Molecular Engineering
Molecular engineering aims to advance disease detection, customize drug delivery and improve health-care outcomes with faster and more precise technologies and systems.
Check out the case studies below to learn about the exciting research done here at BME:
Nanotechnology
Shape-shifting nanoparticles for delivering cancer drugs to tumours
Chemotherapy isn’t supposed to make your hair fall out — it’s supposed to kill cancer cells.
Professor Warren Chan’s Integrated Nanotechnology & Biomedical Sciences Laboratory builds targeted drug delivery systems designed to enter specific areas of your body. He and his team have created a set of nanoparticles attached to strands of DNA that function like a protein, but can be programmed to change shape and chemistry, allowing them to navigate through the traps in the body and gain access into diseased tissue.
Their discovery will lead to further advances in personalized nanomedicine — enabling tailored particles to deliver drugs into targeted types of tumours, and nowhere else.
Molecular Imaging
Smarter scans for earlier cancer detection
Professor Hai-Ling Margaret Cheng was working as an electrical engineer in the aerospace and defense industry when she realized the signal-processing techniques she was using could also enhance magnetic resonance imaging (MRI) scans.
Today, her team is dedicated to improving MRI technology. Specifically, the Cheng Lab looks at ways to modify and enhance chemicals that give off a strong magnetic resonance signal, known as contrast agents, to accentuate visual accuracy of specific tissues and organs. Her lab is also developing novel, rapid imaging approaches to give us information about tissue physiology and functional dynamics.
Her developments in this area have proven promising in earlier cancer detection and stem cell observations for human tissue repair.
Systems Biology
Shrinking the lab—mini diagnostic tools for rapid, on-site results
Professor Aaron Wheeler is taking the lab to you.
His team builds miniature labs using digital microfluidics — a liquid-handling technology that can analyze tiny drops of chemical and biological fluids on site. Using electrostatic forces, their lab-on-a-chip device can manipulate these samples and probe them with built-in sensors for rapid analysis, all on something the size of a credit card.
The technology aims to allow advanced diagnostic tests to be performed at a patient’s bedside or in remote places around the world to give accurate results in less time.
Read more news about molecular engineering
New research has potential to speed up forensic analysis in sexual assault cases
Professor Aaron Wheeler and his team has developed a new technique for analyzing evidence in sexual assault cases. The new approach could streamline the forensics pipeline and reduce delays in the processing of DNA evidence.
Three BME faculty members awarded Connaught New Researcher Fund
Professors Aereas Aung, Daniel Franklin, and Caitlin Maikawa were awarded the Connaught New Researcher Awards, which support early-career faculty members in establishing their research programs. They are among 8 researchers from the U of T Engineering who received support in the latest round.
Five BME faculty members & collaborators receive a combined $2.6mil+ funding from CIHR
Professors Hai-Ling Margaret Cheng, Leo Chou, Daniel Franklin, Naomi Matsuura, and Cari Whyne and their collaborators have received a combined funding of $2.6mil+ from the Canadian Institute of Health Research (CIHR) as a part of the 2024 Spring CIHR Project Grant. The CIHR Project Grant program funds innovative health research projects with the potential to significantly advance health knowledge, healthcare, health systems, and health outcomes.
11 BME faculty members receive a combined $500,000+ funding from NSERC
The Discovery Grant program is dedicated to supporting researchers as they venture into new territories to find solutions to pressing issues such as environmental protection, food security, and sustainable construction in cold climates. It aims to promote and maintain a diverse and high-quality research capability in the natural sciences and engineering at Canadian universities, foster research excellence, and provide a stimulating environment for research training.
Seven BME members receive Joint Seed Program funding for interdivisional research
Initiated in 2015, the Joint Seed Program is an interdivisional research funding program designed to promote multi-disciplinary research and catalyze new innovative partnerships between researchers from the Faculty of Applied Science and Engineering and those from outside of Engineering. The recipients for this year will undertake unique and innovative research initiatives ranging from developing bioinoculant strategies to equitable healthcare and advanced imaging techniques.
Accelerate Seed Grant recipient aims to improve delivery of drugs that treat brain diseases using self-driving lab technology
Professor Leo Chou have received Acceleration Consortium Seed Grant funding for his research on building DNA origami as a delivery vehicle for therapeutic agents