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X-WR-CALNAME:Institute of Biomedical Engineering (BME)
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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20251007T120000
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UID:10000584-1759838400-1759842000@bme.utoronto.ca
SUMMARY:Invited Academic Seminar Series - Rahima Benhabbour
DESCRIPTION:Abstract: \nLong-acting drug delivery systems (DDSs) can address significant unmet health needs to improve patient compliance and therapeutic outcomes. These DDSs can be designed for treatment\, prevention\, or as multipurpose prevention technologies. \nPreventing HIV infections and unintended pregnancies is a leading public health priority for women’s health. Multipurpose prevention technologies (MPTs) capable of delivering long-acting (LA) contraception and HIV prevention are needed. The Benhabbour lab has been leading the development of three innovative technologies all aiming to address current gaps and unmet needs to accelerate translation of an effective MPT to clinical studies. To that extent\, we combine state-of-the-art engineering tools\, formulation development\, preclinical animal models\, and pharmacology models to design and engineer the next generation LA MPTs for the prevention of HIV\, other sexually transmitted infections (STIs) and unintended pregnancy.  \nOur lab has also focused on addressing critical unmet treatment needs for cancers and regenerative medicine to design novel cell-laden scaffolds for LA delivery of cell therapies. \nIn this seminar\, I will highlight the three large programs that we currently lead on engineering the next generation MPTs and cell-laden scaffolds\, which include 1) an ultra-long-acting injectable formulation for HIV pre-exposure prophylaxis (PrEP) (NIAID R01AI131430) and first-in-line LA injectable MPT (NIAID R01AI162246); 2) a first-in-line 3D printed intravaginal ring MPT (NIAID R61AI136002; NIAID R01 AI150358); and 3) a novel cell-laden hydrogel scaffold for treatment of glioblastoma multiforme (GBM) (NCI 1R01CA286609). This seminar will highlight preclinical results in various animal models (mouse\, sheep\, macaques) to assess safety\, pharmacokinetics\, and efficacy of these technologies and discuss their current stage of development and future directions.
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-rahima-benhabbour/
LOCATION:Toronto Rehabilitation Institute\, 550 University Ave\, 2nd Floor Auditorium\, 550 University Ave\, Toronto\, Ontario\, M5G 2A2\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2025/04/Invited-speaker-series-Rahima-Benhabbour.jpeg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251010T161000
DTEND;TZID=America/Toronto:20251010T162500
DTSTAMP:20251010T172240Z
CREATED:20250905T180505Z
LAST-MODIFIED:20251010T172240Z
UID:10000614-1760112600-1760113500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Kate Kazlovich
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: From Prototype to Practice: Advancing 3D Printing and Surgical Simulation in Thoracic Surgery\nAbstract:\nThree-dimensional (3D) printing is revolutionizing how we design\, test\, and implement surgical simulation tools across medical specialties. In thoracic surgery\, this technology offers an accessible and scalable approach to building procedure-specific training devices that enhance technical skill development outside of the operating room. This presentation builds on our earlier work by showcasing the development and implementation of high-fidelity\, 3D-printed simulation models tailored to key thoracic procedures.\nWe will present the iterative design and validation of simulation tools for transplant anastomosis training and for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)\, a critical cancer biopsy technique. In addition to demonstrating the functionality of these models\, we will discuss how they are being integrated into educational programs both within and beyond formal workshop settings\, including independent practice and team-based learning environments.\nBy combining engineering innovation with surgical education\, this work highlights how simulation can be used not only to teach technical skills but also to expand equitable access to hands-on training opportunities across institutions and experience levels.\nSupervisor Name: Dr. Kazuhiro Yasufuku\nYear of Study: 5\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-kate-kazlovich/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251010T162500
DTEND;TZID=America/Toronto:20251010T164000
DTSTAMP:20251010T172240Z
CREATED:20250905T180505Z
LAST-MODIFIED:20251010T172240Z
UID:10000613-1760113500-1760114400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Hannah Van Lankveld
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: The physiological effect of transcranial photobiomodulation on the healthy human brain\nSupervisor Name: Dr. Jean Chen and Dr. Hai-Ling Cheng\nYear of Study: 4\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-hannah-van-lankveld-2/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251010T164000
DTEND;TZID=America/Toronto:20251010T165500
DTSTAMP:20251010T172240Z
CREATED:20250905T180506Z
LAST-MODIFIED:20251010T172240Z
UID:10000617-1760114400-1760115300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Rachel Leung
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Fracture Prediction using Deep Learning: Pre-Clinical Application in Spinal µCT Imaging\nSupervisor Name: Michael Hardisty\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-rachel-leung/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251010T165500
DTEND;TZID=America/Toronto:20251010T171000
DTSTAMP:20251010T172240Z
CREATED:20250905T180505Z
LAST-MODIFIED:20251010T172240Z
UID:10000615-1760115300-1760116200@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Julia Takimoto
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Quantifying the Rotational Stiffness of 3D Printed Ankle Foot Orthotics\nAbstract:\nBackground and Rationale: Ankle-foot orthoses (AFO) are assistive devices designed to improve gait biomechanics and/or correct structural abnormalities. AFOs are commonly prescribed in a multitude of cases\, including stroke\, osteoarthritis\, cerebral palsy\, spinal cord injury\, foot drop\, and clubfoot. Their use has been found to improve dorsiflexion angle\, gait speed\, stride length\, and reduce energy cost. Recent improvements to 3D printing technology have made it a commercially viable manufacturing method for custom orthoses. To 3D print an orthotic\, a scan of the lower limb is taken and digitally manipulated to achieve the desired AFO characteristics. Key characteristics of AFOs are rotational stiffness and shape\, affecting safety\, comfort and function\, which are fine-tuned during the post-processing phase of manufacturing. While it is not a common part of clinical practice\, the prediction of these characteristics can be assisted using Finite Element Analysis (FEA) of the computer-aided design (CAD) models or empirical testing. Current testing methods to verify the predicted characteristics are modelled after lower-limb prosthetics\, but no ISO standards for AFO testing have been established and methods presented in research are not commercially available. Furthermore\, it is not feasible for many orthotic clinics to develop a custom testing machine\, so this project seeks solutions that can potentially be applied in clinical practice.\nObjectives and aims: The main goal of this project is to develop and assess techniques for assessing the strength and stiffness of AFOs.\nTo achieve this\, I aim to: (1) Develop a testing apparatus and procedure to quantify the material properties and behaviour of 3D printed AFOs under static and dynamic loading conditions and determine the apparatus reliability within testing cycles and across testing sessions. This procedure will serve as a gold standard that other methods will be compared to. (2) Use said apparatus to test key aspects of AFO post-processing. (3) Develop and evaluate a low-technology\, clinically-viable process for AFO stiffness testing.\nMethodology: (1) A custom apparatus will be designed for attaching AFOs to mimic walking within a universal tensile machine (UTM). The apparatus will apply loading to a surrogate shank\, with the AFO footplate fixed (in a non-destructive manner) to isolate motion to the ankle joint. The primary measure will be rotational stiffness in the sagittal plane\, which is the key characteristic in the design and prescription of AFOs\, but also a common cause of structural failure in long-term AFO use. (2) Measure the effects of heat treatment for shape modification and dyeing the AFOs and compare to FEA predictions of AFO behaviour. (3) Analyse current benchtop stiffness testing and develop a methodology optimised for clinical use\, prioritising low cost and ease of use.\nSignificance & Contribution to Advancement of Knowledge: The rotational stiffness of custom and pre-made AFOs is typically unknown. Traditional plaster casting methods for custom AFOs rely on an orthotist to visually determine when an appropriate stiffness has been achieved\, without quantification. Pre-made AFOs are sold with their stiffness on an arbitrary range from low to high. 3D printing provides the opportunity for orthotists to manufacture AFOs with specific stiffnesses; however\, many orthotists are unfamiliar with prescribing a numerical stiffness value. Creating a standard quantification method enables further study of the impact of specific AFO design characteristics on users’ gaits. This leads to better AFO prescriptions and aids the development of AFO standards.\nSupervisor Name: Jan Andrysek\nYear of Study: 3\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-julia-takimoto/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
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