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X-WR-CALNAME:Institute of Biomedical Engineering (BME)
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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20230928T122500
DTEND;TZID=America/Toronto:20230928T124000
DTSTAMP:20230829T212235Z
CREATED:20230829T212235Z
LAST-MODIFIED:20230829T212235Z
UID:10000249-1695903900-1695904800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Kate MacQuarrie
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Endothelization and perfusion of a tubular D-PHI/PCNU vascular construct using patient-derived HAMVECs supported by VSMCs and monocytes\nAbstract:\nCoronary and peripheral artery disease are two forms of cardiovascular disease that cause occlusion in small-diameter arteries. The treatment of these conditions has been a challenge\, as endovascular procedures do not provide long-term revascularization\, and synthetic grafts that remain patent at larger diameters quickly stenose at diameters under 6 mm. While autologous grafts using the internal mammary artery or the saphenous vein are the current gold standard\, these vessels have limited availability\, and their quality may be compromised in patients with ischemic conditions. When synthetic grafts are used at small diameters\, the primary modes of failure are thrombosis and intimal hyperplasia\, often due to the lack of a luminal endothelium\, and a mismatch in mechanical properties between the graft and the native vasculature.\nThe objective of my work is to generate a tissue-engineered vascular graft composed of a novel electrospun polyurethane/polycarbonate scaffold\, co-cultured with endothelial cells and stromal cells isolated from patients’ adipose tissue. Briefly\, the four objectives of my project include: (1) evaluating the utility of indirectly co-culturing stromal and endothelial cells across the electrospun membrane\, (2) determining which types of support cells are optimal for the production of a biomimetic vascular graft (differentiated or undifferentiated stromal cells)\, (3) endothelializing the support cell-seeded graft in a perfusion bioreactor\, then treating the construct with physiological levels of shear stress\, and (4) implanting the endothelialized graft in a small animal model for preliminary in vivo studies.\nSupervisor Name: Paul Santerre\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-kate-macquarrie-2/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230928T122500
DTEND;TZID=America/Toronto:20230928T124000
DTSTAMP:20230927T222255Z
CREATED:20230829T212235Z
LAST-MODIFIED:20230927T222255Z
UID:10000250-1695903900-1695904800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Kate MacQuarrie
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Endothelization and perfusion of a tubular D-PHI/PCNU vascular construct using patient-derived HAMVECs supported by VSMCs and monocytes\nAbstract:\nCoronary and peripheral artery disease are two forms of cardiovascular disease that cause occlusion in small-diameter arteries. The treatment of these conditions has been a challenge\, as endovascular procedures do not provide long-term revascularization\, and synthetic grafts that remain patent at larger diameters quickly stenose at diameters under 6 mm. While autologous grafts using the internal mammary artery or the saphenous vein are the current gold standard\, these vessels have limited availability\, and their quality may be compromised in patients with ischemic conditions. When synthetic grafts are used at small diameters\, the primary modes of failure are thrombosis and intimal hyperplasia\, often due to the lack of a luminal endothelium\, and a mismatch in mechanical properties between the graft and the native vasculature.\nThe objective of my work is to generate a tissue-engineered vascular graft composed of a novel electrospun polyurethane/polycarbonate scaffold\, co-cultured with endothelial cells and stromal cells isolated from patients’ adipose tissue. Briefly\, the four objectives of my project include: (1) evaluating the utility of indirectly co-culturing stromal and endothelial cells across the electrospun membrane\, (2) determining which types of support cells are optimal for the production of a biomimetic vascular graft (differentiated or undifferentiated stromal cells)\, (3) endothelializing the support cell-seeded graft in a perfusion bioreactor\, then treating the construct with physiological levels of shear stress\, and (4) implanting the endothelialized graft in a small animal model for preliminary in vivo studies.\nSupervisor Name: Paul Santerre\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-kate-macquarrie/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230928T124000
DTEND;TZID=America/Toronto:20230928T125500
DTSTAMP:20230927T222255Z
CREATED:20230906T213729Z
LAST-MODIFIED:20230927T222255Z
UID:10000273-1695904800-1695905700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Vrushali Guruji
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Echocardiogram-Based Detection of Congenital Valvular Malformations\nAbstract:\nBicuspid aortic valve disease (BAVD) is a congenital abnormality that impacts over 2% of the global population. The condition involves the fusion of two of the three leaflets of the aortic valve\, leading to aberrant blood flow into the aorta. Disturbed hemodynamics is associated with increased risk of aortopathies\, such as ascending aortic dilatation (AAD)\, which can lead to fatal aortic dissection or rupture.\nWe hypothesize that the elevated risk of developing AAD in BAVD is a result of disruptions local cell function and signaling caused by changes in hemodynamics. To test this hypothesis\, we will leverage a novel mouse model with a mutation in natriuretic peptide 2 receptor (Npr2): ~10% of Npr2+/- mice develop BAVD\, whereas the remaining 90% have normal tricuspid aortic valves (TAV)\, enabling the effects of BAVD-associated hemodynamics to be decoupled from the underlying genetic mutation.\nWe first established echocardiography-based criteria to identify normal tricuspid vs. congenitally abnormal (bicuspid) aortic valves in neonatal Npr2+/- mice. Approximately 10-15% of neonatal mice exhibited echocardiographic features associated with valve malformations and disrupted flow\, including: i) regurgitation and recirculation by color Doppler; ii) peak systolic velocities >1300 mm/sec by pulse Doppler; and iii) putative fusion of leaflets along commissures by electrocardiogram-gated kilohertz visualization. Valves with these echographic features were confirmed by gross anatomy visualization to have stenotic and thickened leaflets\, with partial to full bicuspid fusions. Movat’s pentachrome staining confirmed a range of fusions in BAVs\, mimicking the gradient of malformations observed in human BAVD.\nThis study establishes a robust method to classify and characterize valve morphologies in neonatal mice as an essential first step to studying the role of BAV-associated hemodynamics in AAD. On-going work will determine focal transcriptional and proteomic perturbations in the ascending aorta specifically associated with BAV-associated hemodynamics.\nSupervisor Name: Craig Simmons\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-vrushali-guruji/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230929T120000
DTEND;TZID=America/Toronto:20230929T140000
DTSTAMP:20230911T193735Z
CREATED:20230911T193735Z
LAST-MODIFIED:20230911T193735Z
UID:10000282-1695988800-1695996000@bme.utoronto.ca
SUMMARY:CARTE 2023 Student Networking Event
DESCRIPTION:Attention University of Toronto students: Join us for an in-person networking event to learn from your peers about opportunities to get involved in Analytics/Artificial Intelligence/Machine Learning research projects. \nConfirmed speakers include: \n\nNadia Muhe\, Statistical Support Specialist at UofT’s Map and Data Library\nSoumita Ghosh\, Eric and Wendy Schmidt AI in Science Postdoctoral Fellow at UofT\nPreet Mistry\, Data Sciences Institute (DSI) Summer Undergraduate Data Science (SUDS) Scholar\nGemma Postill and Abhishek Moturu\, Student Education Co-Leads at UofT Temerty Centre for Artificial Intelligence Research and Education in Medicine (T-CAIREM)\nWilliam Gao\, Transform Heart Failure Trainee Awardee\nBilal Taha\, Schwartz Reisman Institute for Technology and Society Graduate Fellow\nSreeja Guhan\, MITACS Accelerate Intern in Analytics/Artificial Intelligence/Machine Learning\nNimit Bhanshali and Richard Shuai\, UofT Machine Intelligence Student Team (UTMIST) Co-Presidents\nMai Ali\, Indigenous and Black Engineering and Technology (IBET) Momentum Fellow\n\nThis is an in-person event at the University of Toronto St. George campus. Capacity is limited and free registration is required. To register\, please fill out this form. Location will be shared with confirmed registrants.
URL:https://bme.utoronto.ca/event/carte-2023-student-networking-event/
LOCATION:Myhal Centre for Engineering Innovation & Entrepreneurship\, 55 St George St.\, Toronto\, Ontario\, M5S 0C9\, Canada
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