Plasmon-enhanced Fluorescence Induced Stimulated Raman Scattering as Non-destructive Non-linear Optical Method in Nanobiosensing and Bioimaging

MC 331 5 King's College Rd, Toronto, ON, Canada

Mohammad E. Khosroshahi Nanobiophotonics & Biomedical Research Laboratory, MIS-Electronics Inc., Richmond Hill, Canada   Abstract This work describes the generation and observation of multi-wavelengths due to stimulated Raman scattering (SRS) from deep red to near-infrared (NIR) induced by plasmon-enhanced fluorescence (PEF) of fluorescein isothiocyanate (FITC) conjugated gold nanoparticles (F-AuNP). The plasmonic solution was excited by […]

Polymer Nanoparticle Design and Delivery Strategies to Resolve Vascular Inflammation

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Dr. Laura Bracaglia, PhD Villanova University Polymer nanoparticles (NPs) can provide a safe and efficient delivery mechanism for therapy directly at specific tissues and cells, but achieving sufficient levels of NPs and therefore therapeutics in target tissues in humans has remained a barrier to the translation of this technology. The in vivo efficacy of polymeric […]

Carbon nanomaterials for cardiac regenerative medicine

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Dr. Sanjiv Dhingra, PhD University of Manitoba Abstract: Donor derived allogeneic stem cells including mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) are being tested in animal studies and clinical trials for cardiac regeneration and repair. The outcome of initial studies was very encouraging and transplanted cells were safe in the recipient heart. However, […]

Following the Rabbit into Chemical Space

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Dr. Brian K. Shoichet, PhD University of California, San Francisco  https://utoronto.zoom.us/j/86086638773 Meeting ID: 860 8663 8773 Passcode: 484696 Structure-based docking can be used to screen compound libraries for novel ligands. Recently, docking libraries  have expanded from three million “in-stock” to over four billion make-on-demand (“tangible”) molecules. Docking these new libraries versus the dopamine, melatonin, and […]

Tiny Bubbles: New Applications of Nanoscale Contrast Media in Ultrasound-based Cancer Diagnosis and Therapy

Princess Margaret Cancer Research Tower (PMCRT) Room 4-204 101 College St, 4th Floor, Rm 4-204, Toronto, Ontario, Canada

Princess Margaret Special Seminar presents:   AGATA EXNER, Ph.D Henry Willson Payne Professor & Vice Chair for Basic Research Department of Radiology Case Western Reserve University School of Medicine University Hospitals of Cleveland, Ohio   Host: Dr. Gang Zheng Sponsored by Medical Biophysics, University of Toronto

Delivery of Biologics for Rotator Cuff Muscle Healing – Dr. Johnna Temenoff

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Speaker Dr. Johnna Temenoff, PhD Georgia Tech/Emory University Abstract After rotator cuff tendon tear, marked degeneration of the attached muscle is apparent clinically, with both fibrous and fatty infiltration of the tissue. Our laboratory is working on delivery strategies for biologics, including proteins and cells, that might slow or reverse this degeneration. In particular, our […]

Immune Engineering: Detection and Treatment of Undesired Immune Responses – Dr. Johnna Temenoff

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Speaker Dr. Lonnie Shea, PhD University of Michigan Abstract Vaccines are the initial immunotherapy by providing a means to activate an immune response to specific antigens to protect against disease. This success has motivated the development of alternative immunotherapies for treating undesired immune responses, such as those found in autoimmune disease, allergy, organ transplantation, and […]

Chemistry in Medicine: translating optical probes to the clinic – Princess Margaret Seminar Series

Prof. Marc Vendrell Chair of Translational Chemistry and Biomedical Imaging Co-Head of IRR Chemistry Hub Centre for Inflammation Research Institute of Regeneration and Repair, The University of Edinburgh   Princess Margaret Cancer Centre Dr. Bob Bell Auditorium, 6th Floor, 6-604 Host:  Dr. Gang Zheng   Everyone Welcome to attend!   Slice & Science event:  Come […]

Using Patient Derived Induced Pluripotent Stem Cells to Model and Treat Inherited Retinal Disease

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Dr. Budd A. Tucker, PhD University of Iowa Abstract: Inherited retinal degenerative disorders, ranging from relatively common conditions such as Stargardt disease to rare forms of retinitis pigmentosa, are extraordinarily genetically heterogeneous. To date more than 100 different genes and thousands of different disease-causing mutations have been identified. The unifying feature of these conditions is […]

TBEP Research Seminar (Dr. Sheng Xu): Wearable ultrasound technology for monitoring deep tissues

Dr. Sheng Xu (University of California San Diego, Associate Professor and Jacobs Faculty Scholar) will demonstrate a soft ultrasonic technology that can noninvasively and continuously acquire dynamic information about deep tissues and central organs. He will also showcase examples of this technology's use in recording blood pressure and flow waveforms in central vessels, monitoring cardiac […]

Targeting myeloid cells for cancer and other human diseases

Princess Margaret Cancer Centre, 610 University Ave, 6th floor, Bob Bell Auditorium

Betty Y.S. Kim, MD, PhD, FRCSC, FAANS Professor, Physician Scientist Department of Neurosurgery UT - MD Anderson Cancer Center Princess Margaret Cancer Centre, 610 University Ave, 6th floor, Bob Bell Auditorium Monday, November 27, 2023 11:00 – 12:00 p.m. Host: Dr. Gang Zheng

Peptide-based materials for soft tissue and organ repair

Emilio I. Alarcóna,b* aUniversity of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology,. bUniversity of Ottawa Heart Institute, Cardiac Surgery, Ottawa, Canada. Abstract Bioinspired synthetic materials offer reliable and cost-effective access to biomaterials. However, the use of potentially toxic chemical crosslinkers for matrix assembly added to the limitations in finely tuning their mechanical properties […]