Graduate Student Seminar Series – Hugo Higueros

Graduate Student Seminar Series
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Location: WB116
Presentation Title: Long-term Renal Fibrosis Evaluation Through Implantable Spectrometry-based Device
Abstract: It is estimated that renal fibrosis affects 10% of the global population. There is also no widely accepted paradigm for slowing the progression of renal fibrosis, attributed to a limited understanding of how renal fibrosis functions and evolves. In recent years there have been several attempts at studying renal fibrosis in a non-invasive manner through different technologies, that range from elastography to Magnetic Resonance Imaging. However, the proposed methods are highly limited in sensitivity and time resolution/duration. Therefore, it is of high interest to develop a technology capable of tracking the progression of renal fibrosis. Recent advancements in miniaturized, wireless optoelectronic devices have made it possible to detect and monitor biomarker chromophores in vivo, including tissue oximetry and blood volume. Here, we propose the development and validation of a long-term implantable, wireless spectroscopy device for assessing fibrotic load on the kidney on a comprehensive manner. Said device will utilize the UV-VIS and SWIR wavelength regimes to characterize collagen deposition and the effects it has on the hemodynamics of renal tissue. The device will probe various location of the renal tissue in order to account for the spatial heterogeneity of fibrotic deposition on kidney diseases. The sum of all these state-of-the-art technologies has the potential to substantially better the diagnosis and prognosis the currently irreversible and poorly characterized pathology.
Supervisor Name: Dr. Daniel Franklin
Year of Study: 2
Program of Study: PhD
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