Following the Rabbit into Chemical Space

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Dr. Brian K. Shoichet, PhD University of California, San Francisco  https://utoronto.zoom.us/j/86086638773 Meeting ID: 860 8663 8773 Passcode: 484696 Structure-based docking can be used to screen compound libraries for novel ligands. Recently, docking libraries  have expanded from three million “in-stock” to over four billion make-on-demand (“tangible”) molecules. Docking these new libraries versus the dopamine, melatonin, and […]

Tiny Bubbles: New Applications of Nanoscale Contrast Media in Ultrasound-based Cancer Diagnosis and Therapy

Princess Margaret Cancer Research Tower (PMCRT) Room 4-204 101 College St, 4th Floor, Rm 4-204, Toronto, Ontario, Canada

Princess Margaret Special Seminar presents:   AGATA EXNER, Ph.D Henry Willson Payne Professor & Vice Chair for Basic Research Department of Radiology Case Western Reserve University School of Medicine University Hospitals of Cleveland, Ohio   Host: Dr. Gang Zheng Sponsored by Medical Biophysics, University of Toronto

Delivery of Biologics for Rotator Cuff Muscle Healing – Dr. Johnna Temenoff

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Speaker Dr. Johnna Temenoff, PhD Georgia Tech/Emory University Abstract After rotator cuff tendon tear, marked degeneration of the attached muscle is apparent clinically, with both fibrous and fatty infiltration of the tissue. Our laboratory is working on delivery strategies for biologics, including proteins and cells, that might slow or reverse this degeneration. In particular, our […]

Immune Engineering: Detection and Treatment of Undesired Immune Responses – Dr. Johnna Temenoff

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Speaker Dr. Lonnie Shea, PhD University of Michigan Abstract Vaccines are the initial immunotherapy by providing a means to activate an immune response to specific antigens to protect against disease. This success has motivated the development of alternative immunotherapies for treating undesired immune responses, such as those found in autoimmune disease, allergy, organ transplantation, and […]

Chemistry in Medicine: translating optical probes to the clinic – Princess Margaret Seminar Series

Prof. Marc Vendrell Chair of Translational Chemistry and Biomedical Imaging Co-Head of IRR Chemistry Hub Centre for Inflammation Research Institute of Regeneration and Repair, The University of Edinburgh   Princess Margaret Cancer Centre Dr. Bob Bell Auditorium, 6th Floor, 6-604 Host:  Dr. Gang Zheng   Everyone Welcome to attend!   Slice & Science event:  Come […]

Using Patient Derived Induced Pluripotent Stem Cells to Model and Treat Inherited Retinal Disease

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Dr. Budd A. Tucker, PhD University of Iowa Abstract: Inherited retinal degenerative disorders, ranging from relatively common conditions such as Stargardt disease to rare forms of retinitis pigmentosa, are extraordinarily genetically heterogeneous. To date more than 100 different genes and thousands of different disease-causing mutations have been identified. The unifying feature of these conditions is […]

TBEP Research Seminar (Dr. Sheng Xu): Wearable ultrasound technology for monitoring deep tissues

Dr. Sheng Xu (University of California San Diego, Associate Professor and Jacobs Faculty Scholar) will demonstrate a soft ultrasonic technology that can noninvasively and continuously acquire dynamic information about deep tissues and central organs. He will also showcase examples of this technology's use in recording blood pressure and flow waveforms in central vessels, monitoring cardiac […]

Targeting myeloid cells for cancer and other human diseases

Princess Margaret Cancer Centre, 610 University Ave, 6th floor, Bob Bell Auditorium

Betty Y.S. Kim, MD, PhD, FRCSC, FAANS Professor, Physician Scientist Department of Neurosurgery UT - MD Anderson Cancer Center Princess Margaret Cancer Centre, 610 University Ave, 6th floor, Bob Bell Auditorium Monday, November 27, 2023 11:00 – 12:00 p.m. Host: Dr. Gang Zheng

Peptide-based materials for soft tissue and organ repair

Emilio I. Alarcóna,b* aUniversity of Ottawa, Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology,. bUniversity of Ottawa Heart Institute, Cardiac Surgery, Ottawa, Canada. Abstract Bioinspired synthetic materials offer reliable and cost-effective access to biomaterials. However, the use of potentially toxic chemical crosslinkers for matrix assembly added to the limitations in finely tuning their mechanical properties […]

Bioinspired Protein-based Cancer Immunotherapy (Dr. Yanpu He, UBC)

Donnelly Centre for Cellular and Biomolecular Research, Red Room, 160 College Street, Toronto, Ontario, M5S 3E1, Canada

Abstract Immunotherapy has revolutionized the field of cancer treatment over the past two decades, though only a small fraction of patients treated will achieve complete remission. As such, new paradigms to overcome resistance to immunotherapies are urgently needed. My research seeks to tailor immunotherapies towards individual differences in immune systems and the inherent heterogeneity of […]

Microfluidic Systems for Cell Biology and Translation into Practice – Majid Warkian

When: October 10, 2024 @ 2:00 pm Location: 160 College Street, Toronto                   CCBR Red Room Abstract: Microfluidics, a technology characterized by the engineered manipulation of fluids at the microscale, has shown considerable promise in point-of-care diagnostics and clinical research. By offering precise control over the cellular microenvironment, microfluidic platforms are becoming valuable tools for […]

Recent Developments in Zwitterionic Materials and Drug Delivery Systems

Special Seminar Date: Friday November 1, 2024 Time: 11:00am – 12:00pm Location: Donnelly Centre, 160 College Street, 2nd Floor, Red Seminar Room Host: Molly Shoichet Speaker: Dr. Shaoyi Jiang, PhD Cornell University “Recent Developments in Zwitterionic Materials and Drug Delivery Systems” Highly biocompatible zwitterionic materials have been applied to implants, medical devices, human induced pluripotent […]