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X-WR-CALNAME:Institute of Biomedical Engineering (BME)
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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20230418T130000
DTEND;TZID=America/Toronto:20230418T140000
DTSTAMP:20230414T202721Z
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LAST-MODIFIED:20230414T202721Z
UID:10000211-1681822800-1681826400@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Tian He\, Harvard University
DESCRIPTION:Illuminating Bioelectricity in the Brain\nDr. He Tian\,\nPostdoctoral Associate\, Harvard University\nThe brain encodes and processes information through the dynamic membrane voltage of neurons. However\, in vivo electrophysiology\, i.e.\, the study of the membrane voltage of individual cells in live animals\, has been a major challenge for neuroscience. In this seminar\, I will present voltage imaging\, an emerging technology using genetically encoded voltage indicators (GEVIs) to visualize the membrane voltage dynamics of cells. Voltage imaging can be combined with optogenetic stimulation to enable “all-optical electrophysiology”\, a technology that enabled cell membrane voltage to be simultaneously recorded and perturbed with light\, opening a path for high-throughput electrophysiology study in live animals. Thus far\, the performance of GEVIs has been a bottleneck for many applications. I will describe my directed evolution effort to improve a far-red GEVI. In order to optimize the transient voltage response of this biosensor\, I developed a novel video-based pooled screening platform that enabled thousands of genetic variants to be screened expeditiously. Using this platform\, I developed far-red GEVIs with improved signal-to-noise ratios and kinetics. Importantly\, this platform may be adapted for many types of genetic screens where optical readouts are required. I will discuss the application of these new GEVIs for tracking electric signal propagation within neurons. In particular\, I will demonstrate how to use voltage imaging and all-optical electrophysiology to understand neuron network dynamics in the live mouse brain. Together\, these molecular and optical tools will greatly expand our ability to decipher the brain. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-tian-he-harvard-university/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Tian-He-faculty-search.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230419T120000
DTEND;TZID=America/Toronto:20230419T123000
DTSTAMP:20230418T200726Z
CREATED:20221003T213809Z
LAST-MODIFIED:20230418T200726Z
UID:10000139-1681905600-1681907400@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Hrishikesh Suresh
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Optimizing Response to Neuromodulation\nAbstract: Epilepsy is the most common and debilitating disorder of childhood. Children with epilepsy have mortality rates three times higher than the general population and experience significant morbidity\, including injuries and hospitalizations. One treatment option for children who have uncontrolled seizures is vagus nerve stimulation (VNS). This surgical procedure involves the implantation of an electric pulse generator to deliver stimulation to the vagus nerve at the level of the neck. However\, only 25-50% of patients achieve meaningful improvement in their seizure burden after VNS. Consequently\, many children undergo the risk of surgery without benefit. Furthermore\, the inability to identify children most likely to benefit results in inefficient allocation of Canadian healthcare resources and precludes care for other children who may be better candidates for VNS. There is\, therefore\, a critical and unmet need to develop novel means to pre-surgically predict seizure reduction following VNS. This work leverages advances in brain network mapping and machine learning to test the hypothesis that differences in brain network organization can predict outcomes following VNS\, and consequently\, identify ideal candidates for surgical intervention.\nSupervisor Name: Dr. George Ibrahim & Dr. James Drake\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-hrishikesh-suresh/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230419T123000
DTEND;TZID=America/Toronto:20230419T130000
DTSTAMP:20230418T200726Z
CREATED:20230103T200744Z
LAST-MODIFIED:20230418T200726Z
UID:10000175-1681907400-1681909200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Clinical Stream - Megh Rathod
DESCRIPTION:Graduate Seminar Series: Clinical Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Development of Accurate and Equitable Wearable Non-Invasive Optical Devices for Continuous Hemodynamic Monitoring\nAbstract:\nThe prevalence of heart failure (HF) is increasing with an estimated 26 million people affected worldwide. Current patient monitoring tools are often inconvenient\, uncomfortable\, and limited in application and accuracy. This has led to the rise of non-invasive continuous monitoring devices\, known as wearables. Advances in wearable technologies are led by miniaturized sensors\, predominantly optoelectronic – which leverage light-tissue interactions to monitor physiology.\nHowever\, existing non-invasive tools rely on numerous assumptions about the physiology of the user\, and often do not account for forms of interpersonal variability (e.g. the presence of melanin in the skin). This work aims to develop optoelectronic strategies for continuous remote monitoring of metrics using multiwavelength (MW) photoplethysmography. To achieve this\, I will implement miniaturized MW spectroscopy platforms into wearable electronic devices and develop algorithms that estimate these physiological metrics and account for interpersonal variability. The custom-developed wearable will use MW photoplethysmography via miniature spectrometers and light sources (across 400 nm – 1000 nm) and will be tested via simulations\, phantoms\, and bench tests before clinical validation.\nThis work will demonstrate a methodology for skin-tone invariant cardiovascular metrics relevant to both clinical-grade and commercial health monitors. Optical sensors will serve a major role in the future of physiological monitoring\, however\, correcting this technology is a key refinement needed to prevent the perpetuation of inaccuracies in marginalized groups. Implementation into a wearable device will allow continuous monitoring of cardiac health that may improve patient outcomes and predict catastrophic events.\nSupervisor Name: Dr. Daniel Franklin (BME) and Dr. Heather Ross (Medicine)\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-clinical-stream-megh-rathod/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230420T120000
DTEND;TZID=America/Toronto:20230420T123000
DTSTAMP:20230419T202235Z
CREATED:20220830T170740Z
LAST-MODIFIED:20230419T202235Z
UID:10000084-1681992000-1681993800@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Ana Maria Carmo
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Actin regulation in embryonic wound repair\nAbstract: TBD\nSupervisor Name: Rodrigo Fernandez-Gonzalez\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-ana-maria-carmo/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230420T123000
DTEND;TZID=America/Toronto:20230420T130000
DTSTAMP:20230419T202235Z
CREATED:20220830T170740Z
LAST-MODIFIED:20230419T202235Z
UID:10000083-1681993800-1681995600@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Cell and Tissue Stream - Negar Balaghi
DESCRIPTION:Graduate Seminar Series: Cell and Tissue Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: Mechanisms of collective cell migration during Drosophila cardiac morphogenesis\nAbstract: TBD\nSupervisor Name: Rodrigo Fernandez-Gonzalez\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-cell-and-tissue-stream-negar-balaghi/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230420T160000
DTEND;TZID=America/Toronto:20230420T170000
DTSTAMP:20230417T185113Z
CREATED:20230417T185113Z
LAST-MODIFIED:20230417T185113Z
UID:10000213-1682006400-1682010000@bme.utoronto.ca
SUMMARY:Copper depletion cancer therapy
DESCRIPTION:Speaker:  \nJianghong Rao\, PhD\nProfessor\, Department of Radiology\nLucas Imaging Center\nStanford University\, California \nHost: Dr. Gang Zheng
URL:https://bme.utoronto.ca/event/copper-depletion-cancer-therapy/
LOCATION:Princess Margaret Cancer Centre\, 610 University Ave\, 6th floor\, Bob Bell Auditorium
CATEGORIES:External Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230421T120000
DTEND;TZID=America/Toronto:20230421T123000
DTSTAMP:20230420T202244Z
CREATED:20220824T165254Z
LAST-MODIFIED:20230420T202244Z
UID:10000063-1682078400-1682080200@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Kai Slaughter
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Molly Shoichet\nYear of Study: 4\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-kai-slaughter/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230421T123000
DTEND;TZID=America/Toronto:20230421T130000
DTSTAMP:20230420T202244Z
CREATED:20230404T180810Z
LAST-MODIFIED:20230420T202244Z
UID:10000201-1682080200-1682082000@bme.utoronto.ca
SUMMARY:Graduate Seminar Series: Molecular Stream - Katie Doran
DESCRIPTION:Graduate Seminar Series: Molecular Stream\nGraduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.\nIf you would like to invite your Principal Investigator\, please add their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nPresentation Title: TBD\nAbstract: TBD\nSupervisor Name: Gang Zheng\nYear of Study: 2\nProgram of Study: PhD\nZoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09\nMeeting ID: 896 1037 2821\nPassword: 483329\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-seminar-series-molecular-stream-katie-doran-2/
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230421T130000
DTEND;TZID=America/Toronto:20230421T140000
DTSTAMP:20230417T183542Z
CREATED:20230417T183542Z
LAST-MODIFIED:20230417T183542Z
UID:10000212-1682082000-1682085600@bme.utoronto.ca
SUMMARY:BME Faculty Search Seminar - Freeman Lan
DESCRIPTION:Revolutionizing biological discovery through ultrahigh-throughput experimentation\nDr. Freeman Lan\,\nPostdoctoral Fellow\, University of Winsconsin-Madison\nBiological assays have for decades been carried out primarily in reaction tubes and microtiter plates\, which are low throughput and difficult to scale. Microfluidics technology can overcome this limitation through miniaturization of reaction volumes and efficient scaling of liquid handling. I will describe my work pioneering droplet microfluidics as a platform to conduct biological assays at ultrahigh-throughput (>10\,000 assays per run) and how I am now applying this technology to study microbial systems. I show that ultrahigh-throughput experimentation can rapidly generate large amounts of data and bring fresh insights that would previously be unattainable using traditional methods. Given our rapidly increasing capacity to analyze large scale data through advances in machine learning\, ultrahigh-throughput experimentation will become an important way of conducting biological research in the future. \nTalk will be in-person and virtual\, see information below.
URL:https://bme.utoronto.ca/event/bme-faculty-search-seminar-freeman-lan/
LOCATION:MSB 4171
CATEGORIES:BME Faculty Search
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/04/Freeman-Lan.jpg
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