Research Interests

Cells are continuously processing and reacting to external signals that elicit various responses including cell division, migration, differentiation and death. Decades of research in cell biology has revealed these responses are controlled by cellular signalling pathways that resemble computer networks and electrical circuits. Signalling pathways, however, are composed of a coordinated interaction of proteins mediated by modular domains.

Our lab is interested in elucidating the fundamental rules for the engineering of signalling pathways by mutation and recombination of these basic modular domains. Such studies will ultimately improve our understanding of how pathways function and inspire therapies for inhibiting or regulating certain pathways responsible for illness.