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DTSTART;TZID=America/Toronto:20240409T120000
DTEND;TZID=America/Toronto:20240409T130000
DTSTAMP:20240326T181449Z
CREATED:20230804T154946Z
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SUMMARY:Robotically Steerable Devices for Transcatheter and Endovascular Interventions – Jaydev Desai
DESCRIPTION:Speaker\nJaydev Desai\nProfessor\nWallace H. Coulter Department of Biomedical Engineering\nGeorgia Institute of Technology \n\nAbstract\nMitral regurgitation is a common heart valve disease. Current approaches for mitral valve repair include open heart surgery (which carries the risk of post-operative complications) and transcatheter mitral valve repair (TMVr). TMVr is a relatively new approach that is performed on a beating heart using a catheter that is guided to the target location to implant the device to reduce or eliminate mitral regurgitation. Given the tortuosity of the path that needs to be taken to reach the mitral valve\, TMVr is a clinically challenging procedure. The first part of the talk will focus on our work in developing  a highly articulated\, intravascular meso-scale robot that can be guided to deploy the mitral valve implant under image guidance. \nThe second part of the talk will focus on the area of micro-scale robotic systems involving steerable guidewires. One of the primary requirements of an endovascular robotic system is to be able to successfully steer the guidewire towards the target location with minimal or no harm to the vessel. Chronic total occlusions (CTOs) remain the riskiest\, most challenging\, and least successful vascular lesions to treat with traditional endovascular devices. Peripheral artery disease (PAD) in particular\, is one of the most common causes of cardiovascular deaths worldwide. Procedural complexity in treating CTOs are attributed to multiple causes. The second part of the talk will present our work on the development of 400 microns (~0.016”) robotically steerable guidewire as a potential solution to this challenging clinical problem. \nBiography \nDr. Jaydev P. Desai is currently a Professor at Georgia Tech in the Wallace H. Coulter Department of Biomedical Engineering and holds the G.P. “Bud” Peterson and Valerie H. Peterson Faculty Professorship in Pediatric Research. He is the Associate Chair for Undergraduate studies in BME at GT\, founding Director of the Georgia Center for Medical Robotics (GCMR)\, and an Associate Director of the Institute for Robotics and Intelligent Machines (IRIM). He completed his undergraduate studies from the Indian Institute of Technology\, Bombay\, India\, in 1993. He received his MA in Mathematics in 1997 and MSE and Ph.D. in Mechanical Engineering and Applied Mechanics in 1995 and 1998 respectively\, all from the University of Pennsylvania. He was also a Post-Doctoral Fellow in the Division of Engineering and Applied Sciences at Harvard University.  He is a recipient of several NIH R01 grants\, NSF CAREER award\, and was the lead inventor on the “Outstanding Invention in the Physical Science Category” at the University of Maryland\, College Park\, where he was formerly employed. He is also the recipient of the Ralph R. Teetor Educational Award and the 2021 IEEE Robotics and Automation Society (RAS) Distinguished Service Award. He has been an invited speaker at the National Academy of Sciences “Distinctive Voices” seminar series and also invited to attend the National Academy of Engineering’s U.S. Frontiers of Engineering Symposium. He has over 200 publications\, is the founding Editor-in-Chief of the Journal of Medical Robotics Research\, and Editor-in-Chief of the four-volume Encyclopedia of Medical Robotics. At 2018 ICRA\, his prior work was the finalist for “IEEE RAS Award for the Most Influential Paper from ICRA 1998” (20-years impact). Most recently\, he was selected as the recipient of the 2024 IEEE RAS George Saridis Leadership Award in Robotics and Automation from the IEEE RAS. His research group has received several accolades including the best student paper award\, best symposium paper award\, cover image of IEEE Transactions on Biomedical Engineering\, and featured article in the IEEE Transactions on Biomedical Engineering. His current research interests are primarily in the areas of image-guided surgical robotics\, pediatric robotics\, endovascular robotics\, and rehabilitation and assistive robotics. He is a Fellow of IEEE\, ASME\, and AIMBE. \n\nHost\nLueder Kahrs
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-jaydev-desai/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/08/Jaydev-Desai-e1710353874337.jpg
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DTSTART;TZID=America/Toronto:20240312T120000
DTEND;TZID=America/Toronto:20240312T130000
DTSTAMP:20240205T220444Z
CREATED:20230804T154209Z
LAST-MODIFIED:20240205T220444Z
UID:10000235-1710244800-1710248400@bme.utoronto.ca
SUMMARY:Merging Humans and Machines to Assist Human Movement – Daniel Ferris
DESCRIPTION:Speaker\nDaniel Ferris\nRobert W. Adenbaum Professor\nJ. Crayton Pruitt Family Department of Biomedical Engineering\nUniversity of Florida \n\nAbstract\nThe University of Florida Human Neuromechanics Laboratory studies the science and engineering of bionic prostheses\, robotic exoskeletons\, and mobile brain computer interfaces. The two goals are to better understand how humans control their bodies and to develop new technologies to assist human movement in health and disability. Prof. Dan Ferris will discuss why both neuroscience and biomechanics are necessary to engineer new human augmentation technologies and how studying humans using prostheses\, exoskeletons\, and mobile brain imaging can enhance our understanding of human physiology. \n  \nShort Bio: \nDaniel Ferris is the Robert W. Adenbaum Professor of Engineering Innovation at the University of Florida. Dr. Ferris completed his Ph.D. at UC Berkeley\, M.S. at the University of Miami\, and B.S. at the University of Central Florida. After completing postdoctoral fellowships at the UCLA Department of Neurology and the University of Washington Department of Electrical Engineering\, he joined the faculty at the University of Michigan for 16 years. In 2017\, Dr. Ferris moved to the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida. \n\nHost\nKei Masani
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-daniel-ferris/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/08/2016-07-18_Daniel_Ferris-0017_4.jpg
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DTSTART;TZID=America/Toronto:20240213T120000
DTEND;TZID=America/Toronto:20240213T130000
DTSTAMP:20240108T172905Z
CREATED:20230804T153944Z
LAST-MODIFIED:20240108T172905Z
UID:10000234-1707825600-1707829200@bme.utoronto.ca
SUMMARY:Targeting Nucleic Acids to Combat Inflammation – Kam Leong
DESCRIPTION:Speaker\nKam Leong\nSamuel Y. Sheng Professor of Biomedical Engineering\nDepartment of Biomedical Engineering\nColumbia University \n\nAbstract\nInflammation serves as a crucial defense mechanism\, alerting our bodies to damage and aiding in the restoration of homeostasis. However\, when inflammation becomes excessive or chronic\, it can manifest as a range of debilitating diseases\, including cancer\, autoimmune disorders\, and wound healing. Controlling the inflammatory response is a pivotal aspect of managing these conditions. While conventional drug therapies remain the mainstay of treatment\, biomaterials are increasingly gaining traction as an alternative approach. Biomaterials offer a promising strategy for targeted drug delivery to inflamed sites\, enhancing bioavailability and minimizing systemic side effects. Additionally\, they can act as scavengers\, removing pro-inflammatory factors to directly suppress inflammation. This scavenging approach has demonstrated efficacy in treating inflammatory diseases such as rheumatoid arthritis\, psoriasis\, multiple sclerosis\, and systemic lupus erythematosus. A key factor in the pathogenesis of these diseases appears to be the aberrant activation of innate immune sensors\, particularly Pattern Recognition Receptors (PRRs)\, triggered by nucleic acids released from damaged or dying cells. In this presentation\, I will discuss the application of nucleic acid-binding polymers as a multifaceted strategy for combating inflammation. These polymers not only effectively neutralize pro-inflammatory nucleic acids but also serve as versatile therapeutic carriers for drug delivery. Through an exploration of their mechanisms of action and therapeutic potential\, I will present the promise of nucleic acid-binding polymers as a new approach to managing inflammatory diseases. \n  \nKam W. Leong is the Samuel Y. Sheng Professor of Biomedical Engineering at Columbia University\, where he focuses on three major research directions: 1) Nonviral gene editing in vivo; 2) Biomaterials-assisted modulation of inflammation; 3) Human-tissue chips for disease modeling and drug screening. He has published ~500 manuscripts holds more than 60 issued patents. He is the recipient of the IEEE-EMBS Academic Career Achievement Award\, Founder’s Award of the Society for Biomaterials\, Editor-in-Chief of Biomaterials\, and a member of the National Academy of Inventors\, the National Academy of Engineering\, and the National Academy of Medicine. \n\nHost\nMilica Radisic
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-kam-leong/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Invited Academic Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2023/08/kam_leong_square.jpg
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DTSTART;TZID=America/Toronto:20230314T120000
DTEND;TZID=America/Toronto:20230314T130000
DTSTAMP:20230313T183736Z
CREATED:20220512T153722Z
LAST-MODIFIED:20230313T183736Z
UID:10000022-1678795200-1678798800@bme.utoronto.ca
SUMMARY:Invited Academic Seminar Series - Peter Yingxiao Wang- Remote Control of the Genetics within Tumors via Focused Ultrasound for Cancer Immunotherapy (Hybrid Delivery)
DESCRIPTION:Speaker\nPeter Yingxiao Wang\nAssociate Professor\, Bioengineering\nUniversity of Southern California \n\nAbstract\nFocused ultrasound (FUS) can deliver energy safely and noninvasively into tissues at depths of centimeters. We show that the genetics and cellular functions of chimeric antigen receptor T cells (CAR-T cells) within tumors can be reversibly controlled by the heat generated by short pulses of FUS via a CAR cassette under the control of a promoter for the heat-shock protein. In mouse tumor models\, locally injected T cells with the inducible CAR and activated via FUS guided by magnetic resonance imaging (MRI) mitigated on-target off-tumor activity and enhanced the suppression of tumor growth\, compared with the performance of standard CAR-T cells. Integrated with CRISPR\, FUS was also be applied to modulate the genetics and epigenetics of tumor cells\, which facilitated and enhanced the efficacy of the CAR T immunotherapy. Therefore\, acoustogenetic control of tumor cells and CAR T by FUS may facilitate the design of safer cell therapies. \n\nHost\nLidan You
URL:https://bme.utoronto.ca/event/invited-academic-seminar-series-peter-yingxiao-wang/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
ATTACH;FMTTYPE=image/jpeg:https://bme.utoronto.ca/wp-content/uploads/2022/05/20180118-Wang_Peter-2513-full_res-export.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220707T140000
DTEND;TZID=America/Toronto:20220707T150000
DTSTAMP:20220624T151521Z
CREATED:20220624T143324Z
LAST-MODIFIED:20220624T151521Z
UID:10000006-1657202400-1657206000@bme.utoronto.ca
SUMMARY:Faculty Search Candidate Talk - Unconventional Nanobiophotonics: Upconversion/Persistent Luminescence Nanoparticles for Anti-cancer Therapy
DESCRIPTION:Kai Huang\, PhD \nDepartment of Biochemistry and Molecular Biotechnology\nUniversity of Massachusetts Chan Medical School \nAbstract: Biophotonics has been widely applied as versatile and powerful approaches for biomedical applications\, such as for bioimaging\, biodetection\, photodynamic therapy\, and optogenetics. However\, conventional biophotonics suffers from several constraints. For example\, the short-wavelength excitation light cannot penetrate deep into the tissue\, thus requiring an invasive light delivery system for deep-tissue photodynamic therapy or optogenetics. In addition\, luminescence signal is interfered with autofluorescence noise\, bringing difficulties for high-quality bioimaging and biodetection. Here\, we address these issues by developing unconventional nanobiophotonics\, where we apply upconversion or persistent luminescence nanoparticles for anti-cancer therapy. Upconversion nanoparticles (UCNPs) convert near-infrared (NIR) excitation into short-wavelength visible light emission and thus serve as the light-transducer to bring deep tissue penetration NIR excitation for wireless photoactivations. We applied versatile nanoengineering approaches to produce UCNPs with controllable size/morphology\, tunable and enhanced luminescence\, and desirable biofunctionalizations. These UCNPs were applied for NIR-optogenetic control of CAR-T cell immunotherapy. We demonstrated that by wirelessly and spatiotemporally controlling the CAR-T cell activity\, we can achieve effective and safer immunotherapy of cancer\, overcoming the safety issue of conventional CAR-T immunotherapy. Persistent luminescence nanoparticles (PLNPs) are unique nanomaterials that emit long-lasting afterglow after excitation stops. PLNPs are significant for bioimaging by avoiding the autofluorescence induced by real-time excitation. We have developed the bottom-up syntheses of PLNPs with fine control of their energy traps\, heterostructures\, and energy accepting from dye-sensitizations\, contributing to enhanced persistent luminescence. We have demonstrated that PLNPs with enhanced luminescence are excellent for ultrasensitive imaging-guided tumor surgery. In addition\, we also demonstrated that by developing X-ray-excitable PLNPs\, we can achieve X-ray-photodynamic therapy with limitless tissue penetration and enhanced tumor eradication.
URL:https://bme.utoronto.ca/event/faculty-search-candidate-talk-2/
LOCATION:Medical Sciences Building 3154\, 1 King's College Cir\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:BME Faculty Search
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