Graduate Seminar Series: Cell and Tissue Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.
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Presentation Title: Development of a Biodegradable Polymeric Nanoparticle Vascular Delivery System for Therapeutic Peptides
Abstract: Balloon angioplasty, often in conjunction with stenting, is the current standard of care to restore immediate blood flow in arteries affected by atherosclerosis. However, long-term prevention of arterial re-occlusion, known as restenosis, is lacking. Persistent inflammation, heightened immunogenicity, neointimal hyperplasia, and poor reendothelialization remain significant barriers to effective treatment. The proposed research investigates noninflammatory biodegradable nanoparticles as an excipient for therapeutic peptides that can be coupled with traditional endovascular balloon angioplasty techniques to address these longterm treatment concerns. Therapeutic peptide coated nanoparticles incorporated onto an endovascular balloon are hypothesized to establish a sustained controlled release of peptide capable of inhibiting smooth muscle cell migration without compromising vessel reendothelialization upon release from the balloon surface.
Supervisor Name: Dr. Paul Santerre
Year of Study: 2
Program of Study: MASc
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
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