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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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DTSTART;TZID=America/Toronto:20251209T120000
DTEND;TZID=America/Toronto:20251209T130000
DTSTAMP:20251119T151633Z
CREATED:20250408T173702Z
LAST-MODIFIED:20251119T151633Z
UID:10000586-1765281600-1765285200@bme.utoronto.ca
SUMMARY:Invited Academic Seminar Series - Ross Ethier - Signalling pathways in myopia
DESCRIPTION:Abstract: \nMyopia (near-sightedness) is predicted to affect 50% of all people worldwide by 2050. Although near-sightedness itself can be corrected optically (glasses\, contacts)\, myopia increases the risk of blinding diseases (glaucoma\, retinal detachment\, etc.) and thus the increased incidence of myopia is predicted to be an important driver of vision loss worldwide. Most cases of myopia are due to excessive axial eye growth; unfortunately\, the signaling pathways underlying this axial growth are very poorly understood. We have found that oral administration of all-trans retinoic acid (atRA) causes myopia in mice\, implicating atRA as an important player in the myopigenic signaling cascade. In this talk\, I will describe our ongoing studies of myopigenic atRA signaling in the eye based on the use of mouse models\, atRA tracer studies and mathematical modeling. I will also describe studies of how atRA interacts with dopaminergic signaling and light levels (two known modulators of myopia).
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-ross-ethier/
LOCATION:Toronto Rehabilitation Institute\, 550 University Ave\, 2nd Floor Auditorium\, 550 University Ave\, Toronto\, Ontario\, M5G 2A2\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2025/11/Invited-speaker-series-2025-Ross-Ethier.jpeg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251212T161000
DTEND;TZID=America/Toronto:20251212T162500
DTSTAMP:20251211T213854Z
CREATED:20251015T172231Z
LAST-MODIFIED:20251211T213854Z
UID:10000637-1765555800-1765556700@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Osama Khan
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Drug delivery to lung cancer using prodrug-loaded microbubbles and endobronchial ultrasound\nSupervisor Name: Naomi Matsuura\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-osama-khan/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251212T162500
DTEND;TZID=America/Toronto:20251212T164000
DTSTAMP:20251211T213854Z
CREATED:20251015T172231Z
LAST-MODIFIED:20251211T213854Z
UID:10000638-1765556700-1765557600@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Rena Far
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: The effect of musical rhythms on human brain cell and circuit dynamics\nSupervisor Name: Dr. Taufik Valiante\nYear of Study: 2\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-rena-far/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251212T164000
DTEND;TZID=America/Toronto:20251212T165500
DTSTAMP:20251211T213854Z
CREATED:20251015T172231Z
LAST-MODIFIED:20251211T213854Z
UID:10000639-1765557600-1765558500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Reut Shor
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Reversing Outer Retinal Corrugations: Toward Optimized RRD Management\nAbstract:\nObjective: To develop and validate a quantitative biomechanical framework that models outer retinal corrugations (ORC) formation and progression in rhegmatogenous retinal detachment (RRD) patients\, to predict the development of post-op outer retinal fold (ORF).\nMethods: In a prospective\, multicenter cohort at St. Michael’s Hospital (Toronto\, Canada) and the Department of Medicine and Health Sciences “V. Tiberio” (Campobasso\, Italy) from January 1\, 2023\, to January 1\, 2025\, sequential OCT scans of detached retinas in RRD patients were obtained at presentation\, within 24h before treatment\, and at 1-\, 3-\, and 6-months post-treatment. Regions of interest (ROIs) were aligned across scans using shared anatomic landmarks\, manually segmented\, and automatically analyzed in MATLAB to compute strain mismatch and elasticity-modulus mismatch. Measured values were compared with theoretical predictions for surface-instability patterns in a bilayer system with differential expansion rates. Temporal changes in strain and modulus mismatch were evaluated against kinetic models of gel swelling. Correlation between strain values\, post-op ORF development and visual acuity (VA) were tested.\nResults: 42 patients (60 ROIs) met inclusion criteria. Post-op ORF occurred in 13/60 ROIs (21.7%). Elasticity-modulus mismatch versus strain was mapped to a bilayer phase diagram within a high-adhesion regime\, with non-corrugated ROIs in the “flat” region and corrugated ROIs in the “wrinkle/fold” domains. The minimum strain for the flat-to-corrugated transition was 0.13. No ORFs were observed for strain 5. The strain threshold associated with ~50% ORF risk differed by treatment: ≥0.25 for Pars Plana Vitrectomy (PPV) or Scleral Buckle (SB) and ≥0.43 for Pneumatic Retinopexy (PnR). A kinetic model of ORC progression based on gel-swelling theory showed good agreement with the data. Across cohorts\, higher pre-op strain trended toward worse post-op VA.\nConclusions: ORC behavior in RRD can be quantitatively characterized by strain and elasticity-modulus mismatch. Treatment-dependent strain thresholds predict post-op ORF and align with observed visual acuity trends. This mechanics-based framework elucidates ORC pathophysiology and may support risk stratification in choosing timing and selection of reattachment strategies.\nSupervisor Name: Prof Frank Gu\, Dr Rajeev Muni\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-reut-shor/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251212T165500
DTEND;TZID=America/Toronto:20251212T171000
DTSTAMP:20251211T213854Z
CREATED:20251016T172233Z
LAST-MODIFIED:20251211T213854Z
UID:10000642-1765558500-1765559400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Michael Lam
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Design and Feasibility of a Dynamic Difficulty Adjustment Algorithm for Rehabilitation Video Games\nSupervisor Name: Elaine Biddiss\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-michael-lam/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
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