Posts Tagged: Cell & Tissue Engineering
Researchers at the University of Toronto have developed a method for co-delivering therapeutic RNA and potent drugs directly into cells, potentially leading to a more effective treatment of diseases in the future. This research, recently published in Advanced Materials, explores how ionizable drugs can be used to co-formulate small interfering RNA (siRNA) for more effective intracellular delivery.
Professors Aereas Aung, Daniel Franklin, and Caitlin Maikawa were awarded the Connaught New Researcher Awards, which support early-career faculty members in establishing their research programs. They are among 8 researchers from the U of T Engineering who received support in the latest round.
Listen to the podcast hosted by The Hub, where they chat with University of Toronto professor and Canadian Research Chair of organ-on-a-chip engineering Milica Radisic discussing her world-leading research on organ-on-a-chip technology.
Professors Hai-Ling Margaret Cheng, Leo Chou, Daniel Franklin, Naomi Matsuura, and Cari Whyne and their collaborators have received a combined funding of $2.6mil+ from the Canadian Institute of Health Research (CIHR) as a part of the 2024 Spring CIHR Project Grant. The CIHR Project Grant program funds innovative health research projects with the potential to significantly advance health knowledge, healthcare, health systems, and health outcomes.
Researchers at the University of Toronto have developed a novel, cost-effective method called Porous Membrane Electrical Cell–Substrate Impedance Spectroscopy (PM-ECIS) to assess the function of biological barriers in Petri dishes. In a subsequent study, the researchers characterized its sensitivity and further validated the method against a gold-standard barrier assessment technique. This new method could enhance research in fields like drug development and disease modeling.
Researchers at the University of Toronto have made strides in heart disease research by incorporating primitive macrophages—a crucial immune cell—into heart-on-a-chip technology. This innovative approach promises to enhance the functionality and stability of engineered heart tissues, potentially transforming drug testing and disease modeling.
Professor Alison McGuigan has been honored with the prestigious Tissue Engineering and Regenerative Medicine International Society Americas Chapters (TERMIS-AM) Senior Scientist Award. This esteemed award was presented to Professor McGuigan on the final day of the 7th TERMIS World Congress Conference, held from June 25-28 in Seattle, Washington. The Senior Scientist Award is conferred upon individuals who have made significant contributions to the fields of tissue engineering and regenerative medicine.
The Discovery Grant program is dedicated to supporting researchers as they venture into new territories to find solutions to pressing issues such as environmental protection, food security, and sustainable construction in cold climates. It aims to promote and maintain a diverse and high-quality research capability in the natural sciences and engineering at Canadian universities, foster research excellence, and provide a stimulating environment for research training.
Researchers at the University of Toronto have developed a new miniaturized assay platform, mini-MEndR, designed to evaluate muscle stem cell-mediated repair in a more efficient and scalable manner. This novel platform, funded by CFREF “Medicine by Design”, represents a significant advancement in the field of regenerative medicine, offering the potential to accelerate the discovery of therapeutic targets for muscle repair and regeneration.
Researchers from the Institute of Biomedical Engineering (BME) at the University of Toronto and the Translational Biology and Engineering Program in the Ted Rogers Centre for Heart Research have developed an ultrasound imaging protocol that promises to transform how congenital heart valve diseases are studied in mice. This new technique allows scientists to identify structural abnormalities in the aortic valve of juvenile mice as young as four weeks old, paving the way for more efficient, cost-effective, and humane research practices.
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