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X-WR-CALNAME:Institute of Biomedical Engineering (BME)
X-ORIGINAL-URL:https://bme.utoronto.ca
X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250203T171000
DTEND;TZID=America/Toronto:20250203T172500
DTSTAMP:20241217T173745Z
CREATED:20241217T173745Z
LAST-MODIFIED:20241217T173745Z
UID:10000523-1738602600-1738603500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Danielle Serra
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Promoter Toolkit for Regenerative Medicine\nSupervisor Name: Dr. Michael Garton\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-danielle-serra/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250203T172500
DTEND;TZID=America/Toronto:20250203T174000
DTSTAMP:20250203T190735Z
CREATED:20241217T173745Z
LAST-MODIFIED:20250203T190735Z
UID:10000525-1738603500-1738604400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Chuk Shing Jones Law
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Mechanics and Design of a Follow-the-Leader Hyper-redundant Robots with Variable Stiffness for Craniosynostosis Surgery\nAbstract:\nContinuum robots are flexible\, continuous structures inspired by biological organisms such as elephant trunks or snake bodies\, enabling smooth and continuous motion in confined spaces. Their inherent mechanical compliance is often viewed as a feature of safety and adaptability\, making them well-suited for minimally invasive surgery. However\, their flexibility also poses difficulties in modeling and controlling them accurately under external stress. As a result\, continuum robot is most effective in surgery that interacts with soft tissues.\nThis research addresses the challenges associated with the development and modeling of a continuum robot mechanism for medical procedures involving high contact forces. Therefore\, the advantages dexterity of continuum robot can be applied to wider field of surgery. A specific surgical application is considered in this research\, namely\, osteotomy (bone cutting) for craniosynostosis. It is a defect that involves premature fusion of the cranial sutures leading to an abnormal head shape and functional consequences such as elevated intracranial pressure\, neurocognitive deficits\, and psychosocial issues. Surgery is required to cut the cranial bone in order to correct the head shape and to allow for unrestricted brain growth. Endoscopic surgical approach can be performed by inserting a bone cutting instrument through small incisions. And this approach has reduced blood loss\, operative time\, and cost in comparison to the open approach. However\, the drawbacks of the endoscopic approach include limited control of dural sinuses for current surgical tools. The limitations and constraints in this surgical procedure demanding precise path-following motion and contact with rigid materials\, and therefore motivated the investigation of the research.\nSupervisor Name: Eric Diller\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-chuk-shing-jones-law-3/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250203T174000
DTEND;TZID=America/Toronto:20250203T175500
DTSTAMP:20250203T190735Z
CREATED:20241217T173745Z
LAST-MODIFIED:20250203T190735Z
UID:10000524-1738604400-1738605300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Joanna Chen
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Real-time evolution of the fMRI response to transcranial photobiomodulation in the human brain\nAbstract:\nIntroduction\nTranscranial photobiomodulation (tPBM) uses near-infrared light to stimulate neural tissue1. Recent research on tPBM reports significant potential for applications in the treatment of neurological conditions such as neurodegenerative disorders\, neurotrauma\, and neuropsychiatric conditions2-5\, as well as producing improvements in emotional and cognitive function in healthy individuals6-7. However\, the exact underlying mechanism of action is still unclear; little is known about the localization of the brain response to the site of stimulation and how it spreads and dissipates depending on dose parameters.\nMethods\n14 healthy adults (7M\, aged 24.4 ± 3.7 years) were scanned on a Siemens Prisma 3T system while receiving pulsed tPBM via single laser to the right forehead (spot size 1cm). The tPBM protocol included a 4-minute stimulation period with equivalent pre-stimulus and post-stimulus baseline blocks. The laser was pulsed at two frequencies (10 and 40Hz)\, with two wavelengths (808 and 1064nm) and three optical power densities (100\, 150 and 200 mW/cm2). The brain response was measured using a dual-echo pseudo-continuous arterial-spin labeling sequence (TR=4.5s\, TE1=9.4ms\, TE2=30ms\, voxel size=2x2x2 mm). Surround averaging of the TE2 data was used to generate the blood-oxygenation-level-dependent (BOLD) signal.\nBrain extraction\, motion & distortion correction\, slice timing\, and bandpass filtering to  Hz were performed using FSL. Rapid time delay analysis was then applied using Rapidtide8 (v2.9.6)\, with the stimulus timing vector as the probe regressor9. The cross-correlation maps with the probe were thresholded at p  0.85 density were used to characterize the dose dependence of the spatial fMRI response. Group-averaged time courses were also generated from the voxels demonstrating the maximum cross-correlations (p<0.05).\nTo quantify the temporal evolution of the fMRI response\, significant voxels per time window were counted and then plotted\, and voxel-count decline fitted to an exponential function. Along with the peak voxel count (V)\, the time till peak voxel count (Tp\, to represent the response ramp-up) and the exponential time constant (τ\, to represent the ramp-down) and submitted to a stepwise linear mixed-effects model (LME)\, with the predictor variables being wavelength\, frequency\, and power density.\nResults\nBased on the density maps in Fig. 1\, the brain response is not confined to the site of stimulation. Rather\, it quickly spreads across the anterior brain. 10 Hz pulsation produced a larger spatial extent in the BOLD response\, with the use of 808 nm at 10 Hz resulting in the largest extent among the four combinations. However\, while 1064 nm at 10 Hz produced the lowest peak response\, the 1064-nm-40-Hz combination produced the highest % BOLD amplitude. The bulk of the common responding voxels disappear by ~20 s irrespective of parameter setting. The stepwise LME of the parameters of temporal evolution revealed that higher power resulted in slower decline of the response voxel count\, and higher frequency resulted in a faster decline (higher τ\, p<0.05 and shorter τ\, p<0.05\, respectively).\nConclusion\nIn this work\, we illustrate how quickly the tPBM response spreads from the stimulation site and how quickly it subsides post stimulation. We also show that the response is predominantly in the frontal brain regions\, in accordance with a forehead stimulation\, but that different regions respond at different lags. Furthermore\, 808 nm at 10 Hz elicited the strongest and most consistent response across different subjects. This work lays the foundation for a better understanding of the mechanisms of action of tPBM.\nSupervisor Name: Jean Chen\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-joanna-chen/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250203T175500
DTEND;TZID=America/Toronto:20250203T181000
DTSTAMP:20250203T190735Z
CREATED:20241217T173746Z
LAST-MODIFIED:20250203T190735Z
UID:10000526-1738605300-1738606200@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Koorosh Roohi
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Nursing Activity Monitoring to Prevent Hospital-Acquired Infections\nSupervisor Name: Atena Roshan Fekr\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-koorosh-roohi/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250204T150000
DTEND;TZID=America/Toronto:20250204T160000
DTSTAMP:20250203T175717Z
CREATED:20250203T175717Z
LAST-MODIFIED:20250203T175717Z
UID:10000540-1738681200-1738684800@bme.utoronto.ca
SUMMARY:Bioengineered tumor microenvironments on a chip: from adipose interactions to CAR-T cell therapy assessment
DESCRIPTION:
URL:https://bme.utoronto.ca/event/bioengineered-tumor-microenvironments-on-a-chip-from-adipose-interactions-to-car-t-cell-therapy-assessment/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Events & Workshops
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