Cell and Tissue Engineering
Cell and tissue engineering has the potential to change how we think about disease and aging is happening at BME. Regenerative medicine uses stem cells and biomaterials to repair, replace or regenerate damaged tissue, organ structures and function.
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Biomaterials
Growing heart and liver tissue for safer drug testing and more
Professor Milica Radisic’s team works on growing human tissue in artificial environments as platforms for developing and testing new drugs, and with the potential to one day, repair or replace damaged organs.
Their creations have included Biowire™, a method of growing heart cells around a silk suture, “Hook-in-Tissue,” a biocompatible scaffold that allows sheets of beating heart cells to snap together like Velcro®, and AngioChip, a system built in a normal cell culture dish that allows lab-grown heart and liver tissue to function and interact like the real thing.
Today, the team is already working on commercializing these technologies through TARA Biosystems Inc., a spinoff company co-founded by Radisic.
Tissue Engineering
Advancing treatments for heart failure
Professor Craig Simmons leads an interdisciplinary team of eight researchers and their students from U of T Engineering, Medicine and Dentistry to advance discoveries and accelerate new treatments for heart failure and cardiovascular disease.
As the scientific director of the Translational Biology & Engineering Program (TBEP), the U of T arm of the Ted Rogers Centre for Heart Research (TRCHR), he brings together experts in engineering and medicine to uncover mechanisms of disease, develop new diagnostic tests for early detection, and create therapeutic strategies using molecules, cells and biomaterials to regenerate heart tissues.
The goal: improve the lives of one million Canadians with heart failure and reduce the estimated $3-billion cost to our health-care system.
Regenerative Medicine
Restoring muscle function through regenerative medicine
Professor Penney Gilbert is harnessing the potential of muscle stem cells to advance therapies for muscle repair and regeneration. By investigating how these cells function in healthy and diseased states, the lab is driving innovations to restore skeletal muscle health.
Using lab-grown, miniature human muscle models, the Gilbert lab replicates muscle repair processes in a controlled setting. These "muscles in a dish" enable the study of conditions like aging, Duchenne muscular dystrophy, and ICU-acquired weakness, providing a platform to test new treatments and explore the regenerative potential of muscle stem cells.
Their work brings new hope for therapies aimed at restoring muscle function and improving quality of life for those affected by muscle disorders.
Read more news about cell & tissue engineering
Professor Craig Simmons receives the Engineers Canada Medal for Distinction in Engineering Education
Professor Craig Simmons (MIE, BME) has received the 2026 Engineers Canada Medal for Distinction in Engineering Education. This national award recognizes exemplary contributions to the education and development of engineering students and to engineering education in Canada.
U of T Engineering professor honoured nationally for excellence in training Canada’s next generation of regenerative medicine leaders
Professor Milica Radisic has been named a recipient of the Talent Builder Award as part of the Stem Cell Network’s 25 for 25 Silver Anniversary Awards, a national initiative recognizing 25 individuals and organizations whose contributions have shaped Canada’s regenerative medicine ecosystem over the past 25 years.
Tiny immune cell particles help blood vessels grow in lab-made human heart tissue
University of Toronto researchers (left: Karl Wagner, right: Milica Radisic) found that tiny particles released by immune cells help blood vessels form in lab grown human heart tissue, offering new insights into heart repair and tissue engineering.
U of T researchers improve maturity of lab-grown heart cells for disease modelling
Professor Craig Simmons and his collaborators have developed a new way to mature lab-grown heart cells so they more closely mimic adult human heart tissue, improving their structure, electrical signaling, and contraction for better heart disease research and drug testing.
Rebuilding the injured brain | Cindi Morshead Lab
The human brain has only a limited ability to repair itself after injury, but scientists are working to change that. In Professor Cindi Morshead’s lab, researchers study neural stem cells: the rare cells capable of generating new neurons and support cells in the brain. Her team investigates how these stem cells grow, migrate, and specialize, and how they can be guided to help repair damage caused by stroke, spinal cord injury, and childhood brain injuries.
Researchers highlight “regenerative healing” as a holistic framework for future health innovations
A new paper by Professors Michael V. Sefton (University of Toronto) and Malcolm King and Alexandra King (University of Saskatchewan) introduces the term “regenerative healing” as a complementary, more holistic concept to regenerative medicine. The authors suggest the framework may better reflect Indigenous perspectives on health and wellness and support more inclusive conversations about emerging biomedical therapies.