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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20251024T161000
DTEND;TZID=America/Toronto:20251024T162500
DTSTAMP:20251024T180735Z
CREATED:20250905T180506Z
LAST-MODIFIED:20251024T180735Z
UID:10000622-1761322200-1761323100@bme.utoronto.ca
SUMMARY:Canceled: Graduate Student Seminar Series - Madhumitha Ramamurthy
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Understanding the roles of resident macrophages in osteoarthritis progression\nSupervisor Name: Sowmya Viswanathan\nYear of Study: 2\nProgram of Study: PhD\nCancellation Reason:\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-madhumitha-ramamurthy/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251024T162500
DTEND;TZID=America/Toronto:20251024T164000
DTSTAMP:20251024T180735Z
CREATED:20250905T180506Z
LAST-MODIFIED:20251024T180735Z
UID:10000623-1761323100-1761324000@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Matthew Jenkins
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Ultrasound Guided Histotripsy for IVH Clot Lysis\nSupervisor Name: Adam Waspe and George Ibrahim\nYear of Study: 3\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-matthew-jenkins/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251024T164000
DTEND;TZID=America/Toronto:20251024T165500
DTSTAMP:20251024T180735Z
CREATED:20250905T180506Z
LAST-MODIFIED:20251024T180735Z
UID:10000625-1761324000-1761324900@bme.utoronto.ca
SUMMARY:Canceled: Graduate Student Seminar Series - Fanglin Gong
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Engineering of Amino Acid-Derived Ionizable Lipids Enables Inhaled Base Editing for Therapeutic Gene Correction in the Lung\nAbstract: CRISPR-based gene editing holds promise for treating genetic diseases\, yet its application to lung disorders has been hindered by the challenges of pulmonary delivery. Inspired by the modularity and biocompatibility of amino acid-derived chemistries\, we report the combinatorial synthesis of 960 ionizable lipids incorporating chemically diverse backbones from both proteinogenic and non-proteinogenic α-amino acids. Through high-throughput screening and structure-function analysis\, we identify CHCha-10\, a cyclohexyl amino acid-derived lipid that forms biodegradable nanoparticles capable of efficiently delivering mRNA-based gene editors to lung epithelial cells. Following intratracheal administration\, CHCha-10 nanoparticles exhibit enhanced mucus penetration\, and epithelial-specific transfection in both mice and ferrets. As a functional application\, we demonstrate the first instance of in vivo base editing in the lung via inhalation. Delivery of adenine base editor mRNA and guide RNA targeting the CFTR G542X mutation restores CFTR expression and chloride channel function in G542X human airway epithelial cells\, mouse-derived intestinal organoids\, and the lungs of cystic fibrosis mice. This work establishes a chemically modular design framework for ionizable lipids and a translatable platform for RNA-based pulmonary gene correction.\nSupervisor Name: Dr. Bowen Li\nYear of Study: 3\nProgram of Study: PhD\nCancellation Reason:\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-fanglin-gong/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251024T164000
DTEND;TZID=America/Toronto:20251024T165500
DTSTAMP:20251024T180735Z
CREATED:20251007T165244Z
LAST-MODIFIED:20251024T180735Z
UID:10000631-1761324000-1761324900@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Barry Bytensky
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Simulating Focused Ultrasound Therapies for Paediatric Retinoblastoma\nAbstract: Retinoblastoma is the most common eye cancer in children and has a high survival rate due to the removal of eyes with large tumours. In most cases\, chemotherapy is used to reduce the size of tumours\, which may fail to prevent the cancer from coming back and can damage surrounding tissues in the eye. New treatments seek to precisely target tumours without harming healthy tissues. Focused ultrasound is a non-invasive therapeutic tool that concentrates sound waves within a volume the size of a grain of rice. This may be used for burning eye tumours directly\, or to improve the delivery of chemotherapy drugs. This\, in turn\, may enable improved eye tumour treatment. To investigate potential ultrasound therapies\, a computer program was developed that can simulate the ultrasound and thermal properties of the eye in 3D. Using paediatric eye models from patient MRI scans\, simulations have suggested focused ultrasound can be used to heat retinoblastoma tumours without damaging surrounding structures such as the lens. In this research project\, tissue-mimicking eye models will be developed\, and their ultrasound and thermal properties will be measured. Simulated and experimentally measured temperatures in these models will be compared to ensure the computer program can accurately predict treatment results. Furthermore\, this computer program will be developed into a comprehensive treatment planning tool to determine ideal treatment configurations and design new ultrasound systems. Finally\, this tool will be used in animal studies investigating the use of ultrasound to treat eye cancers. This will result in a simulation platform which can be used to predict the outcomes of a wide range of ultrasound treatments.\nSupervisor Name: George Ibrahim\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-barry-bytensky/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251024T165500
DTEND;TZID=America/Toronto:20251024T171000
DTSTAMP:20251024T180735Z
CREATED:20250905T180506Z
LAST-MODIFIED:20251024T180735Z
UID:10000624-1761324900-1761325800@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Dianoosh Kalhory
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: In Vitro Model for Screening RNA/Drug Delivery by Lipid Nanoparticles for Treatment of Lung Diseases\nAbstract:\nThe goal of my research is to create a medium- or high-throughput LOC model for screening RNA-based drugs encapsulated in LNPs by using a bioprinting-on-chip technique. To reach this goal\, my thesis will be structured around three specific aims that will develop into a MF platform for in vitro lung disease modeling and screening RNA-based drugs for the treatment of lung diseases.\nAim 1: Formation of a gel-embedded bi-layer lung epithelial cells and microvascular endothelial cells at the air-liquid interface\nAim 2: Design\, fabrication\, and development of a lung-on-chip platform\nAim 3: Encapsulation of micro-ribonucleic acids in lipid nanoparticles and their delivery to lung cells\nSupervisor Name: Eugenia Kumacheva & Gilbert Walker\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-dianoosh-kalhory/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
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