Graduate Seminar Series: Cell and Tissue Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.
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Presentation Title: Extracellular Matrix Modification of Vascularizing Methacrylic Acid-based Hydrogel
Abstract: Pancreatic islet transplantation is a promising therapy for type 1 diabetes that can re-introduce intrinsic glycemic regulation. The Sefton lab has shown that an inherently vascularizing, degradable poly(sodium methacrylate)-poly(ethylene glycol) (MAA-PEG) hydrogel is a suitable material for subcutaneous islet delivery. However, enzymatic digestion of the native extracellular matrix (ECM) during islet isolation (collagenase) disrupts islet cell-matrix communications, impairing islet function and inducing anoikis (apoptosis due to a loss of ECM connections). We hypothesize that the addition of collagen to the synthetic MAA-PEG hydrogel will restore cell-matrix communication, thereby improving islet health and function after transplantation.
Supervisor Name: Michael Sefton
Year of Study: 2
Program of Study: MASc
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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