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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20250303T171000
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CREATED:20250215T193752Z
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UID:10000575-1741021800-1741022700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Shana Alexander
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: From random to rational: Engineering programable immune complex vaccines with DNA nanoparticles\nSupervisor Name: Leo Chou\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-shana-alexander/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250303T172500
DTEND;TZID=America/Toronto:20250303T174000
DTSTAMP:20250303T202302Z
CREATED:20250215T193753Z
LAST-MODIFIED:20250303T202302Z
UID:10000576-1741022700-1741023600@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Meghan Rothenbroker
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Engineering the lymph node delivery of cargo-functionalized DNA origami\nSupervisor Name: Leo Chou\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-meghan-rothenbroker/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250303T174000
DTEND;TZID=America/Toronto:20250303T175500
DTSTAMP:20250303T202302Z
CREATED:20250214T193743Z
LAST-MODIFIED:20250303T202302Z
UID:10000543-1741023600-1741024500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Bernadette Ng
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Scalable Phage Susceptibility Testing using Digital Microfluidics\nSupervisor Name: Aaron Wheeler\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-bernadette-ng/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20250303T175500
DTEND;TZID=America/Toronto:20250303T181000
DTSTAMP:20250303T202302Z
CREATED:20250215T193753Z
LAST-MODIFIED:20250303T202302Z
UID:10000577-1741024500-1741025400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Richard Saint-Laurent
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: HS610 – 155 College St\, Room 610\nPresentation Title: Designing silencing-resistant promoters for hiPSC development\nAbstract: Synthetic cell & gene therapies are designed to drive therapeutic gene expression and can enhance the current field of living therapies by augmenting cell function to overcome roadblocks like poor cell engraftment and mediocre efficacy. Synthetic therapies drive the expression of genes using promoter DNA sequences which recruit and position RNA polymerase upstream of the gene of interest. In human induced pluripotent stem cells (hiPSCs)\, many of the available promoter sequences undergo a phenomenon known as transgene silencing\, where the promoters are functionally active after transgene delivery but are epigenetically turned off\, or “silenced”\, by the host cell over days to weeks. Transgene silencing in hiPSCs severely limits the lifespan and potency of engineered cell & gene therapies. The current repertoire of mammalian promoters available are not immune to transgene silencing and are often large (>1 kb) and difficult to clone due to high GC% and repetitive DNA regions. Therefore\, this project aims to design a library of short\, silencing-resistant promoters that can be used to engineer robust hiPSCs. An assay capable of screening the silencing tendency of integrated promoters in a high-throughput manner will be developed using massively parallel reporter assays (MPRA) and iPSC landing pad cells. Using this assay\, thousands of candidate promoter sequences will be assessed and scored on strength and silencing. These data will be analyzed to determine what in the DNA sequence contributes to silencing\, allowing biomedical engineers to use\, predict\, and design a repertoire of synthetic promoters that are robust\, long-lasting\, and fine-tuned for the treatment of debilitating disease.\nSupervisor Name: Michael Garton\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-richard-saint-laurent/
LOCATION:HS610
CATEGORIES:Graduate Seminar Series
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