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Graduate Seminar Series: Cell and Tissue Stream – Keyu Zhuang
March 23, 2023 @ 12:30 pm - 1:00 pm EDT
Graduate Seminar Series: Cell and Tissue Stream
Graduate Seminar Series for the Institute of Biomedical Engineering (BME). This day is for cell and tissue stream presenters.
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Presentation Title: Novel Magnetic Resonance Imaging Approach for In-vivo Long-term Stem Cell Tracking
Abstract:
Many tissues and organs in the human body, such as the heart and the brain, cannot regenerate after injury or disease. Stem cells are a source for regeneration, as they are self-renewing and can become diverse specialized cell types. Currently, when stem cells are injected into the body, there is no information on whether or not they survive, grow, and contribute to improved tissue function until histology is performed. While this approach can be adopted in animal studies, it nonetheless precludes probing cell viability, retention, distribution, and interaction with host tissue in a temporal manner. A technology that enables non-invasive cell tracking in deep tissue would address these hurdles and pave the way for stem cell treatment optimization and translation.
The main objective of this project is to develop and apply a novel magnetic resonance imaging (MRI) cell tracking platform for non-invasive, high resolution visualization, monitoring, and evaluation of therapeutic stem cells inside a living subject. In the current research, we develop and apply our cell tracking platform to human embryonic stem cells (hESC)-derived cardiomyocytes for cardiac regeneration. The stem cells will be “labeled” by inserting a reporter gene into the genome. When the edited cells are exposed to MR-active metal ions, the cells will light up on MRI.
Supervisor Name: Hai-Ling Margaret Cheng
Year of Study: 4
Program of Study: PhD
Zoom link: https://us02web.zoom.us/j/89610372821?pwd=azd4SCtYVWtreVovaGNPV1c2NGY2Zz09
Meeting ID: 896 1037 2821
Password: 483329
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