Research News and Stories
Explore the latest news, stories, and groundbreaking research happening at the Institute of Biomedical Engineering. Stay updated on innovative projects, impactful discoveries, and the achievements of our talented students, faculty, and alumni shaping the future of biomedical science and engineering.
Quick Navigation
Joint efforts propel transformative scientific discoveries
Professor Caitlin Maikawa, a Schmidt Science Fellow, was recently featured by Times Higher Education about her interdisciplinary research at the Institute of Biomedical Engineering.
Five BME faculty members & collaborators receive a combined $2.6mil+ funding from CIHR
Professors Hai-Ling Margaret Cheng, Leo Chou, Daniel Franklin, Naomi Matsuura, and Cari Whyne and their collaborators have received a combined funding of $2.6mil+ from the Canadian Institute of Health Research (CIHR) as a part of the 2024 Spring CIHR Project Grant. The CIHR Project Grant program funds innovative health research projects with the potential to significantly advance health knowledge, healthcare, health systems, and health outcomes.
New technique improves measurement of cell barriers
Researchers at the University of Toronto have developed a novel, cost-effective method called Porous Membrane Electrical Cell–Substrate Impedance Spectroscopy (PM-ECIS) to assess the function of biological barriers in Petri dishes. In a subsequent study, the researchers characterized its sensitivity and further validated the method against a gold-standard barrier assessment technique. This new method could enhance research in fields like drug development and disease modeling.
Immune cells pave the way for advanced Heart-on-a-Chip Technology
Researchers at the University of Toronto have made strides in heart disease research by incorporating primitive macrophages—a crucial immune cell—into heart-on-a-chip technology. This innovative approach promises to enhance the functionality and stability of engineered heart tissues, potentially transforming drug testing and disease modeling.
Professor Alison McGuigan awarded Senior Scientist Award at 7th TERMIS World Congress
Professor Alison McGuigan has been honored with the prestigious Tissue Engineering and Regenerative Medicine International Society Americas Chapters (TERMIS-AM) Senior Scientist Award. This esteemed award was presented to Professor McGuigan on the final day of the 7th TERMIS World Congress Conference, held from June 25-28 in Seattle, Washington. The Senior Scientist Award is conferred upon individuals who have made significant contributions to the fields of tissue engineering and regenerative medicine.
11 BME faculty members receive a combined $500,000+ funding from NSERC
The Discovery Grant program is dedicated to supporting researchers as they venture into new territories to find solutions to pressing issues such as environmental protection, food security, and sustainable construction in cold climates. It aims to promote and maintain a diverse and high-quality research capability in the natural sciences and engineering at Canadian universities, foster research excellence, and provide a stimulating environment for research training.
Molly Shoichet named inaugural Pamela and Paul Austin Chair in Precision and Regenerative Medicine
University Professor Molly Shoichet (ChemE, BME) has been named the inaugural Pamela and Paul Austin Chair in Precision and Regenerative Medicine. The chair, situated within the Department of Chemical Engineering & Applied Chemistry, was created in November 2023 via a gift from the The P. Austin Family Foundation.
Functional Electrical Stimulation sleeve to improve rehabilitation for motor control impairments
A recent study published in BioMedical Engineering OnLine introduces a novel smart sleeve designed for Functional Electrical Stimulation (FES) applications. This new technology integrates advanced carbon-based dry electrodes within a textile structure, offering significant improvements in comfort and usability for patients with motor control impairments.
Miniaturized assay promises faster discovery of stem cell therapies
Researchers at the University of Toronto have developed a new miniaturized assay platform, mini-MEndR, designed to evaluate muscle stem cell-mediated repair in a more efficient and scalable manner. This novel platform, funded by CFREF “Medicine by Design”, represents a significant advancement in the field of regenerative medicine, offering the potential to accelerate the discovery of therapeutic targets for muscle repair and regeneration.
New imaging technique to improve the study of heart valve disease in mice
Researchers from the Institute of Biomedical Engineering (BME) at the University of Toronto and the Translational Biology and Engineering Program in the Ted Rogers Centre for Heart Research have developed an ultrasound imaging protocol that promises to transform how congenital heart valve diseases are studied in mice. This new technique allows scientists to identify structural abnormalities in the aortic valve of juvenile mice as young as four weeks old, paving the way for more efficient, cost-effective, and humane research practices.
Seven BME members receive Joint Seed Program funding for interdivisional research
Initiated in 2015, the Joint Seed Program is an interdivisional research funding program designed to promote multi-disciplinary research and catalyze new innovative partnerships between researchers from the Faculty of Applied Science and Engineering and those from outside of Engineering. The recipients for this year will undertake unique and innovative research initiatives ranging from developing bioinoculant strategies to equitable healthcare and advanced imaging techniques.
CIHR awards grant to training program integrating sex, gender, and intersectionality in health research
A team of researchers has been awarded an operating grant from the Canadian Institutes of Health Research (CIHR). The team, led by Dr. Tatyana Mollayeva, Dr. Milos Popovic, and Dr. France Légaré, is set to improve the landscape of health research by integrating sex, gender, and intersectionality into scientific inquiry.
Enhancing Neurostimulation
Researchers at UHN’s KITE Research Institute have recently leveraged the power of deep learning to improve nerve signalling interpretation, paving the way for more effective neuroprosthetic devices and offering new hope for those with impaired motor function.
New Models for Eye Disease
A research team at UHN’s Donald K. Johnson Eye Institute in collaboration with the Institute of Biomedical Engineering at the University of Toronto (U of T) has discovered that transplanted retinal cells can share essential materials with host cells in the lab, offering a promising avenue for delivering therapies directly to damaged areas of the eye.
Canadian Hub for Health Intelligence and Innovation in Infectious Diseases awarded $72 million to strengthen talent development and health intelligence
One of the CBRF-funded programs is the Biomanufacturing Hub Network, an immersive talent development program based at the University of Toronto led by U of T University Professor Molly Shoichet (ChemE, BME) along with Darius Rackus, an assistant professor of chemistry and biology at Toronto Metropolitan University, and Gilbert Walker, a professor of chemistry at U of T.
Computational model unveils dynamics of Deep Brain Stimulation
Deep Brain Stimulation (DBS) has been a longstanding adjunctive therapy for movement disorders like Parkinson’s disease, yet its precise mechanisms of action have remained elusive. In a recent study published in the journal Neuromodulation, Dr. Milad Lankarany and his team have introduced a computational model that accurately predicts the dynamics of neuronal activity during DBS across various frequencies.
New research aimed to improve early childhood music education
Researchers from the University of Toronto have unveiled a new technological breakthrough that promises to transform early childhood music education. The study addresses a critical gap in musical instrument classification, particularly concerning non-pitched percussion instruments. The findings are published in a recent issue of PLOS one.
Accelerate Seed Grant recipient aims to improve delivery of drugs that treat brain diseases using self-driving lab technology
Professor Leo Chou have received Acceleration Consortium Seed Grant funding for his research on building DNA origami as a delivery vehicle for therapeutic agents
Dr. Omar F. Khan honoured with the McCharles Prize for early career research distinction
Professor Omar F. Khan has been awarded the prestigious McCharles Prize for Early Career Research Distinction for his contributions to the fields of biomedical and immune engineering.
Enhancing Balance Rehabilitation
Researchers from UHN’s KITE Research Institute have investigated a new affordable and clinically accessible training system for improving the standing balance of spinal cord injury patients. The team led by Dr. Kei Masani, KITE Senior Scientist and senior author of the study, investigated the integration of low-cost and portable sensors like a depth camera and pressure mat, which use motion tracking and distribution of pressure, respectively, to analyze movement.
New study reveals insights into extracellular matrix’s influence on regeneration
A study published in the Journal of Cell Science, led by Professor Penney Gilbert (BME) and Jo Nguyen at the University of Toronto, shed light on the impact of culture substrate stiffness and extracellular matrix (ECM) ligands on the contractility, proliferation, and various cellular processes of human myoblasts. The study aims to understand how these factors influence the regenerative activities of muscle stem cells and their progeny, with implications for aging and disease.
Research utilizes machine learning to improve gait analysis in rehabilitation
The latest research led by Prof. Jan Andrysek published in a peer-reviewed article showcases a pioneering approach to gait analysis, a crucial aspect of rehabilitation and clinical diagnosis. Clinicians have long relied on gait indicators like step length, stride velocity, and joint angles to assess and treat gait issues. However, traditional statistical methods have limitations in analyzing the vast sets of data generated by instrumented gait analysis techniques.
BME Professor secures CIHR funding to improve autism medication selection
Dr. Azadeh Kushki (BME) has been awarded funding from the Canadian Institutes of Health Research (CIHR) for her work in improving medication selection for autistic children. Along with Dr. Danielle Baribeau, Dr. Melanie Penner, and Marlee Vandewouw at the Holland Bloorview Kids Rehabilitation Hospital, this funding provides operational support to perform research.
Heart-on-a-chip model created by U of T researchers uncovers insights into heart problems caused by COVID-19
University of Toronto researchers have created a unique heart-on-a-chip model that is helping untangle the causes of COVID-19-induced heart inflammation and uncover strategies to reduce its impact.