Graduate Student Seminar Series – Adam Gravitis

Graduate Student Seminar Series
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Location: WB116
Presentation Title: Wavelet Phase Coherence of Ictal Scalp EEG-Extracted Muscle Activity (SMA) as a Biomarker for Sudden Unexpected Death in Epilepsy
Abstract:
Objective Approximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with epilepsy are attributed to sudden unexpected death in epilepsy (SUDEP). The goal of the present work was to establish a biomarker for SUDEP so that preventive treatment can be instituted.
Approach Seizure activity in patients with SUDEP and non-SUDEP was analyzed, specifically, the scalp EEG extracted muscle activity (SMA) and the average wavelet phase coherence (WPC) during seizures was computed for two frequency ranges (1-12 Hz, 13-30 Hz) to identify differences between the two groups.
Main results Ictal SMA in SUDEP patients showed a statistically higher average WPC value when compared to non-SUDEP patients for both frequency ranges. Area under curve for a cross-validated logistic classifier was 81%.
Significance Average WPC of ictal SMA is a candidate biomarker for early detection of SUDEP.
Supervisor Name: Berj Bardakjian
Year of Study: 4
Program of Study: PhD
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