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DTSTART;TZID=America/Toronto:20230412T123000
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UID:10000082-1681302600-1681304400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Craig Macsemchuk
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: A Magnetic Resonance Imaging Guided High Intensity Focused Ultrasound Platform for Fetal Interventions\nAbstract:\nBackground:\nCongenital abnormalities cause 20% of all perinatal deaths in North America\, where some\nrequire fetal intervention to improve outcomes . Due to routine ultrasound imaging during\npregnancy\, most fetal anomalies are detected before birth; however\, many are progressive before\nbirth\, leading to fetal death . All current options for fetal therapy involve entering the\namniotic sac for surgical procedures\, which carry a significant risk of premature birth due to\nmembrane rupture . Ultrasound energy creates no incision and is non-ionizing\, therefore\, it\nreduces the risk of infection and does not damage adjacent non-targeted tissues. These attributes\nmake it an ideal modality for fetal surgical interventions. Magnetic resonance-guided high\nintensity focused ultrasound (MRgHIFU) is a non-invasive therapy modality that is clinically\napproved in Canada to treat uterine fibroids\, bone metastasis and essential tremor. All currently\navailable MRgHIFU devices generate ultrasound energy from a transducer integrated into a\npurpose-built MRI table. This ultrasound energy source transmits upward\, focusing into the\npatient\, and creating a thermal lesion as small as a grain of rice (8x2x2mm). This focal point can\nbe mechanically and electronically steered to cover a large treatment volume. However\, in these\napproved devices\, the ultrasound energy sources are situated so they cannot accommodate a\npregnant mother and therefore are not conducive to an ergonomically feasible or safe treatment\nof fetuses. A pregnant mother cannot lay on her stomach in a prone position. Such is the rational\nfor developing an MRgHIFU robot that brings the ultrasound energy source to the pregnant\nmother inside an MRI scanner in such a way that she can lay on her back in a supine position.\nObjective and Hypothesis:\nThe objective of this project is to design and build an MRgHIFU robot for fetal interventions\nthat can accommodate a pregnant mother. My hypothesis is that robotic positioning of\nultrasound energy will demonstrate that MRIgHIFU is safe\, effective\, and feasible for treating\ncongenital fetal defects.\nMethods:\nI will achieve my objective by: 1) Designing and developing an MRgHIFU platform for fetal\napplications. This will incorporate MRgHIFU infrastructure in our laboratory at SickKids  and\ncreate an MRgHIFU robot that brings the ultrasound transducer to the patient to accommodate\nprenatal interventions. 2) Assessing the workspace range and targeting accuracy of the produced\nMRgHIFU robot in phantoms to ensure it performs appropriately for fetal interventions.\n3) Demonstrating the safety and efficacy of the produced robot by ablating multiple targets in\nour lab’s established pregnant rabbit model . This will consist of an MRgHIFU survival study\nin a pregnant rabbit model targeting placental and fetal lung\, kidney\, liver\, and heart tissues.\nSignificance of the research:\nDeveloping an MRIgHIFU robot for fetal therapies is critical for making it available to pregnant\npatients. Our lab’s partnership with Profound Medical\, a HIFU device company with experience\nreleasing multiple clinical devices\, will allow the developed robot to become accessible to\npatients in the future. The availability of MRIgHIFU in a clinical setting can decrease the risk of\ncomplications in fetal therapies\, lead to better patient outcomes\, shorter patient recovery times\nand also reduce the average healthcare cost attributed to fetal surgery.\nSupervisor Name: James Drake\nYear of Study: 2\nProgram of Study: MASc\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-craig-macsemchuk/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230413T120000
DTEND;TZID=America/Toronto:20230413T123000
DTSTAMP:20230412T195231Z
CREATED:20220825T165236Z
LAST-MODIFIED:20230412T195231Z
UID:10000069-1681387200-1681389000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Chuan Liu
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Milica Radisic\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-chuan-liu/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230413T123000
DTEND;TZID=America/Toronto:20230413T130000
DTSTAMP:20230412T195231Z
CREATED:20220913T210755Z
LAST-MODIFIED:20230412T195231Z
UID:10000115-1681389000-1681390800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Liyang Zhong
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Investigating the Molecular Control of Collagen Biomineralization\nAbstract: Mineralized collagen fibrils are the basic building blocks of various mineralized connective tissues. The process of collagen biomineralization is an intricate and highly controlled process which makes it difficult to study in vivo. To date\, many in vitro models have been developed aiming to understand and mimic native collagen biomineralization. However\, despite the recent advances\, the molecular control of collagen biomineralization still remains unclear. I aim to study the effect of chemical and enzymatic collagen crosslinking\, as well as the effect of glycosaminoglycan\, an extracellular biomolecule\, on collagen biomineralization. Findings from this study will result in an effective in vitro model that can highly mimic native collagen. It will also help with the development of collagen-based materials that will benefit tissue repair and regeneration applications.\nSupervisor Name: Eli Sone\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-liyang-zhong/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230414T120000
DTEND;TZID=America/Toronto:20230414T123000
DTSTAMP:20230413T195231Z
CREATED:20230406T182229Z
LAST-MODIFIED:20230413T195231Z
UID:10000209-1681473600-1681475400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Gabriel Ng
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Jan Andrysek\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-gabriel-ng/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230414T123000
DTEND;TZID=America/Toronto:20230414T130000
DTSTAMP:20230413T195231Z
CREATED:20220914T210735Z
LAST-MODIFIED:20230413T195231Z
UID:10000119-1681475400-1681477200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Qin Ji
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Investigating the relationship between tumour metabolism and nanoparticle accumulation\nAbstract:\nCancer is one of the leading causes of death in the world. The principle has guided nanoparticles designed for\ncancer treatment that nanoparticle transport into the tumour is a passive and concentration-driven process.\nRecent studies have found that nanoparticle transport into tumours is predominantly an active process.\nUnderstanding the driving force of this active transport enables us to design the next generation of\nnanoparticles. Metabolism describes all the energy-producing processes in a biological system. As tumours\ngrow\, their need for nutrients and other building blocks increases. This may lead to nonspecific uptake of\navailable resources circulating in the tumour blood vessels. The objective of the proposed thesis is to answer\nthe question: does tumour metabolism drive nanoparticle accumulation? The result of this project will\ndescribe a relationship between tumour nanoparticle accumulation and tumour metabolic activity. The\nsignificance of this study defines the mechanistic cause of nanoparticle transport into tumours under the new\nparadigm. This understanding enables us to exploit metabolism to increase the effectiveness of nanoparticle\ndrug carriers for cancer treatment. For example\, we may manipulate a patient’s diet to increase nanoparticle\ndelivery to solid tumours. This strategy can lead to higher drug delivery and more effective cancer treatment.\nSupervisor Name: Warren Chan\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-qin-ji/
CATEGORIES:Graduate Seminar Series
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