Graduate Student Seminar Series – Jonathan Wu

Graduate Student Seminar Series
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Location: WB116
Presentation Title: Investigation of wearable spectroscopy systems for the characterization of depth-resolved tissue oxygenation
Abstract: Recent advances in optical sensor technology will enable the evaluation and monitoring of ischemic diseases at home. Near infrared spectroscopy (NIRS) is a standard tool in the evaluation of tissue ischemia and a cost-effective method for estimating hemoglobin oxygenation and tissue perfusion without an invasive procedure. However, most continuous-wave NIRS systems are wired, bed-side systems and assume an averaged tissue oxygenation for the tissue depths it probes. The ability to resolve tissue oxygenation at specific tissue layers may allow for greater accuracy and the detection of dynamic vascular activity. The objective of this proposed study is to evaluate the effectiveness of wearable technology in measuring depth-resolved tissue oxygenation. I will achieve this through: (1) fabrication of a wearable multi-detector, continuous-wave spectroscopy device (2) developing a numerical algorithm for the discretization of hemodynamic properties at stratified tissue depths via optical simulations, and (3) evaluation of wearables and methods compared to photoacoustic imaging in healthy individuals during vasomodulatory stimuli. By completing this study, I will develop a method and technology for monitoring tissue ischemia in ambulatory patients. This study will provide valuable insight into the feasibility of using wearable technology to non-invasively monitor tissue oxygenation at different depths, which could have important applications in the monitoring of wound healing and tissue perfusion in medical conditions such as diabetes and peripheral artery disease.
Supervisor Name: Daniel Franklin
Year of Study: 3
Program of Study: PhD
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