Graduate Seminar Series: Clinical Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for clinical stream presenters.
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Presentation Title: A Firing Rate Network Model on the Thalamic Deep Brain Stimulation
Deep brain stimulation (DBS) is a standardized therapy of many neurological motion disorders, e.g., Parkinson’s disease and essential tremor. However, the DBS therapeutic mechanisms on the disease-related neuronal networks remain elusive. DBS mechanism detection is challenging due to insufficient quantitative understandings and the sparsity of human data. For human subjects, neuronal data can only be recorded with safe parameter settings on a very small proportion of neurons.
We developed a firing rate network model on the neuronal circuits receiving DBS, and implemented the model in investigating the network mechanism underlying the thalamus-DBS in treating essential tremor. We accurately reproduced the experimental single-unit recordings on the neurons in thalamic ventral intermediate nucleus (Vim) during DBS; the model fit is precise and consistent across various DBS frequencies (5~200Hz). We found the role of inhibitory nuclei is critical in stabilizing the network and accurately fitting the experimental data. Our model can be potentially implemented in optimizing the DBS frequencies for maximal clinical effects.
Supervisor Name: Milos Popovic and Milad Lankarany
Year of Study: 4
Program of Study: PhD
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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