BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Institute of Biomedical Engineering (BME) - ECPv6.17.4.1//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Institute of Biomedical Engineering (BME)
X-ORIGINAL-URL:https://bme.utoronto.ca
X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Toronto
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20250309T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20251102T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T121000
DTEND;TZID=America/Toronto:20240425T122500
DTSTAMP:20240424T215233Z
CREATED:20240423T215225Z
LAST-MODIFIED:20240424T215233Z
UID:10000414-1714047000-1714047900@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Aaron Rosenstein
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: FAST-STEM: A Human pluripotent stem cell engineering system toolkit for rapid design-build-test-learn development of human cell-based therapeutic devices\nAbstract: Very recent clinical advances in stem cell derived tissue replacement and gene therapy\, in addition to the rise of artificial intelligence-aided scientific discovery\, have placed the possibility of rationally-designed human cell-based therapies firmly within reach. However\, development of such cells and testing of their engineered gene circuit components\, has proven highly challenging\, due to the need for generating stable cell lines for each design–build–test–learn engineering cycle. Current approaches to generating stable human induced pluripotent stem cell (hiPSC) lines are highly time-consuming and suffer from lack of control\, poor integration efficiency\, and limited functionality. Validation in clinically relevant stem cell derived tissues is also broadly lacking. Such drawbacks are prohibitive to repeatably conducting cutting-edge stem cell engineering with broad application within a realistic timescaleframe with broad application\, and will not scale with the future of regenerative medicine. Such drawbacks are prohibitive to repeatably conducting cutting-edge stem cell engineering a realistic timescale with broad application\, and will not scale with the future of regenerative medicine. We have developed FAST-STEM (Facile Accelerated Stem-cell Transgene integration with SynBio Tunable Engineering Modes)\, a hiPSC landing-padengineering platform that drastically reduces the time to engineer generate ‘differentiation ready’ stem cell lines from several weeks to 7 days\, exhibiting a ~612-fold improvement in transgene integration rate over previous methodologies. Additional FAST-STEM innovations include: (i) rapid and highly efficient transgene integration; (ii) copy number control; (iii) simultaneous or consecutive integration of multiple gene cassettes; (iv) library screen capability. In addition to this unique functional versatility\, platform transportability and broad use case for stem cell-engineering was confirmed by differentiation into eight different cell types across nine different laboratories. This platform dramatically lowers the bar for integration of synthetic biology with regenerative medicine\, enabling experiments which were previously deemed logistically impossible\, thus and pavinges the way for sophisticated human cell device development.\nSupervisor Name: Dr. Michael Garton\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-aaron-rosenstein/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T122500
DTEND;TZID=America/Toronto:20240425T124000
DTSTAMP:20240424T215233Z
CREATED:20240423T215225Z
LAST-MODIFIED:20240424T215233Z
UID:10000413-1714047900-1714048800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Tenzin Yangzom
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Development of novel wearable device for remote blood flow monitoring\nAbstract: Cardiovascular diseases (CVD) are estimated to be responsible for 31% of all worldwide deaths. Endothelial Dysfunction (ED) is one of the earliest markers in most CVDs. Despite its significant prognostic value\, endothelial dysfunction has been difficult to implement clinically and non-invasively. The current ‘Gold Standard’ ED assessment method is Coronary Angiogram but is invasive and exposes patients to significant risk. Separately\, Laser Doppler Flowmetry (LDF) device has been developed which measures skin blood flow in response to heat as an indicator of endothelial function. However\, these clinical tools for ED assessment are only accessible at the point-of-care and in the presence of trained specialists. There are currently no low-cost\, practical methods for monitoring blood flow\, continuously or intermittently. Remote monitoring of skin blood flow can provide key information on progression of various disease types\, but more importantly can serve as a cardiovascular risk stratification tool to aid in CVD screening\, management\, and outcomes. The objective of this research project is to demonstrate a novel\, wearable device that non-invasively measures blood flow through multi-wavelength photoplethysmography technology and a newly developed algorithm for deriving the arteriolar Pulse transit time (aPTT) to serve as the skin blood flow metric\, during controlled heating. We have established a strong correlation of our derived skin blood flow metric to the referenced LDF measurements for different body locations at baseline. This work demonstrates validation of our device and the aPTT metric as a surrogate for skin blood flow measurement. Once deployed\, our device will enable clinicians to remotely assess endothelial function\, assess risk\, and intervene before devastating clinical events such as heart failure\, stroke and other cardiovascular diseases. Other use cases of remote skin blow flow assessment include post-surgery monitoring\, wound healing assessment and prescribed treatment validation.\nSupervisor Name: Daniel Franklin\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-tenzin-yangzom/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T124000
DTEND;TZID=America/Toronto:20240425T125500
DTSTAMP:20240424T215233Z
CREATED:20240405T210732Z
LAST-MODIFIED:20240424T215233Z
UID:10000403-1714048800-1714049700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Ana-Maria Oproescu
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Engineering fusogenic molecules as lipid nanoparticle excipients for mitochondrial delivery\nSupervisor Name: Omar Khan\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-ana-maria-oproescu-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T131000
DTEND;TZID=America/Toronto:20240425T132500
DTSTAMP:20240424T215233Z
CREATED:20240405T210732Z
LAST-MODIFIED:20240424T215233Z
UID:10000404-1714050600-1714051500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Sadaf Safa
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: DETECTING PATIENT ENGAGEMENT IN VIRTUAL CARDIAC REHABILITATION\nSupervisor Name: Dr. Shehroz Khan\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-sadaf-safa-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T132500
DTEND;TZID=America/Toronto:20240425T134000
DTSTAMP:20240424T215233Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215233Z
UID:10000405-1714051500-1714052400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Campbell Thom
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Development of an In Vitro Model of the Outer Annulus Fibrosus-Cartilage Endplate Interface within a Perfusion Bioreactor\nAbstract: BACKGROUND: Lower back pain is a leading cause of disability worldwide and is often associated with intervertebral disc (IVD) degeneration. IVDs are fibrocartilaginous tissues between the vertebral bodies of the spine which facilitate load transmission and enable spinal flexibility. Once damaged there is a lack of treatment options that permanently restore functionality. Tissue engineering aims to address the limitations of existing therapeutics by generating living tissue constructs that could replace the diseased disc. Given the complex disc architecture coupled with the limitations of conventional static culturing methods\, the production of tissue constructs that recapitulate the structural features and mechanical strength of the native disc has yet to be achieved. The current study aims to develop an in vitro-formed model of the outer annulus fibrosus (OAF)-cartilage endplate interface\, which is often overlooked in current research despite its critical role in maintaining structural and biochemical integrity of the IVD. It is hypothesized that in vitro-formed OAF can be integrated with in vitro-grown cartilage tissue\, such that the interfacial strength of the tissue interface is significantly enhanced when cultured under perfusion flow within a bioreactor. \,\,METHODS: OAF cells are isolated from bovine caudal discs and seeded onto polyurethane scaffolds\, as described previously1\, in a spinning bioreactor to generate in vitro-formed OAF tissue. These tissues are then co-cultured with deep zone articular chondrocytes that have been isolated from bovine caudal metacarpal-phalangeal joints and cultured on PTFE membranes. OAF-chondrocyte constructs are co-cultured statically for 7 days in mineralizing media containing β-Glycerophosphate. Co-cultures are either maintained in static culture or transferred to a perfusion bioreactor system in which they are dynamically cultured using a flow rate of 5mL/min\, for an additional 7 days before performing histological or mechanical assessment. All experiments\, except for mechanical testing\, were repeated with 3 biological sets\, with each condition done in quadruplicate. Statistical analysis was performed using a T test and significance assigned at p<0.05.\,\,\,RESULTS:\,Co-culture of in vitro-formed OAF tissue and chondrocytes generated an integrated tissue interface composed of cartilage and AF tissue. More tissue appeared to be present\, histologically (Figure 1)\, in constructs grown in the perfusion bioreactor versus static conditions. The interface was also stronger in the perfused constructs as determined using a pull-apart testing\, where the average interfacial strength of perfused and static constructs was 53.3kPa and 18.9kPa\, respectively (preliminary data; N=1). Immunostaining of the OAF-cartilage constructs demonstrate collagen type I\, collagen type II\, and aggrecan distribution for both conditions appear similar to that of the native OAF-CEP interface (Figure 1). Von Kossa staining demonstrates cartilage mineralization under both perfusion and static culture conditions. However\, OAF-cartilage constructs that undergo perfusion appear to have more mineral deposition.\,\,CONCLUSIONS: This study provides a first-generation in vitro OAF-CEP model that incorporates key structural properties of the native interface\, and demonstrates that the use of a perfusion bioreactor enhances development of in vitro-grown IVD tissue interfaces. These findings fill a translation gap in the field of IVD tissue engineering and will support the scale-up of such tissues to physiological sizes.\nSupervisor Name: Rita Kandel\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-campbell-thom-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T134000
DTEND;TZID=America/Toronto:20240425T135500
DTSTAMP:20240424T215233Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215233Z
UID:10000406-1714052400-1714053300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Nitya Gulati
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Comprehensive Investigation of Glucose Metabolism: From Murine Islets to SC-Derived Beta Cell Aggregates\nSupervisor Name: Jonathan Rocheleau\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-nitya-gulati-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T141000
DTEND;TZID=America/Toronto:20240425T142500
DTSTAMP:20240424T215234Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215234Z
UID:10000408-1714054200-1714055100@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Oreoluwa Kolade
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Computational analysis of donor heterogeneity and critical processing parameters in mesenchymal stromal cells identifies suitable donors and CPP conditions for improved MSC expansion and potency\nSupervisor Name: Sowmya Viswanathan and Julie Audet\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-oreoluwa-kolade-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T142500
DTEND;TZID=America/Toronto:20240425T144000
DTSTAMP:20240424T215234Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215234Z
UID:10000407-1714055100-1714056000@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Ranim Maaieh
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Rational Design of the Adeno-associated Virus Capsid for Reduced Cytotoxic T-Cell Responses in Gene Therapy\nSupervisor Name: Michael Garton\nYear of Study: 5\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-ranim-maaieh-2/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240425T144000
DTEND;TZID=America/Toronto:20240425T145500
DTSTAMP:20240424T215234Z
CREATED:20240405T210733Z
LAST-MODIFIED:20240424T215234Z
UID:10000409-1714056000-1714056900@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Evan Kotler
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: TRI-UC (KITE) Basement Auditorium\, 550 University Avenue\nPresentation Title: Transcription factor-driven recovery of nucleus pulposus and notochordal phenotype\nSupervisor Name: Rita Kandel & Paul Santerre\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-evan-kotler-3/
LOCATION:TRI-UC (KITE) Basement Auditorium\, 550 University Avenue
CATEGORIES:Graduate Seminar Series
END:VEVENT
END:VCALENDAR