Graduate Seminar Series: Cell and Tissue Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.
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Presentation Title: Sticky conductive membrane relieves atrial fibrillation: efficacy analysis
Abstract: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia, significantly contributing to public health care expenditure and cardiovascular disease-related mortality. While the mechanisms remain unclear; more evidence has been found to support the spiral wave theory of AF persistence, stating that a high-frequency reentrant circuit originating from the singularity could act as a relatively stable source of disturbed conduction, which would eventually lead to the development of the fibrillation burden. Targeting the electrophysiological features of biological tissues, biomaterial has emerged in recent decades with promising potentials. We have focused on studying the novel conductive biomaterial in cardiac applications to facilitate the propagation of the electrical signals between cardiomyocytes that are physically separated due to structural and functional electrical blockages, including fibrotic scarring. In this study, I hypothesized that the use of conductive biomaterial could facilitate the biological action potential propagation between physically isolated cardiomyocytes, which can then lead to the relief of the rotor-originated spiral electrical waves to relieve the atrial fibrillation burdens. More specifically, a conductive sticky bilayer Gel-PDA membrane is implanted to the right atrial surface of the Lkb1 knockout transgenic AF mouse models to target the electrophysiological pathogenesis of atrial fibrillation. Here, the efficacy evaluation is performed by the in Vivo surface electrocardiogram, echocardiogram, and the programmed electric stimulation (PES) based arrhythmia susceptibility test.
Supervisor Name: Dr. Ren-ke Li
Year of Study: 4
Program of Study: PhD
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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