Graduate Seminar Series: Cell and Tissue Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.
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Presentation Title: Bioadhesion: Reverse Engineering the Adhesion Mechanism of Freshwater Mussels, The Dresseinids
Abstract: Currently, synthetic biocompatible adhesives have been ineffective due to inflammatory reactions or poor strength1. Researchers have attempted to improve upon these adhesives, but limitations still exist. A synthetic bioadhesives that can function in wet conditions could be a better alternative for tissue reconnections1-2. On the other hand, many marine and freshwater organisms have adapted to secrete their own holdfast that is resistant to water3. My research aims to understand how freshwater mussels (of the Dresseina genus) adhere to surfaces underwater. Since the adhesion mechanism is largely underexplored in freshwater mussels, direct translation to a potential bioadhesives will not be the goal of this project. Rather, elucidating the adhesion mechanism of the freshwater mussel, Dresseina bugensis, will be the primary objective. This report presents a biochemical and biophysical approach to elucidate the molecular mechanism of wet adhesion of freshwater mussels. The Dreisseinid byssal proteome and byssal conditions will be described with emphasis on further characterization of Dresseina bugensis foot protein 7 (Dbfp-7) and other adhesive proteins. Characterization of the byssal proteins will provide insight to a potentially novel mechanism of wet adhesion that may improve upon the design requirements of current synthetic wet adhesives.
Supervisor Name: Eli Sone
Year of Study: 2
Program of Study: PhD
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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