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X-ORIGINAL-URL:https://bme.utoronto.ca
X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20240213T120000
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DTSTAMP:20240108T172905Z
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UID:10000234-1707825600-1707829200@bme.utoronto.ca
SUMMARY:Targeting Nucleic Acids to Combat Inflammation – Kam Leong
DESCRIPTION:Speaker\nKam Leong\nSamuel Y. Sheng Professor of Biomedical Engineering\nDepartment of Biomedical Engineering\nColumbia University \n\nAbstract\nInflammation serves as a crucial defense mechanism\, alerting our bodies to damage and aiding in the restoration of homeostasis. However\, when inflammation becomes excessive or chronic\, it can manifest as a range of debilitating diseases\, including cancer\, autoimmune disorders\, and wound healing. Controlling the inflammatory response is a pivotal aspect of managing these conditions. While conventional drug therapies remain the mainstay of treatment\, biomaterials are increasingly gaining traction as an alternative approach. Biomaterials offer a promising strategy for targeted drug delivery to inflamed sites\, enhancing bioavailability and minimizing systemic side effects. Additionally\, they can act as scavengers\, removing pro-inflammatory factors to directly suppress inflammation. This scavenging approach has demonstrated efficacy in treating inflammatory diseases such as rheumatoid arthritis\, psoriasis\, multiple sclerosis\, and systemic lupus erythematosus. A key factor in the pathogenesis of these diseases appears to be the aberrant activation of innate immune sensors\, particularly Pattern Recognition Receptors (PRRs)\, triggered by nucleic acids released from damaged or dying cells. In this presentation\, I will discuss the application of nucleic acid-binding polymers as a multifaceted strategy for combating inflammation. These polymers not only effectively neutralize pro-inflammatory nucleic acids but also serve as versatile therapeutic carriers for drug delivery. Through an exploration of their mechanisms of action and therapeutic potential\, I will present the promise of nucleic acid-binding polymers as a new approach to managing inflammatory diseases. \n  \nKam W. Leong is the Samuel Y. Sheng Professor of Biomedical Engineering at Columbia University\, where he focuses on three major research directions: 1) Nonviral gene editing in vivo; 2) Biomaterials-assisted modulation of inflammation; 3) Human-tissue chips for disease modeling and drug screening. He has published ~500 manuscripts holds more than 60 issued patents. He is the recipient of the IEEE-EMBS Academic Career Achievement Award\, Founder’s Award of the Society for Biomaterials\, Editor-in-Chief of Biomaterials\, and a member of the National Academy of Inventors\, the National Academy of Engineering\, and the National Academy of Medicine. \n\nHost\nMilica Radisic
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-kam-leong/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/08/kam_leong_square.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240215T121000
DTEND;TZID=America/Toronto:20240215T122500
DTSTAMP:20240214T215244Z
CREATED:20231121T183739Z
LAST-MODIFIED:20240214T215244Z
UID:10000323-1707999000-1707999900@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Alyssa Apilan
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Examining the Therapeutic Potential of Porphyrin Lipid Nanoparticles for Hepatocelluar Carcinoma\nSupervisor Name: Gang Zheng\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-alyssa-apilan/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240215T122500
DTEND;TZID=America/Toronto:20240215T124000
DTSTAMP:20240214T215244Z
CREATED:20240214T215244Z
LAST-MODIFIED:20240214T215244Z
UID:10000364-1707999900-1708000800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mohammad Saleh
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Immunocloaking for Organ Transplantation\nSupervisor Name: Michael Garton\nYear of Study: 5\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mohammad-saleh/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240215T124000
DTEND;TZID=America/Toronto:20240215T125500
DTSTAMP:20240214T215245Z
CREATED:20231121T183739Z
LAST-MODIFIED:20240214T215245Z
UID:10000324-1708000800-1708001700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Farshad Murtada
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: WB116\nPresentation Title: Engineering DNA Barcoded Nanostructures for the High-Throughput Capture of Low-Affinity T Cells\nSupervisor Name: Leo Chou\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-farshad-murtada/
LOCATION:WB116
CATEGORIES:Graduate Seminar Series
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