Graduate Seminar Series: Cell and Tissue Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.
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Presentation Title: Injectable Mineralized Collagen Hydrogel for Bone Repair
Abstract: Despite the bone’s natural capacity to self-heal (due to innervation and vascularization), critical-sized defects lack such capacities without surgical procedures. Recent advances have explored cell therapy for bone regeneration, such as using bone marrow-derived mesenchymal stromal cells (BM-MSCs), as a surgical alternative. BM-MSCs are multipotent and low-immunogenic cells that also have self-renewal and differentiation properties. Specifically, these cells have been robustly demonstrated in murine models to develop osteoblast-like phenotypes. However, the injection of BM-MSCs alone is challenged by poor cellular retention and localization to the areas of defect, resulting in insufficient cell populations for subsequent differentiation processes. To overcome this limitation, biomaterials development, specifically in the form of hydrogels and scaffolds, has been an area of interest. Although both synthetic and natural hydrogels have been developed, there has not yet been a biomaterial that is injectable, capable of encapsulating cells, and can provide a biomechanical environment for better bone repair potentials. We propose to develop a novel hydrogel by finetuning the nanostructure, mineralization, and stiffness of reconstituted collagen fibrils to promote the differentiation of BM-MSCs into bone cell phenotypes for new bone formation. Understanding the optimal biomechanical properties of a mineralized collagen hydrogel for bone regeneration will broaden the applicability of current hydrogel technologies and BM-MSC therapies.
Supervisor Name: Eli Sone, Sowmya Viswanathan
Year of Study: 2
Program of Study: PhD
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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