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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20230314T120000
DTEND;TZID=America/Toronto:20230314T130000
DTSTAMP:20230313T183736Z
CREATED:20220512T153722Z
LAST-MODIFIED:20230313T183736Z
UID:10000022-1678795200-1678798800@bme.utoronto.ca
SUMMARY:Invited Academic Seminar Series - Peter Yingxiao Wang- Remote Control of the Genetics within Tumors via Focused Ultrasound for Cancer Immunotherapy (Hybrid Delivery)
DESCRIPTION:Speaker\nPeter Yingxiao Wang\nAssociate Professor\, Bioengineering\nUniversity of Southern California \n\nAbstract\nFocused ultrasound (FUS) can deliver energy safely and noninvasively into tissues at depths of centimeters. We show that the genetics and cellular functions of chimeric antigen receptor T cells (CAR-T cells) within tumors can be reversibly controlled by the heat generated by short pulses of FUS via a CAR cassette under the control of a promoter for the heat-shock protein. In mouse tumor models\, locally injected T cells with the inducible CAR and activated via FUS guided by magnetic resonance imaging (MRI) mitigated on-target off-tumor activity and enhanced the suppression of tumor growth\, compared with the performance of standard CAR-T cells. Integrated with CRISPR\, FUS was also be applied to modulate the genetics and epigenetics of tumor cells\, which facilitated and enhanced the efficacy of the CAR T immunotherapy. Therefore\, acoustogenetic control of tumor cells and CAR T by FUS may facilitate the design of safer cell therapies. \n\nHost\nLidan You
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-peter-yingxiao-wang/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2022/05/20180118-Wang_Peter-2513-full_res-export.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230315T120000
DTEND;TZID=America/Toronto:20230315T123000
DTSTAMP:20230314T165233Z
CREATED:20220824T165254Z
LAST-MODIFIED:20230314T165233Z
UID:10000057-1678881600-1678883400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Aliaa Gouda
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Development and Evaluation of a Wearable Biofeedback System for Lower Limb Amputee Gait Training\nAbstract:\nndividuals with lower-limb amputations typically regain their independent mobility through focused gait rehabilitation . Since effective prosthesis use requires precise coordination between the neuromusculoskeletal processes of the body and the prosthesis\, focused training associated with motor-learning based strategies is important to maximize functional mobility outcomes . Conventional gait training consists of a physiotherapist guiding an individual through a variety of gait and balance exercises based on observation of gait deviations or atypical movement patterns \, . In some cases\, quantitative assessments of gait patterns\, using advanced lab- or clinic- based technologies\, are conducted to augment the rehabilitation process \, . However\, such technologies are not always easily accessible to many clinics due to the cost\, space and time for setup associated with it . Finally\, patients often have access to only an hour of guided training every one or two weeks. . All of these factors may contribute to the continuation of long-term mobility challenges or secondary musculoskeletal disorders –.\nBiofeedback (BFB)\, the measurement of gait parameters to provide a user with real-time feedback that can elicit changes in gait patterns\, has been shown to improve lower limb amputee (LLA) rehabilitation outcomes –. BFB offers a quantitative method for evaluating an individual’s gait pattern to provide a more accurate corrective training method in real-time. There are two major gaps my research seeks to address. (1) Current BFB research focuses on gait analysis and training in controlled lab environments . However\, portable and wearable solutions that can be used in and beyond the clinic are critical to enhance long-term retention outcomes . Furthermore\, most BFB systems strictly target one or a few gait parameters without considering effects on the non-targeted parameters. (2) For a wearable gait training system to be used outside of a lab or clinic in a passive manner\, where the user does not have to explicitly inform the system the type of activity they are doing\, real-time recognition of a user’s activity (i.e. stair ascent\, incline walking) is critical to effectively provide the appropriate biofeedback . To address the aforementioned research gaps\, this project aims to develop and assess a wearable system for prosthetic gait training and evaluate changes in secondary gait parameters allowing us to understand how overall gait changes during BFB training.\nSupervisor Name: Jan Andrysek\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-aliaa-gouda/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230315T123000
DTEND;TZID=America/Toronto:20230315T130000
DTSTAMP:20230315T165246Z
CREATED:20230112T203738Z
LAST-MODIFIED:20230315T165246Z
UID:10000181-1678883400-1678885200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Shaurya Gupta
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: OCT Imaging of Injured Rat Spinal Cord\nAbstract: TBD\nSupervisor Name: Dr. Albert Yee and Dr. Victor Yang\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-shaurya-gupta-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230316T120000
DTEND;TZID=America/Toronto:20230316T123000
DTSTAMP:20230315T165246Z
CREATED:20230101T200731Z
LAST-MODIFIED:20230315T165246Z
UID:10000169-1678968000-1678969800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Zi Zhang
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Injectable Mineralized Collagen Hydrogel for Bone Repair\nAbstract: Despite the bone’s natural capacity to self-heal (due to innervation and vascularization)\, critical-sized defects lack such capacities without surgical procedures. Recent advances have explored cell therapy for bone regeneration\, such as using bone marrow-derived mesenchymal stromal cells (BM-MSCs)\, as a surgical alternative. BM-MSCs are multipotent and low-immunogenic cells that also have self-renewal and differentiation properties. Specifically\, these cells have been robustly demonstrated in murine models to develop osteoblast-like phenotypes. However\, the injection of BM-MSCs alone is challenged by poor cellular retention and localization to the areas of defect\, resulting in insufficient cell populations for subsequent differentiation processes. To overcome this limitation\, biomaterials development\, specifically in the form of hydrogels and scaffolds\, has been an area of interest. Although both synthetic and natural hydrogels have been developed\, there has not yet been a biomaterial that is injectable\, capable of encapsulating cells\, and can provide a biomechanical environment for better bone repair potentials. We propose to develop a novel hydrogel by finetuning the nanostructure\, mineralization\, and stiffness of reconstituted collagen fibrils to promote the differentiation of BM-MSCs into bone cell phenotypes for new bone formation. Understanding the optimal biomechanical properties of a mineralized collagen hydrogel for bone regeneration will broaden the applicability of current hydrogel technologies and BM-MSC therapies.\nSupervisor Name: Eli Sone\, Sowmya Viswanathan\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-zi-zhang-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230316T123000
DTEND;TZID=America/Toronto:20230316T130000
DTSTAMP:20230315T165246Z
CREATED:20221211T193747Z
LAST-MODIFIED:20230315T165246Z
UID:10000164-1678969800-1678971600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Elana Sefton
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: modRNA as a Modular Tool for Improving Outcomes with Human Pluripotent Stem Cell-Derived Cardiomyocyte Transplantation\nAbstract:\nFollowing myocardial infarction (MI)\, necrotic cardiomyocytes are replaced by non-contractile scar tissue\, often leading to progressive heart failure requiring heart transplantation. The scarcity of donor hearts prompted the Laflamme team to use human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) to remuscularize the scar tissue\, and they have successfully demonstrated partial remuscularization and improved contractile function in multiple animal models of MI. However\, the resultant grafts are often relatively small with limited host-graft integration. To improve engraftment outcomes\, pro-survival\, mitogenic\, or pro-migratory proteins can be used but they diffuse away rapidly\, limiting the benefit. Moreover\, to avoid negative effects of prolonged signaling\, such proteins should only be present for a few days post-transplantation. Modified mRNA (modRNA) delivery to hPSC-CMs prior to transplantation facilitates short-term protein translation. modRNA is also not immunogenic and there is no risk of aberrant mutations since the genome is not altered.\nHence\, my objective is to demonstrate that modRNA can be used as a tunable protein translation tool to improve the survival and migration of hPSC-CMs post-transplantation. First\, I will show that graft size and function can be improved by treating hPSC-CMs with modRNA encoding for the known cytoprotective and mitogenic factor\, insulin growth factor 1 (IGF-1). Second\, I will show that graft distribution can be modulated by treating cells with the cardiomyocyte chemokinetic factor (Wnt family member 5A) Wnt5a. Finally\, I will engineer a cell-specific protein expression tool to enable expression of the protein of interest in graft cells at any time post-transplant. My project will demonstrate the utility of modRNA to improve outcomes post-hPSC-CM transplant in the guinea pig MI model. Replenishing the cardiomyocytes lost after MI will ultimately benefit patients suffering from post-MI heart failure.\nSupervisor Name: Michael Laflamme\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-elana-sefton/
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230316T160000
DTEND;TZID=America/Toronto:20230316T170000
DTSTAMP:20230315T175542Z
CREATED:20230315T175542Z
LAST-MODIFIED:20230315T175542Z
UID:10000199-1678982400-1678986000@bme.utoronto.ca
SUMMARY:Targeting Tumor Extracellular Matrix for Precision Cancer Imaging and Therapy
DESCRIPTION:Speaker:  \nZheng-Rong Lu\, PhD\nProfessor\, Department of Biomedical Engineering\,\nCase Western Reserve University\,\nCleveland\, Ohio \nHost: Dr. Gang Zheng
URL:https://bme.utoronto.ca/event/targeting-tumor-extracellular-matrix-for-precision-cancer-imaging-and-therapy/
LOCATION:Princess Margaret Cancer Centre\, 610 University Ave\, 6th floor\, Bob Bell Auditorium
CATEGORIES:External Speaker Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230317T120000
DTEND;TZID=America/Toronto:20230317T123000
DTSTAMP:20230316T170824Z
CREATED:20220930T213739Z
LAST-MODIFIED:20230316T170824Z
UID:10000136-1679054400-1679056200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Meghan Rothenbroker
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Leo Chou\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-meghan-rothenbroker/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230317T123000
DTEND;TZID=America/Toronto:20230317T130000
DTSTAMP:20230316T170824Z
CREATED:20230207T212237Z
LAST-MODIFIED:20230316T170824Z
UID:10000192-1679056200-1679058000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Ryan Lee
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Towards neural-network-on-a-chip: integrating microfluidics with DNA-based computers for powerful point-of-care diagnostics\nAbstract:\nMachine learning can diagnose diseases based on the amount of different RNA present in patient samples. However\, this requires costly computers\, equipment\, and trained operators. DNA-based computers are a cheap and accessible alternative for reading and processing patient RNA. Currently\, DNA computers are limited in processing power due to “leak”\, interference from two interacting signals. By designing DNA computers that integrate with microfluidic devices\, we can overcome leak for powerful point-of-care diagnostics.\nHere we introduce DNA-based biomolecular neurons for low-cost machine-learning-capable DNA computers. These neurons assemble together to form in vitro neural networks. First\, we use enzymes to create highly pure DNA components to reduce leak. Second\, we immobilize the DNA strands onto magnetic beads for modular assembly. DNA by-products from neuron assembly and computation can then be removed from solution using magnets\, further reducing leak. This immobilization also allows us to synchronize computation across each layer of the neural network. Integration with microfluidics will replace manual magnetic separation with automated fluid exchange\, allowing massively parallel computing for neural-network-on-a-chip.\nWe demonstrate proof-of-concept for biomolecular neurons and enzymatic synthesis through modular primer mix-and-match and nucleic acid hybridization. We show synthesis of 6 unique species of neurons with input-specific actuation and high purity\, requiring only 2 hours of preparation from start to finish. Our neurons actuate quickly\, in less than 15 minutes\, with 8-fold signal-to-background ratio\, and are capable of making synaptic connections with up to 10 other neurons. Furthermore\, we demonstrate self-assembly of these biomolecular neurons into computational layers\, and show basic neural network features\, such as neuron cascading\, fan-in and fan-out motifs.\nOur proposed design enables computer-free neural networks for complex decision making in portable diagnostics\, autonomous lab-on-a-chips\, compact data storage\, and development of other in vitro neural network architectures. We plan for near future integration with microfluidic devices to bring further programmability and ease of operation to DNA-based computing.\nSupervisor Name: Leo Chou\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-ryan-lee/
CATEGORIES:Graduate Seminar Series
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