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DTSTART;TZID=America/Toronto:20220920T120000
DTEND;TZID=America/Toronto:20220920T130000
DTSTAMP:20220919T195231Z
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SUMMARY:Global Speaker Series: Gordon Fishell\, PhD – Harvard University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. Medicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Gordon Fishell\, PhD\, Professor of Neurobiology\, Harvard Medical School and the Stanley Center at the Broad. The title of this talk will be\, “The intimate dependence and remarkable precision of cortical interneurons.” In Person – Register Here\nVirtual – Register Here\nHybrid event\, with in-person and virtual options\nIn-person will be held at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.\nVirtual event links will be sent after registration.\nMore About gordon fishell:\nProfessor Fishell teaches in the department of Neurobiology at Harvard Medical center and is an institute member of the Broad institute. He was previously the associate director of the New York University (NYU) Neuroscience Institute\, Julius Raines Professor of Neuroscience and Physiology at NYU\, and director of the graduate program in neuroscience and physiology at the NYU School of Medicine. Professor Fishell completed his Ph.D. in neurobiology from the University of Toronto and conducted postdoctoral research at Columbia University and the Rockefeller University. His laboratory is interested in how the architecture of brain circuits are assembled\, with a special focus on the diverse populations of inhibitory interneurons that are found in both pallial and subpallial telencephalon. Professor Fishell’s laboratory has spent the past 20 years working to understand the inhibitory cells that regulate excitatory signaling in the brain.\n Learn more about Gordon Fishell
URL:https://bme.utoronto.ca/event/global-speaker-series-gordon-fishell-phd-harvard-university/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:External Speaker Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220921T120000
DTEND;TZID=America/Toronto:20220921T123000
DTSTAMP:20220920T213744Z
CREATED:20220906T175315Z
LAST-MODIFIED:20220920T213744Z
UID:10000094-1663761600-1663763400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Runjie (Bill) Shi
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Next Generation Visual Field Testing\nAbstract: The visual field test (also known as perimetry) is a psychophysical test to test the light sensitivity across a grid of locations in a patient’s visual field. It is an indispensable tool for ophthalmologists to diagnose and monitor eye diseases\, such as glaucoma. Current perimetry machines (“perimeters”) are big\, expensive\, and require trained technicians to operate. Current algorithms take a long time (3-5 minutes) to perform each eye’s test. In this talk I will briefly describe our efforts on modernizing the visual field test. On the hardware front\, we are making the test portable and inexpensive by adapting the test to a portable VR platform. On the software front\, we are incorporating data-driven algorithms to reconstruct the visual field at test time using fewer trials. Lastly I will describe how these advances allow for unprecedented novel applications of the visual field test\, such as in mobile clinics in low-resource settings.\nSupervisor Name: Willy Wong\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-runjie-bill-shi/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220921T123000
DTEND;TZID=America/Toronto:20220921T130000
DTSTAMP:20220907T175245Z
CREATED:20220907T175245Z
LAST-MODIFIED:20220907T175245Z
UID:10000097-1663763400-1663765200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Azadeh Assadi
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Applying clinician macrocognition in designing decision support\nAbstract:\nIntroduction: Compared to children without congenital heart disease (CHD)\, those with CHD\nexperience a significantly higher hospital admission\, morbidity\, and mortality associated with\ntheir acute presentation to the emergency department (ED). The burden of residual lesions and\nthe natural history of many CHDs predisposes these children to hemodynamic fragility with\ncommon childhood illnesses and altered response to traditional resuscitative measures. Their\noptimal outcome requires CHD-expertise which is limited in local EDs. Hence\, there is an urgent\nneed for a sociotechnological solution to support the management of these patients in the ED. In\nthis study\, a CHD-specific clinical decision support system (CDSS) is developed and evaluated\nbased on CHD-experts and ED physicians’ macrocognition.\nMethods: Using the critical decision method\, a cognitive task analysis (CTA) of CHD-experts\nand ED physicians was conducted to understand their macrocognitive differences when\nmanaging acutely ill pediatric CHD patients. Framework analysis was then used to identify key\ndecision requirements and design concepts to design the prototype CDSS using decision centered\ndesign. Heuristic and usability testing was completed on versions of the proposed CDSS while the effect of the CDSS on ED physicians’ decision making was tested using a scenario-based\nsimulation study.\nResults: The most pertinent differences in decision making between CHD-experts and ED\nphysicians were in sensemaking\, anticipation\, and managing complexity. Accordingly\, the key\ndecision requirements and design concepts incorporated into the prototype CDSS involved\nappreciating the CHD physiology\, identifying CHD-specific diagnoses\, and selecting\nappropriate CHD interventions. Use of the CDSS significantly improved ED physicians’ CHDspecific decision-making (M= 5.43\, 95%CI 3.7-7.2).\nConclusion: This study reveals differences in CHD-expert and ED physicians’ macrocognition\nand decision making while also proposing a design approach to develop and evaluate a CHDspecific CDSS. These findings can be used to design other sociotechnological solutions to\nsupport the care of pediatric CHD patients.\nSupervisor Name: Patricia Trbovich\nYear of Study: 5\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-azadeh-assadi-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220921T123000
DTEND;TZID=America/Toronto:20220921T130000
DTSTAMP:20220920T213744Z
CREATED:20220907T175245Z
LAST-MODIFIED:20220920T213744Z
UID:10000098-1663763400-1663765200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Azadeh Assadi
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Applying clinician macrocognition in designing decision support\nAbstract:\nIntroduction: Compared to children without congenital heart disease (CHD)\, those with CHD\nexperience a significantly higher hospital admission\, morbidity\, and mortality associated with\ntheir acute presentation to the emergency department (ED). The burden of residual lesions and\nthe natural history of many CHDs predisposes these children to hemodynamic fragility with\ncommon childhood illnesses and altered response to traditional resuscitative measures. Their\noptimal outcome requires CHD-expertise which is limited in local EDs. Hence\, there is an urgent\nneed for a sociotechnological solution to support the management of these patients in the ED. In\nthis study\, a CHD-specific clinical decision support system (CDSS) is developed and evaluated\nbased on CHD-experts and ED physicians’ macrocognition.\nMethods: Using the critical decision method\, a cognitive task analysis (CTA) of CHD-experts\nand ED physicians was conducted to understand their macrocognitive differences when\nmanaging acutely ill pediatric CHD patients. Framework analysis was then used to identify key\ndecision requirements and design concepts to design the prototype CDSS using decision centered\ndesign. Heuristic and usability testing was completed on versions of the proposed CDSS while the effect of the CDSS on ED physicians’ decision making was tested using a scenario-based\nsimulation study.\nResults: The most pertinent differences in decision making between CHD-experts and ED\nphysicians were in sensemaking\, anticipation\, and managing complexity. Accordingly\, the key\ndecision requirements and design concepts incorporated into the prototype CDSS involved\nappreciating the CHD physiology\, identifying CHD-specific diagnoses\, and selecting\nappropriate CHD interventions. Use of the CDSS significantly improved ED physicians’ CHDspecific decision-making (M= 5.43\, 95%CI 3.7-7.2).\nConclusion: This study reveals differences in CHD-expert and ED physicians’ macrocognition\nand decision making while also proposing a design approach to develop and evaluate a CHDspecific CDSS. These findings can be used to design other sociotechnological solutions to\nsupport the care of pediatric CHD patients.\nSupervisor Name: Patricia Trbovich\nYear of Study: 5\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-azadeh-assadi/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220923T120000
DTEND;TZID=America/Toronto:20220923T123000
DTSTAMP:20220922T213737Z
CREATED:20220903T173742Z
LAST-MODIFIED:20220922T213737Z
UID:10000093-1663934400-1663936200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Thaisa Luup Kannen
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Multi-axes electromagnetic sample handler for live imaging of organoids structure and dynamics\nAbstract:\nOrganoids are a flexible experimental model to explore countless human conditions. They can emulate essential specific functions of an in vivo system in physiological and pathological conditions. Acquiring three-dimensional (3D) volumetric images is critical while challenging in many live organoid-based studies due to these sample structures. Non-idealities worsen as more profound images are acquired. Furthermore\, there are unavoidable distortions from the imaging system. Current methods to decrease these issues are often expensive\, highly complex\, limited to specific usage\, or unsuitable for live organoid experiments.\nBy increasing the samples’ freedom of movement within the microscope field of view for imaging samples at different angles\, these non-idealities can be minimized. We are developing a spherical-shaped electromagnetic sample handler to provide a multi-axis rotational imaging system. The sample handler has evenly distributed electromagnets individually controlled by an open-loop micro-stepping control system. It controls the electromagnetic sample handler over samples’ x-y-z-theta space. Methods were developed to measure the sample handler quality\, rotation precision\, handling\, and imaging stability.\nAn image reconstruction methodology is coded to minimize light penetration limitations\, and the same will be made for the point spread function distortion in the z axis. An optimization algorithm will select the optimum angle\, which better shows the organoid structure and dynamics. The algorithm will use images from different angles to build the reconstructed image\, reducing non-idealities for thicker live organoids. The algorithm’s validation will be made with a nano printed sample.\nImage acquisition through this device will better represent biological specimens and promote more precise quantitative microscopy analyses. It can improve the quality of live 3D organoid images by optimizing angular positioning during imaging acquisition\, reducing non-idealities and working distance limitations. It is a cost-effective\, robust\, and user-friendly tool\, and it will open new possibilities for organoid research.\nSupervisor Name: Christopher Yip\nYear of Study: 3\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-thaisa-luup-kannen/
CATEGORIES:Graduate Seminar Series
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