Dr. Laura Bracaglia, PhD Villanova University Polymer nanoparticles (NPs) can provide a safe and efficient delivery mechanism for therapy directly at specific tissues and cells, but achieving sufficient levels of NPs and therefore therapeutics in target tissues in humans has remained a barrier to the translation of this technology. The in vivo efficacy of polymeric […]

Dr. Sanjiv Dhingra, PhD University of Manitoba Abstract: Donor derived allogeneic stem cells including mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) are being tested in animal studies and clinical trials for cardiac regeneration and repair. The outcome of initial studies was very encouraging and transplanted cells were safe in the recipient heart. However, […]

Dr. Brian K. Shoichet, PhD University of California, San Francisco  https://utoronto.zoom.us/j/86086638773 Meeting ID: 860 8663 8773 Passcode: 484696 Structure-based docking can be used to screen compound libraries for novel ligands. Recently, docking libraries  have expanded from three million “in-stock” to over four billion make-on-demand (“tangible”) molecules. Docking these new libraries versus the dopamine, melatonin, and […]

Princess Margaret Special Seminar presents:   AGATA EXNER, Ph.D Henry Willson Payne Professor & Vice Chair for Basic Research Department of Radiology Case Western Reserve University School of Medicine University Hospitals of Cleveland, Ohio   Host: Dr. Gang Zheng Sponsored by Medical Biophysics, University of Toronto

Speaker Dr. Johnna Temenoff, PhD Georgia Tech/Emory University Abstract After rotator cuff tendon tear, marked degeneration of the attached muscle is apparent clinically, with both fibrous and fatty infiltration of the tissue. Our laboratory is working on delivery strategies for biologics, including proteins and cells, that might slow or reverse this degeneration. In particular, our […]

Speaker Dr. Lonnie Shea, PhD University of Michigan Abstract Vaccines are the initial immunotherapy by providing a means to activate an immune response to specific antigens to protect against disease. This success has motivated the development of alternative immunotherapies for treating undesired immune responses, such as those found in autoimmune disease, allergy, organ transplantation, and […]