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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20240909T171000
DTEND;TZID=America/Toronto:20240909T172500
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UID:10000431-1725901800-1725902700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Laura Kondrataviciute
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons\nSupervisor Name: Dr Taufik Valiante\, Dr Luka Milosevic\nYear of Study: 3\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-laura-kondrataviciute/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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DTSTART;TZID=America/Toronto:20240909T172500
DTEND;TZID=America/Toronto:20240909T174000
DTSTAMP:20240904T224620Z
CREATED:20240904T224620Z
LAST-MODIFIED:20240904T224620Z
UID:10000476-1725902700-1725903600@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mohammad Rezaei
DESCRIPTION:Location: HS610 – 155 College St\, Room 610 \nPresentation Title: Inferring cognitive state underlying conflict choices in verbal Stroop task Abstract: The subthalamic nucleus (STN) within the basal ganglia interacts with the medial prefrontal cortex (mPFC) to form a control loop\, particularly active when the brain encounters contradictory information from different sensory systems or conflicting inputs from sensory data and pre-existing knowledge. Experimental studies have shown that significant increases in theta activity (2–8 Hz) in both the STN and mPFC\, along with enhanced phase synchronization between these regions\, are key features of conflict processing. While these neural markers highlight the critical role of the STN-mPFC circuitry in managing conflicts\, a low-dimensional representation of the mPFC-STN interaction—referred to as a cognitive state—that links neural activities to behavioral outcomes\, such as response time\, remains to be fully understood. To address this\, we propose the heterogeneous input discriminative-generative decoder (HI-DGD) model\, designed to infer cognitive states underlying decision-making by integrating neural activities from the STN and mPFC with behavioral signals\, specifically response times recorded from ten Parkinson’s disease (PD) patients performing a Stroop task. PD patients may experience conflict processing that differs quantitatively\, and possibly qualitatively\, from that of healthy individuals. Our results\, derived from extensive synthetic and experimental data\, demonstrate that the HI-DGD model can simultaneously process neural and behavioral data to estimate cognitive states in conflict and non-conflict trials more effectively than traditional methods. Moreover\, the HI-DGD model identifies which neural features significantly contribute to conflict and non-conflict decisions\, with the inferred features closely aligning with those reported in experimental studies. Importantly\, the HI-DGD model’s ability to estimate cognitive states from single trials makes it highly suitable for use in closed-loop neuromodulation systems. \nSupervisor Name: Milos Popovic \nYear of Study: 5 \nProgram of Study: PhD
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mohammad-rezaei-5/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240909T174000
DTEND;TZID=America/Toronto:20240909T175500
DTSTAMP:20240904T224828Z
CREATED:20240904T224828Z
LAST-MODIFIED:20240904T224828Z
UID:10000477-1725903600-1725904500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mohammad Rezaei
DESCRIPTION:Presentation Title: Cognitive State Inference and the Impact of Deep Brain Stimulation on Decision-Making in Parkinson’s Disease \nAbstract: Human cognition arises from the intricate interplay of neural and behavioral signals\, shaped by dynamic interactions across distributed brain networks. Understanding these hidden cognitive states is particularly important in neurological disorders like Parkinson’s disease (PD)\, which impair cognitive functions and disrupt normal brain activity. This thesis focuses on developing computational models to infer cognitive states from high-dimensional neural and behavioral data and to evaluate the impact of deep brain stimulation (DBS) on cognitive abilities during decision-making processes. Specifically\, it explores the temporal effects of DBS on PD patients’ cognitive abilities in high-conflict and no-conflict decision-making situations\, introducing the Cognet model. This model\, which simulates the dynamic interactions between the subthalamic nucleus (STN) and the medial prefrontal cortex (mPFC)\, provides insights into the optimal timing and modulation strategies for DBS to enhance cognitive function. The proposed models open new pathways for understanding the generation of neural and behavioral signals and the effects of neuromodulation on cognitive processes\, contributing to the advancement of cognitive state inference and therapeutic interventions in neuroscience. \nSupervisor Name: Milos Popovic \nYear of Study: 5 \nProgram of Study: PhD
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mohammad-rezaei-6/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240910T120000
DTEND;TZID=America/Toronto:20240910T130000
DTSTAMP:20240820T200047Z
CREATED:20240722T130649Z
LAST-MODIFIED:20240820T200047Z
UID:10000419-1725969600-1725973200@bme.utoronto.ca
SUMMARY:Innovation Illuminated: Through Personal and Professional Breakthroughs- Jeff Karp
DESCRIPTION:Abstract\nFeeling stuck in a rut\, trapped in the repetitive motions of daily life? Imagine if the key to breaking free was already within your grasp\, ready to be unlocked by adopting transformative tools and mindsets. \n\n\nJoin us for an enlightening lecture with Jeff Karp\, a distinguished professor at Brigham and Women’s Hospital and a dedicated innovator in medical research at Harvard Medical School and MIT. Jeff’s journey from a child struggling with learning differences and ADHD to a scientist and entrepreneur is a testament to the power of unconventional thinking and deliberate action. \nJeff developed a set of innovative tools and processes\, which he calls “Life Ignition Tools\,” by drawing inspiration from nature. These tools helped him not only adapt and flourish but also led to significant innovations in science and industry. His achievements include co-founding 12 companies\, securing over 100 patents\, and receiving awards for innovations like a tissue glue that seals holes in a beating heart. \nIn his new book\, “LIT: Life Ignition Tools: Use Nature’s Playbook to Energize Your Brain\, Spark Ideas\, and Ignite Action\,” Jeff shares profound lessons on how to intercept routine patterns and actively think and decide instead of reacting with habitual responses. This lecture will delve into the key principles from “LIT” that helped Jeff overcome learning challenges and transform cutting-edge research into real-world solutions. \nDiscover how adopting these Life Ignition Tools can help you break free from autopilot\, make intentional decisions\, and lead a more creative and purposeful life. \n\n\nBiography \nhttps://hsci.harvard.edu/people/jeffrey-karp-phd
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-jeff-karp/
CATEGORIES:BME Invited Academic Speaker Series
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