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X-WR-CALDESC:Events for Institute of Biomedical Engineering (BME)
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251219T161000
DTEND;TZID=America/Toronto:20251219T162500
DTSTAMP:20251219T180755Z
CREATED:20251016T172233Z
LAST-MODIFIED:20251219T180755Z
UID:10000643-1766160600-1766161500@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Mahmoud Abdelkarim
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Hydrodynamic focusing to synthesize lipid-based nanoparticles: Computational and experimental analysis of chip design and formulation parameters\nSupervisor Name: Hagar Labouta\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-mahmoud-abdelkarim/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251219T162500
DTEND;TZID=America/Toronto:20251219T164000
DTSTAMP:20251219T180755Z
CREATED:20251015T172231Z
LAST-MODIFIED:20251219T180755Z
UID:10000640-1766161500-1766162400@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Fanglin Gong
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Engineering of Amino Acid-Derived Ionizable Lipids Enables Inhaled Base Editing for Therapeutic Gene Correction in the Lung\nAbstract: CRISPR-based gene editing holds promise for treating genetic diseases\, yet its application to lung disorders has been hindered by the challenges of pulmonary delivery. Inspired by the modularity and biocompatibility of amino acid-derived chemistries\, we report the combinatorial synthesis of 960 ionizable lipids incorporating chemically diverse backbones from both proteinogenic and non-proteinogenic α-amino acids. Through high-throughput screening and structure-function analysis\, we identify CHCha-10\, a cyclohexyl amino acid-derived lipid that forms biodegradable nanoparticles capable of efficiently delivering mRNA-based gene editors to lung epithelial cells. Following intratracheal administration\, CHCha-10 nanoparticles exhibit enhanced mucus penetration\, and epithelial-specific transfection in both mice and ferrets. As a functional application\, we demonstrate the first instance of in vivo base editing in the lung via inhalation. Delivery of adenine base editor mRNA and guide RNA targeting the CFTR G542X mutation restores CFTR expression and chloride channel function in G542X human airway epithelial cells\, mouse-derived intestinal organoids\, and the lungs of cystic fibrosis mice. This work establishes a chemically modular design framework for ionizable lipids and a translatable platform for RNA-based pulmonary gene correction.\nSupervisor Name: Dr. Bowen Li\nYear of Study: 3\nProgram of Study: PhD\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-fanglin-gong-2/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251219T164000
DTEND;TZID=America/Toronto:20251219T165500
DTSTAMP:20251219T180755Z
CREATED:20251016T172233Z
LAST-MODIFIED:20251219T180755Z
UID:10000644-1766162400-1766163300@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Sima Buchnak
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Functional and Structural Connectivity in Paediatric Post-Stroke Dystonia\nAbstract:\nIntroduction: Dystonia is a motor impairment that affects 20% of children post basal ganglia arterial ischemic stroke (CAIS). Disrupted inhibitory processing in the sensorimotor cortex is implicated and reflected by alterations in beta event-related desynchronization (ERD). In a prior magnetoencephalography (MEG) study during a cognitive-motor task\, beta ERD response amplitude was larger in both hemispheres of CAIS with no dystonia (D-)\, and the non-lesioned hemisphere of CAIS with dystonia (D+)\, compared to healthy controls (HC). This finding was suggestive of compensatory sensorimotor plasticity.\nObjective: To determine whether beta ERD shows similar trends during a passive movement task and explore associations with corticospinal tract (CST) microstructure.\nMethods: Diffusion magnetic resonance imaging (MRI) and MEG data were collected in CAIS (D+/D-) and HC participants from a prior study. A passive movement task assessed beta reactivity without the confounding effects of impaired motor execution. CST microstructure was evaluated using tractography and diffusion metrics.\nResults: Twenty-six participants (16CAIS: 8D+/8D- ;10HC) were included (Table 1). Compared to HC\, beta ERD amplitude during passive movement was greater in the lesioned hemisphere of D+ (p = 0.036) and the non-lesioned hemisphere of D- (p = 0.030) patients\, with similar trends in the other hands (Fig 1). In the lesioned hemisphere\, mean diffusivity (MD) was highest in D+\, intermediate in the D-\, and lowest in the HC group. Fractional anisotropy (FA) showed an inverse trend. Non-lesioned hemispheres showed comparable MD and FA across groups (Fig 2).\nConclusion: Group differences in CST.microstructure were consistent with motor outcomes but did not mirror the functional measures of inhibitory processing. Our finding of higher beta ERD during passive movement of both hands\, in all CAIS groups (D+/D-) compared to controls\, was unexpected.\nThese studies suggest that the basic function of the CST is relatively preserved in dystonia. Future studies should investigate the potential role of cognition in the maladaptive response of dystonia.\nHsu P.\, et al.\, (2025) Hum Brain Mapp. 46 e7020\nSupervisor Name: Douglas Cheyne\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-sima-buchnak/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20251219T165500
DTEND;TZID=America/Toronto:20251219T171000
DTSTAMP:20251219T180756Z
CREATED:20251016T172233Z
LAST-MODIFIED:20251219T180756Z
UID:10000645-1766163300-1766164200@bme.utoronto.ca
SUMMARY:Graduate Student Seminar Series - Amy Huang
DESCRIPTION:Graduate Student Seminar Series\nPlease ensure you invite your Principal Investigator by adding their email via the ‘Add Guest’ button and they will also be notified of your presentation.\nLocation: MS2158 – 1 King’s College Circle\nPresentation Title: Evaluating the hemodynamic fidelity of idealized versus intraoperative boundary conditions in acute type B aortic dissection simulations\nSupervisor Name: Cristina Amon\nYear of Study: 2\nProgram of Study: MASc\nPowered by Calendly.com
URL:https://bme.utoronto.ca/event/graduate-student-seminar-series-amy-huang/
LOCATION:MS2158
CATEGORIES:Graduate Seminar Series
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