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DTSTART;TZID=America/Toronto:20230214T120000
DTEND;TZID=America/Toronto:20230214T130000
DTSTAMP:20230203T183030Z
CREATED:20220512T153455Z
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SUMMARY:Invited Academic Seminar Series - Silvestro Micera- Soft Embodiment for Engineering Artificial Limbs (Virtual Only)
DESCRIPTION:Speaker\nSilvestro Micera\nFull Professor\, Bertarelli Foundation Chair in Translational Neuroengineering\nEcole Polytechnique Fédérale de Lausanne (EPFL) \n\nAbstract\nNeural engineering is a novel discipline combining engineering including micro and nanotechnology\, electrical and mechanical\, and computer science with cellular\, molecular\, cognitive neuroscience. Our of the most important goals of neural engineering is to develop approaches to repair\, restore\, and augment sensory and motor functions. \nWe recently proposed to achieve this goal by exploiting also a new general approach\, which we term ‘soft embodiment’. We posit that the objective for (neural) engineers is not always to create systems that are processed exactly like their natural counterparts. It is also to create technologies that can exploit the processing of the body for their own sake.  In short\, the aim is not always to mimic but also to “recycle” neural resources. \nIn this presentation\, I will provide several examples on how this concept can be used to develop bionic systems to restore and augment sensory and motor functions in different conditions. In particular\, I will show how implantable interfaces can be used to restore sensory (tactile and temperature feedback for artificial limbs\, visions)\, motor (grasping\, locomotion)\, and autonomic functions (for cardiovascular problems) and how it is possible to develop effective control strategies for supernumerary limbs. \n\nHost\nMilos Popovic
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-silvestro-micera/
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230215T120000
DTEND;TZID=America/Toronto:20230215T123000
DTSTAMP:20230214T212239Z
CREATED:20230210T212230Z
LAST-MODIFIED:20230214T212239Z
UID:10000195-1676462400-1676464200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Jakson Paterson
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Automated Safety and Usability Assessment Methods for Outdoor Street Crossings\nAbstract:\nPedestrians (including wheeled mobility device users) can face safety and usability challenges at street crossings because of the inherent risks associated with winter weather\, low lighting levels\, and by interactions with other road users (e.g.\, bicycles\, vehicles). Each of these environmental factors have both physical and psychological influences on the perceived safety and risk of fall and injury. As a result\, many older adults and persons with disabilities choose to reduce their outdoor activity levels and become more isolated in their homes\, restricting their daily mobility\, and potentially triggering a downward spiral of deconditioning\, frailty\, and physical decline.\nHowever\, these challenges have gotten limited attention\, likely because of a lack of efficient methods for practical analysis of pedestrian movements and interactions with external risk factors in real-world outdoor settings. The objective of this project is to develop an automated pedestrian detection and tracking system that can help assess the behavior of pedestrians and understand the day-to-day challenges these at-risk road users face at street crossings in urban environments.\nThe pedestrian street crossing evaluation system will use a portable video recording setup that includes a 4k video camera (Z-CAM E2) mounted on a 10 m tall mast to capture the movements of pedestrians and other road users. Computer vision approaches including YOLOv7 and DeepSORT will be used automate the detection and measurement pedestrian walking speed and trajectory\, as well as the classification of conflicts between pedestrians and other road users.\nThis project will provide new automated observation tools for evaluating the safety and usability of street crossings. The goal of this work is to understand the complex relationship between pedestrians and the built environment and highlight limitations in current infrastructure design and/or maintenance so that they can be made safer and more accessible for all individuals.\nSupervisor Name: Tilak Dutta\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-jakson-paterson/
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230216T120000
DTEND;TZID=America/Toronto:20230216T123000
DTSTAMP:20230215T212253Z
CREATED:20221207T193729Z
LAST-MODIFIED:20230215T212253Z
UID:10000163-1676548800-1676550600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Benedikt Licht
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Extracellular Matrix Modification of Vascularizing Methacrylic Acid-based Hydrogel\nAbstract: Pancreatic islet transplantation is a promising therapy for type 1 diabetes that can re-introduce intrinsic glycemic regulation. The Sefton lab has shown that an inherently vascularizing\, degradable poly(sodium methacrylate)-poly(ethylene glycol) (MAA-PEG) hydrogel is a suitable material for subcutaneous islet delivery. However\, enzymatic digestion of the native extracellular matrix (ECM) during islet isolation (collagenase) disrupts islet cell-matrix communications\, impairing islet function and inducing anoikis (apoptosis due to a loss of ECM connections). We hypothesize that the addition of collagen to the synthetic MAA-PEG hydrogel will restore cell-matrix communication\, thereby improving islet health and function after transplantation.\nSupervisor Name: Michael Sefton\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-benedikt-licht/
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230217T120000
DTEND;TZID=America/Toronto:20230217T123000
DTSTAMP:20230217T155514Z
CREATED:20230217T155506Z
LAST-MODIFIED:20230217T155514Z
UID:10000197-1676635200-1676637000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Tahmid Hussain
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Towards reconstructing the Human Olfactory System in-vitro\nAbstract: G-protein-coupled receptors (GPCRs) form a large group of cell surface receptors that is involved with the majority of physiological responses to a variety of molecules\, both biological and synthetic. As a result\, the function and response of GPCRs is a major target for drug development research and studies of intercellular signalling mechanisms. Almost 50% of drugs present in the market target GPCRs. Another fascinating aspect of GPCRs is that the human genome encodes for more than 800 different GPCRs and almost half of them are olfactory receptors. However\, the expression of olfactory receptors (ORs) in other non-olfactory cells like the kidneys and heart leads to the theory that olfactory receptors may have other physiological functions beyond olfaction. However\, due to the nature of ORs\, their sheer number and current receptor observation methods\, the identification of receptors and linking them to a particular molecule is a daunting task. In fact\, presently\, only a small fraction of olfactory GPCRs have been linked to a particular ligand. The goal of the research project is to create a microfluidic platform that can act as a bioelectronic nose which can simulate the sense of smell as faithfully as it exists in nature. The platform will utilize heterologous expression of olfactory GPCRs on HEK-293 cells detect real-time activation of GPCRs in a manner that allows for rapid\, reliable\, and repeatable measurements using the same cell culture.\nSupervisor Name: Michael Garton\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-tahmid-hussain/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230217T123000
DTEND;TZID=America/Toronto:20230217T130000
DTSTAMP:20230217T155514Z
CREATED:20230210T212230Z
LAST-MODIFIED:20230217T155514Z
UID:10000196-1676637000-1676638800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Danielle Serra
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Building a Synthetic Biology based Toolkit for Regenerative Medicine\nAbstract: Synthetic biology has been used to engineer new biological components and allow the construction of synthetic gene circuits with a broad array of useful applications. Creating these circuits requires components with consistent and predictable function\, that can be efficiently delivered and expressed by the host organism. Organism-specific toolkits with standardized building blocks such as promoters\, coding sequences\, and terminators have been developed for a wide range of useful organisms and cell types. These have been highly effective in accelerating the design–build–test cycle\, supporting communities with a validated repository\, and ensuring reproducibility. However\, despite an oft vaunted promise of synthetic biology to revolutionize cell-based therapeutics\, a standardized synthetic biology toolkit for human stem cells and tissues derived from them does not currently exist. Translation of synthetic gene circuits from immortalized cell line models to stem cells remains poor\, due to epigenetic silencing\, off target effects\, and resource loading\, among other challenges. We posit that a dedicated toolkit\, with parts designed to mitigate these issues\, is required for the field to move forward effectively. In this study I venture to establish a synthetic biology toolkit for stem cells and their derived progeny. A testbed circuit is first established to measure promoter expression intensity\, allowing high-throughput promoter design–build–testing of constitutive\, tissue-specific\, and inducible promoters. Development of these and other validated parts will aid creation of a therapeutically relevant genetic circuit that can toggle therapeutic circuits on\, off\, or prompt self-excision from the genome. Generating standardized stem-cell validated parts will aid in the development of sophisticated cell and gene therapies in regenerative medicine.\nSupervisor Name: Dr. Michael Garton\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-danielle-serra-2/
CATEGORIES:Graduate Seminar Series
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