Graduate Seminar Series: Molecular Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for molecular stream presenters.
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Presentation Title: The role of nanoparticle surface protein residence time on uptake by cells
Abstract: Nanoparticles are designed to deliver a high volume of cancer drugs to tumors. However, less than 1% of injected nanoparticles reach tumors. This can be attributed to blood proteins adsorbing to the nanoparticle surface and targeting them for clearance. Long circulating nanoparticles were designed to increase nanoparticle tumor payload. Long circulating nanoparticles are conjugated with hydrophilic polymers that decrease protein residence time on their surface. This leads to less protein adsorption, decreased clearance, and increased accumulation in tumors. Paradoxically the rate of long circulating nanoparticle cell uptake is slower than that of short circulating nanoparticle designs. This project investigates the effect of decreasing nanoparticle protein residence time on cell uptake kinetics.
Supervisor Name: Dr Warren Chan
Year of Study: 3
Program of Study: PhD
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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