Graduate Seminar Series: Molecular Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.
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Presentation Title: Investigating the relationship between tumour metabolism and nanoparticle accumulation
Cancer is one of the leading causes of death in the world. The principle has guided nanoparticles designed for
cancer treatment that nanoparticle transport into the tumour is a passive and concentration-driven process.
Recent studies have found that nanoparticle transport into tumours is predominantly an active process.
Understanding the driving force of this active transport enables us to design the next generation of
nanoparticles. Metabolism describes all the energy-producing processes in a biological system. As tumours
grow, their need for nutrients and other building blocks increases. This may lead to nonspecific uptake of
available resources circulating in the tumour blood vessels. The objective of the proposed thesis is to answer
the question: does tumour metabolism drive nanoparticle accumulation? The result of this project will
describe a relationship between tumour nanoparticle accumulation and tumour metabolic activity. The
significance of this study defines the mechanistic cause of nanoparticle transport into tumours under the new
paradigm. This understanding enables us to exploit metabolism to increase the effectiveness of nanoparticle
drug carriers for cancer treatment. For example, we may manipulate a patient’s diet to increase nanoparticle
delivery to solid tumours. This strategy can lead to higher drug delivery and more effective cancer treatment.
Supervisor Name: Warren Chan
Year of Study: 2
Program of Study: PhD
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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