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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20240930T172500
DTEND;TZID=America/Toronto:20240930T174000
DTSTAMP:20240930T193831Z
CREATED:20240823T172235Z
LAST-MODIFIED:20240930T193831Z
UID:10000454-1727717100-1727718000@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Julien Couture-Senecal
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Rational design of ionizable lipids for mRNA vaccines\nSupervisor Name: Omar F. Khan\nYear of Study: 5\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-julien-couture-senecal/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240930T174000
DTEND;TZID=America/Toronto:20240930T175500
DTSTAMP:20240930T193831Z
CREATED:20240823T172235Z
LAST-MODIFIED:20240930T193831Z
UID:10000453-1727718000-1727718900@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Grayson Tilstra
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Design of ionizable lipids for mRNA delivery\nSupervisor Name: Omar F. Khan\nYear of Study: 5\nProgram of Study: PhD\nReschedule Reason: Venue and time change of BME Seminars\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-grayson-tilstra/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240930T175500
DTEND;TZID=America/Toronto:20240930T181000
DTSTAMP:20240930T193831Z
CREATED:20240903T173728Z
LAST-MODIFIED:20240930T193831Z
UID:10000472-1727718900-1727719800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Suyue Lyu
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Variational autoencoder for design of synthetic viral vector serotypes\nAbstract: Recent\, rapid advances in deep generative models for protein design have focused on small proteins with lots of data. Such models perform poorly on large proteins with limited natural sequences\, for instance\, the capsid protein of adenoviruses and adeno-associated virus\, which are common delivery vehicles for gene therapy. Generating synthetic viral vector serotypes could overcome the potent pre-existing immune responses that most gene therapy recipients exhibit—a consequence of previous environmental exposure. We present a variational autoencoder (ProteinVAE) that can generate synthetic viral vector serotypes without epitopes for pre-existing neutralizing antibodies. A pre-trained protein language model was incorporated into the encoder to improve data efficiency\, and deconvolution-based upsampling was used for decoding to avoid degenerate repetition seen in long protein sequence generation. ProteinVAE is a compact generative model with just 12.4 million parameters and was efficiently trained on the limited natural sequences. Viral protein sequences generated were used to produce structures with thermodynamic stability and viral assembly capability indistinguishable from natural vector counterparts. ProteinVAE can be used to generate a broad range of synthetic serotype sequences without epitopes for pre-existing neutralizing antibodies in the human population\, effectively addressing one of the major challenges of gene therapy. It could be used more broadly to generate different types of viral vector\, and any large\, therapeutically valuable proteins\, where available data are sparse.\nSupervisor Name: Michael Garton\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-suyue-lyu-3/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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