an hour of guided training every one or two weeks. . All of these factors may contribute to the continuation of long-term mobility challenges or secondary musculoskeletal disorders –.\nBiofeedback (BFB)\, the measurement of gait parameters to provide a user with real-time feedback that can elicit changes in gait patterns\, has been shown to improve lower limb amputee (LLA) rehabilitation outcomes –. BFB offers a quantitative method for evaluating an individual’s gait pattern to provide a more accurate corrective training method in real-time. There are two major gaps my research seeks to address. (1) Current BFB research focuses on gait analysis and training in controlled lab environments . However\, portable and wearable solutions that can be used in and beyond the clinic are critical to enhance long-term retention outcomes . Furthermore\, most BFB systems strictly target one or a few gait parameters without considering effects on the non-targeted parameters. (2) For a wearable gait training system to be used outside of a lab or clinic in a passive manner\, where the user does not have to explicitly inform the system the type of activity they are doing\, real-time recognition of a user’s activity (i.e. stair ascent\, incline walking) is critical to effectively provide the appropriate biofeedback . To address the aforementioned research gaps\, this project aims to develop and assess a wearable system for prosthetic gait training and evaluate changes in secondary gait parameters allowing us to understand how overall gait changes during BFB training.\nSupervisor Name: Jan Andrysek\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-aliaa-gouda/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230315T123000
DTEND;TZID=America/Toronto:20230315T130000
DTSTAMP:20260411T043531
CREATED:20230112T203738Z
LAST-MODIFIED:20230315T165246Z
UID:39731-1678883400-1678885200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Shaurya Gupta
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: OCT Imaging of Injured Rat Spinal Cord\nAbstract: TBD\nSupervisor Name: Dr. Albert Yee and Dr. Victor Yang\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-shaurya-gupta-2/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230316T120000
DTEND;TZID=America/Toronto:20230316T123000
DTSTAMP:20260411T043531
CREATED:20230101T200731Z
LAST-MODIFIED:20230315T165246Z
UID:39601-1678968000-1678969800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Zi Zhang
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Injectable Mineralized Collagen Hydrogel for Bone Repair\nAbstract: Despite the bone’s natural capacity to self-heal (due to innervation and vascularization)\, critical-sized defects lack such capacities without surgical procedures. Recent advances have explored cell therapy for bone regeneration\, such as using bone marrow-derived mesenchymal stromal cells (BM-MSCs)\, as a surgical alternative. BM-MSCs are multipotent and low-immunogenic cells that also have self-renewal and differentiation properties. Specifically\, these cells have been robustly demonstrated in murine models to develop osteoblast-like phenotypes. However\, the injection of BM-MSCs alone is challenged by poor cellular retention and localization to the areas of defect\, resulting in insufficient cell populations for subsequent differentiation processes. To overcome this limitation\, biomaterials development\, specifically in the form of hydrogels and scaffolds\, has been an area of interest. Although both synthetic and natural hydrogels have been developed\, there has not yet been a biomaterial that is injectable\, capable of encapsulating cells\, and can provide a biomechanical environment for better bone repair potentials. We propose to develop a novel hydrogel by finetuning the nanostructure\, mineralization\, and stiffness of reconstituted collagen fibrils to promote the differentiation of BM-MSCs into bone cell phenotypes for new bone formation. Understanding the optimal biomechanical properties of a mineralized collagen hydrogel for bone regeneration will broaden the applicability of current hydrogel technologies and BM-MSC therapies.\nSupervisor Name: Eli Sone\, Sowmya Viswanathan\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-zi-zhang-2/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230316T123000
DTEND;TZID=America/Toronto:20230316T130000
DTSTAMP:20260411T043531
CREATED:20221211T193747Z
LAST-MODIFIED:20230315T165246Z
UID:39505-1678969800-1678971600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Elana Sefton
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: modRNA as a Modular Tool for Improving Outcomes with Human Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation\nAbstract:\nFollowing myocardial infarction (MI)\, necrotic cardiomyocytes are replaced by non-contractile scar tissue\, often leading to progressive heart failure requiring heart transplantation. The scarcity of donor hearts prompted the Laflamme team to use human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) to remuscularize the scar tissue\, and they have successfully demonstrated partial remuscularization and improved contractile function in multiple animal models of MI. However\, the resultant grafts are often relatively small with limited host-graft integration. To improve engraftment outcomes\, pro-survival\, mitogenic\, or pro-migratory proteins can be used but they diffuse away rapidly\, limiting the benefit. Moreover\, to avoid negative effects of prolonged signaling\, such proteins should only be present for a few days post-transplantation. Modified mRNA (modRNA) delivery to hPSC-CMs prior to transplantation facilitates short-term protein translation. modRNA is also not immunogenic and there is no risk of aberrant mutations since the genome is not altered.\nHence\, my objective is to demonstrate that modRNA can be used as a tunable protein translation tool to improve the survival and migration of hPSC-CMs post-transplantation. First\, I will show that graft size and function can be improved by treating hPSC-CMs with modRNA encoding for the known cytoprotective and mitogenic factor\, insulin growth factor 1 (IGF-1). Second\, I will show that graft distribution can be modulated by treating cells with the cardiomyocyte chemokinetic factor (Wnt family member 5A) Wnt5a. Finally\, I will engineer a cell-specific protein expression tool to enable expression of the protein of interest in graft cells at any time post-transplant. My project will demonstrate the utility of modRNA to improve outcomes post-hPSC-CM transplant in the guinea pig MI model. Replenishing the cardiomyocytes lost after MI will ultimately benefit patients suffering from post-MI heart failure.\nSupervisor Name: Michael Laflamme\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-elana-sefton/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230316T160000
DTEND;TZID=America/Toronto:20230316T170000
DTSTAMP:20260411T043531
CREATED:20230315T175542Z
LAST-MODIFIED:20230315T175542Z
UID:41064-1678982400-1678986000@bme.utoronto.ca
SUMMARY:Targeting Tumor Extracellular Matrix for Precision Cancer Imaging and Therapy
DESCRIPTION:Speaker:  \nZheng-Rong Lu\, PhD\nProfessor\, Department of Biomedical Engineering\,\nCase Western Reserve University\,\nCleveland\, Ohio \nHost: Dr. Gang Zheng
URL:https://bme.utoronto.ca/event/targeting-tumor-extracellular-matrix-for-precision-cancer-imaging-and-therapy/
LOCATION:Princess Margaret Cancer Centre\, 610 University Ave\, 6th floor\, Bob Bell Auditorium
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230317T120000
DTEND;TZID=America/Toronto:20230317T123000
DTSTAMP:20260411T043531
CREATED:20220930T213739Z
LAST-MODIFIED:20230316T170824Z
UID:38977-1679054400-1679056200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Meghan Rothenbroker
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Leo Chou\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-meghan-rothenbroker/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230317T123000
DTEND;TZID=America/Toronto:20230317T130000
DTSTAMP:20260411T043531
CREATED:20230207T212237Z
LAST-MODIFIED:20230316T170824Z
UID:40117-1679056200-1679058000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Ryan Lee
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Towards neural-network-on-a-chip: integrating microfluidics with DNA-based computers for powerful point-of-care diagnostics\nAbstract:\nMachine learning can diagnose diseases based on the amount of different RNA present in patient samples. However\, this requires costly computers\, equipment\, and trained operators. DNA-based computers are a cheap and accessible alternative for reading and processing patient RNA. Currently\, DNA computers are limited in processing power due to “leak”\, interference from two interacting signals. By designing DNA computers that integrate with microfluidic devices\, we can overcome leak for powerful point-of-care diagnostics.\nHere we introduce DNA-based biomolecular neurons for low-cost machine-learning-capable DNA computers. These neurons assemble together to form in vitro neural networks. First\, we use enzymes to create highly pure DNA components to reduce leak. Second\, we immobilize the DNA strands onto magnetic beads for modular assembly. DNA by-products from neuron assembly and computation can then be removed from solution using magnets\, further reducing leak. This immobilization also allows us to synchronize computation across each layer of the neural network. Integration with microfluidics will replace manual magnetic separation with automated fluid exchange\, allowing massively parallel computing for neural-network-on-a-chip.\nWe demonstrate proof-of-concept for biomolecular neurons and enzymatic synthesis through modular primer mix-and-match and nucleic acid hybridization. We show synthesis of 6 unique species of neurons with input-specific actuation and high purity\, requiring only 2 hours of preparation from start to finish. Our neurons actuate quickly\, in less than 15 minutes\, with 8-fold signal-to-background ratio\, and are capable of making synaptic connections with up to 10 other neurons. Furthermore\, we demonstrate self-assembly of these biomolecular neurons into computational layers\, and show basic neural network features\, such as neuron cascading\, fan-in and fan-out motifs.\nOur proposed design enables computer-free neural networks for complex decision making in portable diagnostics\, autonomous lab-on-a-chips\, compact data storage\, and development of other in vitro neural network architectures. We plan for near future integration with microfluidic devices to bring further programmability and ease of operation to DNA-based computing.\nSupervisor Name: Leo Chou\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-ryan-lee/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230322T120000
DTEND;TZID=America/Toronto:20230322T123000
DTSTAMP:20260411T043531
CREATED:20220824T165254Z
LAST-MODIFIED:20230321T170741Z
UID:38504-1679486400-1679488200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Kaylie Lau
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: A Novel Method for the Prediction of Slip-Resistance Quality of Winter Footwear\nAbstract: N/A\nSupervisor Name: Dr. Atena Roshan Fekr and Dr. Geoff Fernie\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-kaylie-lau/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230322T123000
DTEND;TZID=America/Toronto:20230322T130000
DTSTAMP:20260411T043531
CREATED:20220825T165236Z
LAST-MODIFIED:20230321T170741Z
UID:38526-1679488200-1679490000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Guijin Li
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Can baseline sEMG predict strength recovery of upper extremity muscles undergoing FES therapy after cervical SCI?\nAbstract: TBD\nSupervisor Name: Prof. José Zariffa\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-guijin-li/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230323T120000
DTEND;TZID=America/Toronto:20230323T123000
DTSTAMP:20260411T043531
CREATED:20220824T165254Z
LAST-MODIFIED:20230322T170732Z
UID:38505-1679572800-1679574600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Chantal Trepanier
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Development of a Biodegradable Polymeric Nanoparticle Vascular Delivery System for Therapeutic Peptides\nAbstract: Balloon angioplasty\, often in conjunction with stenting\, is the current standard of care to restore immediate blood flow in arteries affected by atherosclerosis. However\, long-term prevention of arterial re-occlusion\, known as restenosis\, is lacking. Persistent inflammation\, heightened immunogenicity\, neointimal hyperplasia\, and poor reendothelialization remain significant barriers to effective treatment. The proposed research investigates noninflammatory biodegradable nanoparticles as an excipient for therapeutic peptides that can be coupled with traditional endovascular balloon angioplasty techniques to address these longterm treatment concerns. Therapeutic peptide coated nanoparticles incorporated onto an endovascular balloon are hypothesized to establish a sustained controlled release of peptide capable of inhibiting smooth muscle cell migration without compromising vessel reendothelialization upon release from the balloon surface.\nSupervisor Name: Dr. Paul Santerre\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-chantal-trepanier/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230323T123000
DTEND;TZID=America/Toronto:20230323T130000
DTSTAMP:20260411T043531
CREATED:20220825T165236Z
LAST-MODIFIED:20230322T170732Z
UID:38528-1679574600-1679576400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Keyu Zhuang
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Novel Magnetic Resonance Imaging Approach for In-vivo Long-term Stem Cell Tracking\nAbstract:\nMany tissues and organs in the human body\, such as the heart and the brain\, cannot regenerate after injury or disease. Stem cells are a source for regeneration\, as they are self-renewing and can become diverse specialized cell types. Currently\, when stem cells are injected into the body\, there is no information on whether or not they survive\, grow\, and contribute to improved tissue function until histology is performed. While this approach can be adopted in animal studies\, it nonetheless precludes probing cell viability\, retention\, distribution\, and interaction with host tissue in a temporal manner. A technology that enables non-invasive cell tracking in deep tissue would address these hurdles and pave the way for stem cell treatment optimization and translation.\nThe main objective of this project is to develop and apply a novel magnetic resonance imaging (MRI) cell tracking platform for non-invasive\, high resolution visualization\, monitoring\, and evaluation of therapeutic stem cells inside a living subject. In the current research\, we develop and apply our cell tracking platform to human embryonic stem cells (hESC)-derived cardiomyocytes for cardiac regeneration. The stem cells will be “labeled” by inserting a reporter gene into the genome. When the edited cells are exposed to MR-active metal ions\, the cells will light up on MRI.\nSupervisor Name: Hai-Ling Margaret Cheng\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-keyu-zhuang/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230324T120000
DTEND;TZID=America/Toronto:20230324T123000
DTSTAMP:20260411T043531
CREATED:20220916T212233Z
LAST-MODIFIED:20230323T172253Z
UID:38828-1679659200-1679661000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Anish Jadav
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: IFNa as a potential anti-tumour therapeutic\nAbstract: There is significant clinical precedence for the use of IFNa as an anti-tumour therapeutic. However\, these uses are hampered by toxicities associated with high-dose/high-frequency regimens\, and by the immune-evasive properties of the tumour environment. Herein\, we demonstrate how IFNa expressed by tumour cells can prevent tumour formation in vivo\, with no observable toxicities. However\, this rejection does not result in protective effects against a subsequent rechallenge of the tumour cell line. These results demonstrate the utility of IFNa as an anti-tumour therapeutic\, though indicate that the mechanism by which the tumour cells are being rejected does not result in protective immunity against cancer\, thereby limiting the use of IFNa as a monotherapy against cancer.\nSupervisor Name: Dr. Kevin Truong\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-anish-jadav/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230324T123000
DTEND;TZID=America/Toronto:20230324T130000
DTSTAMP:20260411T043531
CREATED:20230323T172253Z
LAST-MODIFIED:20230323T172253Z
UID:41118-1679661000-1679662800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Jurgen Frasheri
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Development a Limulus Amoebocyte Lysate Assay for Bacterial Endotoxin Testing on a Digital Microfluidic Platform\nAbstract:\nBacterial endotoxin is a pyrogenic substance that can trigger a severe immune response\, resulting in death. The Limulus amoebocyte lysate (LAL) assay\, derived from the blood of horseshoe crabs\, is the globally approved gold standard method for detecting endotoxin. The pharmaceutical and biomedical industries conduct regular endotoxin checks\, and the increased demand for LAL has led to a significant decline in horseshoe crab populations worldwide. In light of this\, we propose a digital microfluidics (DMF) method that minimizes reagent consumption to address this issue. Our approach uses less than 1 μL of LAL reagent per test\, representing a 100x to 1000x reduction in volume compared to traditional methods.\nTo detect bacterial endotoxin\, I am introducing an image-based and capacitance-based method that can reduce the total assay time. However\, to make these assays practical and minimize the risk of contamination\, I plan to develop an enclosure that integrates seamlessly with the endotoxin assay workflow. My goal is to provide optimal incubation conditions and mitigate potential sources of contamination\, making the assay workflow easy to use.\nSupervisor Name: Aaron Wheeler\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-jurgen-frasheri/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230329T120000
DTEND;TZID=America/Toronto:20230329T123000
DTSTAMP:20260411T043531
CREATED:20221102T203737Z
LAST-MODIFIED:20230328T172229Z
UID:39259-1680091200-1680093000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Yupeng Tian
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: A Firing Rate Network Model on the Thalamic Deep Brain Stimulation\nAbstract:\nDeep brain stimulation (DBS) is a standardized therapy of many neurological motion disorders\, e.g.\, Parkinson’s disease and essential tremor. However\, the DBS therapeutic mechanisms on the disease-related neuronal networks remain elusive. DBS mechanism detection is challenging due to insufficient quantitative understandings and the sparsity of human data. For human subjects\, neuronal data can only be recorded with safe parameter settings on a very small proportion of neurons.\nWe developed a firing rate network model on the neuronal circuits receiving DBS\, and implemented the model in investigating the network mechanism underlying the thalamus-DBS in treating essential tremor. We accurately reproduced the experimental single-unit recordings on the neurons in thalamic ventral intermediate nucleus (Vim) during DBS; the model fit is precise and consistent across various DBS frequencies (5~200Hz). We found the role of inhibitory nuclei is critical in stabilizing the network and accurately fitting the experimental data. Our model can be potentially implemented in optimizing the DBS frequencies for maximal clinical effects.\nSupervisor Name: Milos Popovic and Milad Lankarany\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-yupeng-tian/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230329T123000
DTEND;TZID=America/Toronto:20230329T130000
DTSTAMP:20260411T043531
CREATED:20221124T192233Z
LAST-MODIFIED:20230328T172229Z
UID:39428-1680093000-1680094800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Lindsay Stern
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: A Novel Approach for Body Position Monitoring during Sleep using a Smart Mat\nAbstract: TBD\nSupervisor Name: Atena Roshan-Fekr\, Geoff Fernie\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-lindsay-stern/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230330T120000
DTEND;TZID=America/Toronto:20230330T123000
DTSTAMP:20260411T043531
CREATED:20220825T165236Z
LAST-MODIFIED:20230329T172322Z
UID:38529-1680177600-1680179400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Safwat Khan
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Defining and validating a pancreatic tissue-specific endothelial cell transcriptional signature\nAbstract: The vasculature shows intricate tissue-specific structural and functional heterogeneity. Vessels in the pancreas display specialized structures\, called fenestrae\, which allow for rapid glucose sensing and response by insulin secreting β-cells. Moreover\, intra-islet ECs have been implicated in a unique cross-talk with β-cells\, which is essential for their survival and function. We reasoned that a unique\, pancreas-specific molecular signature enables ECs to adopt a pancreatic-specific microvascular identity\, specializing them to support glucose/Islet function and homeostasis. To uncover this signature\, we have performed a meta-analysis of published single-cell and single-nuclei RNA-sequencing datasets of the pancreas. Using multi-organ gene expression atlases we have uncovered and validated a pancreas-specific endothelial gene signature. We also introduce a transcriptomic map of human pancreatic ECs integrating 3 human pancreas EC datasets. We define gene signatures for different vascular bed segments within the pancreas\, including 2 unique capillary populations\, which are reminiscent of exocrine pancreas ECs and islet-like/endocrine ECs. We have validated our transcriptomic profile using RNAScope and immunofluorescence staining on mouse e18.5 pancreatic tissue cross-sections. Further characterization of our pancreas-specific endothelial gene signatures and vascular subtype signatures within the pancreas will provide novel insights into the molecular mechanisms that drive islet EC specialization in glucose homeostasis and their role in diabetes.\nSupervisor Name: Sara Vasconcelos\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-safwat-khan/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230330T123000
DTEND;TZID=America/Toronto:20230330T130000
DTSTAMP:20260411T043531
CREATED:20221011T220810Z
LAST-MODIFIED:20230329T172322Z
UID:39075-1680179400-1680181200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Omar Mourad
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Modeling HFpEF-like diastolic dysfunction in a heart-on -a-chip platform\nAbstract: TBD\nSupervisor Name: Sara Vasconcelos\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-omar-mourad/
LOCATION:ON
CATEGORIES:Graduate Seminar Series
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END:VCALENDAR